Abstract: Masses of ground states of triply heavy tetraquarks are calculated within the relativistic quark model based on the quasipotential approach and the diquark–antidiquark picture of tetraquarks. The relativist...
Landfilling remains the primary disposal method for fly ash produced from municipal solid waste incineration(MSWI)following stabilization/***,the increasing generation of stabilized fly ash(SFA)is accelerating the dep...
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Landfilling remains the primary disposal method for fly ash produced from municipal solid waste incineration(MSWI)following stabilization/***,the increasing generation of stabilized fly ash(SFA)is accelerating the depletion of landfill ***,the small particle size and low bulk density of SFA present significant environmental risks during handling and *** mitigate these issues,a cost-effective compaction method was introduced into the SFA disposal *** results show that SFA from both grate furnaces and fluidized bed incinerators exhibited high porosity,loose structure,and irregular particle morphology,indicating substantial potential for *** parameters influencing compaction effectiveness included compaction pressure,holding duration,and moisture content,with optimal values identified as 100–200 MPa,20 s,and 10%–15%moisture,respectively,depending on the incinerator *** compaction treatment,the density of SFA more than doubled,while its volume was reduced by over 60%,significantly increasing landfill capacity and enhancing the efficiency of SFA *** compaction process was effectively modeled using the Huang Peiyun equation for gerate furnace ash and the Heckel equation for fluidized bed ***,the unconfined compressive strength and three-point bending strength of compacted SFA met the MU10 standard for lime-sand bricks,making the material suitable for transportation and ***,the compaction-based disposal method for SFA demonstrated clear techno-economic advantages and significant potential for broader application in waste management strategies.
Immune checkpoint blockade therapy provides a new strategy for tumor treatment;however,the insufficient infiltration of cytotoxic T cells and immunosuppression in tumor microenvironment lead to unsatisfied ***,we repo...
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Immune checkpoint blockade therapy provides a new strategy for tumor treatment;however,the insufficient infiltration of cytotoxic T cells and immunosuppression in tumor microenvironment lead to unsatisfied ***,we reported a lipid/PLGA nanocomplex(RDCM)co-loaded with the photosensitizer Ce6 and the indoleamine 2,3-dioxygenase(IDO)inhibitor 1MT to improve immunotherapy of colon ***–glycine–aspartic acid(RGD)as the targeting moiety was conjugated on 1,2-distearoyl-snglycero-3-phosphoethanolamine lipid via polyethylene glycol(PEG),and programmed cell death-ligand 1(PDL1)peptide inhibitor DPPA(sequence:CPLGVRGK-GGG-d(NYSKPTDRQYHF))was immobilized on the terminal group of PEG via matrix metalloproteinase 2 sensitive peptide *** Ce6 and 1MT were encapsulated in PLGA *** drug loaded nanoparticles were composited with RGD and DPPA modified lipid and lecithin to form lipid/PLGA *** the nanocomplexes were delivered to tumor,DPPA was released by the cleavage of a matrix metalloproteinase 2-sensitive peptide linker for PD-L1 *** facilitated the cellular internalization of nanocomplexes via avβ3 *** immunogenic cell death was induced by 1 O2 generated from Ce6 irradiation under 660 nm laser.1MT inhibited the activity of IDO and reduced the inhibition of cytotoxic T cells caused by kynurenine accumulation in the tumor *** RDCM facilitated the maturation of dendritic cells,inhibited the activity of IDO,and markedly recruited the proportion of tumor-infiltrating cytotoxic T cells in CT26 tumor-bearing mice,triggering a robust immunological memory effect,thus effectively preventing tumor *** results indicated that the RDCM with dual IDO and PD-L1 inhibition effects is a promising platform for targeted photoimmunotherapy of colon cancer.
Mobile robots represented by smart wheelchairs can assist elderly people with mobility *** paper proposes a multi-mode semi-autonomous navigation system based on a local semantic map for mobile robots,which can assist...
