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Plasmonic antenna coupling to hyperbolic phonon-polaritons for sensitive and fast mid-infrared photodetection with graphene

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arXiv 2020年

作者： Castilla, Sebastián Vangelidis, Ioannis Pusapati, Varun-Varma Goldstein, Jordan Autore, Marta Slipchenko, Tetiana Rajendran, Khannan Kim, Seyoon Watanabe, Kenji Taniguchi, Takashi Martín-Moreno, Luis Englund, Dirk Tielrooij, Klaas-Jan Hillenbrand, Rainer Lidorikis, Elefterios Koppens, Frank H.L. ICFO - Institut de Ciències Fotòniques Barcelona Institute of Science and Technology CastelldefelsBarcelona08860 Spain Department of Materials Science and Engineering University of Ioannina Ioannina45110 Greece Department of Electrical Engineering and Computer Sciences Massachusetts Institute of Technology CambridgeMA02139 United States CIC nanoGUNE E-20018 Donostia-San Sebastián Spain Instituto de Ciencia de Materiales de Aragón Departamento de Física de la Materia Condensada CSIC-Universidad de Zaragoza Zaragoza50009 Spain Advanced Materials Laboratory National Institute for Material Science Tsukuba305-0044 Japan Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain IKERBASQUE Basque Foundation for Science Bilbao48013 Spain Institute of Materials Science and Computing Ioannina45110 Greece ICREA - Institució Catalana de Recerca i Estudis Avançats Barcelona08010 Spain

Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical signal. Here, we overcome all of those challenges in one device, by efficient coupling of a plasmonic antenna to hyperbolic phonon-polaritons in hexagonal-BN to highly concentrate mid-infrared light into a graphene pn-junction. We balance the interplay of the absorption, electrical and thermal conductivity of graphene via the device geometry. This novel approach yields remarkable device performance featuring room temperature high sensitivity (NEP of 82 pW/√Hz) and fast rise time of 17 nanoseconds (setup-limited), among others, hence achieving a combination currently not present in the state-of-the-art graphene and commercial mid-infrared detectors. We also develop a multiphysics model that shows excellent quantitative agreement with our experimental results and reveals the different contributions to our photoresponse, thus paving the way for further improvement of these types of photodetectors even beyond mid-infrared range. Copyright © 2020, The Authors. All rights reserved.

关键词： Graphene

Merging Deep Learning, Chemistry, and Diffraction for High-Throughput Material Structure Prediction

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Microscopy and Microanalysis 2019年第S2期25卷 168-169页

作者： Matthew L. Gong Brandon D. Miller Ray R. Unocic Khallid Hattar Bryan Reed Dan Masiel Tolga Tasdizen Jeffery A. Aguiar Idaho National Laboratory Nuclear Materials Department Idaho Falls IdahoUSA. University of Utah Scientific Computing Imaging Institute Department of Electrical and Computer Engineering Salt Lake City UtahUSA. Oak Ridge National Laboratory Center for Nanophase Materials Science Oak Ridge TennesseeUSA. Sandia National Laboratories Center for Integrated Nanotechnologies Albuquerque New MexicoUSA. Integrated Dynamic Electron Solutions Pleasanton CaliforniaUSA.

A chaotic artificial bee colony algorithm based on lévy search

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A chaotic artificial bee colony algorithm based on lévy sea...

作者： Lin, Shijie Dong, Chen Wang, Zhiqiang Guo, Wenzhong Chen, Zhenyi Ye, Yin College of Mathematics and Computer Science Fuzhou University Fuzhou350116 China Key Laboratory of Information Security of Network Systems Fuzhou350116 China Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou350116 China Department of Electrical Engineering University of South Florida TampaFL33620 United States

A Lévy search strategy based chaotic artificial bee colony algorithm (LABC) is proposed in this paper. The chaotic sequence, global optimal mechanism and Lévy flight mechanism were introduced respectively into the initialization, the employed bee search and the onlooker bee search. The experiments show that the proposed algorithm performed better in convergence speed, global search ability and optimization accuracy than other improved ABC. Copyright © 2018 The Institute of Electronics, Information and Communication Engineers.

