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Erratum for Pelegrin et al., "High-risk International Clones of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Endemic to Indonesian Intensive Care Units: Impact of a Multifaceted Infection Control Intervention Analyzed at the Genomic Level"

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mBio 2020年第3期11卷 e01372-20页

作者： Andreu Coello Pelegrin Yulia rosa Saharman Aurélien Griffon Mattia Palmieri Caroline Mirande Anis Karuniawati rudyanto Sedono dita Aditianingsih Wil H F Goessens Alex van Belkum Henri A Verbrugh Corné H W Klaassen Juliëtte A Severin Clinical Unit bioMérieux La Balme Les Grottes France. Vaccine & Infectious Disease Institute Laboratory of Medical Microbiology Faculty of Medicine and Health Sciences University of Antwerp Antwerp Belgium. Department of Clinical Microbiology Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital Jakarta Indonesia. Department of Medical Microbiology and Infectious Diseases Erasmus MC University Medical Center Rotterdam The Netherlands. R&D Systems & Development bioMérieux Marcy l'Etoile France. Microbiology R&D bioMérieux La Balme Les Grottes France. Critical Care Division Department of Anesthesia and Intensive Care Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General Hospital Jakarta Indonesia. Clinical Unit bioMérieux La Balme Les Grottes France alex.vanbelkum@***.

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TEAd–YAP Interaction Inhibitors and MdM2 Binders from dNA-Encoded Indole-Focused Ugi Peptidomimetics

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Angewandte Chemie 2020年第46期132卷

作者： Kunig V.B.K. Potowski M. Akbarzadeh M. Klika Škopić M. dos Santos Smith d. Arendt L. dormuth I. Adihou H. Andlovic B. Karatas H. Shaabani S. Zarganes-Tzitzikas T. Neochoritis C.G. Zhang r. Groves M. Guéret S.M. Ottmann C. rahnenführer J. Fried r. dömling A. Brunschweiger A. TU Dortmund University Faculty of Chemistry and Chemical Biology Otto-Hahn-Strasse 6 Dortmund 44227 Germany Max Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Strasse 11 Dortmund 44227 Germany TU Dortmund University Faculty of Statistics Vogelpothsweg 87 Dortmund 44227 Germany Medicinal Chemistry Research and Early Development Cardiovascular Renal and Metabolism (CVRM) BioPharmaceuticals R&D AstraZeneca Gothenburg 43150 Sweden AstraZeneca-Max Planck Institute Satellite Unit Max-Planck Institute of Molecular Physiology Department of Chemical Biology Otto-Hahn-Strasse 11 Dortmund 44227 Germany Lead Discovery Center GmbH (Germany) Otto-Hahn-Strasse 15 Dortmund 44227 Germany Laboratory of Chemical Biology Department of Biomedical Engineering and Institute for Complex Molecular Systems Eindhoven University of Technology Den Dolech 2 Eindhoven AZ 5612 Netherlands University of Groningen Drug Design Deusinglaan 1 Groningen AV 7313 Netherlands University of Crete Department of Chemistry Heraklion 70013 Greece

dNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or “hot spot”, regions of protein–protein interactions. A dNA-encoded combinatorial peptoid library was designed based on the Ugi four-component reaction by employing tryptophan-mimetic indole side chains to probe the surface of target proteins. Several peptoids were synthesized on a chemically stable hexathymidine adapter oligonucleotide “hexT”, encoded by dNA sequences, and substituted by azide-alkyne cycloaddition to yield a library of 8112 molecules. Selection experiments for the tumor-relevant proteins MdM2 and TEAd4 yielded MdM2 binders and a novel class of TEAd-YAP interaction inhibitors that perturbed the expression of a gene under the control of these Hippo pathway effectors. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

关键词： combinatorial chemistry dNA-encoded library peptidomimetics protein–protein interaction inhibition Ugi reaction

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A new approach for advanced plasticity and fracture modelling

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IOP Conference Series: Materials Science and Engineering 2019年第1期651卷

