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International Conference on Electrical Machines and systems (ICEMS)

作者： Shuhei Shimmyo Hiroshi Mochikawa Yoichi Morishima Power and Industrial Systems R&D Center Toshiba Corporation Japan Industrial Power Electronics Development & Engineering Department Toshiba Corporation Japan

ISBN: (纸本)9781467388634

This paper describes a development of a high power density power converter using flying capacitor multilevel circuits for PV systems. To connect the PV systems to a power grid, a power conditioner system (PCS) is required. Sine wave filters and EMI filters are required to satisfy harmonics regulations such as CISPr. These filters are dominant in a total volume of the PCSs. To design a small PCS to interconnect power grids and the PV systems of homes, the total volume of the PCS must be reduced. In this paper, a high power density converter is designed by using the topology of flying-capacitor multilevel circuits. The experimental results validate the effectiveness of the proposed circuit.

关键词： Capacitors Inverters Power harmonic filters Switches Harmonic analysis Topology Bridge circuits

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Sequential auto-reclosing method for hybrid HVdC breaker in VSC HVdC links

Sequential auto-reclosing method for hybrid HVDC breaker in ...

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IEEE Annual Southern Power Electronics Conference (SPEC)

作者： K Vinothkumar Inger Segerqvist Niclas Johannesson Arman Hassanpoor Grid Systems R&D India Development Center ABB Global Industries and Services Private Limited Chennai Tamilnadu India Grid Systems HVDC ABB AB Ludvika Sweden

ISBN: (纸本)9781509015474

Voltage source converters (VSC) are increasingly being used in high voltage direct current (HVdC) systems and with higher power ratings of these converters, the interest for usage with long transmission system is also increasing. With long overhead transmission dc links, many faults would be transient or temporary in nature. Such faults are mainly caused by lightning. The objective of this paper lies in proposing and implementing an auto-reclose feature to the operation of Hybrid HVdC breaker (HHB). The proposed method has been evaluated in a point-to-point HVdC link along with HHB at each end. This study shows that the proposed sequential operation of HHB can quickly and cost-effectively re-close the faulty line with minimal impact on connected ac grid and where the converters can continue to support the ac network with reactive power. Furthermore, the proposed soft start procedure adopted in auto-reclosing operation of HHB assists in reducing the dc current inrush and distribute the energy stress among the non-linear resistors in the main breaker modules of HHB.

关键词： resistors HVdC transmission Circuit faults Power conversion Voltage control Surges

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Ultralight vector dark matter search using data from the KAGrA O3GK run

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Physical review d 2024年第4期110卷 042001页

