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Fabrication of an Electrode Insulated by Using Hot dip Aluminizing and Micro-arc Oxidation Method for Electrochemical Microhole Machining

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Procedia CIrP 2018年 68卷 438-443页

作者： Jung-Chou Hung Chih-Yang Ku Zhi-Wen Fan Department of Mechanical and Computer Aided Engineering Feng Chia University Taichung 407 Taiwan Structure and Material Systems Department Aeronautical Systems Research Division NATIONAL CHUNG-SHAN INSTITUTE OF SCIENCE & TECHNOLOGY Taichung 407 Taiwan Regional R&D Service Department Metal Industries Research & Development Centre Taichung 407 Taiwan

In this research, electrode insulation of the electrochemical machining tool has been produced by hot dip aluminized micro arc oxidation techniques. In order to form an effective layer on the tungsten carbide tool and achieve higher precision, the tool will then be micro-arc oxidizing, convert the aluminum-rich into aluminum oxide insulating layer. Withstanding Voltage of the tool is being tested afterward by sodium chloride electrolysis method, and the surface and the cross section is being observed. Eventually, the tools were examined and discussed for their machining performance by ECM drilling through stainless steel plate. We were expecting to produce a precise and better insulation. By reducing ECM stray effect, the precision can be achieved. The experimental result shows the optimum parameters are aluminum dipping for 4 minutes, 450 V of micro-arc voltage for 20 minutes and 40 minutes of boiling water sealing, reaching 10.2 V of withstanding voltage. A further electrochemical drilling has been done to explore the effect of insulation. Two electrodes, with and without insulation had been compared. The difference between the entrance and the exit diameter of the hole of insulated tool reaches 17um, compare to the one without insulation, we have successfully reduced 81um. The result shows that the insulation has effectively reduced the stray effect, and achieve high precision machining.

关键词： Hot dip aluminizing aluminum oxide micro-arc oxidation insulation electrochemical machining

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24 GHz BiCMOS Single-Stage rectifier

24 GHz BiCMOS Single-Stage Rectifier

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IEEE-APS Conference on Antennas and Propagation for Wireless Communications

作者： Andreas Brönner Paulius Sakalas Frank Ellinger R&D - Advance Development WIKA Alexander Wiegand SE & Co. KG Klingenberg Germany Semiconductor Physics Institute Center for Physical Sciences and Technology Vilnius Lithuania Chair for Circuit Design and Network Theory Technische Universität Dresden Dresden Germany

This paper presents a fully integrated 24 GHz single-stage rectifier which is designed for passive millimeter wave wireless systems on-chip. The rectifier is converting the rF power captured by the antenna into dC power necessary to supply the active components of a passive radio-frequency identification (rFId)-tag. By increasing the sensitivity of the rectifier, the read range of a passive rFId tag is maximized. The sensitivity is defined as the minimum input power necessary to achieve the output voltage with a given load. In the proposed work we target an output voltage of 1 V, a load of 200 kΩ and achieved a sensitivity of -14 dBm using a single-stage rectifier. The occupied chip size is 0.09 mm 2 , fabricated in a 130 nm BiCMOS technology. Furthermore, the used source pull technique is discussed, which is used to characterize the nonlinear time-variant rectifier in simulation and measurement.

关键词： Sensitivity radio frequency Voltage measurement Millimeter wave technology Impedance Tuners BiCMOS integrated circuits

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Correction to: Understanding the carbonation of concrete with supplementary cementitious materials: a critical review by rILEM TC 281-CCC

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Materials and Structures 2020年第1期54卷 1-2页

