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Investigation of the anti-inflammatory mechanisms of fermented Chinese herbal residue solution in an APEC-Infected Hd11 cell model through the PI3K/AKT and NF-κB pathways

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Poultry Science 2025年第9期104卷 105383页

作者： Bowen Huang Shuanghao Mo Chengguang He Junhui Zhu Zining Tan Linlin Chen Yiming Wang Hongxia Ma College of Animal Science and Technology College of Veterinary Medicine Jilin Agricultural University Changchun 130118 China Jilin Provincial Key Laboratory of New Veterinary Drug R&D and Creation Changchun 130118 China College of Life Sciences Jilin Agricultural University Changchun 130118 China Jilin Agricultural University Bioreactor and Drug Development Engineering Research Center of the Ministry of Education Changchun 130118 China School of Public Health Beihua University Jilin 132013 China

Avian pathogenic Escherichia coli ( APEC ) infection poses a significant challenge to the poultry industry, severely threatening poultry health and industrial development. The emergence of antibiotic resistance in conventional treatments underscores the urgent need for novel alternative therapies. Fermented Chinese herbal residue solution, as a potential substitute, is rich in bioactive components and exhibits multifaceted effects, including anti-inflammatory, antioxidant, and immunomodulatory properties. This study investigates the anti-inflammatory mechanisms and key active compounds of the fermented herbal residue solution ( BY3 ) in an APEC infection model. An in vitro APEC-infected Hd11 cell model was established, with optimal infection conditions determined as a multiplicity of infection ( MOI ) of 0.1 and an infection duration of 6 hours, based on cytotoxicity assays and qPCr analysis. results demonstrated that BY3 intervention significantly downregulated the expression of inflammatory cytokines. APEC infection markedly upregulated the expression of key target genes in the PI3K/AKT and NF-κB pathways, whereas BY3 treatment significantly reduced their expression. Western blot analysis further confirmed that BY3 significantly decreased the phosphorylation levels of AKT, P65, and IκB proteins, as well as the total PI3K protein content. These findings suggest that BY3 mitigates APEC-induced inflammation by modulating the PI3K/AKT and NF-κB pathways. To elucidate the active components of BY3, non-targeted metabolomics sequencing, database comparison, and molecular docking were employed, identifying four key bioactive compounds: Tangeretin, Arctigenin, rhein, and Phloretin. All tested compounds significantly reduced APEC-induced inflammatory cytokine expression. qPCr and Western blot analyses revealed differential regulatory effects on the PI3K/AKT and NF-κB pathways. In the PI3K/AKT pathway, Tangeretin exhibited the most comprehensive inhibitory effect, significan

关键词： Avian Pathogenic Escherichia coli (APEC) Fermented Chinese herbal residue solution Anti-inflammatory Hd11 cell

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Haloscope Searching for dark Photons at Q-band with a Novel Coupling Tuning Structure

arXiv

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arXiv 2025年

作者： Yin, Yue Kang, runqi Jiao, Man rong, Xing Laboratory of Spin Magnetic Resonance School of Physical Sciences University of Science and Technology of China Hefei230026 China Anhui Province Key Laboratory of Scientific Instrument Development and Application University of Science and Technology of China Hefei230026 China Hefei National Laboratory University of Science and Technology of China Hefei230088 China Institute for Advanced Study in Physics Zhejiang University Hangzhou310027 China Institute of Quantum Sensing School of Physics Zhejiang University Hangzhou310027 China Zhejiang Key Laboratory of R&D and Application of Cutting-edge Scientific Instruments Zhejiang University Hangzhou310027 China

Laboratory searching for dark matter is crucial for understanding several fundamental conundrums in physics and cosmology. Most cavity-based haloscope searches focus on the frequency range below 10 GHz, while the parameter space with higher frequency remains rarely explored, due to the challenges lying in the fabrication of microwave cavities. Here we report the first Q-band haloscope searching for dark photons with a 33.141 GHz cavity. A novel coupling tuning structure separated from the cavity was designed so as not to degrade the quality factor of the cavity. We have established the most stringent constraints χ −12 at a confidence level of 90 % in the frequency range from 33.139 GHz to 33.143 GHz, corresponding to the mass of dark photons ranging from 137.05 µeV to 137.07 µeV. The results surpass the previous astronomical constraints by nearly three orders of magnitude. This work has demonstrated the feasibility of dark matter haloscopes at Q band. In the future, the constraints can be further improved by more than one order of magnitude through low-temperature experiments, and the setup can be extended to search for axions, axion-like particles, and high-frequency gravitational waves. © 2025, CC BY.

关键词： dark Matter

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research on Combat deduction Platform technology for Intelligent Operational decision

Research on Combat Deduction Platform Technology for Intelli...

