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17th International Conference on Photonics and Imaging in Biology and Medicine, PIBM 2024

作者： Gao, Xiali Xiao, Zhibo Wang, Xuanhao Shi, Junhui College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou310027 China Research Center for Novel Computational Sensing and Intelligent Processing Zhejiang Lab Hangzhou311100 China

ISBN: (数字)9781510688070

ISBN: (纸本)9781510688063

Flow field analysis is vital for biomedical applications such as drug delivery, dosage optimization, and hemodynamic studies. Conventional optical particle image velocimetry (PIV) struggles with dynamic three-dimensional analysis in turbid media. This study introduces a photoacoustic volumetric particle image velocimetry (PAV-PIV) system to address these challenges, enabling rapid three-dimensional flow field reconstruction in optically opaque environments without complex calibration. Vascular phantoms made from silicone, polyurethane, and agarose were tested, with the optimal material selected based on acoustic impedance contrast. Nickel-coated polystyrene particles served as tracers, uniformly dispersed in the fluid. Particle displacement was measured at 20 ms intervals, allowing for flow field analysis, including velocity and vorticity distributions. Reconstructed three-dimensional photoacoustic signals demonstrated superior imaging quality in turbid media, with detailed flow field characteristics derived from the best-quality images. The system's performance and measurement precision were further evaluated. Results confirm that the PAV-PIV system effectively overcomes the limitations of traditional optical methods, offering robust and dynamic flow field analysis in challenging environments. This approach shows great potential for advancing real-time biomedical applications requiring the analysis of complex flow behaviors. © 2025 SPIE.

关键词： Drug dosage

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Ptychographic characterization of spatiotemporal wavepackets

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Optica 2025年第4期12卷 498-504页

作者： Liu, Yuanyuan Xu, Yingming Zhang, Nianjia Liu, Dawei Wei, Lijin Cao, Qian Shi, Junhui Zhan, Qiwen School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology Shanghai200093 China Zhangjiang Laboratory 100 Haike Road Shanghai201204 China Research Center for Novel Computational Sensing and Intelligent Processing Zhejiang Lab. Hangzhou311100 China College of Mechatronics and Control Engineering Shenzhen University Shenzhen518060 China

Exciting advances in spatiotemporal wavepackets have shown great potential in a range of applications, including particle manipulation, time-resolved imaging, and unique light–matter interactions. In particular, spatiotemporal optical vortice (STOV) pulse beams characterized by a helical phase structure in space and time are a recently emerging type of complex structured ultrashort pulse. However, the high-resolution measurement and manipulation of ultrashort spatiotemporal wavepackets still face major challenges due to their inseparable properties in space and time. In this study, based on spectra-encoded ptychography, we implement a simple, compact, reference-free STOV characterization technique with a temporal resolution of 6 fs and a spatial resolution of 11.05 µm. This technique can be employed to analyze various intricate spatiotemporal structural beams, contributing to the growing field of spatiotemporally engineered ultrafast laser pulse beams. Additionally, as a lensless measurement technique, this characterization method may be extended to other spectral ranges, including the extreme ultraviolet and X-ray domains. © 2025 Optica Publishing Group.

关键词： Wave packets

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A Dual-Capture and Dual-Output 3D DNA Walker System Integrated with Ligases Enables Ultrasensitive Detection of Single-Nucleotide Polymorphisms

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Analytical Chemistry 2025年第17期97卷 9316-9325页

作者： Zhang, Yunshan Tan, Qianglong Yang, Fang Huang, Tuo Yu, Siyu Ye, Jing Zeng, Jianxian Feng, Xianzhong Zhang, Diming Key Laboratory of Soybean Molecular Design Breeding National Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun130102 China Research Center for Novel Computing Sensing and Intelligent Processing Zhejiang Laboratory Hangzhou311121 China Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Zhejiang Hangzhou310024 China School of Chemistry and Chemical Engineering Hunan University of Science and Technology Hunan Xiangtan411201 China

