Currently,experimental research on variable stiffness design mainly focuses on *** ensure adaptability in practical application,it is imperative to conduct a systematic study on stiffened variable stiffness structures...
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Currently,experimental research on variable stiffness design mainly focuses on *** ensure adaptability in practical application,it is imperative to conduct a systematic study on stiffened variable stiffness structures,including design,manufacture,experiment,and *** on the minimum curvature radius and process schemes,two types of T-stiffened panels were designed and *** compression tests have been carried out and the results indicate that the buckling load of variable stiffness specimens is increased by 26.0%,while the failure load is decreased by 19.6%.The influence mechanism of variable stiffness design on the buckling and failure behavior of T-stiffened panels was explicated by numerical *** primary reason for the reduced strength is the significantly increased load bearing ratio of *** experimental investigations of stiffened variable stiffness structures are very rare,this study can be considered a reference for future work.
The design of swing and stance control for path following of a prosthetic leg robot subject to uncertain dynamics and exterior disturbances is a serious issue, which affects the development of wearable robots. In wear...
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To solve the problems of a large number of parameters, low detection accuracy, slow detection speed of human flow target detection model, this paper proposes a YOLOv5 human flow target detection model based on GhostNe...
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Path planning is crucial for various robots, including manipulators, that autonomously perform non-repetitive tasks in obstacle-rich environments. In this paper we focus on path planning for an n-DoF (degrees of ...
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Background Newborn screening(NBS)for severe combined immunodefciency(SCID),X-linked agammaglobulinemia(XLA),and spinal muscular atrophy(SMA)enables early diagnosis and intervention,signifcantly improving patient *** i...
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Background Newborn screening(NBS)for severe combined immunodefciency(SCID),X-linked agammaglobulinemia(XLA),and spinal muscular atrophy(SMA)enables early diagnosis and intervention,signifcantly improving patient *** in real-time polymerase chain reaction(PCR)technology have been instrumental in facilitating their inclusion in NBS *** We employed multiplex real-time PCR to simultaneously detect T-cell receptor excision circles(TRECs),kappadeleting recombination excision circles(KRECs),and the absence of the survival motor neuron(SMN)1 gene in dried blood spots from 103,240 newborns in Zhejiang Province,China,between July 2021 and December *** Of all the samples,122 were requested further *** fow cytometry evaluation and/or genetic diagnostics,we identifed one patient with SCID,two patients with XLA,nine patients with SMA[one of whom also had Wiskott–Aldrich Syndrome(WAS)],and eight patients with other medical *** positive predictive values(PPVs)of NBS for SCID,XLA,and SMA were 2.44%,2.78%,and 100%,*** estimated prevalence rates in the Chinese population were 1 in 103,240 for SCID,1 in 51,620 for XLA,and 1 in 11,471 for *** This study represents the frst large-scale screening in China's Mainland using a TREC/KREC/SMN1 multiplex assay,providing valuable epidemiological *** fndings suggest that this multiplex assay is an efective screening method for SCID,XLA,and SMA,potentially supporting the universal implementation of NBS programs across China.
Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under ...
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Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER ***,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic ***,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during *** hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)*** obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER *** work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.
The electrochemical reduction reaction of carbon dioxide(CO_(2)RR)is considered to be an effective way to realize carbon *** a type of intensively studied materials,covalent organic frameworks(COFs)with a tunable pore...
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The electrochemical reduction reaction of carbon dioxide(CO_(2)RR)is considered to be an effective way to realize carbon *** a type of intensively studied materials,covalent organic frameworks(COFs)with a tunable pore structure and various functional groups are promising catalysts for CO_(2)***,COF synthesized by 2,6‐diaminoanthraquinone and 2,4,6‐triformylphloroglucinol is employed to assist the synthesis of electrocatalysts from Cu single atoms(SAs)to nanoclusters by controlling the electrodeposition.A tandem catalyst for CO_(2)‐to‐CH4 conversion is thus achieved by the Cu nanoclusters dispersed among the isolated Cu SAs in the COF *** is proposed that CO_(2) is first reduced to CO over the atomically isolated Cu SAs,followed by diffusion onto the neighboring Cu nanoclusters for further reduction into *** addition,mechanistic analysis suggests that the coordinated K^(+)ions on the COF network promote the activation of CO_(2) and the adsorption of reaction intermediates,thus realizing the suppressed hydrogen evolution reaction and selective production of *** study presents a new insight of COFs for the confined synthesis of a tunable SA to nanocluster electrocatalysts,disclosing the great potential of COFs in electrocatalysis.
Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor *** study was aimed to investigate how the morphology of...
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Clathrin-mediated endocytosis plays a critical role for hydroxyapatite nanoparticles(HANPs)to enter tumor cells,induce mitochondrial apoptosis,and inhibit tumor *** study was aimed to investigate how the morphology of HANPs impacts the endocytosis of the particles in melanoma cells,and their anti-tumor effect by using in vitro cell experiments and in vivo tumor animal *** shapes of HANPs,including granular HANPs(G-HANPs),rod-like HANPs(R-HANPs),and needle-like HANPs(N-HANPs),were successfully prepared by wet chemical *** the three HANPs could be internalized into A375 melanoma cells as indicated by cellular transmission electron microscopy *** these HANPs,only G-HANPs induced morphological change of mitochondria and loss of mitochondrial membrane potential(Δψm),and exhibited the greatest intracellular internalization efficiency in the tumor ***,the results of immunofluorescence staining and western blotting indicated that the level of adaptin-2(AP2)protein was up-regulated by all the HANPs,and highest in G-HANPs treated A375 ***,in the tumor-bearing mouse model,we found that tumor growth was delayed by all the three HANPs,of which,G-HANPs delayed tumor growth most efficiently and presented a highest expression level of AP2 protein in tumor ***,this study suggested that the morphology of HANPs regulated their endocytosis efficiency and their effect to inhibit tumor *** work facilitates to direct the rational design of nano-materials for tumor therapy.
Pt-modified amorphous alloy(Pt@PdNiCuP)catalyst exhibits excellent electro-catalytic activity and high experimental durability for hydrogen evolution reaction(HER).However,the physical origin of the catalytically acti...
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Pt-modified amorphous alloy(Pt@PdNiCuP)catalyst exhibits excellent electro-catalytic activity and high experimental durability for hydrogen evolution reaction(HER).However,the physical origin of the catalytically active remains *** this paper,we constructed a distance contribution descriptor(DCD)for the feature engineering of machine learning(ML)potential,and calculated the Gibbs free energies(ΔGH)of 46,000*H binding sites on the Pt@Pd Ni Cu P surface by ML-accelerated density functional theory(DFT).The relationship betweenΔGHand DCD revealed that in the H-Pt distance region of 2.0-2.5 A where the parabolic tail and disordered scatters coexist,the H-metal bonding configuration is mainly the bridge-or hollow-bonding *** contribution analysis of DCD indicates that the joint effect of Pt,Pd and Ni atoms determines the catalytical behavior of amorphous alloy,which agrees well with experimental *** counting atomic percentages in different energy intervals,we obtained the atomic ratio for the best catalytic performance(Pt:Pd:Ni:Cu:P=0.33:0.17:0.155:0.16:0.185).Projected density of states(PDOS)show that H 1s orbital,Pt 5d orbital,and Pd 4d orbital form a bonding state at-2 e *** results provide new ideas for designing more active amorphous alloy catalysts.
In order to solve the problems of long cycle and the difficulty of test, this paper proposes a method of power-in-the-loop motor simulator. Firstly, the topology of the motor simulator is proposed, composed of an inte...
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