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2019中国智能自动化大会(CIAC 2019)

作者： Xin Liao Zheng-hao Sun Aerospace System Development Research Center China Aerospace Science and Technology Corporation R&D Center China Academy of Launch Vehicle Technology

Artificial intelligence technology is expected to become a powerful force to promote the evolution of war patterns in the *** technology has the ability to use data fusion for rapid decision-making,and will become a key supporting technology for operational *** paper analyzes the relation between military and intelligent decision-making,analyzes the structural characteristics of combat problems according to the requirements of command decision-making learning and training of artificial intelligence,proposes a design idea of antagonistic deduction platform,and explains the key problems in its architecture design,as well as the data exchange method between platform and intelligent learning ***,the system implementation and technical verification are carried out in a small area denial *** platform supports the access to intelligent command program based on autonomous game decision net,can run real-time intelligent confrontation under asymmetric information,and provides intelligent opponent and benchmark for combat command training.

关键词： Artificial intelligence Assistant decision-making Combat deduction

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digital Biomarkers 2024年第1期8卷 30-39页

作者： Maetzler, Walter Correia Guedes, Leonor Emmert, Kirsten Nele Kudelka, Jennifer Hildesheim, Hanna Luise Paulides, Emma Connolly, Hayley davies, Kristen dilda, Valentina Ahmaniemi, Teemu Avedano, Luisa Bouça-Machado, raquel Chambers, Michael Chatterjee, Meenakshi Gallagher, Peter Graeber, Johanna Maetzler, Corina Kaduszkiewicz, Hanna Kennedy, Norelee Macrae, Victoria Carrasco Marín, Laura Moses, Anusha Padovani, Alessandro Pilotto, Andrea ratcliffe, Natasha reilmann, ralf rosario, Madalena Schreiber, Stefan de Sousa, dina Van Gassen, Geert Warring, Lori Ann Seppi, Klaus Van der Woude, C. Janneke Ferreira, Joaquim J. Ng, Wan-Fai Department of Neurology University Medical Centre Schleswig-Holstein Campus Kiel and Kiel University Kiel Germany Instituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz Faculdade de Medicina da Universidade de Lisboa Lisbon Portugal Department of Gastroenterology and Hepatology Erasmus University Medical Centre Rotterdam Netherlands School of Allied Health Faculty of Education and Health Sciences and Health Research Institute University of Limerick Limerick Ireland Translational and Clinical Research Institute Newcastle University and NIHR Newcastle Biomedical Research Centre Newcastle upon Tyne United Kingdom CHDI Management CHDI Foundation PrincetonNJ United States Teknologian Tutkimuskeskus VTT Oy Espoo Finland European Federation of Crohn's and Ulcerative Colitis Brussels Belgium MC Healthcare Evaluation London United Kingdom Janssen Research and Development CambridgeMA United States Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne United Kingdom Institute of General Medicine University Medical Centre Schleswig-Holstein Kiel University Kiel Germany Asociación Parkinson Madrid Madrid Spain University of Twente Department of Medical Cell Biophysics TechMed Centre Enschede Netherlands Neurology Unit Department of Clinical and Experimental Sciences University of Brescia Brescia Italy Parkinson's UK London United Kingdom George-Huntington-Institute R&D-Campus/Technology-Park Münster Münster Germany Institute of Clinical Radiology University of Münster Münster Germany Department of Neurodegeneration Hertie Institute for Clinical Brain Research University of Tübingen Tübingen Germany Department of Internal Medicine I University Medical Centre Schleswig-Holstein Kiel University Kiel Germany European Huntington's Association Moerbeke Belgium Medical Department Takeda Brussels Belgium Janssen LLC GCSO Immunology HorshamPA United States Department of Neurology Medical University Inns

Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatiguerelated changes of daily function. Key Messages: results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area. © 2024 The Author(s). Published by S. Karger AG, Basel.

关键词： Wearable technology

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A Machine Learning approach to transferable Loss-in-Weight feeder mass flow prediction from equipment configuration and material properties

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Powder technology 2025年 463卷

作者： Torrecillas, Carlota Mendez Jolliffe, Hikaru G. Elkes, richard reynolds, Gavin Aroniada, Magdalini Shier, Andrew Verrier, Hugh Fathollahi, Sara robertson, John CMAC 99 George Street GlasgowG1 1RD United Kingdom GSK Ware R&D Harris's Lane Ware HertfordshireSG12 0GX United Kingdom Pharmaceutical Technology & Development Operations AstraZeneca MacclesfieldSK10 2NA United Kingdom Pfizer Research and Development UK Ltd Ramsgate Road SandwichCT13 9NJ United Kingdom DFE Pharma GmbH & Co. KG Kleverstrasse 187 Goch47568 Germany

