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Machine Learning Approach to Enhance the Performance of MNP?Labeled Lateral Flow Immunoassay

Nano-Micro Letters 2019年第1期11卷 132-146页

作者： Wenqiang Yan Kan Wang Hao Xu Xuyang Huo Qinghui Jin Daxiang Cui Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentKey Laboratory of Thin Film and Microfabrication (Ministry of Education) Shanghai Jiao Tong University School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Department of Biomedical Engineering JiLin Medical University State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Faculty of Electrical Engineering and Computer Science Ningbo University

The use of magnetic nanoparticle(MNP)-labeled immunochromatography test strips(ICTSs) is very important for point-ofcare testing(POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic signal from ICTSs, limiting the applications of POCT. In this study, an ultrasensitive multiplex biosensor was designed to overcome the limitations of capturing and normalization of the weak magnetic signal from MNPs on ICTSs. A machine learning model for sandwich assays was constructed and used to classify weakly positive and negative samples, which significantly enhanced the specificity and sensitivity. The potential clinical application was evaluated by detecting 50 human chorionic gonadotropin(HCG) samples and 59 myocardial infarction serum samples. The quantitative range for HCG was 1–1000 mIU mL^(-1) and the ideal detection limit was 0.014 mIU mL^(-1), which was well below the clinical threshold. Quantitative detection results of multiplex cardiac markers showed good linear correlations with standard values. The proposed multiplex assay can be readily adapted for identifying other biomolecules and also be used in other applications such as environmental monitoring, food analysis, and national security.

关键词： Point-of-care testing Immunochromatography test strips Magnetic nanoparticles Machine learning Support vector machine

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Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence

arXiv

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arXiv 2025年

作者： Sun, Yingying Jun, A. Liu, Zhiwei Sun, Rui Qian, Liujia Payne, Samuel H. Bittremieux, Wout Ralser, Markus Li, Chen Chen, Yi Dong, Zhen Perez-Riverol, Yasset Khan, Asif Sander, Chris Aebersold, Ruedi Vizcaíno, Juan Antonio Krieger, Jonathan R. Yao, Jianhua Wen, Han Zhang, Linfeng Zhu, Yunping Xuan, Yue Sun, Benjamin Boyang Qiao, Liang Hermjakob, Henning Tang, Haixu Gao, Huanhuan Deng, Yamin Zhong, Qing Chang, Cheng Bandeira, Nuno Li, Ming Weinan, E. Sun, Siqi Yang, Yuedong Omenn, Gilbert S. Zhang, Yue Xu, Ping Fu, Yan Liu, Xiaowen Overall, Christopher M. Wang, Yu Deutsch, Eric W. Chen, Luonan Cox, Jürgen Demichev, Vadim He, Fuchu Huang, Jiaxing Jin, Huilin Liu, Chao Li, Nan Luan, Zhongzhi Song, Jiangning Yu, Kaicheng Wan, Wanggen Wang, Tai Zhang, Kang Zhang, Le Bell, Peter A. Mann, Matthias Zhang, Bing Guo, Tiannan Affiliated Hangzhou First People’s Hospital State Key Laboratory of Medical Proteomics School of Medicine Westlake University Zhejiang Province Hangzhou China Westlake Center for Intelligent Proteomics Westlake Laboratory of Life Sciences and Biomedicine Zhejiang Province Hangzhou China Biology Department Brigham Young University ProvoUT84602 United States Department of Computer Science University of Antwerp Antwerp2020 Belgium Department of Biochemistry CharitéUniversitätsmedizin Berlin Berlin Germany Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology Monash University MelbourneVICVIC 3800 Australia Wellcome Genome Campus Hinxton CambridgeCB10 1SD United Kingdom Harvard Medical School Ludwig Center at Harvard United States Harvard Medical School Broad Institute Ludwig Center at Harvard Dana-Farber Cancer Institute United States Department of Biology Institute of Molecular Systems Biology ETH Zürich Zürich Switzerland Bruker Ltd. MiltonONL9T 6P4 Canada AI for Life Sciences Lab Tencent Shenzhen518057 China State Key Laboratory of Medical Proteomics AI for Science Institute Beijing100080 China Beijing Institute of Lifeomics Beijing102206 China Thermo Fisher Scientific GmbH Hanna-Kunath Str. 11 Bremen28199 Germany Informatics and Predictive Sciences Research Bristol Myers Squibb United States Department of Chemistry Fudan University Songhu Road 2005 Shanghai200438 China Department of Computer Science Luddy School of Informatics Computing and Engineering Indiana University IN47408 United States ProCan® Children’s Medical Research Institute Faculty of Medicine and Health The University of Sydney WestmeadNSW Australia La Jolla CA United States Central China Institute of Artificial Intelligence University of Waterloo Canada AI for Science Institute Center for Machine Learning Research School of Mathematical Sciences Peking University China Research Institute of Intelligent Complex Systems Fudan U

