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Fabricating high-strength color resin composite via material jetting using ink with added fillers

INTErNATIONAL JOUrNAL OF AdVANCEd MANUFACTUrING TECHNOLOGY 2024年第7-8期135卷 3765-3776页

作者： Naito, Hiroyuki Shingai, Yuki Okada, Noriaki Ricoh Co Ltd Adv Technol R&D Div 2-7-1 Izumi Ebina Kanagawa Japan

The mechanical properties of models are crucial in determining the industrial applications of additive manufacturing techniques. Material jetting (MJ) has been primarily limited to mold-making, prototyping, etc., owing to its low strength. Low viscosity and rapid curing, which are essential ink characteristics of MJ, lead to the low strength of MJ models. This study aimed to develop methods to increase the strength of MJ models by adding fillers to the ink. We optimized the shape and size of the filler, modified the surface properties, and optimized the methacrylate monomer formulation of the ink. To develop a colorization process suitable for filler-added inks, we investigated a method to apply transparent ink over small-colored ink droplets. We achieved a bending strength of 180 MPa for colorless models and 177 MPa for colored models, which is remarkable compared to the typical MJ product strength of 90 MPa or less. These findings clarify the design guidelines for high-strength MJ ink, making the direct manufacturing of production parts requiring both esthetic beauty and high strength in colors, such as artificial teeth, dentures, and eyeglass frames, more realistic.

关键词： Material jetting Mechanical property High strength Ink filler Colorization process

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The effects of lactose hydrolysis on a sensory evaluation and the physical properties of a nonfat set yogurt

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JOUrNAL OF dAIrY rESEArCH 2024年第4期91卷 471-476页

作者： Ichimura, Takefumi Ichiba, Tomoko Meiji Co Ltd R&D Div Lact Acid Bacteria & Fermentat Technol Res Unit 1-29-1 Nanakuni Hachioji Tokyo 1920919 Japan Meiji Co Ltd R&D Div Fermentat Dev Res Unit 1-29-1 Nanakuni Hachioji Tokyo 1920919 Japan

Nonfat set yogurts are very popular in Japan because of their health properties, but have the disadvantage of being hard and having large curd particles compared to fat-containing yogurts. We investigated the effect of lactose hydrolysis on nonfat set yogurt to determine whether this technique can improve the sensory evaluation and the texture of a nonfat set yogurt. We prepared nonfat yogurt mixes with 0, 50, 75, and 100% lactose hydrolysis and fermented them. The sensory properties, physical properties, fermentation characteristics, extracellular polysaccharide (EPS) concentration and lactic acid bacteria count were then assessed. The results demonstrated that the lactose hydrolysis rate had no effect on the fermentation time. The 75% lactose hydrolysis increased the EPS concentration and inhibited post-acidification. The 100% lactose hydrolysis increased the number of Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and further increased the EPS concentration, and despite the increase in the number of L. bulgaricus, the 100% lactose hydrolysis suppressed post-acidification. The results of a sensory evaluation showed that the 100% lactose hydrolysis increased the yogurt's viscosity and overall acceptability and suppressed its acidity. The physical-properties evaluation revealed that when the lactose hydrolysis rate was >= 75%, the curd hardness decreased, and the curd particles became smaller. We inferred that these sensory and physical changes originated from an increase in the EPS concentration, and we thus speculate that a 100% lactose hydrolysis rate before fermentation would be a useful means of solving the hardness and large curd particles of nonfat set yogurt.

关键词： EPS L. bulgaricus lactose hydrolysis nonfat set yogurt

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Warpage Observation of Liquid Compression Mold Underfill on Strip Substrate 12

Warpage Observation of Liquid Compression Mold Underfill on ...

