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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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science China Chemistry 2025年

作者： Yuxun Lu Weisi Wang Le Yu Yuqiang Zhao Ying Chen Yunhai Guo Bingrong Luo Yuhua Liu Shizhu Li Liping Duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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Dynamic Camouflage Characteristics of a Thermal Infrared Film Inspired by Honeycomb Structure

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Journal of Bionic engineering 2022年第2期19卷 458-470页

作者： Lujia Li Huanhuan Li Gang Kou Dafeng Yang Wei Hu Jinghui Peng Songjing Li Department of Fluid Control and Automation Harbin Institute of TechnologyHarbin 150001China Research Institute for National Defense Engineering of Academy of Military Science PLA China Luoyang 471023China

Thermal infrared camouflage technology has attracted increasing attention with the progress of infrared surveillance *** by honeycombs,a thermal infrared camouflage film with honeycomb sandwich structure based on fluid and temperature control is proposed to cloak objects and display false targets in the thermal infrared *** structure and manufacturing method of the film are introduced,and the fluid and temperature control system is established and tested to explore the thermal infrared characteristics of the film composed of different thermal *** camouflage performance of the film is intuitively displayed through the temperature frequency histograms of the infrared images photographed by an infrared *** temperature control accuracy of the thermal infrared camouflage system and the dynamic camouflage response of the film are evaluated by the temperature distribution map of each pixel in infrared images and the salient degree ***,the influential factors on the camouflage responding time are investigated,including the heating and cooling time of the liquid,the flow rate of pumps inside the driving module,and the energy loss along the liquid *** application of displaying false target is also introduced and *** results show that the camouflage film has a well camouflage effect and a wide adjustment temperature range,showing promise for a broad range of potential applications,such as counter-surveillance,thermal control and heat shielding.

关键词： Bioinspiration Film Thermal camoufage Honeycomb structure Temperature control

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Recovery and reuse of floc sludge for high-performance capacitors

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Frontiers of Environmental science & engineering 2022年第6期16卷 133-144页

作者： Di Zhang Rong Hou Wenbo Wang He Zhao Beijing Engineering Research Center of Process Pollution Control CAS Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In this paper,floc sludge was transformed into porous carbon matrix composites by acidification and KOH activation at high temperature and used as an electrode material for application in *** effects of different treatment processes on the electrochemical properties of sludge materials were *** results of electrochemical tests showed that the sludge electrode exhibited excellent energy storage performance after HNO3 acidification and KOH activation with a mass ratio of 3:1(KOH/C).The specific capacitance of the sludge electrode reached 287 F/g at a current density of 1 A/*** addition,the sludge electrode material showed excellent cycle stability(specific capacity retained at 93.4%after 5000 cycles at 5 A/g).Based on XRD,FTIR,SEM,TEM,and BET surface analysis,the morphology of sludge electrode materials can be effectively regulated by chemical *** best-performing material showed a 3D porous morphology with a large specific surface area(2588 m^(2)/g)and optimal pore size distribution,improving ion channels and charge *** to the life cycle assessment of floc sludge utilization,it reduced the resource consumption and toxicity risk by more than 90%compared with ordinary sludge disposal *** work provided a cost-effective and eco-friendly sludge reuse method and demonstrated the application potential of sludge-based materials in high-performance supercapacitors.

关键词： Floc sludge Porous carbon electrode Energy storage performance Supercapacitors

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Visually-guided Order-fixed Speech Separation Algorithm 9

Visually-guided Order-fixed Speech Separation Algorithm

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9th International Conference on Image, Vision and Computing, ICIVC 2024

作者： Shi, Diya Deng, Yuanjie Wei, Ying School of Control Science and Engineering Shandong University Ji’nan China Shandong University Industrial Technology Research Institute of Shandong Province Ji’nan China

ISBN: (纸本)9798350385991

Existing research on multi-modal speech separation algorithms focuses on two types of tasks: multi-speaker speech separation and target speech separation. Multiple speech output from the multi-speaker speech separation task is usually disordered and requires a speaker matching network to achieve speaker identity and speech matching. The target speech separation task outputs only the target speaker speech, cannot flexibly switch the target speaker in a multi-speaker scenario, and requires difficult-to-obtain auxiliary information such as identity labels and registered speech. We propose a visually-guided order-fixed speech separation algorithm, which determines the speaker’s output order based on visual information. It utilizes a two-branch structure to achieve the speaker’s speech sequential output, and introduces a cross-modal loss to urge the two branches to optimise each other. By using only visual information from one speaker, the model is able to separate and order the speech signals of two speakers without relying on external speaker labels or registered speech. Experimental results show that the proposed approach achieves performance comparable to state-of-the-art methods on the VoxCeleb2 dataset. This research provides a new perspective on speech separation by leveraging visual information to solve the problem of speaker ordering in multi-speaker separation tasks. © 2024 IEEE.