作者： von Greve-dierfeld, Stefanie Lothenbach, Barbara Vollpracht, Anya Wu, Bei Huet, Bruno Andrade, Carmen Medina, César Thiel, Charlotte Gruyaert, Elke Vanoutrive, Hanne Saéz del Bosque, Isabel F. Ignjatovic, Ivan Elsen, Jan Provis, John L. Scrivener, Karen Thienel, Karl-Christian Sideris, Kosmas Zajac, Maciej Alderete, Natalia Cizer, Özlem Van den Heede, Philip Hooton, robert douglas Kamali-Bernard, Siham Bernal, Susan A. Zhao, Zengfeng Shi, Zhenguo de Belie, Nele TFB Technology and Research for Concrete Structures Wildegg Switzerland Swiss Federal Laboratories for Materials Science and Technology (Empa) Laboratory for Concrete and Construction Chemistry Dübendorf Switzerland Faculty of Civil Engineering Institute of Building Materials Research RWTH Aachen University Aachen Germany Microlab Faculty of Civil Engineering and Geosciences Delft University of Technology Delft The Netherlands LafargeHolcim Innovation Center Saint-Quentin-Fallavier Cedex France International Centre for Numerical Methods in Engineering (CIMNE) Barcelona Spain Department of Construction Institute for Sustainable Regional Development (INTERRA) University of Extremadura Cáceres Spain Technical University of Munich Center for Building Materials Munich Germany Department of Civil Engineering Structural Mechanics and Building Materials KU Leuven Ghent Belgium Department of Materials and Structures Faculty of Civil Engineering Institute of Materials and structures University of Belgrade Belgrade Serbia Department of Earth and Environmental Sciences KU Leuven Louvain Belgium Department of Materials Science and Engineering University of Sheffield Sheffield UK Construction Materials Laboratory École polytechnique fédérale de Lausanne Lausanne Switzerland Department of Civil Engineering and Environmental Sciences University of the Bundeswehr Munich Neubiberg Germany Department of Civil Engineering Democritus University of Thrace Xanthi Greece Global R&D HeidelbergCement AG Leimen Germany Department of Structural Engineering and Building Materials Ghent University Ghent Belgium Departement of Civil Engineering KU Leuven Louvain Belgium Department of Civil and Mineral Engineering University of Toronto Toronto Canada National Institute of Applied Sciences of Rennes Rennes France School of Civil Engineering University of Leeds Leeds UK Building Materials Urban and Environment Research University of Liège Liège Belgium

dr. Isabel Martins was missing from the rILEM membership list that was published in the original article. The original article has been corrected.

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Point of view: Challenges in implementation of new immunotherapies for Alzheimer's disease

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The journal of prevention of Alzheimer's disease 2025年第1期12卷 100022-100022页

作者： Aye, Sandar Johansson, Gunilla Hock, Christoph Lannfelt, Lars Sims, John r. Blennow, Kaj Frederiksen, Kristian S. Graff, Caroline Molinuevo, José Luis Scheltens, Philip Palmqvist, Sebastian Schöll, Michael Wimo, Anders Kivipelto, Miia Handels, ron Frölich, Lutz Zilka, Norbert Tolar, Martin Johannsen, Peter Jönsson, Linus Winblad, Bengt Division of Neurogeriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet 171 64 Solna Sweden Neurimmune Switzerland Dept. of Public Health Geriatrics Uppsala University Sweden BioArctic AB Stockholm Sweden Eli Lilly and Company Indianapolis IN United States Inst. of Neuroscience and Physiology University of Gothenburg Mölndal Sweden Clinical Neurochemistry Lab Sahlgrenska University Hospital Mölndal Sweden Paris Brain Institute ICM Pitié-Salpêtrière Hospital Sorbonne University Paris France Neurodegenerative Disorder Research Center Division of Life Sciences and Medicine and Department of Neurology Institute on Aging and Brain Disorders University of Science and Technology of China and First Affiliated Hospital of USTC Hefei PR China Danish Dementia Research Center Department of Neurology Copenhagen University Hospital - Rigshospitalet Copenhagen Denmark Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Division of Neurogeriatrics Department of Neurobiology Care Sciences and Society Karolinska Institutet BioClinicum 171 64 Solna Sweden Theme Inflammation and Aging Unit for hereditary dementias Karolinska University Hospital Solna Sweden Global Clinical Development H. Lundbeck A/S 2500 Valby Denmark BarcelonaBeta Brain Research Center 08005 Barcelona Spain EQT Group Dementia Fund Amsterdam Netherlands Clinical Memory Research Unit Department of Clinical Sciences in Malmö Lund University Lund Sweden Memory Clinic Skåne University Hospital Sweden Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden Wallenberg Centre for Molecular and Translational Medicine University of Gothenburg Gothenburg Sweden Department of Psychiatry Cognition and Aging Psychiatry Sahlgrenska University Hospital Mölndal Sweden Dementia Research Centre Institute of Neurology Unive