Artificial intelligence (AI) is transforming scientific research, including proteomics. Advances in mass spectrometry (MS)-based proteomics data quality, diversity, and scale, combined with groundbreaking AI techniques, are unlocking new challenges and opportunities in biological discovery. Here, we highlight key areas where AI is driving innovation, from data analysis to new biological insights. These include developing an AI-friendly ecosystem for proteomics data generation, sharing, and analysis;improving peptide and protein identification and quantification;characterizing protein-protein interactions and protein complexes;advancing spatial and perturbation proteomics;integrating multi-omics data;and ultimately enabling AI-empowered virtual cells. © 2025, CC BY.

关键词： Biotic

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A service-oriented priority-based resource scheduling scheme for virtualized utility computing 08

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Proceedings of the 15th international conference on High performance computing

作者： Ying Song Yaqiong Li Hui Wang Yufang Zhang Binquan Feng Hongyong Zang Yuzhong Sun Key Lab. of Computer System and Architecture Inst. of Computing Techn. Chinese Academy of Sciences China and National Research Center for Intelligent Computing Systems ICT China and Graduate Univ. of Chinese Academy of Sciences China Key Laboratory of Computer System and Architecture Institute of Computing Technology Chinese Academy of Sciences China and National Research Center for Intelligent Computing Systems ICT China

ISBN: (纸本)9783540898931

In order to provide high resource utilization and QoS assurance inutility computing hosting concurrently various services, this paper proposes aservice computing framework-RAINBOW for VM(Virtual Machine)-basedutility computing. In RAINBOW, we present a priority-based resourcescheduling scheme including resource flowing algorithms (RFaVM) to optimizeresource allocations amongst services. The principle of RFaVM is preferentiallyensuring performance of some critical services by degrading of others to someextent when resource competition arises. Based on our prototype, we evaluateRAINBOW and RFaVM. The experimental results show that RAINBOWwithout RFaVM provides 28%-324% improvements in service performance,and 26% higher the average CPU utilization than traditional service computingframework (TSF) in typical enterprise environment. RAINBOW with RFaVMfurther improves performance by 25%-42% for those critical services whileonly introducing up to 7% performance degradation to others, with 2%-8%more improvements in resource utilization than RAINBOW without RFaVM.

关键词： resource scheduling utility computing virtualization

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Robust Decentralized Control of Interconnected Nonlinear systems Subject to Uncertainties and Disturbances via Generalized Extended state Observers 34

Robust Decentralized Control of Interconnected Nonlinear Sys...

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第三十四届中国控制会议

作者： ZHANG Chuanlin YANG ning HE Shuaipeng JIA Ruting Shanghai Engineering Research Center of Intelligent Management and Control for Power Process College of Automation EngineeringShanghai University of Electric Power Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of Education Southeast University Electrical and Computer Engineering Department California State University

ISBN: (纸本)9789881563897

This paper studies the problem of robust decentralized control for a class of large-scale interconnected systems subject to uncertainties and disturbances via a generalized active disturbance rejection control method. First, a novel extended state observer(ESO) is constructed separately for each subsystem with less dependence of the precise system information and structure. Second, an explicit formula of the decentralized active disturbance rejection control(DADRC) law is presented by utilizing the output feedback domination approach. It is shown that by a delicate analysis procedure, the closed-loop system can be rendered semi-globally asymptotically stable only using decentralized output feedback anti-disturbance controller. Numerical simulations show the efficiency of the proposed method.