关键词： Evolutionary algorithms

Erratum: Towards a muon collider

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The European Physical Journal C 2024年第1期84卷 1-4页

作者： Accettura, Carlotta Adams, Dean Agarwal, Rohit Ahdida, Claudia Aimè, Chiara Amapane, Nicola Amorim, David Andreetto, Paolo Anulli, Fabio Appleby, Robert Apresyan, Artur Apyan, Aram Arsenyev, Sergey Asadi, Pouya Mahmoud, Mohammed Attia Azatov, Aleksandr Back, John Balconi, Lorenzo Bandiera, Laura Barlow, Roger Bartosik, Nazar Barzi, Emanuela Batsch, Fabian Bauce, Matteo Berg, J. Scott Bersani, Andrea Bertarelli, Alessandro Bertolin, Alessandro Black, Kevin Boattini, Fulvio Bogacz, Alex Bonesini, Maurizio Bordini, Bernardo Bottaro, Salvatore Bottura, Luca Braghieri, Alessandro Breschi, Marco Bruhwiler, Natalie Buffat, Xavier Buonincontri, Laura Burrows, Philip N. Burt, Graeme Buttazzo, Dario Caiffi, Barbara Calviani, Marco Calzaferri, Simone Calzolari, Daniele Capdevilla, Rodolfo Carli, Christian Casaburo, Fausto Casarsa, Massimo Castelli, Luca Catanesi, Maria Gabriella Cavallucci, Lorenzo Cavoto, Gianluca Celiberto, Francesco Giovanni Celona, Luigi Cerri, Alessandro Cesarini, Gianmario Cesarotti, Cari Chachamis, Grigorios Chance, Antoine Chen, Siyu Chien, Yang-Ting Chiesa, Mauro Colaleo, Anna Collamati, Francesco Collazuol, Gianmaria Costa, Marco Craig, Nathaniel Curatolo, Camilla Curtin, David Da Molin, Giacomo Dam, Magnus Damerau, Heiko Dasu, Sridhara de Blas, Jorge De Curtis, Stefania De Matteis, Ernesto De Rosa, Stefania Delahaye, Jean-Pierre Denisov, Dmitri Denizli, Haluk Densham, Christopher Dermisek, Radovan Di Luzio, Luca Di Meco, Elisa Di Micco, Biagio Dienes, Keith Diociaiuti, Eleonora Dorigo, Tommaso Dudarev, Alexey Edgecock, Robert Errico, Filippo Fabbrichesi, Marco Farinon, Stefania Ferrari, Anna Somoza, Jose Antonio Ferreira Filthaut, Frank Fiorina, Davide Fol, Elena Forslund, Matthew Franceschini, Roberto Ximenes, Rui Franqueira Gabrielli, Emidio Gallinaro, Michele Garosi, Francesco Giambastiani, Luca Gianelle, Alessio Gilardoni, Simone Giove, Dario Augusto Giraldin, Carlo Glioti, Alfredo Greco, Mario Greljo, Admir Groeber, Ramona Grojean, Christophe Grudiev, Alexej Gu, Jiayin Han, Chengcheng Han, T Organisation Européenne pour la Recherche Nucléaire (CERN) Geneva Switzerland STFC Rutherford Appleton Laboratory (RAL) Oxford UK Computer Science Department University of California (UC) Berkeley USA Dipartimento di Fisica Università di Pavia Pavia Italy INFN Sezione di Pavia Pavia Italy INFN Sezione di Torino Turin Italy Dipartimento di Fisica Università di Torino Turin Italy INFN Sezione di Padova Padua Italy INFN Sezione di Roma Rome Italy School of Physics and Astronomy University of Manchester Manchester UK Fermi National Accelerator Laboratory Batavia USA Department of Physics Brandeis University Waltham USA IRFU CEA University Paris-Saclay Gif-sur-Yvette France Center for Theoretical Physics Massachusetts Institute of Technology Cambridge USA Center for High Energy Physics (CHEP-FU) Fayoum University El-Fayoum Egypt SISSA International School for Advanced Studies Trieste Italy INFN Sezione di Trieste Trieste Italy Department of Physics University of Warwick Coventry UK Dipartimento di Fisica Università di Milano Milan Italy INFN Laboratori Acceleratori e Superconduttività Applicata (LASA) Milan Italy INFN Sezione di Ferrara Ferrara Italy School of Computing and Engineering The University of Huddersfield Huddersfield UK Ohio State University Columbus USA Brookhaven National Laboratory Upton USA INFN Sezione di Genova Genoa Italy University of Wisconsin Wisconsin USA Center for Advanced Studies of Accelerators Jefferson Lab Newport News USA INFN Sezione di Milano Bicocca Milan Italy Dipartimento di Fisica Università di Milano Bicocca Milan Italy Scuola Normale Superiore Pisa Italy INFN Sezione di Pisa Pisa Italy Dipartimento di Ingegneria dell’Energia Elettrica e dell’Informazione Università di Bologna Bologna Italy INFN Sezione di Bologna Bologna Italy Department of Physics University of California (UC) Berkeley USA Dipartimento di Fisica e Astronomia Università di Padova Padoa Italy John Adams Institute University of O

The association for the advancement of artificial intelligence 2020 workshop program

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The association for the advancement of artificial intelligen...