The advancement of disease-modifying treatments (dMTs) for Alzheimer's disease (Ad), along with the approval of three amyloid-targeting therapies in the US and several other countries, represents a significant development in the treatment landscape, offering new hope for addressing this once untreatable chronic progressive disease. However, significant challenges persist that could impede the successful integration of this class of drugs into clinical practice. These challenges include determining patient eligibility, appropriate use of diagnostic tools and genetic testing in patient care pathways, effective detection and monitoring of side effects, and improving the healthcare system's readiness by engaging both primary care and dementia specialists. Additionally, there are logistical concerns related to infrastructure, as well as cost-effectiveness and reimbursement issues. This article brings together insights from a diverse group of international researchers and dementia experts and outlines the potential challenges and opportunities, urging all stakeholders to prepare for the introduction of dMTs. We emphasize the need to develop appropriate use criteria, including patient characteristics, specifically for the European healthcare system, to ensure that treatments are administered to the most suitable patients. It is crucial to improve the skills and knowledge of physicians to accurately interpret biomarker results, share decision-making with patients, recognize treatment-related side effects, and monitor long-term treatment. We advocate for investment in patient registries and unbiased follow-up studies to better understand treatment effectiveness, evaluate treatment-related side effects, and optimize long-term treatment. Utilizing amyloid-targeting therapies as a starting point for combination therapies should also be a priority. Copyright © 2024. Published by Elsevier Masson SAS.

关键词： Alzheimer's disease Amyloid-targeting therapies Challenges in clinical implementation disease-modifying treatments

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Infrared Bubble recognition in the Milky Way and Beyond Using deep Learning

arXiv

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arXiv 2025年

作者： Nishimoto, Shimpei Onishi, Toshikazu Nishimura, Atsushi Fujita, Shinji Kawanishi, Yasutomo Nakatani, Shuyo Tokuda, Kazuki Shimajiri, Yoshito Kaneko, Hiroyuki Miyamoto, Yusuke Inoue, Tsuyoshi Ito, Atsushi M. Department of Physics Graduate School of Science Osaka Metropolitan University 1-1 Gakuen-cho Naka-ku Osaka Sakai599-8531 Japan Nobeyama Radio Observatory 462-2 Minamimaki-mura Nagano Saku384-1305 Japan The Institute of Statistical Mathematics 10-3 Midori-cho Tachikawa Tokyo190-8562 Japan RIKEN Information R&D and Strategy Headquarters 2-2-2 Hikaridai Seika-cho Soraku-gun Kyoto619-0288 Japan Cybozu Labs Inc Tokyo Nihombashi Tower 27F 2-7-1 Nihombashi Chuo-ku Tokyo103-6027 Japan Kyushu University 6-10-1 hakozaki higashi-ku Fukuoka City812-8581 Japan National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Kyushu Kyoritsu University 1-8 Jiyugaoka Yahatanishi-ku Kitakyushu-shi Fukuoka807-8585 Japan Department of Physical Science Niigata University 8050 Ikarashi 2-no-cho Nishi-ku Niigata950-2181 Japan Fukui University of Technology Faculty of Engineering Development of Electronic Engineering 3-6-1 Gakuen Fukui Fukui910-8505 Japan Department of Physics Konan University 8-9-1 Higashinada Hyogo Kobe658-8501 Japan 322-6 Oroshi Gifu Toki509-5292 Japan

We propose a deep learning model that can detect Spitzer bubbles accurately using two-wavelength near-infrared data acquired by the Spitzer Space Telescope and JWST. The model is based on the Single Shot MultiBox detector as an object detection model, trained and validated using Spitzer bubbles identified by the Milky Way Project (MWP-Bubble). We found that using only MWP-Bubbles with clear structures, along with normalization and data augmentation, significantly improved performance. To reduce the dataset bias, we also use the data without bubbles in the dataset selected by combining two techniques: negative sampling and clustering. The model was optimized by hyperparameter tuning using Bayesian optimization. Applying this model to a test region of the Galactic plane resulted in a 98 % detection rate for MWP-Bubbles with 8 µm emission clearly encompassing 24 µm emission. Additionally, we applied the model to a broader area of 1◦ ≤ |l| ≤ 65◦, |b| ≤ 1◦, including both training and validation regions, and the model detected 3,006 bubbles, of which 1,413 were newly detected. We also attempted to detect bubbles in the high-mass star-forming region Cygnus X, as well as in the external galaxies Large Magellanic Cloud (LMC) and NGC 628. The model successfully detected Spitzer bubbles in these external galaxies, though it also detected Mira-type variable stars and other compact sources that can be difficult to distinguish from Spitzer bubbles. The detection process takes only a few hours, demonstrating the efficiency in detecting bubble structures. Furthermore, the method used for detecting Spitzer bubbles was applied to detect shell-like structures observable only in the 8 µm emission band, leading to the detection of 469 shell-like structures in the LMC and 143 in NGC 628. © 2025, CC BY-NC-Nd.

