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Investigation of dynamic behavior of human skin tissue under micro-particle impact in the context of transdermal drug delivery:numerical and analytical perspectives

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Theoretical & Applied Mechanics Letters 2025年第2期15卷 188-193页

作者： Jianbo Shen Jiacai Huang Yaoke Wen Sebastien Roth School of Mechanical Engineering Nanjing Institute of TechnologyNanjing 211167China Jiangsu Provincial Engineering Research Center for Bionics Control Technology and Equipment Nanjing 211167China School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303CNRS/Université de Technologie de Belfort-MontbéliardSite UTBMBelfort 90010France

The understanding of the impact of high-velocity microparticles on human skin tissue is important for the ad-ministration of drugs during transdermal drug *** paper aims to numerically investigate the dynamic behavior of human skin tissue under micro-particle impact in transdermal drug *** numerical model was developed based on a coupled smoothed particle hydrodynamics(SPH)and FEM method via commercial FE software *** analysis was conducted applying the Poncelet model and was used as validation data.A hyperelastic one-term Ogden model with one pair of material parameters(μ,α)was implemented for the skin *** studies reveal that the effect of parameter α on the penetration process is much more significant than μ.Numerical results correlate well with the analytical curves with various particle diameters and impact velocities,its capability of predicting the penetration process of micro-particle impacts into skin *** work can be further investigated to guide the design of transdermal drug delivery equipment.

关键词： Micro-particle impact Dynamic behavior Human skin tissue Smoothed particle hydrodynamics FEM penetration

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Valley-selective manipulation of moiréexcitons through optical Stark effect

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Chinese Physics B 2025年第1期34卷 14-18页

作者： Chenran Xu Jichen Zhou Zhexu Shan Wenjian Su Kenji Watanabe Takashi Taniguchi Dawei Wang Yanhao Tang School of Physics Zhejiang UniversityHangzhou 310027China Zhejiang Key Laboratory of Micro-Nano Quantum Chips and Quantum Control Zhejiang UniversityHangzhou 310027China Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan

Semiconductor moirésuperlattices provide great platforms for exploring exotic collective *** Stark effect,a shift of the electronic transition in the presence of a light field,provides an ultrafast and coherent method of manipulating matter states,which,however,has not been demonstrated in moiré***,we report the valleyselective optical Stark effect of moiréexcitons in the WSe_(2)/WS_(2)superlattice by using transient reflection *** valley-selective energy shifts up to 7.8 meV have been observed for moiréexcitons,corresponding to pseudomagnetic fields as large as 34 *** results provide a route to coherently manipulate exotic states in moirésuperlattices.

关键词： optical Stark effect moir´e exciton transient reflection spectroscopy

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Path Integral Policy Improvement and Dynamic Movement Primitives Fusion-Based Impedance Force control With Error Loop Correction

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IEEE Transactions on Automation science and engineering 2025年 22卷 15034-15044页

作者： Liu, Mujie Chen, Haifei Li, Lijun Ma, Zhiqiang Xu, Yong Zhang, Hui Central South University of Forestry and Technology National Forestry and Grassland Engineering Technology Research Center for Harvesting Equipment of Nonwood Forest Fruits Engineering Research Center for Forestry Equipment of Hunan Province School of Mechanical and Intelligent Manufacturing Changsha410004 China Northwestern Polytechnical University Research Center for Intelligent Robotics School of Astronautics Xi’an710072 China Beijing Institute of Technology School of Automation Beijing100081 China Hunan University National Engineering Research Center of Robot Visual Perception and Control Technology School of Robotics Changsha410082 China

Path Integral Strategy Improvement(PI2)-based impedance control is a superior scheme for preventing damage to the physical structure of the fruit during the harvesting process. However, it is highly sensitive to disturbances and has limited generalization ability during the parameter learning process, making it difficult to apply the correct gripping force to fruits with uncertain stiffness. To solve this problem, this paper proposes a variable impedance force control method that integrates PI2 with Dynamic Movement Primitives (DMPs), supplemented by a force error correction loop. Firstly, an adaptive impedance parameter matching mechanism based on gain schedules is designed to facilitate dynamic estimation of impedance parameters and enable precise force control. To further accelerate impedance parameter matching in unknown environments, the PI2 algorithm is introduced to optimize gain schedules, and DMPs are integrated to suppress disturbances, thereby improving the generalization ability of the impedance model’s parameter learning. In addition, an additional force error control loop has been designed to minimize the deviation between the desired and actual gripping force. Finally, the effectiveness of the proposed method is verified through simulation and experiment in fruit teleoperation picking robot. In the local-remote heterogeneous fruit teleoperation picking robot system, preventing fruit damage is critical to improving harvesting efficiency and quality. However, the existing PI2 algorithm suffers from limited generalization ability during the parameter learning process and is highly susceptible to environmental disturbances, presenting challenges in force control. To address this issue, this study proposes integrating DMPs into PI2 to optimize gain schedules and designing a force error control loop to refine trajectories, thereby achieving the force control objectives and effectively compensating for the shortcomings of PI2. Simulation and experimental res

关键词： Rotation

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Generation of semisynthetic natural-looking 2D barcodes for localization problems 5

Generation of semisynthetic natural-looking 2D barcodes for ...

