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Hox-determined appendage regeneration restores cockroach courtship rituals

Science China(Life Sciences) 2025年第3期68卷 874-876页

作者： Xingmei Mai Mingtao Liao Fangming Zhao Ethan Yihao Li Fangzheng Liu renaguli Aisa Sichen Wu Nan Chen Sheng Li Chonghua ren Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514779China High School Affiliated to South China Normal University Guangzhou 510631China Xinyang Aviation Vocational College Xinyang 464006China

dear Editor,The German cockroach,Blattella germanica(Insecta,Blattodea),is one of the most synanthropic cosmopolitan pests affecting public health,which is often described as“little mighty”because of its extreme vitality and *** characterization in cockroaches is primarily due to two crucial biological traits,strong regenerative capacity and excellent fecundity(ren et al.,2023),but nothing is known about the underlying relationship between these two traits in terms of physiology and *** have evolved diverse appendages(***,labial palp,maxillary palp,leg,wing,and cercus)that are used for locomotion,feeding,communication,and other vital functions(Chen et al.,2022;Li et al.,2024).As a crucial adaptive strategy,appendage regeneration enables animals to restore injured body parts and their associated functions(Tanaka,2016),significantly enhancing survival ability and ecological adaptation(Zhong et al.,2023).Moreover,cockroaches exhibit extremely prominent capacity of leg regeneration in the insect kingdom(Li et al.,2018;ren et al.,2024;Zhang et al.,2024).

关键词： traits antenna regeneration

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dynamic distribution and temporal transcriptome adaptations elucidate lithium accumulation pattern in Cardamine violifolia

Environmental Chemistry and Ecotoxicology

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Environmental Chemistry and Ecotoxicology 2025年 7卷 1106-1118页

作者： Lulu Chen Mingwei Yue Xiaomeng Liu Xin Cong Shuiyuan Cheng Shen rao National R&D Center for Se-rich Agricultural Products Processing Technology School of Modern Industry for Selenium Science and Engineering Wuhan Polytechnic University Wuhan 430048 China Enshi Se-Run Material Engineering Technology Co. Ltd Enshi 445000 China

The growing use of electronic devices and power batteries has introduced lithium (Li) as a new environmental contaminant. However, knowledge on the toxicity of Li to plants remains scarce. In this study, Cardamine violifolia was exposed to 200 mg L −1 of LiCl, with samples collected on 3, 6, 9, and 12 d. results showed that Li concentration in C. violifolia increased over time. By 12 d, the shoots and roots accumulated 164.67 mg kg −1 and 8.41 mg kg −1 FW of Li, respectively. Li was primarily found in the blade edges and was mainly distributed in cell walls and soluble components. Activities of peroxidase (POd), superoxide dismutase (SOd), catalase (CAT), and ascorbate peroxidase (APX) enzymes were significantly increased under Li exposure. Transcriptome analysis identified 15,810 differentially expressed genes (dEGs). In the shoots, dEGs were enriched in plant hormone signal transduction, phenylpropanoid biosynthesis, and pentose and glucuronate interconversion pathways. In the roots, dEGs were mainly enriched in phagosome and ribosome pathways. Weighted gene co-expression network analysis indicated that potassium transporter 5 ( HAK5 ), potassium transporter 9 ( KT9 ), metal transporter ( Nramp ), metal-nicotianamine transporter ( YSL ), Glutathione S-transferase U ( GSTU ), potassium channel ( KAT ), nitrate transporter ( NrT1 ), heavy metal-associated isoprenylated plant protein ( HMA ), odium/calcium exchanger ( NCL ), and ATP-binding cassette transporter C family member ( ABCC ) genes may be involved in Li uptake and transport in C. violifolia . This study systematically revealed the unique distribution patterns of Li in C. violifolia . By integrating physiological, biochemical, and transcriptomic analyses, we identified multiple gene families associated with Li transport in plants. These findings not only provide novel insights into the spatial regulatory mechanisms underlying plant responses to emerging pollutants but also establish a theoretical foundation

关键词： Cardamine violifolia distribution Gene regulation Lithium Uptake

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research on the Calculation Method of CO2 Storage Volume and its Application in L reservoir

Research on the Calculation Method of CO2 Storage Volume and...

