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Weak-binding molecules are not drugs?-toward a systematic strategy for finding effective weak-binding drugs

BrIEFINGS IN BIOINFOrMATICS 2017年第2期18卷 321-332页

作者： Wang, Jinan Guo, Zihu Fu, Yingxue Wu, Ziyin Huang, Chao Zheng, Chunli Shar, Piar Ali Wang, Zhenzhong Xiao, Wei Wang, Yonghua Northwest A&F Univ Ctr Bioinformat Coll Life Sci Computer Aided Drug Design & TCM Syst Pharmacol Xianyang Shaanxi Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life SciModeling Signal Pathway Complex Dis TCM Syst Pharmacol & Machine Learning Xianyang Shaanxi Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life Sci Syst PharmacolNetwork Med & Computat Biol Xianyang Shaanxi Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life Sci TCM Syst PharmacolCell Regulat & Signal Transduc Xianyang Shaanxi Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life Sci Network BiolTCM Syst Pharmacol Xianyang Shaanxi Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life Sci Machine LearningTCM Syst Pharmacol Xianyang Shaanxi Peoples R China Kanion Pharmaceut Co Ltd Chinese Med Pharmaceut Proc State Key Lab New Tech R&D Director Lianyungang Peoples R China New Tech Chinese Med Qual Control New Extracting Tech Chinese Med Lianyungang Peoples R China Kanion Pharmaceut Co Ltd Chinese Med Pharmaceut Proc State Key Lab New Tech Lianyungang Peoples R China New Tech Chinese Med Qual control New Extracting Tech Chinese Med Lianyungang Peoples R China Northwest A&F Univ Ctr Bioinformat Coll Life Sci Xianyang Shaanxi Peoples R China ADME Properties Drug Mol TCM Syst Pharmacol Network Biol Xianyang Shaanxi Peoples R China Northwest A&F Univ Coll Life Sci Ctr Bioinformat Lab Syst Pharmacol Yangling 712100 Shaanxi Peoples R China

designing maximally selective ligands that act on individual drug targets with high binding affinity has been the central dogma of drug discovery and development for the past two decades. However, many low-affinity drugs that aim for several targets at the same time are found more effective than the high-affinity binders when faced with complex disease conditions, such as cancers, Alzheimer's disease and cardiovascular diseases. The aim of this study was to appreciate the importance and reveal the features of weak-binding drugs and propose an integrated strategy for discovering them. Weak-binding drugs can be characterized by their high dissociation rates and transient interactions with their targets. In addition, network topologies and dynamics parameters involved in the targets of weak-binding drugs also influence the effects of the drugs. Here, we first performed a dynamics analysis for 33 elementary subgraphs to determine the desirable topology and dynamics parameters among targets. Then, by applying the elementary subgraphs to the mitogen-activated protein kinase (MAPK) pathway, several optimal target combinations were obtained. Combining drug-target interaction prediction with molecular dynamics simulation, we got two potential weak-binding drug candidates, luteolin and tanshinone IIA, acting on these targets. Further, the binding affinity of these two compounds to their targets and the anti-inflammatory effects of them were validated through in vitro experiments. In conclusion, weak-binding drugs have real opportunities for maximum efficiency and may show reduced adverse reactions, which can offer a bright and promising future for new drug discovery.

关键词： weak-binding drug polypharmacology mathematical modeling systems pharmacology

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Author Correction: π-HuB: the proteomic navigator of the human body

