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A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy

Regenerative Biomaterials 2025年第1期4卷 20-31页

作者： Nan Zhang Qiqi Sun Junhua Li Jing Li Lei Tang Quan Zhao Yuji Pu Gaofeng Liang Bin He Wenxia Gao Jianlin Chen Henan Academy of Sciences Zhengzhou 450046China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China School of Pharmacy Chengdu UniversityChengdu 610106China School of Laboratory Medicine Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-origin FoodChengdu Medical CollegeChengdu 610500China

Immune checkpoint blockade therapy provides a new strategy for tumor treatment;however,the insufficient infiltration of cytotoxic T cells and immunosuppression in tumor microenvironment lead to unsatisfied ***,we reported a lipid/PLGA nanocomplex(RDCM)co-loaded with the photosensitizer Ce6 and the indoleamine 2,3-dioxygenase(IDO)inhibitor 1MT to improve immunotherapy of colon ***–glycine–aspartic acid(RGD)as the targeting moiety was conjugated on 1,2-distearoyl-snglycero-3-phosphoethanolamine lipid via polyethylene glycol(PEG),and programmed cell death-ligand 1(PDL1)peptide inhibitor DPPA(sequence:CPLGVRGK-GGG-d(NYSKPTDRQYHF))was immobilized on the terminal group of PEG via matrix metalloproteinase 2 sensitive peptide *** Ce6 and 1MT were encapsulated in PLGA *** drug loaded nanoparticles were composited with RGD and DPPA modified lipid and lecithin to form lipid/PLGA *** the nanocomplexes were delivered to tumor,DPPA was released by the cleavage of a matrix metalloproteinase 2-sensitive peptide linker for PD-L1 *** facilitated the cellular internalization of nanocomplexes via avβ3 *** immunogenic cell death was induced by 1 O2 generated from Ce6 irradiation under 660 nm laser.1MT inhibited the activity of IDO and reduced the inhibition of cytotoxic T cells caused by kynurenine accumulation in the tumor *** RDCM facilitated the maturation of dendritic cells,inhibited the activity of IDO,and markedly recruited the proportion of tumor-infiltrating cytotoxic T cells in CT26 tumor-bearing mice,triggering a robust immunological memory effect,thus effectively preventing tumor *** results indicated that the RDCM with dual IDO and PD-L1 inhibition effects is a promising platform for targeted photoimmunotherapy of colon cancer.

关键词： lipid/PLGA nanocomplex immune checkpoint blockade photodynamic therapy IDO inhibition colon cancer

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Vanadium(Ⅳ)solvent extraction enhancement in high acidity using di-(2-ethylhexyl)phosphoric acid with[Cl^(-)]present:an experimental and theoretical study

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Frontiers of Chemical science and engineering 2023年第1期17卷 56-67页

作者： Hong Liu Yi-Min Zhang Jing Huang Tao Liu School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Hubei Collaborative Innovation Center for High Efficient Utilization of Vanadium Resources Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Engineering Technology Research Center of High Efficient Cleaning Utilization for Shale Vanadium Resource Wuhan University of Science and TechnologyWuhan 430081China

Separation of vanadium from black shale leaching solution at low pH is very meaningful,which can effectively avoid the generation of alkali neutralization slag and the resulting vanadium *** this study,coordination mechanism of vanadium in acid leaching solution at low pH was investigated with the intervention of chloride *** the conditions of pH 0.8,di-(2-ethylhexyl)phosphoric acid concentration of 20%,phase ratio of 1:2,and extraction time of 8 min,the vanadium extraction could reach 80.00%.The Fourier transform infrared and electrospray ionization results reveal that,despite the fact that the chloride ion in the leachate could significantly promote vanadium extraction,the chloride ion does not enter the organic phase,indicating an intriguing *** Cl^(-)-V,SO_(4)^(2-)-V,and H_(2)O-V,the V-Cl bond is longer and the potential difference between coordinate ions and vanadium is ***,Vo^(2+)gets easily desorbed with chloride ions and enter the organic *** the same time,the hydrogen ions of di-(2-ethylhexyl)phosphoric acid also enter the water phase more easily,which reduces the pH required for the extraction reaction.

