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Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

Biomedical and Environmental Sciences 2024年第1期37卷 112-116页

作者： ZHANG Ying TIAN Qi Qi HU Wen dong ZHANG Shao Bo WANG Shi Gong ZHENG Can Jun Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225SichuanChina Yunnan R&D Institute of Natural Disaster on Chengdu University of Information Technology Kunming 650034YunnanChina Chengdu Plain Urban Meteorology and Environment Sichuan Provincial Field Scientific Observation and Research Station Chengdu 610225SichuanChina Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and PreventionBeijing 102206China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant ***,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

关键词： mixtures monoxide consequences

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Promotional effect of cobalt doping on catalytic performance of cryptomelane-type manganese oxide in toluene oxidation

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Journal of Environmental Sciences 2023年第4期126卷 263-274页

作者： Ning dong Mengyue Chen Qing Ye dan Zhang Hongxing dai Key Laboratory of Beijing on Regional Air Pollution Control Department of Environmental ScienceSchool of Environmental and Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China R&D Department of Atmospheric Prevention and Control Technology Guangdong Suncere Technology Co.Ltd.Guangzhou 510220China Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of Chinaand Laboratory of Catalysis Chemistry and NanoscienceDepartment of Environmental Chemical EngineeringSchool of Environmental and Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The cryptomelane-type manganese oxide (OMS-2)-supported Co (x Co/OMS-2;x=5,10,and15 wt.%) catalysts were prepared via a pre-incorporation *** as-prepared materials were used as catalysts for catalytic oxidation of toluene (2000 ppmV).Physical and chemical properties of the catalysts were measured using the X-ray diffraction (Xrd),Fourier transform infrared spectroscopic (FT-Ir),scanning electron microscopic (SEM),X-ray photoelectron spectroscopy (XPS),and hydrogen temperature-programmed reduction (H_(2)-TPr)*** all of the catalysts,10Co/OMS-2 performed the best,with the T90%,specific reaction rate at 245℃,and turnover frequency at 245℃ (TOFCo) being 245℃,1.23×10^(-3)moltoluene/(gcat·sec),and 11.58×10^(-3)sec-1for toluene oxidation at a space velocity of 60,000mL/(g·hr),*** excellent catalytic performance of 10Co/OMS-2 were due to more oxygen vacancies,enhanced redox ability and oxygen mobility,and strong synergistic effect between Co species and OMS-2 ***,in the presence of poisoning gases CO_(2),SO_(2)or NH_(3),the activity of 10Co/OMS-2 decreased for the carbonate,sulfate and ammonia species covered the active sites and oxygen vacancies,*** the activation treatment,the catalytic activity was partly *** good low-temperature reducibility of 10Co/OMS-2 could also facilitate the redox process accompanied by the consecutive electron transfer between the adsorbed O_(2)and the cobalt or manganese *** the oxidation process of toluene,the benzoic and aldehydic intermediates werefirst generated,which were further oxidized to the benzoate intermediate that were eventually converted into H_(2)O and CO_(2).

关键词： Cryptomelane-type manganese oxide Cobalt doping Volatile organic compound Toluene oxidation

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Oral Combined ProbioticsClostridium butyricumandAkkermansia muciniphilaInhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway

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Cancer Medicine 2025年第11期14卷

作者： Xiaowei Li dengxiong Hua daoyan Wu Wei Hong Yingqian Kang Lei Tang Qin Yang Xinxin Wang Boyan Li renmin Li Zhenghong Chen Guzhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou & Key Laboratory of Medical Molecular Biology of Guizhou Province Guizhou Medical University Guiyang China Joint Laboratory of Helicobacter Pylori and Intestinal Microecology of Affiliated Hospital of Guizhou Medical University Guiyang China Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control Guiyang China Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D Guizhou Medical University Guiyang China School of Public Health Guizhou Medical University Guiyang China Standard Testing Group Co. Ltd. Qingdao China