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Nature 2025年第8046期637卷 E22页

作者： Fuchu He ruedi Aebersold Mark S Baker Xiuwu Bian Xiaochen Bo daniel W Chan Cheng Chang Luonan Chen Xiangmei Chen Yu-Ju Chen Heping Cheng Ben C Collins Fernando Corrales Jürgen Cox Weinan E Jennifer E Van Eyk Jia Fan Pouya Faridi daniel Figeys George Fu Gao Wen Gao Zu-Hua Gao Keisuke Goda Wilson Wen Bin Goh dongfeng Gu Changjiang Guo Tiannan Guo Yuezhong He Albert J r Heck Henning Hermjakob Tony Hunter Narayanan Gopalakrishna Iyer Ying Jiang Connie r Jimenez Lokesh Joshi Neil L Kelleher Ming Li Yang Li Qingsong Lin Cui Hua Liu Fan Liu Guang-Hui Liu Yansheng Liu Zhihua Liu Teck Yew Low Ben Lu Matthias Mann Anming Meng robert L Moritz Edouard Nice Guang Ning Gilbert S Omenn Christopher M Overall Giuseppe Palmisano Yaojin Peng Charles Pineau Terence Chuen Wai Poon Anthony W Purcell Jie Qiao roger r reddel Phillip J robinson Paola roncada Chris Sander Jiahao Sha Erwei Song Sanjeeva Srivastava Aihua Sun Siu Kwan Sze Chao Tang Liujun Tang ruijun Tian Juan Antonio Vizcaíno Chanjuan Wang Chen Wang Xiaowen Wang Xinxing Wang Yan Wang Tobias Weiss Mathias Wilhelm robert Winkler Bernd Wollscheid Limsoon Wong Linhai Xie Wei Xie Tao Xu Tianhao Xu Liying Yan Jing Yang Xiao Yang John Yates Tao Yun Qiwei Zhai Bing Zhang Hui Zhang Lihua Zhang Lingqiang Zhang Pingwen Zhang Yukui Zhang Yu Zi Zheng Qing Zhong Yunping Zhu State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. hefc@***. International Academy of Phronesis Medicine (Guangdong) Guangdong China. hefc@***. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. aebersold@imsb.biol.ethz.ch. Macquarie Medical School Macquarie University Sydney New South Wales Australia. Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Ministry of Education of China Chongqing China. Institute of Health Service and Transfusion Medicine Beijing China. Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA. State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China. Department of Nephrology First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People's Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China. Institute of Chemistry Academia Sinica Taipei China. National Biomedical Imaging Center State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking-Tsinghua Center for Life Sciences College of Future Technology Peking University Beijing China. School of Biological Sciences Queen's University of Belfast Belfast UK. Functional Proteomics Laboratory Centro Nacional de Biotecnología-CSIC Madrid Spain. Computational Systems Biochemistry Research Group Ma

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detection of rS Oph with LST-1 and modelling of its HE/VHE gamma-ray emission

arXiv

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arXiv 2025年

作者： Abe, K. Abe, S. Abhishek, A. Acero, F. Aguasca-Cabot, A. Agudo, I. Alispach, C. Crespo, N. Alvarez Ambrosino, d. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Asano, K. Aubert, P. Baktash, A. Balbo, M. Bamba, A. Larriva, A. Baquero de Almeida, U. Barres Barrio, J.A. Jiménez, L. Barrios Batkovic, I. Baxter, J. González, J. Becerra Bernardini, E. Bernete, J. Berti, A. Bezshyiko, I. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Borkowski, G. Brunelli, G. Bulgarelli, A. Bunse, M. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Castrejón, N. Cerasole, d. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chon, G. Chytka, L. Cicciari, G.M. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. da Vela, P. dalchenko, M. dazzi, F. de Angelis, A. de Bony de Lavergne, M. de Lotto, B. de Menezes, r. del Burgo, r. del Peral, L. delgado, C. delgado Mengual, J. della Volpe, d. dellaiera, M. di Piano, A. di Pierro, F. di Tria, r. di Venere, L. díaz, C. dominik, r.M. dominis Prester, d. donini, A. dore, d. dorner, d. doro, M. Eisenberger, L. Elsässer, d. Emery, G. Escudero, J. Fallah ramazani, V. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukazawa, Y. Garcia López, r. Gasbarra, C. Gasparrini, d. Geyer, d. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, r. Green, d. Green, J. Gunji, S. Günther, P. Hackfeld, J. Hadasch, d. Hahn, A. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, d. Horns, d. Houles, J. Hrabovsky, M. Hrupec, d. Hui, d. Iarlori, M. Imazawa, r. Inada, T. Inome, Y. Inoue, S. Ioka, K. Iori, M. Iuliano, A. Jahanvi, J. Jimenez Martinez, I. Jimenez Quiles, J. Jurysek, J. Kagaya, M. Kalashev, O. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, d. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lacave, B. Lainez, M. Lamanna, G. Lamastra, A. Lemoigne, L. Department of Physics Tokai University 4-1-1 Kita-Kaname Kanagawa Hiratsuka259-1292 Japan Institute for Cosmic Ray Research University of Tokyo 5-1-5 Kashiwa-no-ha Chiba Kashiwa277-8582 Japan Sezione di Fisica Via Roma 56 Siena53100 Italy Université Paris-Saclay Université Paris Cité CEA CNRS AIM Gif-sur-YvetteF-91191 Cedex France FSLAC IRL 2009 CNRS/IAC Tenerife La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Martí i Franquès 1 Barcelona08028 Spain Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomía s/n Granada18008 Spain Department of Astronomy University of Geneva Chemin d’Ecogia 16 VersoixCH-1290 Switzerland IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid Ciudad Universitaria Plaza de Ciencias 1 Madrid28040 Spain INFN Sezione di Napoli Via Cintia ed. G Napoli80126 Italy INAF - Osservatorio Astronomico di Roma Via di Frascati 33 Monteporzio Catone00040 Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany INFN Sezione di Padova Università degli Studi di Padova Via Marzolo 8 Padova35131 Italy Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Universität Hamburg Institut für Experimentalphysik Luruper Chaussee 149 Hamburg22761 Germany Graduate School of Science University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-0033 Japan Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Centro Brasileiro de Pesquisas Físicas Rua Xavier Sigaud 150 RJ Rio de Janeiro22290-180 Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna C. Vía Láctea s/n Santa Cruz de Tenerife La Laguna38205 Spain CIEMAT Avda. Complutense 40 Madrid28040 Spain University of Geneva Département de physique nucléaire et corpusculaire 24 Quai Ernest Ansernet