作者： Bang, Grace Barash, Guy Bea, Ryan Cali, Jacques Castillo-Effen, Mauricio Chen, Xin Cynthia Chhaya, Niyati Dhoopar, Rohan Dumancic, Sebastijan Espinoza, Huáscar Farchi, Eitan Fioretto, Ferdinando Fuentetaja, Raquel Galley, Michel Geib, Christopher Hernández-Orallo, José Huang, Xiaowei Keren, Sarah Kim, Seokhwan Jaidka, Kokil Liu, Xiaomo Lu, Tyler Ma, Zhiqiang Mallah, Richard McDermid, John Michalowski, Martin Mirsky, Reuth Héigeartaigh, Seán Ó. Ramachandran, Deepak Segovia-Aguas, Javier Shaban-Nejad, Arash Shehory, Onn Shwartz, Vered Srivastava, Siddharth Talamadupula, Kartik Tang, Jian Zhang, Dell Zhang, Jian S&P Global. Western Digital University of Southampton United Kingdom Blue Prism Group PLC Lockheed Martin's Advanced Technology Laboratories ArlingtonVA United States University of Hong Kong Hong Kong Adobe Research Google Research Katholieke Universiteit Leuven Belgium Commissariat à ĺÉnergie Atomique France IBM Research Department of Electrical Engineering and Computer Science Syracuse University United States Universidad Carlos III de Madrid Spain Microsoft Research AI SIFT LLC Universitat Politècnica de València Spain Leverhulme Centre for the Future of Intelligence United Kingdom Department of Computer Science University of Liverpool United Kingdom National University of Singapore Singapore Harvard School of Engineering and Applied Sciences in the of Fields of Multiagent Environment Design and Goal Recognition Design Amazon Alexa AI Future of Life Institute United States University of York Assuring Autonomy International Program United Kingdom University of Minnesota School of Nursing MinneapolisMN United States University of Texas at Austin AustinTX United States Institut de Robòtica i Informàtica Industrial Spanish Council for Scientific Research Technical University of Catalonia Spain Oak Ridge National Laboratory Center for Biomedical Informatics Department of Pediatrics University of Tennessee Health Science Center United States Bar Ilan University Israel University of Washington SeattleWA United States Autonomous Agents and Intelligent Robots lab of the School of Computing Informatics Decision Systems Arizona State University United States DiDi AI Labs School of Industrial and System Engineering Georgia Institute of Technology United States University of London United Kingdom Microsoft Azure

The Association for the Advancement of Artificial Intelligence 2020 Workshop Program included twenty-three workshops covering a wide range of topics in artificial intelligence. This report contains the required reports, which were submitted by most, but not all, of the workshop chairs. Copyright © 2020, Association for the Advancement of Artificial Intelligence. All rights reserved.

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The Brain Tumor Sequence Registration (BraTS-Reg) Challenge: Establishing Correspondence Between Pre-Operative and Follow-up MRI Scans of Diffuse Glioma Patients