Background Breast cancer is the most common malignant tumor among women. recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the tumor microenvironment, and inhibiting cancer progression. Methods We established a 4T1 tumor-bearing mice model and analyzed the proportions of Cd4 + T and Cd8 + T cells in the spleen using flow cytometry and immunohistochemistry. The expression levels of TNF-α, IL-6, and IL-10 were measured by enzyme-linked immunosorbent assay. Hematoxylin–eosin staining was used to observe the tumor morphology. Selective protein blotting and quantitative real-time PCr were used to analyze the expression of Bax, Bcl-2, and Caspase-3. Cell proliferation was evaluated using the MTT assay, and apoptosis was detected by flow cytometry. results The results indicated that oral administration of CB and AKK possesses the capability to inhibit the progression of 4T1 breast cancer; however, the combined treatment with both strains (CB-AKK) exhibited significantly superior effects compared to each individual strain. Further mechanistic analysis revealed that the CB-AKK combination could activate the antitumor immunity in mice and reshape the tumor microenvironment. Additionally, it was found that the live bacteria and their metabolites derived from CB-AKK could inhibit cell proliferation and promote tumor apoptosis by activating the Bcl-2/Bax signaling pathway. Conclusion This study is the first to demonstrate that orally administered live bacteria CB-AKK can inhibit the progression of 4T1 breast cancer, providing a promising new strategy for the development of innovative biotherapies for breast cancer.

关键词： Akkermansia muciniphila apoptosis Bcl-2/Bax signaling pathway breast cancer Clostridium butyricum probiotics

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development and case study of a new-generation model-VAT for analyzing the boundary conditions influence on atmospheric mercury simulation

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Frontiers of Environmental Science & Engineering 2018年第1期12卷 149-158页

作者： Wenwei Yang Yun Zhu Carey Jang Shicheng Long Che-Jen Lin Bin Yu Zachariah Adelman Shuxiao Wang Jia Xing Long Wang Jiabin Li Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control College of Environment and Energy South China University of Technology Guangzhou Higher Education Mega Center Guangzhou 510006 China State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China USEPA/Office of Air Quality Planning ＆ Standards RTP NC 27711 USA Guangzhou Urban Environmental Cloud Information Technology R＆D Co. Ltd Guangzhou 510006 China 5 Department of Civil Engineering Lamar University Beaumont TX 77710-0024 USA 6 Guangzhou Environmental Monitoring Center Station Guangzhou 510030 China 7 Institute for the Environment The University of North Carolina at Chapel Hill Chapel Hill NC 27517 USA

atmospheric models are essential tools to study the behavior of air pollutants. To interpret the complicated atmospheric model simulations, a new-generation Model Visualization and Analysis Tool （Model-VAT） has been developed for scientists to analyze the model data and visualize the simulation results. The Model-VAT incorporates analytic functions of conventional tools and enhanced capabilities in flexibly accessing, analyzing, and comparing simulated results from multi-scale models with diflbrent map projections and grid resolutions. The performance of the Model-VAT is demonstrated by a case study of investigating the influence of boundary conditions （BCs） on the ambient Hg formation and transport simulated by the CMAQ model over the Pearl river delta （Prd） region. The alternative BC options are taken from （1） default time-independent profiles, （2） outputs from a CMAQ simulation of a larger nesting domain, and （3） concentration files from GEOS-Chem （re-gridded and re-projected using the Model-VAT）. The three BC inputs and simulated ambient concentrations and deposition were compared using the Model-VAT. The results show that the model simulations based on the static BCs （default profile） underestimates the Hg concentrations by --6.5%, dry depositions by -9.4%, and wet depositions by --43.2% compared to those of the model-derived （e. g. GEOS-Chem or nesting CMAQ） BCs. This study highlights the importance of model nesting approach and demonstrates that the innovative functions of Model-VAT enhances the efficiency of analyzing and comparing the model results from various atmospheric model simulations.