作者： A. G. Abac r. Abbott H. Abe I. Abouelfettouh F. Acernese K. Ackley C. Adamcewicz S. Adhicary N. Adhikari r. X. Adhikari V. K. Adkins V. B. Adya C. Affeldt d. Agarwal M. Agathos O. d. Aguiar I. Aguilar L. Aiello A. Ain P. Ajith T. Akutsu S. Albanesi r. A. Alfaidi A. Al-Jodah C. Alléné A. Allocca S. Al-Shammari P. A. Altin S. Alvarez-Lopez A. Amato L. Amez-droz A. Amorosi C. Amra S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Andia M. Ando T. Andrade N. Andres M. Andrés-Carcasona T. Andrić J. Anglin S. Ansoldi J. M. Antelis S. Antier M. Aoumi E. Z. Appavuravther S. Appert S. K. Apple K. Arai A. Araya M. C. Araya J. S. Areeda N. Aritomi F. Armato N. Arnaud M. Arogeti S. M. Aronson K. G. Arun G. Ashton Y. Aso M. Assiduo S. Assis de Souza Melo S. M. Aston P. Astone F. Aubin K. AultONeal G. Avallone S. Babak F. Badaracco C. Badger S. Bae S. Bagnasco E. Bagui Y. Bai J. G. Baier r. Bajpai T. Baka M. Ball G. Ballardin S. W. Ballmer S. Banagiri B. Banerjee d. Bankar P. Baral J. C. Barayoga B. C. Barish d. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia d. Barta S. d. Barthelmy M. A. Barton I. Bartos S. Basak A. Basalaev r. Bassiri A. Basti M. Bawaj P. Baxi J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale F. Beirnaert M. Bejger d. Belardinelli A. S. Bell V. Benedetto d. Beniwal W. Benoit J. d. Bentley M. Ben Yaala S. Bera M. Berbel F. Bergamin B. K. Berger S. Bernuzzi M. Beroiz d. Bersanetti A. Bertolini J. Betzwieser d. Beveridge N. Bevins r. Bhandare U. Bhardwaj r. Bhatt d. Bhattacharjee S. Bhaumik S. Bhowmick A. Bianchi I. A. Bilenko G. Billingsley A. Binetti S. Bini O. Birnholtz S. Biscoveanu A. Bisht M. Bitossi M.-A. Bizouard J. K. Blackburn C. d. Blair d. G. Blair F. Bobba N. Bode G. Bogaert G. Boileau M. Boldrini G. N. Bolingbroke A. Bolliand L. d. Bonavena r. Bondarescu F. Bondu E. Bonilla M. S. Bonilla A. Bonino r. Bonnand P. Booker A. Borchers V. Boschi S. Bose V. Bossilkov V. Boudart A. Boumerdassi A. Bozzi C. Bradaschia P. r. Brady M. Braglia A. Branch M. Branchesi M. Breschi T. B Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-14476 Potsdam Germany LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Graduate School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8551 Japan LIGO Hanford Observatory Richland Washington 99352 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli I-80126 Napoli Italy University of Warwick Coventry CV4 7AL United Kingdom OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia The Pennsylvania State University University Park Pennsylvania 16802 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA Louisiana State University Baton Rouge Louisiana 70803 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Stanford University Stanford California 94305 USA Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Dipartimento di Fisica Università degli Studi di Torino I-10125 Torino Italy INFN Sezione di Torino I-10125 Torino Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom OzGrav University of Western Austral

Among the various candidates for dark matter (dM), ultralight vector dM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGrA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector dM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson dM using the KAGrA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight dM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of dM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector dM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation timescale of dM.

关键词： dark matter Particle dark matter Gravitational wave detectors

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Corrigendum to ‟On-tissue polysulfide visualization by surface-enhanced raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity" [redox Biol. 41 (2021) 101926]

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redox biology 2021年 44卷 102028页

作者： Kazufumi Honda Takako Hishiki Sohei Yamamoto Takehiro Yamamoto Nami Miura Akiko Kubo Mai Itoh Wei-Yu Chen Masashi Takano Tomoyuki Yoshikawa Takahiro Kasamatsu Shinichiro Sonoda Hirotoshi Yoshizawa Seigo Nakamura Yuichiro Itai Megumi Shiota daisuke Koike Masayuki Naya Noriyo Hayakawa Yoshiko Naito Tomomi Matsuura Keiko Iwaisako Toshihiko Masui Shinji Uemoto Kengo Nagashima Yoshinori Hashimoto Tomohiro Sakuma Osamu Matsubara Wilber Huang Tomoaki Ida Takaaki Akaike Yohei Masugi Michiie Sakamoto Tomoyasu Kato Yoshinori Ino Hiroshi Yoshida Hitoshi Tsuda Nobuyoshi Hiraoka Yasuaki Kabe Makoto Suematsu Department of Biomarkers for Early Detection of Cancer National Cancer Center Research Institute Tokyo Japan AMED-CREST Japan Agency for Medical Research and Development (AMED) Japan Department of Bioregulation Graduate School of Medicine Nippon Medical School Japan. Department Biochemistry Keio University School of Medicine Tokyo Japan. Department of Diagnostic Pathology Anjo Kosei Hospital Aichi Japan. Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Department of Pathology Wan Fang Hospital Taipei Medical University Taipei Taiwan. Department of Obstetrics and Gynecology National Defense Medical College Saitama Japan. Department of Clinical Oncology National Defense Medical College Hospital Saitama Japan. Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital Tokyo Japan. Frontier Core Technology Laboratories R&D Management Headquarters FUJIFILM Corporation Ashigara-gun Kanagawa Japan. FUJIFILM Business Expert Corporation Ashigara-gun Kanagawa Japan. Division of Hepato-Biliary-Pancreatic Surgery and Transplantation Department of Surgery Kyoto University 54 Shogoin Kawaracho Sakyo Kyoto Japan Department of Medical Life Systems Faculty of Life and Medical Sciences Doshisha University 1-3 Tatara Miyakodani Kyotanabe city Kyoto Japan. Division of Hepato-Biliary-Pancreatic Surgery and Transplantation Department of Surgery Kyoto University 54 Shogoin Kawaracho Sakyo Kyoto Japan. Research Center for Medical and Health Data Science The Institute of Statistical Mathematics Tokyo Japan. Scientific Imaging Scanner Department System Division Hamamatsu Photonics Hamamatsu Japan. Bioscience Division Mitsui Knowledge Industry Corporation Ltd. Tokyo Japan. Department of Pathology Hiratsuka Kyosai Hospital The Cancer Institute Kanagawa Japan. Abnova Corporation Taipei Taiwan. Department of Environmental Medicine and Molecular Toxicology Tohoku University Graduate School of Medici