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5th Symposium on Pattern Recognition and Applications, SPRA 2024

作者： Limonova, Elena Zlobin, Pavel Bezmaternykh, Pavel Federal Research Center 'Computer Science and Control' Russian Academy of Sciences Moscow119333 Russia Smart Engines Service LLC Moscow117312 Russia

ISBN: (数字)9781510688803

ISBN: (纸本)9781510688797

The role of barcodes in industrial processes and product labeling is rapidly growing. So, the problem of their recognition using mobile cameras in uncontrolled environments becomes very acute. The development of neural networks and computer vision provides an opportunity to solve it with high accuracy, given that there is enough representative data to train and test algorithms. However, the barcodes can contain sensitive information, and huge amounts of data cannot be published. Synthetic image generation can solve this problem, and in this paper, we propose a method to generate semi-synthetic natural-looking 2D barcodes with illumination changes, blur, and projective distortion, which can be used to create training or testing data for localization problems. We introduce the SE-DMTX-SYN-1000 dataset, designed for Data Matrix fine localization. We validate localization accuracy using Zxing, Zxing-cpp and libdmtx barcode reading libraries and demonstrate that this benchmark is quite challenging and can help to improve Data Matrix localization. Copyright © 2025 SPIE.

关键词： Image coding

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Modeling and Optimization of controlled Conveyor Systems Using Intelligent controllers 15th

Modeling and Optimization of Controlled Conveyor Systems U...

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15th International Conference on Optimization and Applications, OPTIMA 2024

作者： Petrov, Alexey Druzhinina, Olga Masina, Olga Bunin Yelets State University Yelets Russia Federal Research Center "Computer Science and Control" of Russian Academy of Sciences Moscow Russia V. A. Trapeznikov Institute of Control Sciences of Russian Academy of Sciences Moscow Russia

ISBN: (纸本)9783031791185

The construction of generalized mathematical models is proposed that describe the dynamics of a controlled belt conveyor with a variable angle between the horizontal plane and the plane of the belt. The models under consideration are defined using nonlinear nonstationary systems of four differential equations with switching. Switching modes are characterized by a change in the loading and unloading sequence. Statements of optimal control problems are presented under restrictions on the magnitude of control and on the speed of control. Synthesis of neural network controllers for stabilization of the angular position of the conveyor is carried out. controllers are synthesized using such direct propagation neural networks for which reinforcement learning is implemented based on the optimization algorithm of differential evolution. A comparative analysis of the effectiveness of synthesized controllers is carried out. Algorithmic support for modeling controlled conveyor systems is developed using intelligent analysis and global parametric optimization methods. The results of computational experiments are presented. The obtained results can find application in solving problems of optimal stabilization of dynamic systems with switching. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Belt conveyors

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Shifts in phytoplankton communities in inland waterways:Insights from the Beijing-Hangzhou Grand Canal,China

River

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River 2025年第1期4卷 36-43页

作者： Xueru Mao Lin Zhu Boyi Liu Chenjun Zeng Huijian Yang Wenqing Shi Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technologies Jiangsu Key Laboratory of Atmospheric Environmental Monitoring and Pollution ControlSchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjingChina Guangdong Research Institute of Water Resources and Hydropower GuangzhouChina Guangdong Huike Hydraulic Technology Corporation Limited GuangzhouChina

Phytoplankton play a crucial role in maintaining the health of river ecosystems,and their communities are closely linked to river *** inland waterways,disturbances generated by ship propellers alter flow dynamics and may affect phytoplankton *** clarify it,phytoplankton communities in the Zhenjiang section of the Beijing-Hangzhou Grand Canal(BHGC)in China,the world's longest canal,were studied and compared them with its undisturbed *** results revealed major alternations in seasonal patterns of phytoplankton communities in the BHGC,shifting the peak of phytoplankton density from spring to autumn and the lowest diversity from summer to *** disturbances increased water turbidity and created optimal N/P ratios,which provided Cyanobacteria with a competitive advantage in *** proliferation of Cyanobacteria resulted in a phytoplankton density in the BHGC,exceeding that in the tributaries by more than tenfold,accompanied by a decrease in diversity to its lowest *** to habitat alterations,functional groups emerged that are resilient to strong disturbances and high *** findings add to the understanding of the impact of ship traffic on river ecosystems.

关键词： functional group inland waterway N/P ratio phytoplankton ship traffic turbidity

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Multiple Four-way Shuttle Path Planning Problem in Shuttle-Based Storage and Retrieval Systems: An Improved Conflict-Based Search Algorithm 14

Multiple Four-way Shuttle Path Planning Problem in Shuttle-B...