关键词： Model and data wsuahzatlonModel and data analysisCMAQBoundary conditionsMercury

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response surface modeling-based source contribution analysis and VOC emission control policy assessment in a typical ozone-polluted urban Shunde,China

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Journal of Environmental Sciences 2017年第1期29卷 294-304页

作者： Zhiqiang You Yun Zhu Carey Jang Shuxiao Wang Jian Gao Che-Jen Lin Minhui Li Zhenghua Zhu Hao Wei Wenwei Yang Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control College of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China USEPA/offilce of Air Quality Planning&Standards RTPNC 27711USA Chinese Research Academy of Environmental Sciences Beijing 100012China Department of Civil Engineering Lamar UniversityBeaumontTX 77710-0024USA Guangzhou Urban Environmental Cloud Information Technology R&D Co.Ltd Guangzhou 511400China

To develop a sound ozone（O_3） pollution control strategy,it is important to well understand and characterize the source contribution due to the complex chemical and physical formation processes of O_*** the ＂Shunde＂ city as a pilot summer case study,we apply an innovative response surface modeling（rSM） methodology based on the Community Multi-Scale Air Quality（CMAQ） modeling simulations to identify the O_3 regime and provide dynamic analysis of the precursor contributions to effectively assess the O_3 impacts of volatile organic compound（VOC） control *** results show that Shunde is a typical VOC-limited urban O_3 polluted *** ＂Jiangmen＂ city,as the main upper wind area during July 2014,its VOCs and nitrogen oxides（NO_x） emissions make up the largest contribution（9.06%）.On the contrary,the contribution from local（Shunde） emission is lowest（6.35%） among the seven neighbor *** local VOCs industrial source emission has the largest contribution comparing to other precursor emission sectors in *** results of dynamic source contribution analysis further show that the local NO_x control could slightly increase the ground O_3 under low（10.00%） and medium（40.00%）reduction ratios,while it could start to turn positive to decrease ground O_3 under the high NO_x abatement ratio（75.00%）.The real-time assessment of O_3 impacts from VOCs control strategies in Pearl river delta（Prd） shows that the joint regional VOCs emission control policy will effectively reduce the ground O_3 concentration in Shunde.

关键词： O_3 response surface model Source contribution analysis VOCs control policy

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Correction to: 2021 Taxonomic update of phylum Negarnaviricota (riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

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Archives of virology 2021年第12期166卷 3567-3579页