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arXiv 2021年

作者： Baheti, Bhakti Chakrabarty, Satrajit Akbari, Hamed Bilello, Michel Wiestler, Benedikt Schwarting, Julian Calabrese, Evan Rudie, Jeffrey Abidi, Syed Mousa, Mina Villanueva-Meyer, Javier Fields, Brandon K.K. Kofler, Florian Shinohara, Russell Takeshi Iglesias, Juan Eugenio Mok, Tony C.W. Chung, Albert C.S. Wodzinski, Marek Jurgas, Artur Marini, Niccolò Atzori, Manfredo Müller, Henning Grosbröhmer, Christoph Siebert, Hanna Hansen, Lasse Heinrich, Mattias P. Canalini, Luca Klein, Jan Gerken, Annika Heldmann, Stefan Hering, Alessa Hahn, Horst K. Meng, Mingyuan Bi, Lei Feng, Dagan Kim, Jinman Zeineldinal, Ramy A. Karar, Mohamed E. Mathis-Ullrich, Franziska Burgert, Oliver Abderezaei, Javid Pionteck, Aymeric Chopra, Agamdeep Kurt, Mehmet Yan, Kewei Yan, Yonghong Tang, Zhe Ma, Jianqiang Nasser, Sahar Almahfouz Kurian, Nikhil Cherian Meena, Mohit Shamsi, Saqib Sethi, Amit Tustison, Nicholas J. Avants, Brian B. Cook, Philip Gee, James C. Tian, Lin Greer, Hastings Niethammer, Marc Hoopesar, Andrew Hoffmannas, Malte Dalcaar, Adrian V. Christodoulidis, Stergios Estiene, Théo Vakalopoulou, Maria Paragios, Nikos Marcus, Daniel S. Davatzikos, Christos Sotiras, Aristeidis Menze, Bjoern Bakas, Spyridon Waldmannstetter, Diana Division of Computational Pathology Department of Pathology and Laboratory Medicine Indiana University School of Medicine IndianapolisIN United States Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO United States GE HealthCare San RamonCA United States University of Pennsylvania PhiladelphiaPA United States Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA United States Mallinckrodt Institute of Radiology Washington University School of Medicine St. LouisMO United States Institute for Informatics Data Science & Biostatistics Washington University School of Medicine St. LouisMO United States Department of Bioengineering Santa Clara University Santa ClaraCA United States Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Computer Science TUM School of Computation Information and Technology Technical University of Munich Munich Germany Department of Diagnostic and Interventional Neuroradiology School of Medicine Klinikum rechts der Isar Technical University of Munich Munich Germany Department of Nuclear Medicine University Hospital Regensburg Regensburg Germany University Hospital Regensburg Regensburg Germany Department of Radiology & Biomedical Imaging University of California San FranciscoCA United States Department of Radiology Duke University Medical Center DurhamNC United States Department of Radiology University of California San DiegoCA United States Helmholtz AI Helmholtz Munich Neuherberg Germany Penn Statistics in Imaging and Visualization Center Department of Biostatistics Epidemiology and Informatics University of Pennsylvania Philadelphia United States Massachusetts General Hospital Harvard Medical School United States Centre for Medical Imaging Computing University College London United Kingdom The Hong Kong University of Science and Technology Hong Kong University of Applied Sciences West

Registration of longitudinal brain Magnetic Resonance Imaging (MRI) scans containing pathologies is challenging due to dramatic changes in tissue appearance. Although there has been considerable progress in developing general-purpose medical image registration techniques, they have not yet attained the requisite precision and reliability for this task, highlighting its inherent complexity. Here we describe the Brain Tumor Sequence Registration (BraTS-Reg) challenge, as the first public benchmark environment for deformable registration algorithms focusing on estimating correspondences between pre-operative and follow-up scans of the same patient diagnosed with a diffuse brain glioma. The challenge was conducted in conjunction with both the IEEE International Symposium on Biomedical Imaging (ISBI) 2022 and the International Conference on Medical Image computing and computer-Assisted Intervention (MICCAI) 2022. The BraTS-Reg data comprise de-identified multi-institutional multi-parametric MRI (mpMRI) scans, curated for size and resolution according to a canonical anatomical template, and divided into training, validation, and testing sets. Clinical experts annotated ground truth (GT) landmark points of anatomical locations distinct across the temporal domain. The training data with their GT annotations, were publicly released to enable the development of registration algorithms. The validation data, without their GT annotations, were also released to allow for algorithmic evaluation prior to the testing phase, which only allowed submission of containerized algorithms for evaluation on hidden hold-out testing data. Quantitative evaluation and ranking was based on the Median Euclidean Error (MEE), Robustness, and the determinant of the Jacobian of the displacement field. The top-ranked methodologies yielded similar performance across all evaluation metrics and shared several methodological commonalities, including pre-alignment, deep neural networks, inverse consistency

关键词： Magnetic resonance imaging

Learning from learning machines: A new generation of AI technology to meet the needs of science

