Preserving the topology from being inferred by external adversaries has become a paramount security issue for network systems (NSs), and adding random noises to the nodal states provides a promising way. Nevertheless,...
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Acute liver failure is a life-threatening syndrome,for which liver transplantation is presently the most effective ***,such treatment is extremely limited by a shortage of donor *** cell therapy offers a promising tre...
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Acute liver failure is a life-threatening syndrome,for which liver transplantation is presently the most effective ***,such treatment is extremely limited by a shortage of donor *** cell therapy offers a promising treatment strategy for acute liver ***,therapeutic efficacy and potential are hampered by administration route and safety *** this work,we fabricated menstrual blood-derived stem cells-conditioned medium/polymersome hybrid nanoparticles that were self-assembled from amphiphilic block copolymers via the direct hydra-tion method and encapsulated therapeutic bioactive factors within the aqueous core of *** merit of vesicular architecture enabled the loading capacity of dis-tinct proteins and the maintenance of biological *** hybrid nanoparticles can be steadily taken up into cytoplasm and promote hepatocyte proliferation in *** in vivo circulation time brought higher accumulation in *** therapeutic nanoparticles alleviated hepatic injury and promoted liver recovery in mice with carbon tetrachloride-induced liver *** the feasibility and benefit of the hybrid nanoparticle therapy,it provided a potential strategy to treat acute liver failure.
The problem of satellite attitude control under multiple disturbance sources is studied in this paper. Usually, satellites carry multiple payload devices, and each payload has different start-up times, operating hours...
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Al-Cu-Mn alloys are widely used to produce automobile components like cylinder heads and engine blocks because of their capability to retain excellent thermal and mechanical characteristics at high ***,the Al-Cu-Mn-ba...
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Al-Cu-Mn alloys are widely used to produce automobile components like cylinder heads and engine blocks because of their capability to retain excellent thermal and mechanical characteristics at high ***,the Al-Cu-Mn-based alloys demonstrate restricted fluidity,leading to casting defects such as shrinkage and incomplete *** research investigated the microstructure and fluidity of Al-4.7Cu-1.0Mn-0.5Mg(wt%)alloy with minor cerium(Ce)*** as-cast alloys predominantly compriseα-Al matrix,accompanied by the presence of Al_(2)Cu,Al_(6)Mn,and Al_(8)Cu_(4)Ce *** influence of adding Ce on the fluidity of the Al-4.7Cu-1.0Mn-0.5Mg alloy was investigated using a trispiral fluidity test mold in this *** findings suggest that the addition of Ce within the range of 0.1 wt%to 0.5 wt%in the Al-4.7Cu-1.0Mn-0.5Mg alloy results in an enhancement in ***,the alloy containing 0.4 wt%Ce exhibits a significant increase in fluidity distance,from 349.7 to 485.7 *** improvement can be attributed to the reduction in viscosity,the refinement of secondary dendrite arm spacing,and the modification of secondary phase ***,a higher concentration of Ce leads to a decrease in fluidity length,potentially due to the formation of Al_(8)Cu_(4)Ce.
Introduction:Many measures implemented to control the coronavirus disease 2019(COVID-19)pandemic have reshaped the epidemic patterns of other infectious *** study estimated the impact of the COVID-19 pandemic on respi...
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Introduction:Many measures implemented to control the coronavirus disease 2019(COVID-19)pandemic have reshaped the epidemic patterns of other infectious *** study estimated the impact of the COVID-19 pandemic on respiratory and intestinal infectious diseases and potential changes following ***:The optimal intervention and counterfactual models were selected from the seasonal autoregressive integrated moving average(SARIMA),neural network autoregression(NNAR),and hybrid models based on the minimum mean absolute percentage error(MAPE)in the test *** relative change rate between the actual notification rate and that predicted by the optimal model was calculated for the entire COVID-19 epidemic prevention period and the“reopening”***:Compared with the predicted notification rate based on the counterfactual model,the total relative change rates for the 9 infectious diseases were−44.24%,respiratory infections(−55.41%),and intestinal infections(−26.59%)during 2020–*** with the predicted notification rate based on the intervention model,the total relative change rates were+247.98%,respiratory infections(+389.59%),and intestinal infections(+50.46%)in *** them,the relative increases in influenza(+499.98%)and hand-foot-mouth disease(HFMD)(+70.97%)were ***:Measures taken in Jiangsu Province in response to COVID-19 effectively constrained the spread of respiratory and intestinal infectious *** and HFMD rebounded significantly after the lifting of COVID-19 intervention restrictions.
The attitude control problem of microgravity satellite is studied, and a microgravity attitude control scheme using only magnetic torquer for active control is proposed. The paper conducts a force analysis of in orbit...
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This article aims to propose a general control strategy for coordination of multiple nonholonomic agents in three dimensional space. For real-world applications, since the field sensor equipped on the mobile agents fo...
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Immunotherapy,as a groundbreaking cancer treatment,has gained considerable attention for its utilization of the body’s immune system to combat tumors^([1]).This therapy induces tumor cell apoptosis,triggering a susta...
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Immunotherapy,as a groundbreaking cancer treatment,has gained considerable attention for its utilization of the body’s immune system to combat tumors^([1]).This therapy induces tumor cell apoptosis,triggering a sustained anti-tumor immune response and effectively preventing tumor recurrence and metastasis^([2]).The fundamental principle lies in inducing tumor cell death through specific treatment modalities,leading to the release of a cascade of signaling molecules and antigens,thereby mobilizing the immune system to actively identify and attack tumor cells^([3]).
The paper amends the Green Solow model to replace the neoclassical production function by an endogenous production function. This endogenous function incorporates the growth rate, the rate of degradation of production...
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The deep-learning protein structure prediction method AlphaFold2 has garnered enormous attention beyond the realm of structural biology,for its groundbreaking contribution to solving the"protein foiding problem&q...
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The deep-learning protein structure prediction method AlphaFold2 has garnered enormous attention beyond the realm of structural biology,for its groundbreaking contribution to solving the"protein foiding problem"In this perspective,we explore the connection between protein structure studies and environmental research,delving into the potential for addressing specific environmental *** are promising for environmental applications because of the functional diversity endowed by their structural ***,structural studies on proteins with environmental significance remain ***,we present the opportunity to study proteins by advancing experimental determination and deep-learning prediction ***,the latest progress in environmental research via cryogenic electron microscopy is *** allows us to determine the structure of protein complexes in their native state within cells at molecular resolution,revealing environmentally-associated structural *** the remarkable advancements in computational power and experimental resolution,the study of protein structure and dynamics has reached unprecedented depth and *** advancements will undoubtedly accelerate the establishment of comprehensive environmental protein structural and functional *** opportunities for protein engineering exist to enable innovative solutions for environmental applications,such as the degradation of persistent contaminants,and the recovery of valuable metals as well as rare earth elements.
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