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Innovative design of an Air Cooled Ferrite Permanent Magnet Assisted Synchronous reluctance Machine for Automotive Traction Application

Innovative Design of an Air Cooled Ferrite Permanent Magnet ...

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International Conference on Electrical Machines

作者： J. Juergens A. Fricasse L. Marengo J. Gragger M. de Gennaro B. Ponick Institute of Drive Systems and Power Electronics Leibniz-Universitat Hannover R&D EMEA Product Development E/E & Connectivity Vehicle Research & Innovation Centro Ricerche Fiat S.C.p.A. Mobility Department Electric Drive Technologies AIT Austrian Institute of Technology

ISBN: (纸本)9781509025398

This paper presents the innovative design of an air cooled permanent magnet assisted synchronous reluctance machine (PMaSyrM) for automotive traction application. Key design features include low cost ferrite magnets in an optimized rotor geometry with high saliency ratio, low weight and sufficient mechanical strength as well as a tailored hairpin stator winding in order to meet the demands of an A-segment battery electric vehicle (BEV). Effective torque ripple reduction techniques are analyzed and a suitable combination is chosen to keep additional manufacturing measures as low as possible. Although the ferrite magnets exhibit low remanence, it is shown that their contribution to the electrical machine's performance is essential in the field weakening region. Efficiency optimized torque-speed-characteristics are identified, including additional losses of the inverter, showing an overall system efficiency of more than 94%. Lastly, the results of no load measurements of a prototype are compared to the FEM simulation results, indicating the proposed design of a PMaSyrM as a cost-effective alternative to state-of-the-art permanent magnet synchronous machines (PMSM) for vehicle traction purposes.

关键词： Air cooled machine Efficiency-optimized torque-speed-maps Electric vehicle Ferrite magnet Hairpin winding Permanent magnet assisted synchronous reluctance machine Slotted rotor Step-Skewing Torque ripple reduction

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85 kHz Band 44 kW Wireless Power Transfer System for rapid Contactless Charging of Electric Bus

85 kHz Band 44 kW Wireless Power Transfer System for Rapid C...

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International Symposium on Antennas and Propagation

作者： Tetsu Shijo Kenichirou Ogawa Fumi Moritsuka Masatoshi Suzuki Hiroaki Ishihara Yasuhiro Kanekiyo Koji Ogura Masaaki Ishida Shuichi Obayashi Shuhei Shimmyo Koji Maki Fumiaki Takeuchi Nobumitsu Tada Corporate Research & Development Center Toshiba Corporation Kanagawa Japan Power and Industrial Systems R&D Center Toshiba Corporation Tokyo Japan

ISBN: (纸本)9781467379601

A 44 kW wireless power transfer (WPT) system is being developed for rapid contactless charging in an electric bus in the 85 kHz band, the candidate frequency for a wireless charging system for light-duty vehicles that is currently undergoing standardization. A two-channel WPT system with currents of opposite phase in the two transmit pads of the channels is introduced to reduce radiated emissions to within the radio Act limits by cancelling the emission from each channel. In this paper, the measured power for the 44 kW WPT system is shown.