Context. The recurrent nova rS Ophiuchi (rS Oph) underwent a thermonuclear eruption in August 2021. In this event, rS Oph was detected by the High Energy Stereoscopic System (H.E.S.S.), the Major Atmospheric Gamma Imaging Cherenkov (MAGIC), and the first Large-Sized Telescope (LST-1) of the future Cherenkov Telescope Array Observatory (CTAO) at very-high gamma-ray energies above 100 GeV. This means that novae are a new class of very-high-energy (VHE) gamma-ray emitters. Aims. We report the analysis of the rS Oph observations with LST-1. We constrain the particle population that causes the observed emission in hadronic and leptonic scenarios. Additionally, we study the prospects of detecting further novae using LST-1 and the upcoming LST array of CTAO-North. Methods. We conducted target-of-opportunity observations with LST-1 from the first day of this nova event. The data were analysed in the framework of cta-lstchain and Gammapy, the official CTAO-LST reconstruction and analysis packages. One-zone hadronic and leptonic models were considered to model the gamma-ray emission of rS Oph using the spectral information from Fermi-LAT and LST-1, together with public data from the MAGIC and H.E.S.S. telescopes. results. rS Oph was detected at 6.6σ with LST-1 in the first 6.35 hours of observations following the eruption. The hadronic scenario is preferred over the leptonic scenario considering a proton energy spectrum with a power-law model with an exponential cutoff whose position increases from (0.26 ± 0.08) TeV on day 1 up to (1.6 ± 0.6) TeV on day 4 after the eruption. The deep sensitivity and low energy threshold of the LST-1/LST array will allow us to detect faint novae and increase their discovery rate. © 2025, CC BY.

关键词： Gamma radiography

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Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain

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Brain and neuroscience advances 2018年 2卷 2398212818779646页

作者： Laurel S Morris Christian Sprenger Ken Koda daniela M de la Mora Tomomi Yamada Hiroaki Mano Yuto Kashiwagi Yoshichika Yoshioka Yasuhide Morioka Ben Seymour Department of Psychology and Behavioral and Clinical Neuroscience Institute University of Cambridge Cambridge UK. Center for Information and Neural Networks National Institute of Information and Communications Technology Osaka Japan. Computational and Biological Learning Laboratory Department of Engineering University of Cambridge Cambridge UK. Pain & Neuroscience Drug Discovery & Disease Research Laboratory Shionogi & Co. Ltd. Osaka Japan. Translational Research Unit Biomarker R&D Department Shionogi & Co. Ltd. Osaka Japan. Immunology Frontier Research Center Osaka University Osaka Japan. Brain Information Communication Research Laboratory Group Advanced Telecommunications Research Institute International Kyoto Japan.