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2025 International Petroleum technology Conference, IPTC 2025

作者： Wu, Zangyuan Feng, Qihong Lian, Liming Meng, Xiangjuan Xu, YanLong Wang, Sen Wu, Kuankuan Zhou, Wei Luo, Min Li, Yang Fan, Jin Cheng, ronghong Wu, Mimi Huang, Xingning School of Petroleum Engineering China University of Petroleum East China China Tarim Oilfield Company PetroChina Korla China R&D Center for Ultra-Deep Complex Reservoir Exploration and Development CNPC Korla China Research Institute of Petroleum E&D Petrochina CNPC Beijing China Chengdu CK Energy Technology Co. Ltd. Chengdu China

ISBN: (纸本)9781959025436

This paper addresses the difficulty in calculating CO2 storage volume due to the complexity of CO2 occurrence states in the CCUS process. A method for calculating CO2 storage volume is proposed, designing well networks throughout the entire lifecycle of CCUS to meet the demands of both CO2 EOr and storage stages. This extends the implementation time of CO2 EOr to enhance oil recovery and ensures effective CO2 storage while maximizing oil production, aligning with the global strategy of green and low-carbon development. Initially assuming that the pore volume of produced hydrocarbons is completely occupied by CO2 and considering dissolution retention and mineral reaction retention, the theoretical carbon storage volume of the target reservoir is predicted to determine the upper limit of storage volume. Building on flash calculation, utilizing equations of state-activity models, equations of state-equations of state models, and chemical reaction kinetics models, model parameters were fitted and corrected through experiments on CO2 multiphase non-isothermal flow, dissolution, solid-phase deposition, and mineral reactions to develop a CO2 storage volume prediction model and proprietary software. Finally, reliability verification was conducted using analogous block comparison methods. The technology proposed in this paper has been applied in the integrated CO2 EOr and storage scheme for the L reservoir, predicting saturation fields, solubility fields, and various storage mechanisms during the CO2 flooding and storage process and providing three-dimensional field changes. results indicate that the theoretical carbon storage upper limit for the L reservoir is 9.88 million tons;under current reservoir temperature and pressure conditions, CO2 dissolution loss in formation connate water is 0.05 t/m3, and in residual oil it is 0.32 t/t, resulting in an effective storage volume of 7.47 million tons (with analogous block comparison results at 7.78 million tons, verifying the rel

关键词： Oil well flooding

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Suppressed grain boundary scattering effect to enhance electrical transport properties of La0.815Sr0.185MnO3 polycrystalline ceramic via high-temperature sintering process

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Ceramics International 2025年

作者： Liang, Xiaolu Chen, Zihao Wang, Zhenyu Pan, Zimeng Wang, Yao Wang, Haitao Sun, Jiankun Ma, Jun Jiang, Xuexing Peng, Jubo Gu, Xin Zhang, Jing Liu, Xiang Faculty of Material Science and Engineering Kunming University of Science and Technology Yunnan Kunming650093 China Kunming Kaihang Optoelectronic Technology Co. LTD Yunnan Kunming650200 China Company Limited R&D Center Yunnan Kunming650106 China

Polycrystalline La0.815Sr0.185MnO3 (LSMO) ceramic was synthesized using the sol-gel method. The effect of varying sintering temperatures (1763, 1783, 1803 and 1823 K) on the microstructure and electrical transport properties were systematically investigated. The samples exhibited a distinct dual-peak metal-insulator transition, with the first peak (Tp1) primarily influenced by grain boundary (GB) scattering effect. At lower sintering temperatures, lattice strain induced by the ionic size mismatch between La3+ and Sr2+ ions is transferred to the grain boundaries, increasing their contribution to resistivity. As the sintering temperature rises, the grain boundary effect diminish, leading to a suppression of the Tp1 peak. Elevated sintering temperatures further promote hybridization effect, enhancing the double exchange mechanism. As the temperature increases, this mechanism gradually becomes dominant, leading to a more pronounced influence of the Tp2 peak. Additionally, higher sintering temperatures reduce grain boundary scattering, improving the temperature coefficient of resistivity (TCr). At an optimal sintering temperature of 1803 K, the LSMO ceramic achieved a peak TCr of 10.78 % K−1 near room temperature (284.8 K), demonstrating strong potential for improved performance in uncooled infrared bolometers or electronic switch devices. © 2025 Elsevier Ltd and Techna Group S.r.l.