关键词： Wireless power transfer contactless charging electric bus EV

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Open data from the Third Observing run of LIGO, Virgo, KAGrA, and GEO

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Astrophysical Journal, Supplement Series 2023年第2期267卷 29-29页

作者： Abbott, r. Abe, H. Acernese, F. Ackley, K. Adhicary, S. Adhikari, N. Adhikari, r.X. Adkins, V.K. Adya, V.B. Affeldt, C. Agarwal, d. Agathos, M. Aguiar, O.d. Aiello, L. Ain, A. Ajith, P. Akutsu, T. Albanesi, S. Alfaidi, r.A. Al-Jodah, A. Alléné, C. Allocca, A. Almualla, M. Altin, P.A. Amato, A. Amez-droz, L. Amorosi, A. Anand, S. Ananyeva, A. Andersen, r. Anderson, S.B. Anderson, W.G. Andia, M. Ando, M. Andrade, T. Andres, N. Andrés-Carcasona, M. Andrić, T. Ansoldi, S. Antelis, J.M. Antier, S. Aoumi, M. Apostolatos, T. Appavuravther, E.Z. Appert, S. Apple, S.K. Arai, K. Araya, A. Araya, M.C. Areeda, J.S. Arène, M. Aritomi, N. Arnaud, N. Arogeti, M. Aronson, S.M. Arun, K.G. Asada, H. Ashton, G. Aso, Y. Assiduo, M. Assis de Souza Melo, S. Aston, S.M. Astone, P. Aubin, F. AultONeal, K. Babak, S. Badalyan, A. Badaracco, F. Badger, C. Bae, S. Bagnasco, S. Bai, Y. Baier, J.G. Baiotti, L. Baird, J. Bajpai, r. Baka, T. Ball, M. Ballardin, G. Ballmer, S.W. Baltus, G. Banagiri, S. Banerjee, B. Bankar, d. Baral, P. Barayoga, J.C. Barber, J. Barish, B.C. Barker, d. Barneo, P. Barone, F. Barr, B. Barsotti, L. Barsuglia, M. Barta, d. Barthelmy, S.d. Barton, M.A. Bartos, I. Basak, S. Basalaev, A. Bassiri, r. Basti, A. Bawaj, M. Bayley, J.C. Baylor, A.C. Bazzan, M. Bécsy, B. Bedakihale, V.M. Beirnaert, F. Bejger, M. Bell, A.S. Benedetto, V. Beniwal, d. Benoit, W. Bentley, J.d. Ben Yaala, M. Bera, S. Berbel, M. Bergamin, F. Berger, B.K. Bernuzzi, S. Beroiz, M. Berry, C.P.L. Bersanetti, d. Bertolini, A. Betzwieser, J. Beveridge, d. Bevins, N. Bhandare, r. Bhandari, A.V. Bhardwaj, U. Bhatt, r. Bhattacharjee, d. Bhaumik, S. Bianchi, A. Bilenko, I.A. Bilicki, M. Billingsley, G. Bini, S. Birnholtz, O. Biscans, S. Bischi, M. Biscoveanu, S. Bisht, A. Biswas, B. Bitossi, M. Bizouard, M.-A. Blackburn, J.K. Blair, C.d. Blair, d.G. Blair, r.M. Bobba, F. Bode, N. Boër, M. Bogaert, G. Boileau, G. Boldrini, M. Bolingbroke, G.N. Bonavena, L.d. Bondarescu, r. Bondu, F. Bonilla, E. Bonilla, G.S. Bonnand, r. Booker, P. Bork, r. Boschi, V. Bose, N. LIGO Laboratory California Institute of Technology Pasadena 91125 CA United States Graduate School of Science Tokyo Institute of Technology 2-12-1 Ookayama Meguro-ku Tokyo 152-8551 Japan Dipartimento di Farmacia Università di Salerno Salerno Fisciano I-84084 Italy INFN Sezione di Napoli Napoli I-80126 Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 VIC Australia The Pennsylvania State University University Park 16802 PA United States University of Wisconsin-Milwaukee Milwaukee 53201 WI United States Louisiana State University Baton Rouge 70803 LA United States OzGrav Australian National University Canberra 0200 ACT Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) Hannover D-30167 Germany Leibniz Universität Hannover Hannover D-30167 Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Instituto Nacional de Pesquisas Espaciais São Paulo São José dos Campos 12227-010 Brazil Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa Pisa I-56127 Italy International Centre for Theoretical Sciences Tata Institute of Fundamental Research Bengaluru 560089 India Gravitational Wave Science Project National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan 2-21-1 Osawa Mitaka City Tokyo 181-8588 Japan Dipartimento di Fisica Università degli Studi di Torino Torino I-10125 Italy INFN Sezione di Torino Torino I-10125 Italy SUPA University of Glasgow Glasgow G12 8QQ United Kingdom OzGrav University of Western Australia Crawley 6009 WA Australia Univ. Savoie Mont Blanc CNRS Laboratoire d'Annecy de Physique des Particules - IN2P3 Annecy F-74000 France Università di Napoli “Federico II” Napoli I-80126 Italy University of Minnesota Minneapolis 55455 MN United States M

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGrA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://***. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages. © 2023. The Author(s). Published by the American Astronomical Society.