关键词： Time domain analysis

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Simulation method for large span heavy sea clutter in pulsed Doppler radar 4

Simulation method for large span heavy sea clutter in pulsed...

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4th International Conference on Computer science and Communication Technology, ICCSCT 2023

作者： Chen, Siyuan Hao, He Li, Ruirui Luo, Peike Yao, Shujian Shuai, Hanshu Zhang, Xinyin Advanced Communication and Flexible Information Processing Technology Research and Development Center Beijing Institute of Control Engineering Beijing100038 China

ISBN: (纸本)9781510671232

The clutter generated by multiple transmitting pulses overlaps in the time domain, which results in the two-dimensional aliasing of the range domain and Doppler spectrum of the clutter for the medium and high repetition frequency radar. In the simulation of different battlefield environments, a large number of range-Doppler grid units will be generated. It is necessary to establish a simulation model of aircraft based on GPU-CPU architecture to solve the track, attitude and radar parameters in real time to generate grid units, and then add antenna and sea situation information to calculate the cross-heavy sea clutter. This is of great significance for rapidly generating large span heavy sea clutter and improving the speed and reliability of sea clutter simulation. © 2023 SPIE.

关键词： Clutter (information theory)

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A method for establishing a bearing residual life prediction model for process enhancement equipment based on rotor imbalance response analysis

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Chinese Journal of Chemical engineering 2024年第2期66卷 203-215页

作者： Feng Wang Haoran Li Zhenghui Zhang Yan Bai Hong Yin Jing Bian National Foundation Research Laboratory of Fault Prevention and Control in Hazardous Chemicals Production System Engineering Research Center of Chemical Technology SafetyBeijing University of Chemical TechnologyBeijing 100029China China Nuclear Power Engineering Co. LtdBeijing 100840China CNOOC Tianjin Chemical Research and Design Institute Co. LtdTianjin Key Laboratory of Energy and Chemical Explosion SafetyAcademician Expert Collaborative Innovation CenterTianjin 300131China

A rotating packed bed is a typical chemical process enhancement equipment that can strengthen micromixing and mass *** the operation of the rotating packed bed,the nonreactants and products irregularly adhere to the wire mesh packing in the rotor,thus resulting in an imbalance in the vibration of the rotor,which may cause serious damage to the bearing and material *** study proposes a model prediction for estimating the bearing residual life of a rotating packed bed based on rotor imbalance response *** method is used to determine the influence of the mass on the imbalance in the vibration of the rotor on bearing *** major influence on rotor vibration was found to be exerted by the imbalanced mass and its distribution radius,as revealed by the results of orthogonal *** implementing finite element analysis,the imbalance response curve for the rotating packed bed rotor was obtained,and a correlation among rotor imbalance mass,distribution radius of imbalance mass,and bearing residue life was established via data *** predicted value of the bearing life can be used as the reference basis for an early safety warning of a rotating packed bed to effectively avoid accidents.

关键词： Rotating packed bed Mass imbalance Harmonic response analysis Residual life Prediction model

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Self-timed Fused Multiply-add Unit Performance Improvement

Self-timed Fused Multiply-add Unit Performance Improvement

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2022 Conference of Russian Young researchers in Electrical and Electronic engineering, ElConRus 2022

作者： Sokolov, Igor A. Rogdestvenski, Yuri V. Rogdestvenskene, Asta V. Stepchenkov, Yury A. Diachenko, Yuri G. Diachenko, Denis Y. Computer Science and Control of the Russian Academy of Sciences Federal Research Center Moscow Russia Computer Science and Control of the Russian Academy of Sciences Institute of Informatics Problems Federal Research Center Moscow Russia

ISBN: (纸本)9781665409933

The paper presents the results of researching and developing methods accelerating a self-timed unit that performs a fused multiply-add-subtract operation under three operands following the IEEE754 standard. The paper proposes a normalization order of the sum and difference speculative estimation when using ternary self-timed coding. This estimation uses a difference of the 24 most significant bits of the product and the third aligned operand for counting leading zeroes. This technique provides a 20% reduction in complexity when implementing the shifter in the normalization block. The analysis shows that the developed methods accelerate the normalization stage by an average of 32% on the statistical set of the input operands. © 2022 IEEE.

关键词： Timing circuits

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DecStore: a Blockchain-based File Storage System With Autoscaling 24

DecStore: a Blockchain-based File Storage System With Autosc...