关键词： output feedback control global stabilization disturbance rejection control extended state observer

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An Actor-Critic Framework Deep Reinforcement Learning Approach to High-speed Train Timetable Rescheduling Problem 4

An Actor-Critic Framework Deep Reinforcement Learning Approa...

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4th IEEE International Conference on Digital Twins and Parallel Intelligence, DTPI 2024

作者： Tian, Zhilong Li, Runmei Xiong, Gang Zhu, Fenghua Beijing Jiaotong University School of Automation and Intelligence Beijing China Chinese Academy of Sciences Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Beijing China Chinese Academy of Sciences Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing Cloud Computing Center Dongguan China Chinese Academy of Sciences State Key Laboratory for Multimodal Artificial Intelligence Systems Beijing China

ISBN: (纸本)9798350349252

High-speed trains are inevitably affected by emergencies in their daily operation, which may cause the trains to fail to run according to the original planned timetable. Therefore, how to adjust the timetable of subsequent trains in emergencies is crucial for railway operations. This paper introduces a deep reinforcement learning algorithm based on an actor-critic network, which minimizes the total delay time by defining the departure order as an action. Numerical experiments are performed on the timetable of Beijing-Shanghai high-speed railway line. © 2024 IEEE.

关键词： Deep reinforcement learning

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Text Semantic Analysis and intelligent Interaction in Parallel Dispatching systems for Technical Station 4

Text Semantic Analysis and Intelligent Interaction in Parall...

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4th IEEE International Conference on Digital Twins and Parallel Intelligence, DTPI 2024

作者： Jiao, Yuantao Wang, Jian Li, Runmei Xiong, Gang Chen, Shichao Beijing Jiaotong University School of Automation and Intelligence Beijing China Institute of Automation Chinese Academy of Sciences Beijing Engineering Research Center of Intelligent Systems and Technology Beijing China Cloud Computing Center Chinese Academy of Sciences Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing Dongguan China Chinese Academy of Sciences State Key Laboratory for Multimodal Artificial Intelligence Systems Beijing China

ISBN: (纸本)9798350349252

Technical station dispatching system plays an important role in cargo operation, but due to the large number of dispatching systems and complex operation, dispatchers rely on manual experience to complete the task, and many scenarios cannot be applied in the real system. Therefore, this paper utilizes the data-driven form to establish a parallel dispatching system for technical stations, semantically analyzes text data rich in dispatcher experience, completes the Computational Experiments on the textual semantic data in the artificial dispatching system, and synchronizes the Parallel Execution of data interaction with the real dispatching system. © 2024 IEEE.

关键词： parallel intelligence railway dispatching system technical station

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Geometry Problem Solving Based on Counter-Factual Evolutionary Reasoning 19

Geometry Problem Solving Based on Counter-Factual Evolutiona...

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19th IEEE International Conference on Automation Science and Engineering, CASE 2023

作者： Song, Bing Xiong, Gang Shen, Zhen Zhu, Fenghua Lv, Yisheng Ye, Peijun Institute of Automation Chinese Academy of Sciences The State Key Laboratory of Management and Control for Complex Systems Beijing China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China Institute of Automation Chinese Academy of Sciences The Beijing Engineering Research Center of Intelligent Systems and Technology China Chinese Academy of Sciences The Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing The Cloud Computing Center Dongguan523808 China Qingdao Academy of Intelligent Industries Intelligent Manufacturing Center Qingdao266000 China

ISBN: (纸本)9798350320695

As a representative topic in natural language processing and automated theorem proving, geometry problem solving requires an abstract problem understanding and symbolic reasoning. A major challenge here is to find a feasible reasoning sequence that is consistent with given axioms and the theorems already proved. Most recent methods have exploited neural network-based techniques to automatically discover eligible solving steps. Such a kind of methods, however, is greatly impacted by the expert solutions for training. To improve the accuracy, this paper proposes a new method called counterfactual evolutionary reasoning, which uses a generative adversarial network to generate initial reasoning sequences and then introduces counterfactual reasoning to explore potential solutions. By directly exploring theorem candidates rather than the neural network selection, the new method can sufficiently extend the searching space to get a more appropriate reasoning step. Through comparative experiments on the recent proposed Geometry3k, the largest geometry problem solving dataset, our method generally achieves a higher accuracy than most previous methods, bringing an overall improvement about 4.4% compared with the transformer models. © 2023 IEEE.