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12th IEEE CPMT Symposium Japan, ICSJ 2023

作者： Oe, Takayuki Shigeno, Yuto Ikeda, Yukihiro Kamimura, Tsuyoshi Namics Corporation Technical R&d DIV. Niigata Japan

ISBN: (纸本)9798350325157

Liquid Compression Mold Underfill (LCMUF) is a liquid encapsulation material that was developed to encapsulate wafer-level packages of 12-inch silicon wafers using a compression molding machine. In this report, we applied it to a package of Fr-4 strip substrate using a compression molding machine for wider application of LCMUF. To encapsulate the strip substrate, the process used Mold Underfill (MUF) with a transfer molding machine is commonly applied. In comparison, the compression molding process with LCMUF has the advantages of waste reduction of encapsulation material, low risk of chip misalignment, low heat damage to mounted components, and good flowability to chip gaps. On the other hand, since the warpage of the strip substrate after molding may cause problems during subsequent processes, such as grinding and dicing, it is essential to reduce the warpage of the strip substrate. Therefore, we optimized the Coefficient of Thermal Expansion (CTE) property of LCMUF and succeeded in reducing the warpage of the strip substrate after compression molding. Moreover, this LCMUF also shows good flowability to chip gap between mounted chip and strip substrate uniformly without voids. © 2023 IEEE.

关键词： Compression molding

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Shape optimization of Hourglass-shaped damper using Fe-Mn-Si-Based alloy considering target Load-displacement relationship and target fatigue characteristics

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CONSTrUCTION ANd BUILdING MATErIALS 2023年 366卷

作者： Suzuki, Takuya Motomura, Susumu Kinoshita, Takahiro Inoue, Yasuhiko Kushibe, Atsumichi Iida, Tomohiro Takenaka Corp R&D Inst Inzai City Japan Takenaka Corp R&D Inst Future & Adv Res Div Inzai City Japan Takenaka Corp Design Div Tokyo Branch Inzai City Japan Takenaka Corp R&D Inst 1-5-1 Otsuka Inzai City Chiba 2701395 Japan

To reduce the response of buildings during earthquakes, the use of various hysteresis dampers for passive control is increasing. For effective application to buildings, these dampers must meet both load displacement relation-ship and fatigue property requirements. In this study, shape optimization of an Fe-Mn-Si-based alloy damper was conducted to improve the fatigue property while maintaining the target load displacement relationship, and the obtained optimized damper was examined. First, shape optimization was conducted using the modal iterative error correction (MIEC) inverse analysis method. Subsequently, a loading test on the damper fabricated based on the optimized shape was conducted, and its effectiveness was confirmed. As a result, it was confirmed that the optimized shape of the damper, which improves the fatigue performance while maintaining the load displace-ment relationship, was successfully searched using the MIEC inverse analysis method. In addition, it was confirmed that the fatigue performance of the test specimen based on the optimized shape was improved compared to that of the initial-shape.

关键词： Inverse Analysis Nonlinear analysis damper Shape optimization

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Absorption-based colorimetric detection of nickel(II) ion by phase separation of thermoresponsive magnetic nanoparticles under microflow

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ANALYTICAL SCIENCES 2024年第4期40卷 791-798页

作者： Sasaki, ren Inagawa, Arinori Xie, Xiaomao Ohnishi, Noriyuki Uehara, Nobuo Utsunomiya Univ Sch Engn 7-1-2 Yoto Utsunomiya Tochigi 3218585 Japan JNC Corp Yokohama R&D Ctr 5-1 OokawaKanazawa Ku Yokohama Kanagawa 2368605 Japan JNC Corp Corp R&D Div 5-1 Goi Kaigan Ichihara Chiba 2908551 Japan

Therma-Max (TM) LSA Streptavidin is a thermoresponsive magnetic nanoparticle (TMNP). It can be introduced conveniently to molecular recognition groups by avidin-biotin interaction. In this study, we demonstrated the detection of nickel(II) ions by the magnetic separation of TMNP induced by their phase transition under microflow. The NTA-tagged TMNP solution mixed with a Ni2+ sample was introduced into a microchannel with a well structure. Moreover, the sample was heated to induce the thermally induced aggregation of TMNP. The Ni-capturing TMNP were trapped in the well by magnetic fields. The supernatant was removed from the outlet, and a dimethylglyoxime (dMG) solution was introduced into the device for colorimetric detection in the well. Because dMG has a higher stability constant with Ni2+, sensitive colorimetric detection of Ni2+ can be achieved in devices where the sample volume, e.g., optical pathlength, is short. To demonstrate the feasibility of the proposed method, a recovery test was conducted using a commercially available cosmetic sample. Therein, complete collection was achieved.