DNA walkers, as structurally and functionally programmable signal amplification tools, exhibit great potential for application in the field of biosensing. Traditional DNA walkers often rely on enzymes for operation, posing compatibility challenges, while the handful of existing enzyme-free DNA walkers demonstrate limited performance. To address this, we innovatively developed an efficient enzyme-free 3D DNA walker with dual capture and dual output capabilities. Coupled with ligase chain reaction (LCR), this system facilitates highly sensitive and specific detection of single nucleotide polymorphisms (SNPs). Specifically, LCR precisely identifies single-base mutations, effectively transmitting biological information. The 3D DNA walker system is based on entropy-driven circuit cycling reaction technology. In this system, LCR products serve as the driving strands for the DNA walker, independently binding to track strands and walking legs immobilized on gold nanoparticles, forming a unique dual signal capture mechanism. Each track strand carries two signal chains, significantly enhancing signal amplification efficiency. Benefiting from this novel enzyme-free 3D DNA walker strategy, our biosensing system exhibits exceptional sensitivity to mutant targets (MT), detecting MT at concentrations as low as 30.3 aM and distinguishing heterozygous samples with a 0.01% mutation frequency. Furthermore, this system has been successfully applied to genotyping and mutation abundance assessment of genomes from fresh soybean leaves, demonstrating its vast potential for practical applications. In summary, this research pioneers a novel enzyme-free 3D DNA walker with dual capture and dual output capabilities, and develops an ultrasensitive genotyping tool. This provides strong technical support for the advancement of genetic research. © 2025 American Chemical Society.

关键词： Nucleotides

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Suppression of heading errors in Bell-Bloom optically pumped free-induction-decay alkali-metal atomic magnetometers

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Physical Review A 2025年第2期111卷 023119-023119页

作者： S.-Q. Liu X.-K. Wang X.-D. Zhang W. Xiao D. Sheng Department of Precision Machinery and Precision Instrumentation Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of China Hefei 230027 China College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 China Beijing Computational Science Research Center Beijing 100193 China MIIT Key Laboratory of Complex-field Intelligent Sensing Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing 100081 China Hefei National Laboratory University of Science and Technology of China Hefei 230088 China

Heading errors of atomic magnetometers refer to the dependence of measurement results on the sensor orientation with respect to the external magnetic field. There are three main sources of such errors: the light shift effect, the linear nuclear-spin Zeeman effect, and the nonlinear Zeeman effect. In this work, we suppress the first two effects by using the Bell-Bloom optical pumping method and probe the atomic signals while the pumping beam is off, and focus on the heading error induced by nonlinear Zeeman effect while the sensor operates in the geomagnetic field range. We demonstrate several schemes to suppress this remaining heading error within 1 nT using a single magnetometer or a comagnetometer. In the magnetometer system, two schemes are developed to average out the horizontal atomic polarization in space or in time, respectively. In the comagnetometer system, we combine the simultaneously measured Larmor frequencies of two different alkali atoms to either suppress the heading error or extract the orientation of the pumping beam relative to the bias field.

关键词： Bells

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Suppression of heading errors in Bell-Bloom optically pumped free-induction-decay alkali-metal atomic magnetometers

arXiv

引用

arXiv 2025年

作者： Liu, Siqi Wang, Xueke Zhang, Xiangdong Xiao, Wei Sheng, Dong Department of Precision Machinery and Precision Instrumentation Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of China Hefei230027 China College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen518060 China Beijing Computational Science Research Center Beijing100193 China State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Center for Quantum Information Technology Peking University Beijing100871 China MIIT Key Laboratory of Complex-field Intelligent Sensing Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing100081 China Hefei National Laboratory University of Science and Technology of China Hefei230088 China

Heading errors of atomic magnetometers refer to the dependence of measurement results on the sensor orientation with respect to the external magnetic field. There are three main sources of such errors: the light shift effect, the linear nuclear-spin Zeeman effect, and the nonlinear Zeeman effect. In this work, we suppress the former two effects by using the Bell-Bloom optical pumping method and probe the atomic signals while the pumping beam is off, and focus on the heading error induced by nonlinear Zeeman effect while the sensor operates in the geomagnetic field range. We demonstrate several schemes to suppress this remaining heading error within 1 nT using a single magnetometer or a comagnetometer. In the magnetometer system, two schemes are developed to average out the horizontal atomic polarization in space or in time, respectively. In the comagnetometer system, we combine the simultaneously measured Larmor frequencies of two different kinds of alkali atoms to either suppress the heading error or extract the orientation of the pumping beam relative to the bias field. © 2025, CC BY.

关键词： Blooms (metal)

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LMP-GAN: Out-Of-Distribution Detection For Non-Control Data Malware Attacks

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IEEE Transactions on Pattern Analysis and Machine Intelligence 2025年 PP卷 PP页

作者： Wood, David Kapp, David Kebede, Temesgen Hirakawa, Keigo Wuhan University School of Computer Science China Wuhan University National Engineering Research Center for Multimedia Software Hubei Key Laboratory of Multimedia and Network Communication Engineering China Zhongguancun Academy China Wuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing China Sun Yat-sen University School of Geography and Planning China Mohamed bin Zayed University of Artificial Intelligence United Arab Emirates Chongqing University College of Computer Science China The University of Tokyo Japan RIKEN Center for Advanced Intelligence Project Japan Intelligent Science & Technology Academy Limited CASIC China iFlytek Company Ltd. National Engineering Research Center of Speech and Language Information Processing China Nanyang Technological University College of Computing & Data Science Singapore Henan Academy of Sciences Aerospace Information Research Institute China