关键词： Geometry

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Cyber-physical -social systems for smart cities: An overview 1

Cyber-physical -social systems for smart cities: An overview

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1st IEEE International Conference on Digital Twins and Parallel Intelligence, DTPI 2021

作者： Anwar, Noreen Xiong, Gang Lu, Wanze Ye, Peijun Zhao, Hongxia Wei, Qinglai Institute of Automation Chinese Academy of Sciences The State Key Laboratory for Management and Control of Complex Systems Beijing China The Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation The Cloud Computing Center Chinese Academy of Sciences China School of Artificial Intelligence and Automation Beijing University of Technology Beijing100124 China

ISBN: (纸本)9781665433372

Cyber-physical social systems (CPSS) include cyberspace, physical space, and social space. Since the introduction of CPSS, human relationships with machinery and the physical world have altered as a new paradigm. Recent estimates indicate that approximately 60 percent of the world's population will live in cities by 2030. Large, dense cities can be highly productive, innovative, and very green per capita, hence ideal for our future. However, the huge influx of new people poses enormous challenges to their administrations. Smart cities are becoming a reality, therefore, to achieve higher efficiency, optimum use of resources, management and to strengthen several features of modern towns, several elements of modern cities are automated and integrated into Information and Communications Technology (ICT). Cities and infrastructure are growing all over the world, in providing end-users with increased performance, comfort, visibility and convenience, the Smart Cities concept is critical. This paper will discuss smart cities and the CPSS concept intensively with some of its key technologies, challenges, and further development by using CPSS. © 2021 IEEE.

关键词： Smart city

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Collaborative Scheduling of computing Tasks for Edge computing

Collaborative Scheduling of Computing Tasks for Edge Computi...

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2021 China Automation Congress, CAC 2021

作者： Liu, Yue Xiong, Gang Zhu, Fenghua Chen, Shichao Zhang, Liguo Liu, Xudong School of Artificial Intelligence and Automation Beijing University of Technology The State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation The Cloud Computing Center Chinese Academy of Sciences Beijing China The State Key Laboratory for Management and Control of Complex Systems Institute of Automation Qingdao Academy of Intelligent Industries Chinese Academy of Sciences Beijing China Faculty of Information and Technology Beijing University of Technology Beijing China

ISBN: (纸本)9781665426473

In the face of the rapid development of the IoT, the traditional cloud computing, while providing services for mobile intelligent devices, also brings problems such as network bandwidth occupation and communication delay. Edge computing can solve these problems to some extent. But too many offloaded tasks may result in an edge server becoming overloaded and execution delay of tasks increasing, the computing resources of idle edge devices are also not fully utilized. In order to make full use of the computing resources of idle edge devices in the local network and reduce the execution delay for computing tasks, this paper takes the average delay time for all end devices as the optimization objective and proposes an end-edge cooperative scheduling (EECS) model to schedule tasks for edge computing. The scheduling algorithm used in EECS model is improved based on MCT algorithm. We use the EdgeCloudSim to verify the EECS model and scheduling algorithm. The simulation results show that the average completion time of computing tasks in EECS model, compared with only single edge server (SEE) task computing model, can be reduced by up to three times. In addition, the system load can be balanced to a certain extent in local network. © 2021 IEEE

关键词： Edge computing

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An interpretability analysis of travel decision learning in cyber-physical-social-systems 1

An interpretability analysis of travel decision learning in ...

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1st IEEE International Conference on Digital Twins and Parallel Intelligence, DTPI 2021

作者： Guo, Miao Ye, Peijun Liu, Xudong Liu, Sheng Xiong, Gang Zhang, Liguo Institute of Automation Chinese Academy of Sciences The State Key Laboratory of Management and Control for Complex Systems Beijing China Faculty of Information and Technology Beijing University of Technology Beijing China The Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Chinese Academy of Sciences Beijing China The Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing The Cloud Computing Center Chinese Academy of Sciences Beijing China

In the few decades, the rise of Internet and social media has fundamentally changed the management, control, and operation modes of modern engineering and social systems like defense, energy, critical health care and ... 详细信息

ISBN: (纸本)9781665433372

关键词： Deep learning Social networking (online) Scalability Perturbation methods Neurons Transportation Transforms

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