关键词： Thermo-responsive magnetic nanoparticle Phase separaction Nickel(II) ion Microfluidic device

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An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et3N to Easily Generate Lithium Triazinolate

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SYNTHESIS-STUTTGArT 2024年第4期56卷 650-656页

作者： Ohashi, Eisaku Sahara, Naoto Hirano, Yoichi Hosoya, Masahiro Takahashi, Yusaku Tsuno, Naoki Shionogi & Co Ltd API R&D Lab Res Div 1-3Kuise Terajima 2-Chome Amagasaki Hyogo 6600813 Japan

An efficient and robust method was developed to introduce the triazole unit of Ensitrelvir, a COVId-19 therapeutic agent. One of the key steps is introducing the triazole unit in the triazinone with Cs2CO3 and KI in a heterogeneous system. detailed reaction screening revealed that addition of LiCl allowed the reaction to proceed quantitatively in the presence of inexpensive Et3N, and the selectivity of the N-alkylation was greatly improved. The key to promoting the reaction is the mild formation of the lithium triazinolate accompanied by precipitation of *** (the only insoluble matter in this reaction). dissolving all the substrates and reagents should contribute to further improvement of the process robustness.

关键词： Ensitrelvir triazole N -alkylation triazinone LiCl organic base lithium triazinolate precipitation

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development of a Synthetic route to Vonoprazan via Atom Transfer radical Cyclization

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JOUrNAL OF OrGANIC CHEMISTrY 2025年第9期90卷 3485-3488页

作者： Ojima, Ken-ichi Imaizumi, ryoya Komori, Tatsuya Nishikawa, Toru doi, Nobuyoshi Nishiguchi, Shigenobu Towa Pharmaceut Co Ltd API Business Unit API Proc Res Dept 1 R&D Div Amagasaki Hyogo 6600083 Japan

In this Note, a new synthetic route to vonoprazan via atom transfer radical cyclization (ATrC) is described. The pivotal 1,3,5-trisubstituted pyrrole ring of vonoprazan has been accomplished by ATrC, the subsequent aromatization which simultaneously occurred with the introduction of N-methylamine moiety into the cyclic imine, and the sulfonylation at the 1-position of pyrrole. Furthermore, our approach enabled the synthesis of vonoprazan on a 0.7 kg scale without the isolation of intermediates throughout the process.

关键词： Atom transfer radical polymerization

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Low-Power and Fast-response Limiting Current-Type Oxygen Microsensor with a Wide range Oxygen Concentration

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IEEJ TrANSACTIONS ON ELECTrICAL ANd ELECTrONIC ENGINEErING 2024年第5期19卷 796-799页

作者： Akasaka, Shunsuke Kanno, Isaku ROHM Co Ltd Interdisciplinary Technol R&D Div ROHM R&D Ctr 21Saiin Mizozaki ChoUkyo Ku Kyoto 6158585 Japan Kobe Univ Dept Mech Engn 1-1 Rokko DaichoNada Ku Kobe 6578501 Japan

In this study, we fabricated limiting current-type oxygen microsensors capable of sensing a wide range of oxygen concentrations. The oxygen microsensors consist of yttria-stabilized zirconia thin films on spiral Ta2O5 diffusion layers and high-temperature micro-hotplates. At temperatures above 575 degree celsius, we observed a clear limiting current that increased proportionally with oxygen concentration between 0.4% and 94%. This wide-range linearity is attributed to the Knudsen diffusion of the oxygen gas passing through the small gap in the spiral Ta2O5 diffusion layer.(c) 2023 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.

关键词： limiting current wide-range oxygen sensor small low-power fast-response

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Population pharmacokinetics of a novel PCSK9 antisense oligonucleotide

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BrITISH JOUrNAL OF CLINICAL PHArMACOLOGY 2024年第6期90卷 1503-1513页

作者： Clewe, Oskar rekic, dinko Quartino, Angelica L. Carlsson, Bjorn Higashimori, Mitsuo Wernevik, Linda Hofherr, Alexis ryden-Bergsten, Tina Nilsson, Catarina Knochel, Jane AstraZeneca Clin Pharmacol & Quantitat Pharmacol Clin Pharmacol & Safety Sci Biopharmaceut R&D Gothenburg Sweden AstraZeneca Res & Early Dev Cardiovasc Renal & Metab BioPharmaceut R&D Gothenburg Sweden AstraZeneca KK Sci Enablement Dept Data Sci & Innovat Div R&D Osaka Japan AstraZeneca AB R&D Pepparedsleden 1 S-43150 Molndal Sweden AstraZeneca Biopharmaceut Business Unit Gothenburg Sweden