关键词： deep learning

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Simulation and Testing of a Slew-energy-saving System for Mini Excavators

Simulation and Testing of a Slew-energy-saving System for Mi...

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China International Electrical and Energy Conference (CIEEC)

作者： Jun Gong daqing Zhang Shaowei Sun renhong Liu Chi Tang Cheng Zhang Department of Mechanical and Electrical Engineering Hunan University of Science and Technology Xiangtan City China The National Enterprise R&D Center Sunward Intelligent Equipment CO. Ltd. Changsha City China Research and Development Center Anhui Jianghuai Special Purpose Vehicle Co. Ltd. Hefei City China Research and Development Center Hunan Vast Mechanotronics Co. Ltd. Changsha City China The Enterprise R&D Center Sunward Intelligent Equipment CO. Ltd. Changsha City China

ISBN: (纸本)9781538653937

To recover wasted energy in the slew braking of hydraulic excavators, a slew-energy-saving system based on an accumulator is proposed. Mathematical models of the main system components are developed, by which the energy-saving system simulation is constructed using AMESim. A rule-based energy management control strategy is also proposed. The influence of system parameters on the fuel economy and control performance of the system is analyzed through several simulation tests. results demonstrate that the energy-saving system can raise the energy recovery ratio to 42% while maintaining great control performance of the entire machine. Finally, the prototype test verifies the effectiveness of the system and the simulation model.

关键词： Valves Mathematical model Erbium Oils Brakes Urban areas

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New LQG based vector tracking algorithm using additional tracking loops for high disturbances environment

New LQG based vector tracking algorithm using additional tra...

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Institute of Navigation Pacific Positioning, Navigation and Timing Meeting, PACIFIC PNT 2017

作者： Park, Minhuck Jeon, Sanghoon Shin, Beomju No, Heekwon Kee, Changdon Kim, Chongwon Seo, Seungwoo Park, Junpyo School of Mechanical and Aerospace Engineering Institute of Advanced Aerospace Technology Seoul National University Korea Republic of Corporate R&D Center SK Telecom Korea Republic of Agency for Defense Development Deajeon Korea Republic of

A new LQG based vector tracking algorithm using additional tracking loops for high disturbance environment is presented. The conventional vector tracking algorithm does not estimate errors such as atmospheric delay error and multipath because vector tracking algorithm first estimates the position and estimates the measurements. Therefore, additional tracking loops defined as range domain loop in this paper compensate for these errors to enable continuous signal tracking. In order to evaluate the performance of the proposed algorithm, we compare the LQG based vector tracking algorithm with the EKF and loop filter based vector tracking algorithm and confirm that the LQG based vector tracking algorithm is more robust than EKF based vector tracking algorithm especially in a dynamic user environment. In addition, we confirm that the LQG based vector tracking algorithm with range domain loop can maintain the signal tracking successively in high disturbance environment caused by multiple error sources. Finally, LQG based vector tracking algorithm with range domain loop can be similar results compared to LQG-VTL in no disturbance environment. © 2017 Proceedings of the Institute of Navigation Pacific Positioning, Navigation and Timing Meeting, Pacific PNT.

关键词： Errors

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Correction: A robust and flexible bulk superhydrophobic material from silicone rubber/silica gel prepared by thiol–ene photopolymerization

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Journal of Materials Chemistry A 2019年第12期7卷 7256-7256页

作者： Yongsheng Li Meng ren Pengfei Lv Yingzhi Liu Hong Shao Cong Wang Changyu Tang Yuanlin Zhou Maobing Shuai Science and Technology on Surface Physics and Chemistry Laboratory Mianyang China Chengdu Green Energy and Green Manufacturing Technology R&D Center Chengdu Development Center of Science and Technology China Academy of Engineering Physics Chengdu China State Key Laboratory for Environment-Friendly Energy Materials Southwest University of Science and Technology Mianyang China

Correction for ‘A robust and flexible bulk superhydrophobic material from silicone rubber/silica gel prepared by thiol–ene photopolymerization’ by Yongsheng Li et al., J. Mater. Chem. A, 2019, dOI: 10.1039/c8ta11111a.

Correction for ‘A robust and flexible bulk superhydrophobic material from silicone rubber/silica gel prepared by thiol–ene photopolymerization’ by Yongsheng Li et al., J. Mater. Chem. A, 2019, dOI: rget="_blank" title="Select to resolve dOI link in new window: 10.1039/c8ta11111a" href="https://***/10.1039/c8ta11111a">10.1039/c8ta11111a.