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A closed-cycle hydrogen combustion system with Stirling engine for AUV propulsion

A closed-cycle hydrogen combustion system with Stirling engi...

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OCEANS - Europe

作者： Hyunjong Paik Agency for Defense Development Naval Systems R&D Institute Changwon Republic of Korea

A closed-cycle hydrogen combustion system equipped with Stirling engine is developed for the propulsion of large Autonomous Underwater Vehicles (AUVs). Complete hydrogen reaction in the combustion chamber of engine is assured by excessive oxygen. The flame temperature of hydrogen is controlled by dilution gas and water vapor. Combustion product, i.e., water vapor condenses to water liquid, and drains out from the closed-cycle. Simplifications of controller are pursued to increase operational reliability. A demonstration system is manufactured and tested. The test results have justified the adequacy of design concepts. The system is expected to be a promising energy supplier in terms of reliability and cost effectiveness.

关键词： Hydrogen Combustion Stirling engines Fuel cells Underwater vehicles Fires

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GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

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Nature genetics 2023年第9期55卷 1471-1482页

作者： remi Stevelink dorothee Kasteleijn-Nolst Trenite Bobby P. C. Koeleman dick Lindhout Anja C. M. Sonsma Ciarán Campbell Gianpiero L. Cavalleri Norman delanty Hany El-Naggar Austin Lacey Peter Widdess-Walsh Colin P. doherty Siwei Chen Claire Churchhouse Mark J. daly Yen-Chen A. Feng daniel P. Howrigan Mitja I. Kurki Benjamin M. Neale Aarno Palotie Wei Zhou Namrata Gupta Henrike O. Heyne Bassel Abou-Khalil Kevin F. Haas r. S. Taneja Oluyomi M. Adesoji Michael Nothnagel Peter Nürnberg Thomas Sander Zaid Afawi Ilan Blatt Amos d. Korczyn Elisabetta Amadori Ganna Balagura Antonella riva Marcello Scala Paolo Scudieri Pasquale Striano Federico Zara Michele Iacomino Francesca Madia Alison Anderson Patrick Kwan Terence J. O’Brien Slavé Petrovski K. Meng Tan Marian Todaro Joseph Anderson danielle M. Andrade Quratulain Zulfiqar Ali Grazia Annesi Pauls Auce Andreja Avbersek Simona Balestrini Vera Braatz Claudia B. Catarino Krishna Chinthapalli Jennifer Jamnadas-Khoda dalia Kasperavičiūte Costin Leu Josemir W. Sander Sanjay M. Sisodiya Sara Zagaglia Melanie Bahlo Karen L. Oliver Mark d. Baker Beata Fonferko-Shadrach William O. Pickrell Carmen Barba Claudia Bianchini Viola doccini renzo Guerrini davide Mei Martino Montomoli Elena Parrini Annalisa Vetro Karen Barboza Fabrice Bartolomei Thomas Bast Bernhard J. Steinhoff Larry Baum Stacey S. Cherny Pak Sham Tobias Baumgartner Christian E. Elger Kerstin Hallmann Wolfram S. Kunz rainer Surges randi von Wrede Gábor Zsurka Betül Baykan Nerses Bebek Yeşim Kesim Albert J. Becker Susanne Schoch Felicitas Becker Caitlin A. Bennett Samuel F. Berkovic Stephanie L. Leech Brigid M. regan Ingrid E. Scheffer Bianca Berghuis Ahmad Beydoun Wassim Nasreddine Francesca Bisulli Lidia di Vito Lorenzo Ferri Tania Giangregorio Laura Licchetta raffaella Minardi Barbara Mostacci Carlotta Stipa Paolo Tinuper Lorenzo Muccioli Federica Pondrelli dheeraj r. Bobbili Emadeldin Hassanin roland Krause Zied Landoulsi Patrick May Ingo Borggraefe Christian Bosselmann Christian Hengsbach Josua Kegele Stephen Lauxmann Department of Genetics University Medical Center Utrecht Utrecht The Netherlands Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands School of Pharmacy and Biomolecular Sciences The Royal College of Surgeons in Ireland Dublin Ireland The FutureNeuro Research Centre Dublin Ireland Department of Neurology Beaumont Hospital Dublin Ireland Department of Neurology St. James’s Hospital Dublin Ireland Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA USA Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA USA Stanley Center for Psychiatric Research Broad Institute of Harvard and M.I.T Cambridge MA USA Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland Psychiatric & Neurodevelopmental Genetics Unit Department of Psychiatry Massachusetts General Hospital and Harvard Medical School Boston MA USA Division of Biostatistics Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Hasso Plattner Institute Digital Health Center University of Potsdam Potsdam Germany Hasso Plattner Institute Mount Sinai School of Medicine New York City NY USA Department of Neurology Vanderbilt University Medical Center Nashville TN USA Cologne Center for Genomics (CCG) University of Cologne Faculty of Medicine and University Hospital Cologne Cologne Germany University Hospital Cologne Cologne Germany Department of Neurology Charité Universitaetsmedizin Berlin Campus Virchow-Clinic Berlin Germany Tel-Aviv University Sackler Faculty of Medicine Ramat Aviv Israel Department of Neurology Sheba Medical Center Ramat Gan Israel Department of Neurosciences Rehabilitation Ophthalmology Genetics Maternal and Child Health University of Genova Genova Italy IRCCS Istituto Giannina Gaslini Genova Italy Department of Medicine University of Melbour