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arXiv 2021年

作者： Pion-Tonachini, Luca Bouchard, Kristofer Martin, Hector Garcia Peisert, Sean Holtz, W. Bradley Aswani, Anil Dwivedi, Dipankar Wainwright, Haruko Pilania, Ghanshyam Nachman, Benjamin Marrone, Babetta L. Falco, Nicola Prabhat Arnold, Daniel Wolf-Yadlin, Alejandro Powers, Sarah Climer, Sharlee Jackson, Quinn Carlson, Ty Sohn, Michael Zwart, Petrus Kumar, Neeraj Justice, Amy Tomlin, Claire Jacobson, Daniel Micklem, Gos Gkoutos, Georgios V. Bickel, Peter J. Cazier, Jean-Baptiste Müller, Juliane Webb-Robertson, Bobbie-Jo Stevens, Rick Anderson, Mark Kreutz-Delgado, Ken Mahoney, Michael W. Brown, James B. Pattern Computer Inc. Friday HarborWA98250 United States Biosciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computational Research Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Helen Wils Neuroscience Institute Redwood Center for Theoretical Neuroscience Uc Berkeley BerkeleyCA94720 United States Doe Agile BioFoundry Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Joint BioEnergy Institute Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Bcam Basque Center for Applied Mathematics Bilbao48009 Spain Computer Science University of California Davis DavisCA95616 United States Cenic La MiradaCA90638 United States Health Informatics University of California Davis School of Medicine SacramentoCA95817 United States Berkeley Institute for Data Science University of California Berkeley BerkeleyCA94720 United States Industrial Engineering and Operations Research University of California Berkeley BerkeleyCA94720 United States Environmental & Earth Sciences Area Lawrence Berkeley National Laboratory BerkeleyCA94803 United States Nuclear Engineering University of California Berkeley BerkeleyCA94720 United States Materials Science and Technology Division Los Alamos National Laboratory Los AlamosNM87545 United States Physics Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Bioscience Division Los Alamos National Laboratory Los AlamosNM87545 United States Earth and Environmental Sciences Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Energy Technologies Area Lawrence Berkeley National Lab BerkeleyCA94803 United States Computing and Computational Sciences Oak Ridge National Laboratory Oak RidgeTN37831 United States Industrial & Systems Engineering The University of Tennessee KnoxvilleTN37996 United States Department of Computer Science University of Missouri-Saint Louis St. LouisMO63121 United

We outline emerging opportunities and challenges to enhance the utility of AI for scientific discovery. The distinct goals of AI for industry versus the goals of AI for science create tension between identifying patterns in data versus discovering patterns in the world from data. If we address the fundamental challenges associated with "bridging the gap" between domain-driven scientific models and data-driven AI learning machines, then we expect that these AI models can transform hypothesis generation, scientific discovery, and the scientific process itself. © 2021, CC BY.

关键词： Learning systems

Randomized compiling for scalable quantum computing on a noisy superconducting quantum processor

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arXiv 2020年

作者： Hashim, Akel Naik, Ravi K. Morvan, Alexis Ville, Jean-Loup Mitchell, Bradley Kreikebaum, John Mark Davis, Marc Smith, Ethan Iancu, Costin O'Brien, Kevin P. Hincks, Ian Wallman, Joel J. Emerson, Joseph Siddiqi, Irfan Quantum Nanoelectronics Laboratory Department of Physics University of California at Berkeley BerkeleyCA94720 United States Graduate Group in Applied Science and Technology University of California at Berkeley BerkeleyCA94720 United States Computational Research Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Materials Sciences Division Lawrence Berkeley National Lab BerkeleyCA94720 United States Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Quantum Benchmark Inc. KitchenerONN2H 5G5 Canada Institute for Quantum Computing and Department of Applied Mathematics University of Waterloo WaterlooONN2L 3G1 Canada

The successful implementation of algorithms on quantum processors relies on the accurate control of quantum bits (qubits) to perform logic gate operations. In this era of noisy intermediate-scale quantum (NISQ) computing, systematic miscalibrations, drift, and crosstalk in the control of qubits can lead to a coherent form of error which has no classical analog. Coherent errors severely limit the performance of quantum algorithms in an unpredictable manner, and mitigating their impact is necessary for realizing reliable quantum computations. Moreover, the average error rates measured by randomized benchmarking and related protocols are not sensitive to the full impact of coherent errors, and therefore do not reliably predict the global performance of quantum algorithms, leaving us unprepared to validate the accuracy of future large-scale quantum computations. Randomized compiling is a protocol designed to overcome these performance limitations by converting coherent errors into stochastic noise, dramatically reducing unpredictable errors in quantum algorithms and enabling accurate predictions of algorithmic performance from error rates measured via cycle benchmarking. In this work, we demonstrate significant performance gains under randomized compiling for the four-qubit quantum Fourier transform algorithm and for random circuits of variable depth on a superconducting quantum processor. Additionally, we accurately predict algorithm performance using experimentally-measured error rates. Our results demonstrate that randomized compiling can be utilized to leverage and predict the capabilities of modern-day noisy quantum processors, paving the way forward for scalable quantum computing. Copyright © 2020, The Authors. All rights reserved.