A cardinal feature of persistent pain that follows injury is a general suppression of behaviour, in which motivation is inhibited in a way that promotes energy conservation and recuperation. Across species, the anterior cingulate cortex is associated with the motivational aspects of phasic pain, but whether it mediates motivational functions in persistent pain is less clear. Using burrowing behaviour as an marker of non-specific motivated behaviour in rodents, we studied the suppression of burrowing following painful confirmatory factor analysis or control injection into the right knee joint of 30 rats (14 with pain) and examined associated neural connectivity with ultra-high-field resting state functional magnetic resonance imaging. We found that connectivity between anterior cingulate cortex and subcortical structures including hypothalamic/preoptic nuclei and the bed nucleus of the stria terminalis correlated with the reduction in burrowing behaviour observed following the pain manipulation. In summary, the findings implicate anterior cingulate cortex connectivity as a correlate of the motivational aspect of persistent pain in rodents.

关键词： Chronic pain confirmatory factor analysis pain model pain in rodents resting state functional magnetic resonance imaging

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Study of light-meson resonances decaying to KS0Kπ in the B→(KS0Kπ)K channels

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Physical review d 2025年第9期111卷 092009-092009页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio M. Alexander Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk E. Bottalico S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi J. d. Brandenburg A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan L. Buonincontri M. Burgos Marcos A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M. C Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse New York USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland School of Physics and Astronomy University of Glasgow Glasgow United Kingdom Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Authors affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy o

A study is presented of B+→KS0K−π+K+ and B+→KS0K+π−K+ decays based on the analysis of proton-proton collision data collected with the LHCb detector at center-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The KS0Kπ invariant-mass distributions of both B+ decay modes show, in the m(KS0Kπ)<1.85 GeV mass region, large activity which is resolved using an amplitude analysis. A simple model, where JPC amplitudes are described by multiple Breit-Wigner functions with appropriate angular distributions, provides a good description of the experimental data. In this approach a complex mixture of JPC=0−+, 1++ and 1+− amplitudes is observed that is dominated by η(1405), η(1470), η(1760), f1(1285), f1(1420) and h1(1405) resonances. The KS0Kπ dalitz plots are dominated by asymmetric crossing K*K¯ bands which are different for the two B+ decay modes. This is due to a different interference pattern between the 1++ and 1+− amplitudes in the two channels. Branching fractions are measured for each resonant contribution.

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Search for d0 meson decays to π+π−e+e− and K+K−e+e− final states

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Physical review d 2025年第9期111卷 L091101-L091101页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio M. Alexander Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk E. Bottalico S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi J. d. Brandenburg A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan L. Buonincontri M. Burgos Marcos A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. C. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse New York USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland School of Physics and Astronomy University of Glasgow Glasgow United Kingdom Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Authors affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy o

A search for d0 meson decays to the π+π−e+e− and K+K−e+e− final states is reported using a sample of proton-proton collisions collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb−1. The decay d0→π+π−e+e− is observed for the first time when requiring that the two electrons are consistent with coming from the decay of a ϕ or ρ0/ω meson. The corresponding branching fractions are measured relative to the d0→K−π−[e+e−]ρ0/ω decay, where the two electrons are consistent with coming from the decay of a ρ0 or ω meson. No evidence is found for the d0→K+K−e+e− decay and world-best limits are set on its branching fraction. The results are compared to, and found to be consistent with, the branching fractions of the d0→π+π−μ+μ− and d0→K+K−μ+μ− decays recently measured by LHCb and confirm lepton universality at the current precision.

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Measurement of CP asymmetries in Λb0→ph− decays

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Physical review d 2025年第9期111卷 092004-092004页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio M. Alexander Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk E. Bottalico S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi J. d. Brandenburg A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan L. Buonincontri M. Burgos Marcos A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. C. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse New York USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland School of Physics and Astronomy University of Glasgow Glasgow United Kingdom Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy of Scienc

A search for CP violation in Λb0→pK− and Λb0→pπ− decays is presented using the full run 1 and run 2 data samples of pp collisions collected with the LHCb detector, corresponding to an integrated luminosity of 9 fb−1 at center-of-mass energies of 7, 8, and 13 TeV. For the run 2 data sample, the CP-violating asymmetries are measured to be ACPpK−=(−1.4±0.7±0.4)% and ACPpπ−=(0.4±0.9±0.4)%, where the first uncertainty is statistical and the second is systematic. Following significant improvements in the evaluation of systematic uncertainties compared to the previous LHCb measurement, the run 1 dataset is reanalyzed to update the corresponding results. When combining the run 2 and updated run 1 measurements, the final results are found to be ACPpK−=(−1.1±0.7±0.4)% and ACPpπ−=(0.2±0.8±0.4)%, constituting the most precise measurements of these asymmetries to date.