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epilepsy, and 52,538 controls. We identify 26 genome-wide significant loci, 19 of which are specific to genetic generalized epilepsy (GGE). We implicate 29 likely causal genes underlying these 26 loci. SNP-based heritability analyses show that common variants explain between 39.6% and 90% of genetic risk for GGE and its subtypes. Subtype analysis revealed markedly different genetic architectures between focal and generalized epilepsies. Gene-set analyses of GGE signals implicate synaptic processes in both excitatory and inhibitory neurons in the brain. Prioritized candidate genes overlap with monogenic epilepsy genes and with targets of current antiseizure medications. Finally, we leverage our results to identify alternate drugs with predicted efficacy if repurposed for epilepsy treatment.

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On the Mechanical Stresses of Cu Through-Silicon Via (TSV) Samples Fabricated by SK Hynix vs. SEMATECH – Enabling robust and reliable 3-d Interconnect/Integrated Circuit (IC) Technology

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Procedia Engineering 2016年 139卷 101-111页

作者： Tian Tian r. Morusupalli H. Shin H.-Y. Son K.-Y. Byun Y.-C. Joo r. Caramto L. Smith Y-L. Shen M. Kunz N. Tamura A.S. Budiman Maxim Integrated San Jose CA Component Quality and Technology (CQT) Cisco Systems San Jose CA 95134 Department Of Materials Science & Engineering Seoul National University (SNU) Republic of Korea PKG Development Group R&D Division Hynix Semiconductor Inc. Republic of Korea SEMATECH Albany NY 12203 Department Of Mechanical Engineering University of New Mexico (UNM) Albuquerque NM 87131 Advanced Light Source (ALS) Lawrence Berkeley National Laboratory (LBNL)Berkeley CA 94720 Singapore University of Technology and Design (SUTD) Singapore 487372

One of the key enablers for the successful integration of 3-d interconnects using the Through-Silicon Via (TSV) schemes is the control of the mechanical stresses in the Cu TSV itself as well as in the surrounding silicon substrate. The synchrotron-sourced X-ray microdiffraction technique has been recognized to allow some important advantages compared to other techniques in characterization of the mechanical stresses in a TSV sample. This approach have been used to study Cu TSV samples from SK Hynix, Inc. earlier as well as more recently from SEMATECH, and we have found interesting differences in the stress states of the Cu TSV. We proposed a possible explanation of the observed differences. This fundamental understanding could lead to improved stress control and hence reliability in the Cu TSV samples, as well as to reduce its impact to the silicon electron mobility and hence to device performance in general.

关键词： 3-d interconnects Cu TSV X-ray microdiffraction

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