Anomaly detection is a common application of machine learning. Out-of-distribution (OOD) detection in particular is a semi-supervised anomaly detection technique where the detection method is trained only on the inlier (in-distribution) samples - unlike the fully supervised variant, the distribution of the outlier samples are never explicitly modeled in OOD detection tasks. In this work, we design a novel GAN-based OOD detection network specifically designed to protect a cyber-physical signal systems from novel Trojan malware called non-control data (NCD) attack that evades conventional malware detection techniques. Inspired in part by the classical locally most powerful (LMP) test in statistical inferences, the proposed LMP-GAN trains the OOD detector (discriminator) by generating OOD samples that are aimed at making maximal alteration to the inlier samples while evading detection. We experimentally compare the results to the state-of-the-art anomaly detection methods to demonstrate the benefits and the appropriateness of the LMP-GAN OOD detector. © 2025 IEEE.

关键词： Malware

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HyperSIGMA: Hyperspectral Intelligence Comprehension Foundation Model

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IEEE Transactions on Pattern Analysis and Machine Intelligence 2025年

作者： Wang, Di Hu, Meiqi Jin, Yao Miao, Yuchun Yang, Jiaqi Xu, Yichu Qin, Xiaolei Ma, Jiaqi Sun, Lingyu Li, Chenxing Fu, Chuan Chen, Hongruixuan Han, Chengxi Yokoya, Naoto Zhang, Jing Xu, Minqiang Liu, Lin Zhang, Lefei Wu, Chen Du, Bo Tao, Dacheng Zhang, Liangpei Wuhan University School of Computer Science China Wuhan University National Engineering Research Center for Multimedia Software Hubei Key Laboratory of Multimedia and Network Communication Engineering China Zhongguancun Academy China Wuhan University State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing China Sun Yat-sen University School of Geography and Planning China Mohamed bin Zayed University of Artificial Intelligence United Arab Emirates Chongqing University College of Computer Science China The University of Tokyo Japan RIKEN Center for Advanced Intelligence Project Japan Intelligent Science & Technology Academy Limited CASIC China iFlytek Company Ltd. National Engineering Research Center of Speech and Language Information Processing China Nanyang Technological University College of Computing & Data Science Singapore Henan Academy of Sciences Aerospace Information Research Institute China

Accurate hyperspectral image (HSI) interpretation is critical for providing valuable insights into various earth observation-related applications such as urban planning, precision agriculture, and environmental monitoring. However, existing HSI processing methods are predominantly task-specific and scene-dependent, which severely limits their ability to transfer knowledge across tasks and scenes, thereby reducing the practicality in real-world applications. To address these challenges, we present HyperSIGMA, a vision transformer-based foundation model that unifies HSI interpretation across tasks and scenes, scalable to over one billion parameters. To overcome the spectral and spatial redundancy inherent in HSIs, we introduce a novel sparse sampling attention (SSA) mechanism, which effectively promotes the learning of diverse contextual features and serves as the basic block of HyperSIGMA. HyperSIGMA integrates spatial and spectral features using a specially designed spectral enhancement module. In addition, we construct a large-scale hyperspectral dataset, HyperGlobal-450 K, for pre-training, which contains about 450 K hyperspectral images, significantly surpassing existing datasets in scale. Extensive experiments on various high-level and low-level HSI tasks demonstrate HyperSIGMA's versatility and superior representational capability compared to current state-of-the-art methods. Moreover, HyperSIGMA shows significant advantages in scalability, robustness, cross-modal transferring capability, real-world applicability, and computational efficiency. The code and models will be released at HyperSIGMA. © 1979-2012 IEEE.

关键词： Hyperspectral imaging

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High-Performance 1D CdS/2D Te Heterojunction Photodetector

High-Performance 1D CdS/2D Te Heterojunction Photodetector

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2024 International Conference on Next Generation Electronics and Photonics, INGEP 2024

作者： Liu, Shuo Zhang, Liang Wang, Xiaozhi College of Information Science and Electronic Engineering Zhejiang University Hangzhou310027 China Research Center for Novel Computational Sensing and Intelligent Processing Zhejiang Lab Hangzhou311100 China