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Search for resonance-enhanced CP and angular asymmetries in the Λc+→pμ+μ− decay at LHCb

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Physical review d 2025年第9期111卷 L091102-L091102页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio M. Alexander Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk E. Bottalico S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi J. d. Brandenburg A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan L. Buonincontri M. Burgos Marcos A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M. C Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse NewYork USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland School of Physics and Astronomy University of Glasgow Glasgow United Kingdom Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Authors affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy of

The first measurement of the CP asymmetry of the decay rate (ACP) and the CP average (ΣAFB) and CP asymmetry (ΔAFB) of the forward-backward asymmetry in the muon system of Λc+→pμ+μ− decays is reported. The measurement is performed using a data sample of proton-proton collisions, recorded by the LHCb experiment from 2016 to 2018 at a center-of-mass energy of 13 TeV, which corresponds to an integrated luminosity of 5.4 fb−1. The asymmetries are measured in two regions of dimuon mass near the ϕ-meson mass peak. The dimuon-mass integrated results are ACP=(−1.1±4.0±0.5)%, ΣAFB=(3.9±4.0±0.6)%, ΔAFB=(3.1±4.0±0.4)%, where the first uncertainty is statistical and the second systematic. The results are consistent with the conservation of CP symmetry and the Standard Model expectations.

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Test of Lepton Flavor Universality with B+→K+π+π−ℓ+ℓ− decays

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Physical review Letters 2025年第18期134卷 181803-181803页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio M. Alexander Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk E. Bottalico S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi J. d. Brandenburg A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan L. Buonincontri M. Burgos Marcos A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. C. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse New York USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland School of Physics and Astronomy University of Glasgow Glasgow United Kingdom Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Authors affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy o

The first test of lepton flavor universality between muons and electrons using B+→K+π+π−ℓ+ℓ− (ℓ=e, μ) decays is presented. The measurement is performed with data from proton-proton collisions collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The ratio of branching fractions between B+→K+π+π−e+e− and B+→K+π+π−μ+μ− decays is measured in the dilepton invariant-mass-squared range 1.1d is found to be rKππ−1=1.31−0.17+0.18(stat) −0.09+0.12(syst), in agreement with the standard model prediction. The first observation of the B+→K+π+π−e+e− decay is also reported.

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Branching fraction measurement of the decay B+→ψ(2S)ϕ(1020)K+

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Physical review d 2025年第9期111卷 092008-092008页