关键词： vanadium black shale solvent extraction high acidity extraction

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Multi-stream fusion network for continuous gesture recognition based on sEMG

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International Journal of Wireless and Mobile Computing 2024年第4期26卷 374-383页

作者： Li, Jun Zou, Chunlong Tang, Dalai Sun, Ying Fan, Hanwen Li, Boao Tang, Xinjie Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and Technology Hubei Wuhan China College of Mechanical Engineering Hubei University of Automotive Technology Hubei Shiyan China Inner Mongolia University of Finance and Economics Hohhot China Research Centre for Biomimetic Robot and Intelligent Measurement and Control Wuhan University of Science and Technology Hubei Wuhan China Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education Wuhan University of Science and Technology Hubei Wuhan China

Dynamic gesture recognition is an essential step in human-computer interaction. However, dynamic gesture recognition based on Surface Electromyography (sEMG) signals faces issues such as incomplete feature extraction and incomplete recognition of temporal information between continuous gestures. Therefore, this paper proposes a multi-stream fusion network (MSK-LCNN) for dynamic gesture recognition to improve accuracy. We combine CNN and LSTM models into a unified framework which extracts spatio-temporal information both globally and in depth, and combines feature fusion to retain essential information. This framework uses an attention mechanism (SKNet) to learn more intricate feature information. The gesture recognition accuracy of this method on our data set is 95.23%, and on the NinaPro DB1 data set, it is 91.45%, which outperforms other similar networks in recent years. Applying this algorithm to prosthetic hand control has achieved flexible and stable control of the prosthetic hand. © 2024 Inderscience Enterprises Ltd.

关键词： Gesture recognition

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Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

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Stress Biology 2023年第1期3卷 288-299页

作者： Yumeng Li Shiqi Hou Ziwei Ren Shaojie Fu Sunhaoyu Wang Mingpeng Chen Yan Dang Hongshen Li Shizhong Li Pengsong Li Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-Remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Institute of New Energy Technology Tsinghua UniversityBeijing 100084China

The thermotolerant yeast Kluyveromyces marxianus is known for its potential in high-temperature ethanol fermentation,yet it suffers from excess acetic acid production at elevated temperatures,which hinders ethanol *** better understand how the yeast responds to acetic acid stress during high-temperature ethanol fermentation,this study investigated its transcriptomic changes under this *** sequencing(RNA-seq)was used to identify differentially expressed genes(DEGs)and enriched gene ontology(GO)terms and pathways under acetic acid *** results showed that 611 genes were differentially expressed,and GO and pathway enrichment analysis revealed that acetic acid stress promoted protein catabolism but repressed protein synthesis during high-temperature ***-protein interaction(PPI)networks were also constructed based on the interactions between proteins coded by the *** genes and key modules in the PPI networks were identified,providing insight into the mechanisms of this yeast’s response to acetic acid *** findings suggest that the decrease in ethanol production is caused by the imbalance between protein catabolism and protein ***,this study provides valuable insights into the mechanisms of ***’s response to acetic acid stress and highlights the importance of maintaining a proper balance between protein catabolism and protein synthesis for high-temperature ethanol fermentation.

关键词： Kluyveromyces marxianus Acetic acid Transcriptomics Protein-protein interaction network

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Semi-Autonomous Navigation Based on Local Semantic Map for Mobile Robot

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Journal of Shanghai Jiaotong university(science) 2025年第1期30卷 27-33页

作者： ZHAO Yanfei XIAO Peng WANG Jingchuan GUO Rui Department of Automation Institute of Medical RoboticsShanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of System Control and Information Processing Ministry of Education of ChinaShanghai200240China Shanghai Engineering Research Center of Intelligent Control and Management Shanghai200240China State Grid Intelligence Technology Co. Ltd.Jinan250013China

Mobile robots represented by smart wheelchairs can assist elderly people with mobility *** paper proposes a multi-mode semi-autonomous navigation system based on a local semantic map for mobile robots,which can assist users to implement accurate navigation(e.g.,docking)in the environment without prior *** order to overcome the problem of repeated oscillations during the docking of traditional local path planning algorithms,this paper adopts a mode-switching method and uses feedback control to perform docking when approaching semantic *** last,comparative experiments were carried out in the real *** show that our method is superior in terms of safety,comfort and docking accuracy.