作者： Jens H Kuhn Scott Adkins Bernard r Agwanda rim Al Kubrusli Sergey V Alkhovsky Gaya K Amarasinghe Tatjana Avšič-Županc María A Ayllón Justin Bahl Anne Balkema-Buschmann Matthew J Ballinger Christopher F Basler Sina Bavari Martin Beer Nicolas Bejerman Andrew J Bennett dennis A Bente Éric Bergeron Brian H Bird Carol d Blair Kim r Blasdell dag-ragnar Blystad Jamie Bojko Wayne B Borth Steven Bradfute rachel Breyta Thomas Briese Paul A Brown Judith K Brown Ursula J Buchholz Michael J Buchmeier Alexander Bukreyev Felicity Burt Carmen Büttner Charles H Calisher Mengji Cao Inmaculada Casas Kartik Chandran rémi N Charrel Qi Cheng Yuya Chiaki Marco Chiapello Il-ryong Choi Marina Ciuffo J Christopher S Clegg Ian Crozier Elena dal Bó Juan Carlos de la Torre Xavier de Lamballerie rik L de Swart Humberto debat Nolwenn M dheilly Emiliano di Cicco Nicholas di Paola Francesco di Serio ralf G dietzgen Michele digiaro Olga dolnik Michael A drebot J Felix drexler William G dundon W Paul duprex ralf dürrwald John M dye Andrew J Easton Hideki Ebihara Toufic Elbeaino Koray Ergünay Hugh W Ferguson Anthony r Fooks Marco Forgia Pierre B H Formenty Jana Fránová Juliana Freitas-Astúa Jingjing Fu Stephanie Fürl Selma Gago-Zachert George Fú Gāo María Laura García Adolfo García-Sastre Aura r Garrison Thomas Gaskin Jean-Paul J Gonzalez Anthony Griffiths Tony L Goldberg Martin H Groschup Stephan Günther roy A Hall John Hammond Tong Han Jussi Hepojoki roger Hewson Jiang Hong Ni Hong Seiji Hongo Masayuki Horie John S Hu Tao Hu Holly r Hughes Florian Hüttner Timothy H Hyndman M Ilyas risto Jalkanen dàohóng Jiāng Gilda B Jonson Sandra Junglen Fujio Kadono Karia H Kaukinen Michael Kawate Boris Klempa Jonas Klingström Gary Kobinger Igor Koloniuk Hideki Kondō Eugene V Koonin Mart Krupovic Kenji Kubota Gael Kurath Lies Laenen Amy J Lambert Stanley L Langevin Benhur Lee Elliot J Lefkowitz Eric M Leroy Shaorong Li Longhui Li Jiànróng Lǐ Huazhen Liu Igor S Lukashevich Piet Maes William Marciel de Souza Marco Marklewitz Sergio H Marshall Shin-Yi L Marzano Se Integrated Research Facility at Fort Detrick National Institute of Allergy and Infectious Diseases National Institutes of Health Frederick MD USA. kuhnjens@mail.nih.gov. United States Department of Agriculture Agricultural Research Service US Horticultural Research Laboratory Fort Pierce FL USA. Zoology Department National Museums of Kenya Nairobi Kenya. Jomo Kenyatta University of Agriculture & Technology Nairobi Kenya. Division Phytomedicine Faculty of Life Sciences Humboldt-Universität zu Berlin Berlin Germany. D.I. Ivanovsky Institute of Virology of N.F. Gamaleya National Center on Epidemiology and Microbiology of Ministry of Health of Russian Federation Moscow Russia. Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA. Faculty of Medicine University of Ljubljana Ljubljana Slovenia. Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Campus de Montegancedo Pozuelo de Alarcón Madrid Spain. Departamento de Biotecnología-Biología Vegetal Escuela Técnica Superior de Ingeniería Agronómica Alimentaria y de Biosistemas Universidad Politécnica de Madrid Madrid Spain. Center for Ecology of Infectious Diseases Department of Infectious Diseases Department of Epidemiology and Biostatistics Insitute of Bioinformatics University of Georgia Athens GA USA. Institute of Novel and Emerging Infectious Diseases Friedrich-Loeffler-Institut Federal Research Institute for Animal Health Greifswald-Insel Riems Germany. Department of Biological Sciences Mississippi State University Mississippi State MS USA. Center for Microbial Pathogenesis Institute for Biomedical Sciences Georgia State University Atlanta GA USA. Edge BioInnovation Consulting and Mgt Frederick MD USA. Institute of Diagnostic Virology Friedrich-Loeffler-Institut Greifswald-Insel Riems Germany. UFyMA INTA-CONICET Cordoba Argentina. Genomics and Bioinformatics D

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40th EASd Annual Meeting of the European Association for the Study of diabetes : Munich, Germany, 5-9 September 2004

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diabetologia 2004年第SUPPL 1期47卷 A1-A464页