关键词： Sol-gel process

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Performance and wear mechanisms of TiAlN-NbN coated cemented carbide in milling Ti6Al4V with different cooling and lubrication approaches

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Wear 2025年

作者： Lindvall, rebecka Casas Gayubo, Josu Gutnichenko, Oleksandr Auzenat, François M'Saoubi, rachid Bushlya, Volodymyr Division of Production and Materials Engineering Lund University Ole Römers Väg 1 Lund221 00 Sweden R&D Milling and Process Seco Tools France 22 Avenue de La Prospective Bourges18 000 France R&D Materials and Technology Development Seco Tools AB Fagersta737 82 Sweden

Titanium alloys are difficult-to-machine materials given their high strength, the high temperatures generated, and the naturally short contact length that combined result in rapid tool wear. different machining strategies can be employed to cope with the low machinability. This study investigates the machining performance using different cooling and lubrication methods during down face milling of the most employed Ti alloy Ti6Al4V. The conditions include a dry environment, flood coolant, and sustainable vegetable oil applied at minimum quantity lubrication (MQL) condition. The tool life at dry conditions and with MQL applied vegetable oil are similar but MQL shows promising potential in prolonging tool life. Flood coolant provided no beneficial effect and tool life was about 50 % shorter as to dry and MQL conditions. The tool wear evolution on as-worn tools and their cross-sections is studied in scanning electron microscope using X-ray energy-dispersive spectroscopy. The PVd applied TiAlN-NbN coated WC-12%Co tools are worn by mechanical fracturing which is additionally accelerated by the outward diffusion of C from WC and Co binder that facilitate WC grain pull-out. Oxidation of Co binder further weakens the tool material mechanically. © 2025 The Authors

关键词： Titanium alloys

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Sub-surface sinking effect of reinforcement particle in laser assisted machining of metal matrix composites

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CIrP Annals 2025年

作者： Mypati, Omkar Liao, Zhirong Zan, Shusong M'Saoubi, rachid Axinte, dragos Machining and Condition Monitoring Group Faculty of Engineering University of Nottingham United Kingdom R&D Materials and Technology Development Fagersta Sweden Division of Production and Materials Engineering Lund University Lund Sweden

Aluminium-based SiC particle-reinforced metal matrix composites are widely used in engineering applications due to their exceptional mechanical properties. However, their machining remains challenging due to the mismatch of material properties between the brittle SiC particles and the ductile aluminium matrix, causing tool wear and surface damage. To mitigate these issues, laser inverse problem scanning is utilised to strategically melt the top layer aluminium matrix, allowing the SiC particles to sink and promoting more ductile Al-matrix. The strategic hybrid laser milling approach optimises particle sinking, reduces tool wear and enhances surface integrity by minimising particle fracture, pullout and refining microstructure. © 2025 The Author(s)

关键词： Milling (machining)

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Particle-based investigation of excipients stability: the effect of storage conditions on moisture content and swelling †

RSC Pharmaceutics

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rSC Pharmaceutics 2025年第2期2卷 369-386页

作者： Isra Ibrahim Mark Carroll Anas Almudahka James Mann Alexander Abbott Fredrik Winge Adrian davis Bart Hens Ibrahim Khadra daniel Markl Centre for Continuous Manufacturing and Advanced Crystallisation (CMAC) University of Strathclyde Glasgow UK daniel.markl@strath.ac.uk Strathclyde Institute of Pharmacy & Biomedical Sciences University of Strathclyde Glasgow UK Department of Pharmaceutics and Pharmaceutical Technology Yarmouk University Irbid Jordan Department of Pharmaceutics College of Pharmacy Kuwait University Kuwait Oral Product Development Pharmaceutical Technology & Development Operations AstraZeneca Macclesfield UK Oral Product Development Pharmaceutical Technology & Development Operations AstraZeneca Gothenburg Sweden Analytical R&D Pharmaceutical Sciences Small Molecules Pfizer R&D UK Ltd Sandwich UK Drug Product Design Pfizer Zaventem Belgium