The present work presents a model structure to predict Loss-in-Weight feeder mass flow performance equation parameters from material and equipment properties via three Machine Learning (ML) models using an ensemble-of-trees approach;the dataset represents 50 materials and material grades and two feeders (with multiple screws per feeder). One ML model is used for feed factor (mass/screw revolution) magnitude prediction, another for the range of feed factor decay behaviour, and a final ML model for refinement of the range to a scalar value. Feed factor magnitude is accurately predicted (test r2 of 0.94, reducing to 0.84 when inputs e.g. material properties are missing) and decay behaviour range is predicted with good accuracy (weighted F1 score of 86.4 %, and 78.6 % with missing inputs), while decay scalar refinement is challenging due to inherent variability. The present approach can be used for equipment pre-selection to determine which feeder-screw combination will likely deliver the mass flow required. © 2025

关键词： Structural properties

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A testability allocation method suitable for engineering application

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IOP Conference Series: Materials Science and Engineering 2021年第2期1043卷

作者： Jie Gong Min-jing Yang Research and Development Department(R&D). Chengdu Morlab Testing Technology Co. Ltd. CH Hope College Business School.Southwest Jiaotong University CH

Firstly introduces the commonly used distribution methods of testability in engineering, and points out that the existing distribution methods have poor operability and inconvenience.A new method of assigning testability index according to failure rate is proposed. This method uses the undetectable rate and the unisolated rate to distribute the primary testability index. Then according to the data obtained in the designer's design, the secondary distribution is carried out in combination with the reliability index and data. This method not only improves the implementability of testability allocation, but also harmonizes the relationship between testability allocation and reliability allocation. Finally, an airborne wireless communication unit is taken as an example to verify the feasibility and effectiveness of this method.

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New Constraints on dark Photon dark Matter with a Millimeter-Wave dielectric Haloscope

arXiv

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arXiv 2025年

作者： Wei, Guoqing Wu, diguang Kang, runqi Jiang, Qingning Jiao, Man rong, Xing du, Jiangfeng CAS Key Laboratory of Microscale Magnetic Resonance School of Physical Sciences University of Science and Technology of China Hefei230026 China Anhui Province Key Laboratory of Scientific Instrument Development and Application University of Science and Technology of China Hefei230026 China Hefei National Laboratory University of Science and Technology of China Hefei230088 China Institute for Advanced Study in Physics Zhejiang University Hangzhou310027 China Institute of Quantum Sensing School of Physics Zhejiang University Hangzhou310027 China Zhejiang Key Laboratory of R&D and Application of Cutting-edge Scientific Instruments Zhejiang University Hangzhou310027 China

dark matter remains one of the most profound and unresolved mysteries in modern physics. To unravel its nature, numerous haloscope experiments have been implemented across various mass range. However, very few haloscope experiments conducted within millimeter-wave frequency range, which is in the favored mass region for well-motivated dark matter candidates. Here we designed and constructed a millimeter-wave dielectric haloscope featuring a dark matter detector composed of dielectric disks and a mirror. Using this setup, we conducted a search for dark photon dark matter and found no evidence for its existence. Our results established new constraints on the kinetic mixing parameter in the mass range from 387.72 to 391.03 µeV, improving the existing limits by two orders of magnitude. With future enhancements, our system has the potential to explore new parameter space for dark photon as well as axion dark matter within millimeter-wave frequency range. © 2025, CC BY.

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Hetero-atom-doped biochar as a sustainable catalyst for value-added upgrading of lignin derivatives: Optimizing dopant for enhancing conversion

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Journal of Environmental Chemical Engineering 2025年第3期13卷

作者： Thi Thanh Thuy, Vo Wu, Hua-Chen Tsai, Yu-Chih Khiem, Ta Cong Lin, Yi-Feng Bui, Ha Manh Tsang, Yiu Fai Lin, Kun-Yi Andrew Department of Environmental Engineering & Innovation Development Center of Sustainable Agriculture National Chung Hsing University Taichung Taiwan Department of Chemical Engineering R&D Center for Membrane Technology Chung Yuan Christian University 200 Chung Pei Rd. Chungli Taoyuan Taiwan Faculty of Environment Saigon University Ho Chi Minh70000 Viet Nam Department of Science and Environmental Studies The Education University of Hong Kong Tai Po New Territories 999077 Hong Kong