关键词： semi-autonomous navigation mobile robot semantic map voice interaction

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Deep Neural Networks for Gait Cycle Percentage Prediction in Frail Older Adults Using a Foot-Mounted IMU

Deep Neural Networks for Gait Cycle Percentage Prediction in...

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2024 IEEE International Conference on Robotics and Biomimetics, ROBIO 2024

作者： Wang, Jiachen Guan, Zeyang Cai, Jinghao Li, Xiang Wu, Chuanyan Ma, Xin Li, Yibin Song, Rui Zhang, Huanghe Center for Robotics School of Control Science and Engineering Shandong University Jinan Shandong250100 China School of Intelligent Engineering Shandong Management University Jinan Shandong250357 China

ISBN: (纸本)9781665481090

Accurate gait phase prediction is crucial for effective gait training interventions, which are essential for preventing falls in the elderly. This study introduces a novel gait cycle percentage prediction method using end-to-end deep learning networks (DNNs) through a foot-mounted inertial measurement unit (IMU). The model is trained and tested on the GSTRIDE database, comprising data from 158 frail older adults with a total of 176,470 recorded strides. Utilizing 10-fold cross-validation, the model demonstrates a mean absolute error (MAE) of 0.04 and a root mean square error (RMSE) of 0.11. The proposed architecture enables real-time prediction, analyzing each stride in under 0.007 seconds. This demonstrates its potential for integration into wearable devices, allowing continuous monitoring and feedback for gait training. © 2024 IEEE.

关键词： Deep neural networks

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The fiber-bound polyphenols from highland barley with inhibitory effects against carbonyls during in vitro digestion of cookies and French fries

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Food Bioscience 2023年第3期53卷 1742-1747页

作者： Jinxin Li Hao Zhang Xijuan Yang Ling Zhu Gangcheng Wu Hui Zhang National Engineering Research Center for Functional Food Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceSchool of Food Science and TechnologyJiangnan UniversityWuxi214122China Lipid Technology and Engineering School of Food Science and EngineeringHenan University of TechnologyZhengzhou450001China Tibetan Plateau Key Laboratory of Agric-Product Processing Qinghai UniversityXining810000China

The inhibition capacity of bound-polyphenol rich insoluble dietary fiber(BP-IDF)from highland barley to carbonyl compounds was studied during in vitro gastrointestinal(GI)*** than 97%of fiber-bound polyphenols were still presented in highland barley BP-IDF(HBBP-IDF)after GI *** fiber-bound polyphenols in HBBP-IDF effectively inhibit carbonyls when simultaneously digested with cookies and French fries and exhibited more pronounced effect during gastric digestion stage,with inhibition of 63.4%for methylglyoxal,54.3%for glyoxal,47.6%for malondialdehyde and 42.4%for 4-hydroxy-2-nonenel,*** findings suggest that HBBP-IDF could be use as functional ingredients able to inhibit the formation of carbonyls during digestion process and maintain healthful digestive tract environment.

关键词： Bound polyphenols Highland barley Carbonyls Inhibition capacity Gastrointestinal digestion

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Interactive Power Oscillation and Its Suppression Strategy for VSG-DSG Paralleled System in Islanded Microgrid

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Chinese Journal of Electrical engineering 2022年第4期8卷 113-124页

作者： Zhiyong Yuan Xia Shen Yingjie Tan Zhenhua Tan Jinyong Lei Electric Power Research Institute CSGGuangzhou 510663China National Electrical Energy Conversion and Control Engineering Technology Research Center Hunan UniversityChangsha 410082China

A virtual synchronous generator(VSG)can provide inertial support through renewables and energy *** generally operates in parallel with a diesel generator(DSG)in an islanded ***,unforeseen interactive power oscillations occur in the paralleled system when loads *** may also burn out the VSG owing to its low overcurrent *** mechanism and suppression strategy of the power oscillation of a VSG-DSG paralleled system are *** reveals that the interactive power oscillation is caused essentially by the physical difference and parameter mismatch between the VSG and ***,the elimination condition of oscillation generation is ***,a comprehensive suppression control strategy based on virtual inductance and dynamic mutual damping technology is ***,the experimental results verify the effectiveness of the proposed method.