作者： r. Aaij A. S. W. Abdelmotteleb C. Abellan Beteta F. Abudinén T. Ackernley A. A. Adefisoye B. Adeva M. Adinolfi P. Adlarson C. Agapopoulou C. A. Aidala Z. Ajaltouni S. Akar K. Akiba P. Albicocco J. Albrecht F. Alessio Z. Aliouche P. Alvarez Cartelle r. Amalric S. Amato J. L. Amey Y. Amhis L. An L. Anderlini M. Andersson A. Andreianov P. Andreola M. Andreotti d. Andreou A. Anelli d. Ao F. Archilli M. Argenton S. Arguedas Cuendis A. Artamonov M. Artuso E. Aslanides r. Ataíde da Silva M. Atzeni B. Audurier d. Bacher I. Bachiller Perea S. Bachmann M. Bachmayer J. J. Back P. Baladron rodriguez V. Balagura A. Balboni W. Baldini L. Balzani H. Bao J. Baptista de Souza Leite C. Barbero Pretel M. Barbetti I. r. Barbosa r. J. Barlow M. Barnyakov S. Barsuk W. Barter M. Bartolini J. Bartz J. M. Basels S. Bashir G. Bassi B. Batsukh P. B. Battista A. Bay A. Beck M. Becker F. Bedeschi I. B. Bediaga N. A. Behling S. Belin K. Belous I. Belov I. Belyaev G. Benane G. Bencivenni E. Ben-Haim A. Berezhnoy r. Bernet S. Bernet Andres A. Bertolin C. Betancourt F. Betti J. Bex Ia. Bezshyiko J. Bhom M. S. Bieker N. V. Biesuz P. Billoir A. Biolchini M. Birch F. C. r. Bishop A. Bitadze A. Bizzeti T. Blake F. Blanc J. E. Blank S. Blusk V. Bocharnikov J. A. Boelhauve O. Boente Garcia T. Boettcher A. Bohare A. Boldyrev C. S. Bolognani r. Bolzonella r. B. Bonacci N. Bondar A. Bordelius F. Borgato S. Borghi M. Borsato J. T. Borsuk S. A. Bouchiba M. Bovill T. J. V. Bowcock A. Boyer C. Bozzi A. Brea rodriguez N. Breer J. Brodzicka A. Brossa Gonzalo J. Brown d. Brundu E. Buchanan A. Buonaura L. Buonincontri A. T. Burke C. Burr J. S. Butter J. Buytaert W. Byczynski S. Cadeddu H. Cai A. Caillet r. Calabrese S. Calderon ramirez L. Calefice S. Cali M. Calvi M. Calvo Gomez P. Camargo Magalhaes J. I. Cambon Bouzas P. Campana d. H. Campora Perez A. F. Campoverde Quezada S. Capelli L. Capriotti r. Caravaca-Mora A. Carbone L. Carcedo Salgado r. Cardinale A. Cardini P. Carniti L. Carus A. Casais Vidal r. Caspary G. Casse M. Cattaneo G. Cavallero V. Cavallini S. Nikhef National Institute for Subatomic Physics Amsterdam Netherlands Department of Physics University of Warwick Coventry United Kingdom Physik-Institut Universität Zürich Zürich Switzerland Oliver Lodge Laboratory University of Liverpool Liverpool United Kingdom Syracuse University Syracuse New York USA Instituto Galego de Física de Altas Enerxías (IGFAE) Universidade de Santiago de Compostela Santiago de Compostela Spain H.H. Wills Physics Laboratory University of Bristol Bristol United Kingdom Department of Physics and Astronomy Uppsala University Uppsala Sweden (associated with Institution School of Physics and Astronomy University of Glasgow Glasgow United Kingdom) Université Paris-Saclay CNRS/IN2P3 IJCLab Orsay France University of Michigan Ann Arbor Michigan USA (associated with Syracuse University Syracuse New York USA) Université Clermont Auvergne CNRS/IN2P3 LPC Clermont-Ferrand France University of Cincinnati Cincinnati Ohio USA INFN Laboratori Nazionali di Frascati Frascati Italy Fakultät Physik Technische Universität Dortmund Dortmund Germany Also at Lamarr Institute for Machine Learning and Artificial Intelligence Dortmund Germany. European Organization for Nuclear Research (CERN) Geneva Switzerland Department of Physics and Astronomy University of Manchester Manchester United Kingdom Cavendish Laboratory University of Cambridge Cambridge United Kingdom LPNHE Sorbonne Université Paris Diderot Sorbonne Paris Cité CNRS/IN2P3 Paris France Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China INFN Sezione di Firenze Firenze Italy Authors affiliated with an institute formerly covered by a cooperation agreement with CERN INFN Sezione di Ferrara Ferrara Italy INFN Sezione di Milano-Bicocca Milano Italy Also at Università degli Studi di Milano-Bicocca Milano Italy. University of Chinese Academy of Sciences Beijing

The branching fraction of the decay B+→ψ(2S)ϕ(1020)K+, relative to the topologically similar decay B+→J/ψϕ(1020)K+, is measured using proton-proton collision data collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The ratio is found to be 0.061±0.004±0.009, where the first uncertainty is statistical and the second systematic. Using the world-average branching fraction for B+→J/ψϕ(1020)K+, the branching fraction for the decay B+→ψ(2S)ϕ(1020)K+ is found to be (3.0±0.2±0.5±0.2)×10−6, where the first uncertainty is statistical, the second systematic, and the third is due to the branching fraction of the normalization channel.

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