Aims: The aim of this study was to characterize the population pharmacokinetics of AZd8233, an antisense oligonucleotide (ASO) that targets the PCSK9 transcript to reduce hepatocyte PCSK9 protein production and plasma levels. AZd8233 utilizes generation 2.5 S-constrained ethyl motif (cET) chemistry and is conjugated to a triantennary N-acetylgalactosamine (GalNAc3) ligand for targeted hepatocyte uptake. Methods: A non-linear mixed-effect modelling approach utilizing NONMEM software was applied to AZd8233 concentration-time data from 3416 samples in 219 participants from four phase 1-2 studies, one in healthy volunteers (NCT03593785) and three in patients with dyslipidaemia (NCT04155645, NCT04641299 and NCT04823611). results: The final model described the AZd8233 plasma concentration-time profile from four phase 1-2 studies in healthy volunteers or participants with dyslipidaemia, covering a dose range of 4 to 120 mg. The pharmacokinetics of AZd8233 were adequately described by a two-compartment model with first-order absorption. The supra-proportional increase in maximum plasma concentration (C-max) across the observed dose range was described by non-linear Michaelis-Menten elimination (maximum elimination rate, 9.9 mg/h [12% relative standard error];concentration yielding half-maximal elimination rate, 4.8 mg/L [18% relative standard error]). Body weight, sex, estimated glomerular filtration rate and disease status (healthy participant vs. patient with dyslipidaemia) were identified as factors affecting exposure to AZd8233. Conclusions: Covariate analysis showed body weight to be the main factor affecting exposure to AZd8233, which largely explained the higher C-max observed in the Asian population relative to non-Asians.

关键词： ASO modelling and simulation NONMEM PCSK9 pharmacokinetics population analysis

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Techno-economic study and process simulation for a small-scale hydrogen production plant based on ammonia decomposition

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INTErNATIONAL JOUrNAL OF HYdrOGEN ENErGY 2024年 65卷 126-141页

作者： El-Shafie, Mostafa Kambara, Shinji Katikaneni, Sai P. Paglieri, Stephen N. Lee, Kunho Gifu Univ Grad Sch Engn Environm & Renewable Energy Syst Div 1-1 Yanagido Gifu 5011193 Japan Saudi Aramco Res & Dev Ctr Carbon Management R&D Div Dhahran 31311 Saudi Arabia

Hydrogen is a carbon-free fuel and can be expected to play a significant role in the global clean energy transition. In this study, two proposed small-scale hydrogen production plant configurations were designed and simulated for high-purity hydrogen production at a rate of 25 kgH2/day. The feasibility and economic viability of the proposed plant configurations were examined. Additionally, the performance and sensitivity analysis were assessed under different operating conditions. Configuration A proposed to use two reactors for ammonia cracking and H2 separation, respectively. Configuration B considers that the decomposition of ammonia and H2 separation simultaneously occurs in a single integrated reactor. despite the configuration B was more energy efficient than configuration A but both configurations are applicable. The total H2 production cost of configuration A was 6.39 $/kgH2 and that of configuration B was 6.06 $/kgH2. Since the proposed plant configurations generated both hydrogen and nitrogen, the total cost of production was distributed between them. Therefore, the final H2 and N2 separation costs of configuration A was 5.05 $/kgH2 and 1.14 $/kgN2, and configuration B was 4.72 $/kgH2 and 1.08 $/kgN2. The hydrogen production cost from different ammonia synthesis pathways was compared. The technology readiness level (TrL) for hydrogen production from ammonia cracking was assessed and identified at a range of TrL 4-6. It can also be considered that the ammonia synthesis pathway controlled the ammonia prices and subsequently the hydrogen production cost.

关键词： Hydrogen separation Membrane reactor Energy efficiency Permeation rate Ammonia synthesis Hydrogen cost

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