作者： N Park T B Stoughton J W Yoon Metal Forming Technology R&D Group Korea Institute of Industrial Technology Incheon South Korea General Motors Global Research and Development Center Warren USA School of Mechanical Aerospace and Systems Engineering KAIST Daejeon Republic of Korea School of Engineering Deakin University Geelong Waurn Ponds Australia

A solution to the challenge of modelling the general yielding behaviour including fracture initiation is proposed based on non-associated flow rule. A decoupled formulation with employment of a Lagrangian interpolation function is established to develop a general fracture criterion that considers the mutual effect of the material anisotropy, the strain rate, and the temperature on the onset of fracture. An advanced constitutive law is also developed to accurately describe the evolution of the anisotropy/asymmetry-induced distortional yielding behaviour, using neither any interpolation nor optimization techniques for the calibration of the yield surface. The proposed models are successfully applied to various types of metallic materials to validate their noticeable flexibility and applicability in describing the general material behaviour during various forming processes.

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81-1: High Transmittance and High Contrast LCd for 3d Head-Up displays

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SId Symposium digest of Technical Papers 2018年第1期49卷

作者： Mitsuhiro Murata ryoichi Yokoyama Yoshiki Tanaka Toshihiko Hosokawa Kenji Ogura Yasuhiro Yanagihara Kaoru Kusafuka Takuya Matsumoto Corporate Development & Design Group Kyocera Display Corporation Yasu Japan Information Systems R&D Division Kyocera Corporation Yokohama Japan

We achieved high transmittance and high contrast with keeping high response speed by using high aperture ratio technology and high efficiency liquid crystal. Transmittance is improved by 149% from initial mass product... 详细信息

关键词： Liquid crystal display HUd (Head Up display) 3d

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development of ground penetrating radar using 48 channel impulse radar array

Development of ground penetrating radar using 48 channel imp...

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European radar Conference (EUrAd)

作者： Jihoon Kwon Nojun Kwak dongwon Yang Yeosun Yoon Graduate School of Convergence Science and Technology (GSCST) Seoul National University Korea Agency for Defence Development Korea Hanwha systems Radar R&D centre Korea

This paper describes the development and test of Ground Penetrating radar using 48 channel UWB impulse radar array for landmine detection. For getting high-resolution landmine images, a monocycle waveform having 600ps pulse width is applied. In order to analyze performances, we use representative soils of Korea and training landmines similar to landmines buried in the Korea's dMZ. The developed GPr system finds the estimation points with having a high possibility as landmines and provides top-view and down-track landmine images at these points. The test result of this system shows the clear differences between clutter images and landmine images. Therefore, we expect that this system can be applied for effectively removing landmines buried in Korea.

关键词： Landmine detection Ground penetrating radar radar antennas Soil Mathematical model radar imaging

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development Efforts on Wide Area Wireless Access to Accelerate Its Use for M2M

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NTT Technical review 2017年第3期15卷 20-26页

作者： Mochizuki, Nobuaki Katsuda, Hajime Fujino, Yosuke Akabane, Kazunori Nagaoka, Hideki Murao, Takashi Yonesaka, Shinji Senior Research Engineer Wireless Systems Innovation Laboratory NTT Network Innovation Laboratories Japan Wireless System Innovation Laboratory NTT Network Innovation Laboratories Japan Research Engineer Wireless Systems Innovation Laboratory NTT Network Innovation Laboratories Japan Senior Research Engineer Supervisor Wireless Systems Innovation Laboratory NTT Network Innovation Laboratories Japan Project Manager Innovative Development Promotion Group NTT WEST R&D Center Japan Assistant Manager Innovative Development Promotion Group NTT WEST R&D Center Japan User Service Group NTT WEST R&D Center Japan

The Internet of Things (IoT), in which everything is connected to the Internet, has recently been attracting a lot of attention. NTT has been undertaking various initiatives such as research and development and field trials to realize IoT services. This article describes the requirements of IoT/M2M (machine-to-machine) services and outlines the low power wide area (LPWA) network. It also introduces a field trial utilizing the LPWA network implemented by NTT WEST and a wide-area and high-capacity radio relay system developed by NTT. © 2017 Nippon Telegraph and Telephone Corp.. All rights reserved.