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14th International Conference on Logistics and Systems engineering

作者： Wang, Yanyan Wang, Zefeng Wang, Xuemei Man, Rongjun Shenzhen Research Institute of Shandong University Guangdong Shenzhen518057 China School of Control Science and Engineering Shandong University Shandong Jinan250061 China

ISBN: (纸本)9798331314347

A unique automated warehousing system called the four-way shuttle system has gained popularity recently because of its high adaptability and capacity to function across aisles and tiers. The four-way shuttle can move in four directions along fixed guideways. Therefore, the conflict-free routing of multiple four-directional shuttles within the same layer becomes particularly significant. This study develops a mathematical model for optimizing conflict-free path planning for multiple four-way shuttles to minimize total task completion time. We introduce the Dynamic Potential Conflict-Based Search (DPCBS) algorithm to facilitate conflict-free navigation for four-way shuttles. DPCBS enhances the Conflict-Based Search (CBS) algorithm's high-level search strategy by integrating the Dynamic Potential Search algorithm and augments the low-level search strategy with the Safe Interval Path Planning algorithm. This algorithm also incorporates priority strategies to improve its efficacy. Experimental results show that DPCBS with the priority strategy significantly outperforms the original algorithm in computational efficiency and success rate, effectively generating conflict-free paths for the four-way shuttle system. © (2025) by Aussino Academic Publishing House All rights reserved.

关键词： Guideways

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Thermo-responsive microneedles patch for transdermal drug delivery via squeezing in diabetic foot ulcers

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材料科学技术（英文版） 2025年第2期205卷 299-314页

作者： Xiaotong Wu Dan Xia Tingting Shi Baoe Li Donghui Wang Chunyong Liang Mingdong Dong Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Hebei Key Laboratory of Biomaterials and Smart Theranostics School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Hebei Key Laboratory of Biomaterials and Smart Theranostics School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Interdisciplinary Nanoscience Center Aarhus UniversityAarhus CDK-8000Denmark

Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people *** reducing skin resistance or increasing driving force can accelerate the effi-ciency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional ***,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is *** TMN consisted of a bilayer mi-croneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and *** accelerates drug re-lease by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regener-ation and epithelial *** results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80％in the 10th h,and the antibacterial rate of TMN could reach 800％.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.

关键词： Microneedles patch Thermal response Transdermal drug delivery Diabetic foot ulcers

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A logistic-Lasso-regression-based seismic fragility analysis method for electrical equipment considering structural and seismic parameter uncertainty

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Earthquake engineering and engineering Vibration 2025年第1期24卷 169-186页

作者： Cui Jiawei Che Ailan Li Sheng Cheng Yongfeng Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education School of Civil EngineeringHarbin Institute of TechnologyHarbin 150094China School of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Electric Power Research Institute Beijing 100055China

Damage to electrical equipment in an earthquake can lead to power outage of power *** fragility analysis is a common method to assess the seismic reliability of electrical *** further guarantee the efficiency of analysis,multi-source uncertainties including the structure itself and seismic excitation need to be considered.A method for seismic fragility analysis that reflects structural and seismic parameter uncertainty was developed in this *** proposed method used a random sampling method based on Latin hypercube sampling(LHS)to account for the structure parameter uncertainty and the group structure characteristics of electrical ***,logistic Lasso regression(LLR)was used to find the seismic fragility surface based on double ground motion intensity measures(IM).The seismic fragility based on the finite element model of an±1000 kV main transformer(UHVMT)was analyzed using the proposed *** results show that the seismic fragility function obtained by this method can be used to construct the relationship between the uncertainty parameters and the failure *** seismic fragility surface did not only provide the probabilities of seismic damage states under different IMs,but also had better stability than the fragility ***,the sensitivity analysis of the structural parameters revealed that the elastic module of the bushing and the height of the high-voltage bushing may have a greater influence.

关键词： seismic fragility uncertainty logistic lasso regression ±1000 kV main transformer sensitivity analysis

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Development and Testing of an Intelligent Tobacco Leaf Harvesting Robot Based on Machine Vision

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INMATEH - Agricultural engineering 2025年第1期75卷 600-609页

作者： LIN, YuPei YAN, GuoYong WANG, Tao BAI, Tao TANG, Si CHEN, JunJie ZHANG, BaoLin Southwest University College of Artificial Intelligence Chongqing400715 China National & Local Joint Engineering Research Center of Intelligent Transmission and Control Technology Chongqing400715 China Qujing Tobacco Company of Yunnan Province Yunnan 655000 China

The efficiency and quality of tobacco leaf harvesting are crucial for the economic performance of the tobacco industry. To enhance harvesting efficiency, a non-destructive tobacco leaf harvesting robot based on machine vision and robotics technology was developed. Experimental evaluations of key components demonstrated that the biomimetic flexible gripper based on the fin ray effect has good stiffness when the clamping force is 2.5 N, ensuring stable subsequent harvesting and collection of tobacco leaves. The introduction of a 6+1-axis robotic arm significantly expands the working range compared to the original 6-axis design, effectively covering the height of the tobacco stalk. The robotic arm’s speed notably affects harvesting time (P © (2025), American Psychological Association

关键词： Grippers

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