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Mobile robots represented by smart wheelchairs can assist elderly people with mobility *** paper proposes a multi-mode semi-autonomous navigation system based on a local semantic map for mobile robots,which can assist users to implement accurate navigation(e.g.,docking)in the environment without prior *** order to overcome the problem of repeated oscillations during the docking of traditional local path planning algorithms,this paper adopts a mode-switching method and uses feedback control to perform docking when approaching semantic *** last,comparative experiments were carried out in the real *** show that our method is superior in terms of safety,comfort and docking accuracy.
Iron is a fundamental trace element essential for the immune system, and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this stu...
Iron is a fundamental trace element essential for the immune system, and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration, 45 ℃ temperature, and 60 minutes of incubation, utilizing both carboxyl and amino binding sites. Compared to MEPH alone, the MEPH-Fe complexes exhibited fluorescence quenching, ultraviolet shifts, reduced X-ray diffraction peak intensities, stabilization during in vitro digestion, microstructural changes, increased particle size, and decreased absolute values of zeta potential. In the IDA mouse model, the MEPH-Fe complexes were able to restore body weight, hematological indices, organ coefficients, iron content in organs, and antioxidant capacity to normal levels. Additionally, they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion, this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.
Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial *** varied composition tends to influence each VOC’s catalytic behavior i...
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Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial *** varied composition tends to influence each VOC’s catalytic behavior in the reaction *** investigated the catalytic destruction of multi-component VOCs including dichloromethane(DCM)and ethyl acetate(EA),as representatives from pharmaceutical waste gases,over co-supported HxPO_(4)-RuOx/CeO_(2) catalyst.A mutual inhibitory effect relating to concentrations because of competitive adsorption was verified in the binary VOCs oxidation and EA posed a more negative effect on DCM oxidation owing to EA’s superior adsorption *** adsorption of EA on acidic sites(HxPO_(4)/CeO_(2))promoted DCM activation on basic sites(O^(2−))and the dominating EA oxidation blocked DCM’s access to oxidation centers(RuOx/CeO_(2)),resulting in boosted monochloromethane yield and increased chlorine deposition for DCM *** impaired redox ability of Ru species owing to chlorine deposition in turn jeopardized deep oxidation of EA and its by-products,leading to increased gaseous by-products such as acetic acid originating fromEA ***,DCM at low concentration slightly promoted EA conversion at low temperatures with or without water,consistent with the enhanced EA adsorption in co-adsorption *** was mainly due to that DCM impeded the shielding effect of hydrolysate deposition from rapid EA hydrolysis depending on the decreased ***,water benefited EA hydrolysis but decreased CO_(2) selectivity while the generated water derived from EA was likely to affect DCM *** work may provide theoretical guidance for the promotion of applied catalysts toward industrial applications.
Robotic grasping is a crucial topic in robotics and computer vision, with broad applications in industrial production and intelligent manufacturing. Although some methods have begun addressing instance-level grasping,...
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Detecting the openable parts of articulated objects is crucial for downstream applications in intelligent robotics, such as pulling a drawer. This task poses a multitasking challenge due to the necessity of understand...
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Clarifying the climate change effects on the radial growth of trees has implications for sustainable forest management,especially under global *** investigate tree growth responses to regional climate change of Xiaowu...
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Clarifying the climate change effects on the radial growth of trees has implications for sustainable forest management,especially under global *** investigate tree growth responses to regional climate change of Xiaowutai Mountain,four Chinese pine(Pinus tabulaeformis)ring-width index chronologies were established at different elevations(1290–1600 m).Species growth trends were estimated using climate change projections derived from global climate *** results show:(1)the four ring-width chronologies exhibited strong statistical characteristics,making them suitable for dendroclimatology *** growth-climate relationships were highly consistent,showing a negative correlation with previous September temperatures and current May–June temperatures,as well as a positively correlated with precipitation and Palmer Drought Severity Index during the corresponding period;and(2)climate change scenarios revealed that temperature will gradually increase on the Xiaowutai Mountain,and only a slight variation in precipitation is *** pine radial growth may show a decline under future climate change.
This paper considers the optimal control problem of steering a Dubins vehicle with a decaying speed that depends linearly on the turn-rate to a terminal point and heading with maximum kinetic energy. Pontryagin’s min...
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