Moisture sensitivity poses a challenge in formulating oral dosage forms, particularly when considering disintegrants’ swelling due to prior moisture exposure, impacting performance and physical stability. This study utilises dynamic vapour sorption to simulate real-world storage scenarios, investigating the equilibrium moisture content and dynamics of eight commonly used excipients in oral solid dosage forms. A model was developed to determine the kinetic rate constant of moisture sorption and desorption for different storage conditions. dynamic vapour sorption tests revealed that excipients with higher moisture-binding capacities showed slower equilibration to the target relative humidity (rH). Elevated temperatures accelerated the moisture sorption/desorption process for all excipients, reducing the equilibrated moisture content for most, except mannitol and lactose. Particle imaging over a 14-day accelerated storage period quantified swelling, indicating approximately 6% increase in particle diameter for croscarmellose sodium (CCS) and sodium starch glycolate (SSG), and a lesser 2.7% for microcrystalline cellulose (MCC), predominantly caused by the humidity. All excipients reached their swelling peak within the first day of storage, with permanent particle size enlargement for CCS and SSG, whereas MCC displayed a partial reversibility post-storage. Enhancing our understanding of excipients’ stability and interaction with moisture and the resulting particle swelling contributes to the rational design of oral solid dosage formulations and promotes a better understanding of their long-term physical stability.

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Analysis of tool wear in micromilling Ti6Al4V and its impact on generated surface integrity

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Wear 2025年

作者： Gonçalves, Maria Clara Coimbra Alsters, rob Curtis, david Bushlya, Volodymyr M'Saoubi, rachid Ghadbeigi, Hassan University of Sheffield Mechanical Engineering Department Mappin Street Sheffield United Kingdom R&D Materials and Technology Development Seco Tools AB Zandterweg 14 Lottum5973 RC Netherlands Advanced Manufacturing Research Centre University of Sheffield RotherhamS60 5TZ United Kingdom Lund University Ole Römers väg 1 Lund221 00 Sweden R&D Materials and Technology Development Seco Tools AB Fagersta737 82 Sweden

Tool wear is one of the dominant factors that impacts the surface integrity of machined materials. Understanding the impact of tool wear on surface integrity is crucial in micromilling, due to the size of the features being machined and the cutting tools. Therefore, this work aims to analyse the impact of tool wear on surface integrity during the micromilling of Ti6Al4V. In this context, microslots were manufactured on a Ti6Al4V workpiece using both coated and uncoated 1 mm flat end mills at constant cutting parameters with varying cutting lengths in order to analyse the progression of tool wear with machined length and its impact on surface integrity. The microtools were investigated using both Scanning Electron Microscope (SEM) and infinite focus optical imaging (Alicona) to determine the tool wear evolution. Surface integrity was assessed by analysing surface roughness areal parameters, surface microscope images, and subsurface microstructure and microhardness perpendicular to the cutting direction. The results show that surface quality was not affected by the evolution of tool wear, with surface topography, including surface roughness parameters, remaining within a similar range until the catastrophic failure of the tool. Analysis of the machined surface revealed small chips adhered to it, which affected the surface texture height measurements, leading to a predominance of atypical peaks on the surface. Subsurface analysis of the machined material showed that the microstructure and microhardness remained consistent with the bulk material characteristics, indicating no evidence of severe plastic deformation in the machined subsurface. However, once the tool failed and began rubbing against the workpiece surface, swept grains due to material dragging and heat-affected zones were observed in the subsurface microstructure. Swept grains, caused by material extrusion, were also observed in the microstructure of the top burr formation regions throughout the experiments

关键词： Titanium alloys

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Integrated Well Network design Mode for CO2 EOr and Storage and its Application in L reservoir

Integrated Well Network Design Mode for CO2 EOR and Storage ...