Valorization of lignocellulose derivatives into valuable and fine chemicals offers a sustainable pathway for biomass utilization. In this work, we developed phosphorus-doped biochar (CPM) from waste mango peels as a green and non-metal catalyst for the oxidation of vanillyl alcohol (VAL), a lignin-derived molecule, into vanillin (VLN). The CPM catalyst were synthesized through a complete carbonization process at 800 °C for 2 hours. different phosphorus doping conditions were investigated to explore their impact on the textural and chemical characteristics of the materials. Comprehensive analyses (Scanning Electron Microscopy - SEM, Brunauer-Emmett-Teller - BET, X-ray diffraction - Xrd, and Fourier Transform Infrared Spectroscopy - FTIr) revealed that phosphorus doping significantly enhanced surface area, pore volume, and introduced functional groups such as C-P-O, which were pivotal for catalytic performance. The density Functional Theory (dFT) calculations were also applied to gain a deeper understanding of the effect of phosphorous doping at the atomic level. Catalytic studies demonstrated that CPM exhibited remarkable activity for VAL oxidation without requiring external oxidants or metal catalysts, achieving high conversion and selectivity. Mechanistic insights derived from in-situ infrared spectroscopy and electron paramagnetic resonance (EPr) revealed the vital role of phosphorus functionalities in promoting non-radical pathways and facilitating singlet oxygen formation. The effects of operating conditions such as heating method, reaction temperature, reaction time and catalyst dosage were also investigated. The CPM catalyst also showed excellent stability and reusability across multiple cycles with 100 % VAL conversion and 100 % VLN selectivity at 120 °C for 2 hours. This research not only advances the sustainable valorization of lignin derivatives but also underscores the significance of phosphorus modification in tailoring carbon-based catalysts for efficie

关键词： Coking

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A comparative study on the characteristics and properties of cyclodextrans, cyclodextrins, and their complexes with biologically active compounds

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Food Hydrocolloids 2025年 168卷

作者： Hong, Seong-Jin Park, Bo-ram Lee, Byung-Hoo Cho, Jeong-Yong Park, Bu-Soo Kim, Young-Min Research Institute of Agricultural Science and Technology Chonnam National University Gwangju61186 Korea Republic of Department of Integrative Food Bioscience and Biotechnology Chonnam National University Gwangju61186 Korea Republic of Department of Agro-Food Resources National Institute of Agricultural Sciences Rural Development Administration Jeonju55365 Korea Republic of Department of Food Science and Biotechnology Sejong University Seoul05006 Korea Republic of Food Biotech R&D Center Samyang Corp. Seongnam-si Korea Republic of

This study compares and contrasts several structural and thermal characteristics of cyclodextrins (Cds) and cycloisomaltooligosaccharides (CIs) using various analysis techniques. This study demonstrates that, despite both compounds exhibiting similar properties, such as solubilization rate, CI exhibits greater resistance to digestion than Cd, even as the degree of polymerization increases. The physical properties and structural analyses revealed the presence of α-1,4 or α-1,6 linkages in Cds and CIs and distinct variations in their thermal characteristics. This study examined the glucose generation rate, in vitro simulated gastrointestinal digestion, and solubilization of poorly water soluble compounds. The results revealed that CIs are more resistant to digestion than Cds, and natural CIs and β-Cd exhibit higher solubilization rates. These findings suggest that CIs and Cds could be used as carriers for substances in the fields of food and medicine, with CIs offering better protection to the core material against harsh gastrointestinal conditions. © 2025 Elsevier Ltd

关键词： Solubility

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Controlling Factors of Organic Nanopore development: A Case Study on Marine Shale in the Middle and Upper Yangtze region, South China

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Acta Geologica Sinica(English Edition) 2019年第4期93卷 1047-1059页

作者： LIANG Feng ZHANG Qin CUI Huiying MENG Qingqiang MA Chao LIANG Pingping GUO Wei PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China National Energy Shale Gas R&D Experimental Centre Langfang 065007HebeiChina School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Seidment-Tectonic and Reservoir Laboratory PEPRISBeijing 100083China Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Mineral Shandong University of Science and TechnologyQingdao 266590ShandongChina

The Upper Ordovician Wufeng-Lower Silurian Longmaxi and the Lower Cambrian Qiongzhusi shales are the major targets for shale gas exploration and development in *** the two organic-rich shales share similar distribution ranges and thicknesses,they exhibit substantially different exploration and development *** work analyzed the nanopore structures of the shale reservoirs in this *** development of 51 shale samples collected from various formations and locations was compared using the petromineralogical,geochemical,structural geological and reservoir geological *** results indicate that the reservoir space in these shales is dominated by organic pores and the total pore volume of micropores,mesopores,macropores in different tectonic areas and formations show different trends with the increase of *** is suggested that organic pores of shale can be well preserved in areas with simple structure and suitable preservation conditions,and the shale with smaller maximum ancient burial depth and later hydrocarbongeneration-end-time is also more conducive to pore *** pore evolution models are established,and they are as follows:①Organic matter pore development stage,②Early stage of organic matter pore destruction,and③late stage of organic matter pore *** areas conducive to pore development are favorable for shale gas *** results can effectively guide the optimization and evaluation of favorable areas of shale gas.

关键词： marine shale organic matter pores controlling factors pore evolution middle-upper Yangtze regions South China

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