作者： Veitenhansl, M. Stegner, K. Hierl, F.-X. dieterle, C. Feldmeier, H. Gutt, B. Landgraf, r. Garrow, A. P. Vileikyte, L. Findlow, A. Waterman, C. Boulton, A. J. M. Shankhdhar, K. Shankhdhar, L. Shankhdhar, U. Petrova, N. L. Foster, A. V. M. Edmonds, M. E. Ferraresi, r. Caravaggi, C. de Giglio, r. Cavaiani, P. Pogliaghi, I. Sommariva, E. Katz, I. A. Harlan, A. Miranda-Palma, B. Prieto-Sanchez, L. Armstrong, d. G. Bowker, J. H. Mizel, M. S. Cernea, S. Wohlgelernter, J. Kidron, M. Modi, P. raz, I. Arbit, E. Nosek, L. Kapitza, C. Beckett, P. Gelfand, r. Goldberg, M. Heise, T. Testa, M. A. Turner, r. r. Hayes, J. F. Scranton, r. E. Simonson, d. C. Yang, Y.-W. Hsu, Y.-J. Naujok, O. Francini, F. Jörns, A. Tiedge, M. Lenzen, S. Abdel-Wahab, Y. H. A. Marenah, L. Orr, d. F. Shaw, C. Flatt, P. r. Chokkalingam, K. Mansell, P. I. Clausen, P. Ekbom, P. damm, P. Feldt-rasmussen, U. Nielsen, B. Mathiesen, E. r. Feldt-rasmussen, B. dewan, S. da Silva, N. Ternan, P. Mc Leong, K. S. Wilding, J. P. H. Asatiani, N. Kurashvili, r. dundua, M. Shelestova, E. Pagava, K. ramazashvili, M. Hod, M. Smirnov, S. Petersen, J. L. A. Justesen, T. I. ringholm Nielsen, L. Müller, C. Højlund, K. Wensaas, A. Kase, E. T. Aas, V. rustan, A. C. Thoresen, G. H. Levin, K. Beck-Nielsen, H. Gaster, M. Im, S.-S. Kang, S.-Y. Kim, S.-Y. Ahn, Y.-H. Lihn, A. S. Schmoll, d. Werner, T. Kienitz, A. Meyer, M. Barthel, A. Ailett, F. Sutherland, C. Walther, r. Grempler, r. Sasson, S. reich, r. Tenenbaum, T. Alpert, E. Anfossi, G. russo, I. Traversa, M. Massucco, P. Mattiello, L. doronzo, G. Trovati, M. Lally, S. Tan, C. Y. Owens, d. Tomkin, G. H. Porchay, I. Péan, F. Bellili, N. Betoulle, d. Balkau, B. Tichet, J. Marre, M. Fumeron, F. Chatellier, G. Alhenc-Gelas, F. Nichols, G. A. Brown, J. B. Hayes, r. P. Bowman, L. drexel, H. Saely, C. H. Marte, T. Benzer, W. Langer, P. Hoefle, G. Moll, W. Aczel, S. Karagiannis, E. Lübben, G. Urquhart, r. Edwards, G. Bruce, S. Howlett, H. S. C. Cugnardey, N. Turner, K. C. Park, J.-S. Fiedorek, F. T. Avogaro, A. Gallo, A. Pinton, P. riz Innenstadt Klinikum der Universität München München Germany Diabetes Center Medizinische Klinik München Germany Medicine The University of Manchester Manchester UK Medicine University of Manchester Manchester UK Podiatry The University of Salford Manchester UK Department of Medicine/Division of Endocrinology Diabetes and Metabolism University of Miami Miami USA Department of Medicine Manchester Royal Infirmary Manchester UK Podiatry L.K.Diabetes Centre Lucknow India Diabetology L.K.Diabetes Centre Lucknow India Medical Nutrition L.K.Diabetes Centre Lucknow India Diabetic Foot Clinic King’s College Hospital London UK Haemodinamic Department - Cardiovascular Division Magenta Hospital Milan Italy Center for the Study and Treatment of Diabetic Foot Pathology Abbiategrasso Hospital Milan Italy Center for the Study and Treatment of Diabetic Foot Pathology Abbiategrasso Hospital Abbiategrasso Italy Department of Orthopedics University of Miami Miami USA Department of Surgery Southern Arizona Veterans Affairs Medical Center Tucson USA Surgery Southern Arizona VA Medical Center Tucson USA Podiatric Medicine and Surgery Rosalind Franklin University School of Medicine and Science North Chicago USA Diabetes Department Center of Diabetes Nutrition and Metabolic Disorders Clug-Napoca Romania Diabetes Unit Hadassah University Hospital Jerusalem Israel Diabetes Unit Hadassah Hebrew University Hospital Jerusalem Israel Research Department Generex Biotechnology Corporation Toronto Canada Hadassah Hebrew University Hospital Jerusalem Israel Medical Research Emisphere Technologies Inc. New York USA Profil Institut fuer Stoffwechselforschung GmbH Neuss Germany Profil Institute for Metabolic Research Neuss Germany Management Profil Inst. für Stoffwechselforschung Düsseldorf Germany Institute for Metabolic Research Profil Neuss Germany Biostatistics Harvard School of Public Health Boston USA Clinical Research Phase V Technologies Wellesley Hills US

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