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24th International Arab Conference on Information Technology, ACIT 2023

作者： Hammoud, Obadah Tarkhanov, Ivan A. National University of Science and Technology Department of Engineering Cybernetics Moscow Russia State Academic University for the Humanities Moscow Russia Academy of Sciences Federal Research Center 'Computer Science and Control' of Russian Russia

ISBN: (纸本)9798350384307

Digital transformation requires new innovative approaches in the design of data exchange and file storage systems. The analysis of the architecture of well-known IT projects and approaches showed that each of them cannot solve one of three problems at the same time: automatic scaling, the absence of a single point of failure, and minimizing the required storage space for files and their backups. The presented architecture of DecStore, a blockchain-based peer-to-peer file storage system, solves these problems simultaneously. It reduces the total amount of disk space required by 25% through the use of erasure coding. Automatic horizontal scaling and the absence of a single point of failure are provided by a load balancer based on algorithms implemented inside the Hyperledger chaincode. DecStore can become a subsystem for secure data exchange for government-to-business and business-to-business systems for state supervision in various areas, including financial and insurance audits. © 2023 IEEE.

关键词： Autoscaling distributed storage smart contract

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Synergistic Cu single-atoms and clusters on tubular carbon nitride for efficient photocatalytic performances

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Rare Metals 2024年第11期43卷 5891-5904页

作者： Yu-Xiao Feng Hui-Jun Yu Tian-Guang Lu Zi-Ye Zheng Shuang Tian Li Xiang Shan Zhao Shu-Guang Wang Zuo-Li He Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityQingdao 266237China Weihai Research Institute of Industrial Technology of Shandong University Shandong UniversityWeihai 264209China School of Electrical Engineering Shandong UniversityJinan 250061China CEDAR Knight Cancer InstituteSchool of MedicineOregon Health and Science UniversityPortland 97201USA

Metal clusters or even single-atoms dispersed and anchored on the photocatalysts'surface can enhance photocatalytic performances on organic pollutant ***,a simple photoreduction method was used to create atomically dispersed metal single-atoms/clusters(MSCs,M=Cu,Pd,Au and Ag)on P-modulated tubular carbon nitride(TCN).The obtained MSCs@TCN demonstrated excellent photocatalytic performances for the degradation of sulfamethazine(SMZ).In particular,the photocatalyst with 2 wt%Cu loading showed ultrahigh SMZ oxidation efficiency(k=0.06110 min^(-1)),almost three times that of TCN(k=0.02066 min^(-1)).It also shows excellent stability in the 5th-cycle *** improved photocatalytic activity of the CuSCs@TCN is ascribed to the synergistic promotion of photogenerated charge separation by Cu single-atoms/clusters as active sites,accelerated charge transfer from bulk TCN to Cu sites through Cu-N_(x)***,the active sites of Cu single-atoms/clusters could promote the production of·O_(2)^(-),which participates in organic oxidation with strong oxidizing holes(h^(+)).This strategy paves a new avenue for designing high-performance photocatalysts decorated with metal single-atoms and clusters.

关键词： Carbon nitride Photocatalysis Cu single-atom Sulfamethazine Degradation

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Shock initiation performance of NTO-based polymer bonded explosive

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Defence Technology（防务技术） 2022年第9期18卷 1538-1545页

作者： Peng-song Nie Shao-hua Jin Li-xiao-song Du Li-jie Li Kun Chen Yu Chen Rui Yu School of Materials Science and Engineering Beijing Institute of TechnologyZhongguancun South Street 5Beijing100081China Xi'an Modern Control Technology Research Institute Xi'an710065China

3-nitro-1,2,4-tri-azol-5-one(NTO) is a high energy insensitive explosive. To study the shock initiation process of NTO-based polymer bonded explosive JEOL-1(32%octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX), 32% NTO, 28% Al and 8% binder system), the cylinder test, the gap experiments and numerical simulation were carried out. Firstly, we got the detonation velocity(7746 m/s) and the parameters of Jones-Wilkins-Lee(JWL) equation of state(EOS) for detonation product by cylinder test and numerical simulation. Secondly, the Hugoniot curve of unreacted explosive for JEOL-1 was obtained calculating the data of pressure and time at different Lagrangian positions. Then the JWL EOS of unreacted explosive was obtained by utilizing the Hugoniot curve as the reference curve. Finally, we got the pressure growth history of JEOL-1 under shock wave stimulation and the parameters of the ignition and growth reaction rate equation were obtained by the pressure-time curves measured by the shockinitiation gap experiment and numerical simulation. The determined trinomial ignition and growth model(IG model) parameters can be applied to subsequently simulation analysis and design of insensitive ammunition with NTO-based polymer bonded explosive.

关键词： NTO Shock initiation Hugoniot data JWL Ignition and growth reactive model

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