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Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting drug-Food Interactions: an Industry Perspective

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The AAPS journal 2020年第1期23卷 6页

作者： Arian Emami riedmaier Kevin deMent James Huckle Phil Bransford Cordula Stillhart richard Lloyd ravindra Alluri Sumit Basu Yuan Chen Varsha dhamankar Stephanie dodd Priyanka Kulkarni Andrés Olivares-Morales Chi-Chi Peng Xavier Pepin Xiaojun ren Thuy Tran Christophe Tistaert Tycho Heimbach Filippos Kesisoglou Christian Wagner Neil Parrott DMPK and Translational Modeling AbbVie Inc. North Chicago Illinois USA. arian.emamiriedmaier@***. Global DMPK Takeda Pharmaceutical Co. Ltd. San Diego California USA. Drug Product Technology Amgen Thousand Oaks California USA. Modeling & Informatics Vertex Pharmaceuticals Boston Massachusetts USA. Pharmaceutical R&D Formulation & Process Sciences F.Hoffmann-La Roche Ltd. Basel Switzerland. Computational & Modelling Sciences Platform Technology Sci-ences GlaxoSmithKline R&D Ware Hertfordshire UK. Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK. Pharmacokinetic Pharmacodynamic and Drug Metabolism-Quantitative Pharmacology and Pharmacometrics (PPDM-QP2)Merck & Co Inc. West Point Pennsylvania USA. Department of Drug Metabolism and Pharmacokinetics Genentech South San Francisco California USA. Formulation Development Vertex Pharmaceuticals Boston Massachusetts USA. Formulation Development Cyclerion Therapeu-tics Inc. Cambridge Massachusetts USA. Chemical & Pharmaceutical Profiling Novartis Institutes for Biomedical Research Cambridge Massachusetts USA. Department of Pharmacokinetics and Drug Metabolism AmgenInc Cambridge Massachusetts USA. Pharmaceutical Sciences Roche Pharmaceutical Research andEarly Development Roche Innovation Center Basel Switzerland. Drug Metabolism and Pharmacokinetics Theravance Biopharma South San Francisco California USA. New Modalities and Parenteral Development PharmaceuticalTechnology & Development Operations AstraZeneca Maccles-field UK. Modeling & Simulation PK Sciences Novartis Institutes of Biomedical Research East Hanover New Jersey USA. Computational & Modelling Sciences Platform Technology Sci-ences GlaxoSmithKline R&D Collegeville Pennsylvania USA. Pharmaceutical Sciences Janssen Research & Development Beerse Belgium. PBPK & Biopharmaceutics Novartis Institutes of Biomedical Research Wayne New Jersey USA. Pharmaceutical Sciences Merck & Co. Inc. Kenilworth New Jersey US

An Erratum to this paper has been published: https://***/10.1208/s12248-020-00535-z.

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Comparative Performance Analysis of IIr and FIr Filters for 5G Networks

Comparative Performance Analysis of IIR and FIR Filters for ...

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International Conference on Telematics and Future Generation Networks (TAFGEN)

作者： Akram Muhammad razee rudzidatul Akmam dziyauddin Marwan Hadri Azmi Sajaa Kh Sadon Razak School of Engineering and Technology Universiti Teknologi Malaysia Malaysia Ubiquitous Broadband Access Networks (U-BAN) Universiti Teknologi Malaysia Malaysia Wireless Communication Centre Universiti Teknologi Malaysia Malaysia Telekom Malaysia Research & Development (TM R&D) TM Innovation Centre Selangor Malaysia

This paper comprehensively quantifies and compares Infinite Impulse response (IIr) and Finite Impulse response (FIr) bandpass filters that can optimize bandwidth allocation by eliminating noise, side lobes and Intersymbol Interference (ISI) in Orthogonal Frequency division Multiplexing (OFdM) systems. Our goal is to choose a feasible filter that can accommodate more carriers in a bandwidth, so that the spectral efficiency can be increased. For IIr filtering, we employ, namely, Butterworth, Chebyshev and Elliptic, while for FIr Equiripple, Bohman and Hamming are studied. We evaluate these filters in terms of magnitude response and group delay, and also identify the minimum filter order that characterized nearly to an ideal filter response. The results show that the IIr filter has steep transition region when compared to the FIr filter with the same order, but the trade-off is high group delay. due to the fastest roll-off, small transition region and low cost, we found that Elliptic filter is a good candidate to be implemented in the filtered-OFdM (f-OFdM) 5G system.

关键词： Finite impulse response filters IIr filters delays Chebyshev approximation Cutoff frequency Band-pass filters

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