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2025 International Petroleum technology Conference, IPTC 2025

作者： Wu, Zangyuan Tang, Yongliang Lian, Liming Zhou, daiyu Zhao, Haitao Shao, Guangqiang Feng, Qihong Zhou, Wei Li, Hong Bian, Wanjiang Zhang, Liang du, Hongbao Luo, Min Huang, Xingning Tarim Oilfield Company PetroChina Xinjiang Korla China R&D Center for Ultra-Deep Complex Reservoir Exploration and Development CNPC Xinjiang Korla China School of Petroleum Engineering China University of Petroleum East China Qingdao China Research Institute of Petroleum E&D Petrochina CNPC Beijing China Chengdu CK Energy Technology Co. Ltd. Sichuan Chengdu China

ISBN: (纸本)9781959025436

This paper addresses the challenge of difficulty in adjusting late-stage production in water-flooded reservoirs and proposes an integrated well network design mode for CO2 enhanced oil recovery (EOr) and storage. The well network is designed according to the full life cycle of carbon capture, utilization, and storage (CCUS), meeting the requirements of both CO2 EOr and storage phases. It extends the implementation time of CO2 EOr schemes to enhance oil recovery while ensuring effective CO2 storage, aligning with the overall strategy of global green and low-carbon development. The overall approach involves the use of a three-dimensional CO2 flooding injection and recovery well network, with progressive development in the vertical stratigraphic layers to maximize the utilization of existing old wells. The stratigraphic reconstruction involves the CO2 flooding injection and recovery well network, ensuring that new gas injection wells meet the requirements for CO2 injection processes and production rates, while also serving as replacements for gas injection in other stratigraphic layers. Production wells make use of the original old wells, and well completion methods are adjusted to achieve the development of replacement layers. The "top injection, middle production, bottom support" three-stage development method is designed to fully utilize the high points of reservoir microstructures and bottom water energy. Finally, well network optimization is achieved through streamline tracking simulation methods. The proposed technology has been applied in the CO2 enhanced oil recovery plan for the L reservoir. Initially focusing on CO2 flooding for oil recovery and shifting to CO2 storage later, it is projected to achieve a cumulative CO2 injection of tens of millions of tons over 46 years (including 40% recycled injection), with a displacement factor reaching 1.57PV. After deducting the recycled carbon amount, the cumulative carbon storage exceeds 6 million tons, affecting a vo

关键词： Crude oil

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Influence of the design of Ti (C, N)-based cermets with alternative binders on their performance and wear in milling

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Wear 2025年

作者： Premkumar, Vikas B.K. Chalkiadakis, Evangelos M'Saoubi, rachid Bushlya, Volodymyr Production and Materials Engineering Lund University Ole Römers Väg 1F Box 118 Lund221 00 Sweden R&D Materials and Technology Development Seco Tools AB FagerstaSE-73782 Sweden

Ti (C, N) based cermet materials are predominantly used in continuous finishing applications of metal cutting due to their high hardness, excellent resistance to oxidation and high chemical stability. However, their application in interrupted cutting like milling are limited due to their brittle-like failure due to low fracture toughness. In this work, alternative binder systems such as Co-Ni and Ni are investigated to study their influence on the material properties followed by evaluating their performance in face milling of quench and tempered 42CrMo4 steels having a hardness of 35 HrC. The results show that as the concentration of Ni in the binder increases, the hardness (HV) decreases and the Palmqvist fracture toughness (K1C) increases. This trend is more pronounced in the binder containing pure Ni. Thus, Ni helps in transforming the nature of a brittle-like cermet with Co binder to a tougher cermet with Co-Ni and pure Ni binder. Up-milling tests with coolant revealed that as-sintered cermet with pure Co and Co-Ni binder performed similarly while pure Ni binder showed premature failure. CVd coated cermet in as-deposited state shows a substantial improvement in performance of the Co-Ni binder compared to pure Co binder while Ni binder show rapid flaking of coating causing premature failure. Formation of comb cracks and parallel cracks networks followed by adhesion and impaction of steel in the cracks is observed as the main wear mechanism that causes rapid block isolation of the geometry leading to tool catastrophic failure. However, CVd coated Co-Ni binder system showed less adhesion in the crack networks which is speculated to be the reason for its improved performance. © 2025 The Authors

关键词： Cracks

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