Van der Waals heterostructures facilitate the versatile combination of two-dimensional (2D) materials with semiconductors that possess distinctive band structures, offering a promising platform for developing photodetectors with extensive spectral range and high sensitivity. This study showcases the flawless integration of one-dimensional (1D) CdS nanowires with 2D Te nanosheets, resulting in the creation of a high-performance, mixed-dimensional heterojunction photodetector. Bandgap engineering at the CdS/Te interface promotes Type II band alignment, markedly improving the separation and transport of photo-generated charge carriers. Additionally, the interaction between materials of different dimensions significantly enhances the device's photoresponsivity and detectivity. When operated at low bias, the photodetector displays an impressive rectification ratio of up to 8.57×103, along with superior photoelectric performance spanning the ultraviolet to visible light spectrum. Particularly under 450 nm wavelength laser illumination, the device displayed a high photoresponsivity of up to 126 A W-1, a high detectivity of 1.03×1010 Jones, an external quantum efficiency of up to 3.49×102%, and a rapid response time of 35 ms. The photoresponsivity of this device was at least an order of magnitude higher than other reported mixed-dimensional heterojunction photodetectors. The development of the 1D CdS/2D Te heterostructure opens new pathways for high-sensitivity, broad-spectrum photodetection technologies. © Published under licence by IOP Publishing Ltd.

关键词： Van der Waals forces

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Tunable dipole–dipole interactions between nanoparticles levitated by two orthogonally polarized optical traps

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Photonics research 2024年第10期12卷 2139-2147页

作者： TONG LI MIAN WU PEITONG HE NAN LI ZHIMING CHEN ZHENHAI FU XIAOWEN GAO HUIZHU HU Research Center for Advanced Computational Sensing and Intelligent Processing Zhejiang LabHangzhou 310000China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Research Center for Frontier Fundamental Studies Zhejiang LabHangzhou 310000China

Arrays of optically levitated nanoparticles with fully tunable light-induced dipole–dipole interactions have emerged as a platform for fundamental research and sensing ***,previous experiments utilized two optical traps with identical polarization,leading to an interference ***,we demonstrate light-induced dipole–dipole interactions using two orthogonally polarized optical ***,we achieve control over the strength and polarity of the optical coupling by adjusting the polarization and propose a method to simultaneously and stably measure conservative and non-conservative coupling *** results provide a new scheme for exploring entanglement and topological phases in arrays of levitated nanoparticles.

关键词： dipole polarized conservative

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State-of-the-art advances in vacancy defect engineering of graphitic carbon nitride for solar water splitting

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Journal of Semiconductors 2023年第8期44卷 16-34页

作者： Jie Li Kaige Huang Yanbin Huang Yumin Ye Marcin Ziółek Zhijie Wang Shizhong Yue Mengmeng Ma Jun Liu Kong Liu Shengchun Qu Zhi Zhao Yanjun Zhang Zhanguo Wang College of Mechanical and Electrical Engineering Handan UniversityHandan 056005China Hebei International Joint Research Center for Computational Optical Imaging and Intelligent Sensing Hebei International Joint Research Center for Computational Optical Imaging and Intelligent SensingSchool of Mathematics and Physics Science and EngineeringHebei University of EngineeringHandan 056038China Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices Beijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Materials Science and Engineering Faculty of Materials Science and Chemical EngineeringNingbo UniversityNingbo 315211China Faculty of Physics Adam Mickiewicz University Poznan61-614 PoznanPoland Guangdong-Hong Kong Joint Laboratory for Water Security Engineering Research Center of Ministry of Education on Groundwater Pollution Control and RemediationCenter for Water ResearchAdvanced Institute of Natural SciencesBeijing Normal University at ZhuhaiZhuhai 519087China

Developing low-cost,efficient,and stable photocatalysts is one of the most promising methods for large-scale solar water *** a metal-free semiconductor material with suitable band gap,graphitic carbon nitride(g-C_(3)N_(4))has attracted attention in the field of photocatalysis,which is mainly attributed to its fascinating physicochemical and photoelectronic ***,several inherent limitations and shortcomings—involving high recombination rate of photocarriers,insufficient reaction kinetics,and optical absorption—impede the practical applicability of g-C_(3)N_(4).As an effective strategy,vacancy defect engineering has been widely used for breaking through the current limitations,considering its ability to optimize the electronic structure and surface morphology of g-C_(3)N_(4) to obtain the desired photocatalytic *** review summarizes the recent progress of vacancy defect engineered g-C_(3)N_(4) for solar water *** fundamentals of solar water splitting with g-C_(3)N_(4) are discussed *** then focus on the fabrication strategies and effect of vacancy generated in g-C_(3)N_(4).The advances of vacancy-modified g-C_(3)N_(4) photocatalysts toward solar water splitting are discussed ***,the current challenges and future opportunities of vacancy-modified g-C_(3)N_(4) are *** review aims to provide a theoretical basis and guidance for future research on the design and development of highly efficient defective g-C_(3)N_(4).

关键词： g-C_(3)N_(4) vacancy defect water splitting photocatalyst charge carrier

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