关键词： Internet of things

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revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

NPJ drug discovery

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NPJ drug discovery 2025年第1期2卷 3页

作者： Karla P Godinez-Macias daisy Chen J Lincoln Wallis Miles G Siegel Anna Adam Selina Bopp Krypton Carolino Lauren B Coulson Greg durst Vandana Thathy Lisl Esherick Madeline A Farringer Erika L Flannery Barbara Forte Tiqing Liu Luma Godoy Magalhaes Anil K Gupta Eva S Istvan Tiantian Jiang Krittikorn Kumpornsin Karen Lobb Kyle J McLean Igor M r Moura John Okombo N Connor Payne Andrew Plater Srinivasa P S rao Jair L Siqueira-Neto Bente A Somsen robert L Summers rumin Zhang Michael K Gilson Francisco-Javier Gamo Brice Campo Beatriz Baragaña James duffy Ian H Gilbert Amanda K Lukens Koen J dechering Jacquin C Niles Case W McNamara Xiu Cheng Lyn-Marie Birkholtz Alfred W Bronkhorst david A Fidock dyann F Wirth daniel E Goldberg Marcus C S Lee Elizabeth A Winzeler Department of Pediatrics University of California San Diego La Jolla CA USA. Panorama Global 2101 4th Ave Ste 2100 Seattle WA USA. Lgenia Inc. 412 S Maple St Fortville IN USA. MMV Medicines for Malaria Venture 1215 Geneva Switzerland. Department of Immunology and Infectious Diseases Harvard T.H. Chan School of Public Health Boston MA USA. Holistic Drug Discovery and Development (H3D) Centre Institute of Infectious Disease and Molecular Medicine University of Cape Town Cape Town South Africa. Department of Microbiology and Immunology Columbia University Irving Medical Center New York NY USA. Center for Malaria Therapeutics and Antimicrobial Resistance Division of Infectious Diseases Department of Medicine Columbia University Irving Medical Center New York NY USA. Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA. Division of Infectious Diseases Boston Children's Hospital Boston MA USA. Global Health Biomedical Research Novartis Emeryville CA USA. Drug Discovery Unit Division of Biological Chemistry and Drug Discovery School of Life Science University of Dundee Dundee UK. Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. Calibr-Skaggs Institute for Innovative Medicines a division of The Scripps Research Institute La Jolla CA USA. Division of Infectious Diseases Washington University School of Medicine Saint Louis MO USA. São Carlos Institute of Physics University of São Paulo São Carlos São Paulo Brazil. Center for Systems Biology Massachusetts General Hospital Boston MA USA. TropIQ Health Sciences Nijmegen The Netherlands. Infectious Disease and Microbiome Program Broad Institute Cambridge MA USA. Global Health Drug Discovery Institute Beijing China. Global Health Medicines R&D GlaxoSmithKline Tres Cantos Madrid Spain. Department of Biochemistry Genetics & Microbiology Institute for Sustainable Malaria Control University of Pretoria Private B

Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space is also constrained by existing compound libraries and phenotypic assay conditions. Leveraging recent advances in protein structure prediction, we systematically assessed the genome and identified 867 candidate protein targets with evidence of small-molecule binding and blood-stage essentiality. Of these, 540 proteins showed strong essentiality evidence and lack inhibitors that have progressed to clinical trials. Expert review and rubric-based scoring of this subset based on additional criteria such as selectivity, structural information, and assay developability yielded 27 high-priority antimalarial target candidates. This study also provides a genome-wide data resource for and implements a generalizable framework for systematically evaluating and prioritizing novel pathogenic disease targets.