关键词： Islanded microgrid VSG-DSG paralleled system oscillation mechanism virtual inductance dynamic mutual damping suppression strategy

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Preparations of Mytilus edulis protein hydrolysate-iron complexes and their ameliorative effects on mice with iron deficiency anemia

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Food science and Human Wellness 2025年

作者： Guang Li Xuening Yu Shuling Zhou Xiaoyang Liu Fawen Yin Deyang Li Baocai Xu Dayong Zhou School of Food and Biological Engineering， Hefei University of Technology SKL of Marine Food Processing & Safety Control， National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Liaoning Province Key Laboratory for Marine Food Science and Technology， School of Food Science and Technology， Dalian Polytechnic University

Iron is a fundamental trace element essential for the immune system， and current research on iron supplements is increasingly focusing on food-derived peptides capable of binding iron ions. The objectives of this study were to characterize the iron-chelating peptide (MEPH) derived from Mytilus edulis and to investigate the effects of MEPH-Fe complexes on mice with iron deficiency-induced anemia (IDA). MEPH and iron(II) sulfate heptahydrate successfully formed MEPH-Fe complexes under conditions of 4.5 mg/mL concentration， 45 ℃ temperature， and 60 minutes of incubation， utilizing both carboxyl and amino binding sites. Compared to MEPH alone， the MEPH-Fe complexes exhibited fluorescence quenching， ultraviolet shifts， reduced X-ray diffraction peak intensities， stabilization during in vitro digestion， microstructural changes， increased particle size， and decreased absolute values of zeta potential. In the IDA mouse model， the MEPH-Fe complexes were able to restore body weight， hematological indices， organ coefficients， iron content in organs， and antioxidant capacity to normal levels. Additionally， they demonstrated beneficial effects on IDA-induced colonic inflammation by normalizing tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) levels. The results indicated that MEPH-Fe complexes had more positive effects on IDA mice compared to ferrous sulfate. In conclusion， this study provides valuable insights into the potential of MEPH-Fe complexes as iron supplements.

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A microexplosive shockwave-based drug delivery microsystem for treating hard-to-reach areas in the human body

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Microsystems & Nanoengineering 2022年第5期8卷 137-148页

作者： Yi Sun Wenzhong Lou Hengzhen Feng Wenting Su Sining Lv Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of technologyBeijingChina Beijing Institute of Technology Chongqing Innovation Center ChongqingChina

Implantable drug-delivery microsystems have the capacity to locally meet therapeutic requirements by maximizing local drug efficacy and minimizing potential side *** internal organs of the human body including the esophagus,gastrointestinal tract,and respiratory tract,with anfractuos contours,all manifest with endoluminal lesions often located in a curved or zigzag *** ability of localized drug delivery for these organs using existing therapeutic modalities is *** a drug onto these areas and using the adhesion and water absorption properties of the drug powder to attach to lesion areas can provide effective *** study aimed to report the development and application of microsystems based on microshockwave delivery of *** devices comprised a warhead-like shell with a powder placed at the head of the device and a flexible rod that could be inserted at the *** devices had the capacity to deposit drugs on mucous membranes in curved or zigzag areas of organs in the *** explosive impact characteristics of the device during drug delivery were analyzed by numerical *** the experiment of drug delivery in pig intestines,we described the biosafety and drug delivery capacity of the *** anticipate that such microsystems could be applied to a range of endoluminal diseases in curved or zigzag regions of the human body while maximizing the on-target effects of drugs.

关键词： organs drugs curved

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