关键词： Benchmarking

From FAIR to CURE: Guidelines for Computational Models of Biological Systems

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arXiv 2025年

作者： Sauro, Herbert M. Agmon, Eran Blinov, Michael L. Gennari, John H. Hellerstein, Joe Heydarabadipour, Adel Hunter, Peter Jardine, Bartholomew E. May, Elebeoba Nickerson, David P. Smith, Lucian P. Bader, Gary D. Bergmann, Frank Boyle, Patrick M. Dräger, Andreas Faeder, James R. Feng, Song Freire, Juliana Fröhlich, Fabian Glazier, James A. Gorochowski, Thomas E. Helikar, Tomas Hoops, Stefan Imoukhuede, Princess Keating, Sarah M. Konig, Matthias Laubenbacher, Reinhard Loew, Leslie M. Lopez, Carlos F. Lytton, William W. McCulloch, Andrew Mendes, Pedro Myers, Chris J. Myers, Jerry G. Mulugeta, Lealem Niarakis, Anna van Niekerk, David D. Olivier, Brett G. Patrie, Alexander A. Quardokus, Ellen M. Radde, Nicole Rohwer, Johann M. Sahle, Sven Schaff, James C. Sego, T.J. Shin, Janis Snoep, Jacky L. Vadigepalli, Rajanikanth Wiley, H. Steve Waltemath, Dagmar Moraru, Ion Department of Bioengineering University of Washington SeattleWA98195-5061 United States Intelligent Systems Engineering and Biocomplexity Institute Indiana University Street BloomingtonIN47408 United States Center for Cardiovascular Biology University of Washington SeattleWA98195-5061 United States eScience Institute University of Washington SeattleWA98195-5061 United States Institute for Stem Cell and Regenerative Medicine University of Washington SeattleWA98195-5061 United States School of Biological Sciences University of Bristol 24 Tyndall Avenue BristolBS8 1TQ United Kingdom Departments of Physiology & Pharmacology Neurology Downstate Health Science University BrooklynNY11203 United States Department of Neurology Kings County Hospital BrooklynNY11203 United States NASA-John H. Glenn Research Center MS 110-3 21000 Brookpark Road ClevelandOH44135 United States Center for Cell Analysis and Modeling UConn Health 263 Farmington Avenue FarmingtonCT06030-6406 United States Amsterdam Institute for Life and Environment Vrije Universiteit Amsterdam De Boelelaan 1108 Amsterdam1081 HZ Netherlands Department of Pathology and Genomic Medicine Thomas Jefferson University 1020 Locust St PhiladelphiaPA19107 United States Biological Sciences Division Pacific Northwest National Laboratory 902 Battelle Blvd RichlandWA99354 United States Auckland Bioengineering Institute University of Auckland Auckland1010 New Zealand Center of Integrative Biology University of Toulouse III-Paul Sabatier 165 Rue Marianne Grunberg-Manago Toulouse31400 France Lifeware Group Inria Building Alan Turing 1 Rue Honoré d’Estienne d’Orves Palaiseau91120 France Multiscale Modeling Group Altos Labs Redwood CityCA94065 United States partner site Tübingen Tübingen Germany Ottfried-Müller-Str. 37 Tübingen72076 Germany 06120 Germany Department of Computer Science Center for Data Science New York University New YorkNY11201 United States Department of Bi

Guidelines for managing scientific data have been established under the FAIR principles requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data and models are key to progress. For this reason, and recognizing that such models are a very special type of "data", we argue that computational models, especially mechanistic models prevalent in medicine, physiology and systems biology, deserve a complementary set of guidelines. We propose the CURE principles, emphasizing that models should be Credible, Understandable, Reproducible, and Extensible. We delve into each principle, discussing verification, validation, and uncertainty quantification for model credibility;the clarity of model descriptions and annotations for understandability;adherence to standards and open science practices for reproducibility;and the use of open standards and modular code for extensibility and reuse. We outline recommended and baseline requirements for each aspect of CURE, aiming to enhance the impact and trustworthiness of computational models, particularly in biomedical applications where credibility is paramount. Our perspective underscores the need for a more disciplined approach to modeling, aligning with emerging trends such as Digital Twins and emphasizing the importance of data and modeling standards for interoperability and reuse. Finally, we emphasize that given the non-trivial effort required to implement the guidelines, the community moves to automate as many of the guidelines as possible. © 2025, CC BY.

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