关键词： Target identification Target validation

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Fundamental experiments of eddy current testing for additive manufacturing metallic material toward in-process inspection

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AIP Conference Proceedings 2019年第1期2102卷

作者： Noriyasu Kobayashi Setsu Yamamoto Azusa Sugawara Masayo Nakane daisuke Tsuji Takehisa Hino Takahiro Terada Makoto Ochiai 1Nuclear System Technology R&D Dept. Toshiba Energy Systems & Solutions Corporation 8 Shinsugita-cho Isogo-ku Yokohama-shi Kanagawa 235-8523 Japan 2Technology & Production Planning Div. Toshiba Energy Systems & Solutions Corporation 72-34 Horikawa-cho Saiwai-ku Kawasaki-shi Kanagawa 212-8585 Japan 3Structural and Functional Materials Technology R&D Dept. Toshiba Energy Systems & Solutions Corporation 2-4 Suehiro-cho Tsurumi-ku Yokohama-shi Kanagawa 230-0045 Japan 4Corporate Manufacturing Engineering Center Toshiba Corporation 33 Shinisogo-cho Isogo-ku Yokohama-shi Kanagawa 235-0017 Japan 5Power and Industrial Systems Research and Development Center Toshiba Corporation 8 Shinsugita-cho Isogo-u Yokohama-shi Kanagawa 235-8523 Japan

We evaluated the detectability of the eddy current testing for the inner defects of the additive manufacturing specimens with the step and the slope on the surfaces by the fundamental experiments. The eddy current testing was able to detect the inner defects of 0.5 mm or more in diameter which were at the depth of 0.5 mm from the surfaces of the specimens in signal-to-noise ratio of 2 or more at the frequency of 250 kHz. We also confirmed that the signal post-processing for the acquired eddy current testing data had the potential to separate the inner defect signals from the noises caused by the surface shapes using the difference in the phase angle between the signals and the noises.

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Experimental realization of Multi-Service roF System using OCS-PolMux Techniques

Experimental Realization of Multi-Service RoF System using O...

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International Conference on Advanced Communication Technology

作者： M. H. Mohamad Nor T. Kanesan F. Maskuriy A. Yusof F.A. Fatah S. B. A. Anas Telekom Research & Development (TM R&D) TM Innovation Centre 63000 Cyberjaya Malaysia Department of Computer and Communication Systems Engineering Faculty of Engineering Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia

ISBN: (纸本)9781509048922

Optical Carrier Suppression has been proven as an efficient way of generating high frequency optical carrier for radio over Fiber (roF) systems. However, previous studies show that OCS with the combination of rF and optical components can only transmit a single service in roF system. This paper shows that two different services can be transmitted using a single wavelength through roF system with the use of Polarization Multiplexing (PolMux) method. The combination of these two techniques enables multiservice roF such as LTE and WiFi services to be transmitted simultaneously to the customers.

关键词： Local Multipoint distribution Service (LMdS) Multiservice Optical Carrier Suppression (OCS) Polarization Multiplexing (PolMux) radio over Fiber (roF)

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Study for further introduction of the Electronic Frequency converters to the Tokaido Shinkansen

Study for further introduction of the Electronic Frequency c...

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International Power Electronics Conference

作者： Toshimasa Shimizu Ken Kunomura Masahiko Kai Hiroki Miyajima Teruhisa Matsui General Technology Division Technology Research and Development Department Central Japan Railway Company Aichi Japan Construction Department Central Japan Railway Company Kanagawa Japan Railway system Division Toshiba Infrastructure systems & Solutions Corporation Kanagawa Japan Power System Solution and Distribution System R&D Department Toshiba Corporation Tokyo Japan

In the Tokaido Shinkansen, frequency conversion systems are used for unification of the feeding electric power frequency. For the base power, rotary frequency changers are used for these tolerances against inrush current or temporary heavy load current. Then, the frequency conversion equipment are mainly composed by the rotary frequency changers. In this report, studies are done for further introduction of the electronic frequency converters, replacing rotary frequency changers. And, progresses for replacements are realized by investigating controls, blocking and re-drive system, with reducing special rating.

关键词： Shinkansen Frequency converter Inrush current

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