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DeepRisk:A deep learning approach for genome-wide assessment of common disease risk

Fundamental research 2024年第4期4卷 752-760页

作者： Jiajie Peng Zhijie Bao Jingyi Lia Ruijiang Han Yuxian Wang Lu Han Jinghao Peng Tao Wang Jianye Hao Zhongyu Wei Xuequn Shang AI for Science Interdisciplinary Research Center Schoolof Computer ScienceNorthwestern Polyechnical UniversityXi'an 129China Key Laboratoryof Bg Data Sorage and Management Northwestern Polytechnical UniversityMinisty of Industy and Information TechnologyX'an 129Chin College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Data Science Fudan UniversityShanghai 200433China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518000China

The potential for being able to identify individuals at high disease risk solely based on genotype data has garnered significant *** widely applied,traditional polygenic risk scoring methods fall short,as they are built on additive models that fail to capture the intricate associations among single nucleotide polymorphisms(SNPs).This presents a limitation,as genetic diseases often arise from complex interactions between multiple *** address this challenge,we developed DeepRisk,a biological knowledge-driven deep learning method for modeling these complex,nonlinear associations among SNPs,to provide a more effective method for scoring the risk of common diseases with genome-wide genotype *** demonstrated that DeepRisk outperforms existing PRs-based methods in identifying individuals at high risk for four common diseases:Alzheimer's disease,inflammatory bowel disease,type 2diabetes,and breast cancer.

关键词： Disease risk prediction Deep learning Polygenic risk score Common disease risk Disease prevention

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MetaCity: data-driven sustainable development of complex cities

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The Innovation 2025年第2期6卷 88-103,87页

作者： Yunke Zhang Yuming Lin Guanjie Zheng Yu Liu Nicholas Sukiennik Fengli Xu Yongjun Xu Feng Lu Qi Wang Yuan Lai Li Tian Nan Li Dongping Fang Fei Wang Tao Zhou Yong Li Yu Zheng Zhiqiang Wu Huadong Guo Department of Electronic Engineering Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084China John Hopcroft Center for Computer Science Shanghai Jiao Tong UniversityShanghai 200240China University of Chinese Academy of Sciences Beijing 100049China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China Department of Civil and Environmental Engineering Northeastern UniversityBostonMA 02115USA School of Architecture Tsinghua UniversityBeijing 100084China School of Civil Engineering Tsinghua UniversityBeijing 100084China Big Data Research Center University of Electronic Science and Technology of ChinaChengdu 611731China JD iCity JD Technology&JD Intelligent Cities ResearchBeijing 100176China College of Architecture and Urban Planning Tongji UniversityShanghai 200292China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China These authors contributed equally

Cities are complex systems that develop under complicated interactions among their human and environmental *** generates substantial outcomes and opportunities while raising challenges including congestion,air pollution,inequality,etc.,calling for efficient and reasonable solutions to sustainable ***,booming technologies generate large-scale data of complex cities,providing a chance to propose data-driven solutions for sustainable urban *** paper provides a comprehensive overview of data-driven urban sustainability *** this review article,we conceptualize MetaCity,a general framework for optimizing resource usage and allocation problems in complex cities with data-driven *** this framework,we decompose specific urban sustainable goals,e.g.,efficiency and resilience,review practical urban problems under these goals,and explore the probability of using data-driven technologies as potential solutions to the challenge of *** the basis of extensive urban data,we integrate urban problem discovery,operation of urban systems simulation,and complex decision-making problem solving into an entire cohesive framework to achieve sustainable development goals by optimizing resource allocation problems in complex cities.

关键词： resource usage sustainable development urbanization resilience data driven urban systems simulation complex cities complexity

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Secure RFID-Assisted Authentication Protocol for Vehicular Cloud computing Environment

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IEEE Transactions on intelligent Transportation Systems 2024年第9期25卷 12528-12537页

作者： Saleem, Muhammad Asad Li, Xiong Mahmood, Khalid Tariq, Tayyaba Alenazi, Mohammed J. F. Das, Ashok Kumar University of Electronic Science and Technology of China School of Computer Science and Engineering Chengdu611731 China Institute for Cyber Security School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu611731 China Sichuan University Key Laboratory of Data Protection and Intelligent Management Ministry of Education Chengdu610065 China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of China Shenzhen518000 China National Yunlin University of Science and Technology Graduate School of Intelligent Data Science Yunlin Douliu64002 Taiwan National Yunlin University of Science and Technology Graduate School of Engineering Science and Technology Yunlin Douliu64002 Taiwan King Saud University College of Computer and Information Sciences Department of Computer Engineering Riyadh11451 Saudi Arabia International Institute of Information Technology Center for Security Theory and Algorithmic Research Hyderabad500032 India

Vehicular network technology has made substantial advancements in recent years in the field of intelligent Transportation Systems. Vehicular Cloud computing (VCC) has emerged as a novel paradigm with a substantial increase in data exchange within Vehicular ad-hoc networks (VANETs). VCC integrates cloud computing, vehicular networking, and Internet of Things (IoT) technologies. It enables Infrastructure-to-Vehicle (I2V), Vehicle-to-Vehicle (V2V), and Vehicle-to-Device (V2D) communication. VCC optimizes vehicle, cloud infrastructure, and IoT resources while addressing significant communication security and vehicle-user privacy challenges. To address these issues, we developed an RFID-based authentication protocol for VCC based on a Henon map using a hash function. In addition, we also incorporated a Physical Unclonable Function (PUF) to resist physical tampering attacks. We validate the protocol's security formally and informally. The formal security analysis is conducted through a widely used RoR model. We use the Scyther simulation tool to verify the proposed protocol's security against various attacks. Moreover, we compare the performance of our protocol with similar existing protocols across important performance parameters such as communication and computation overheads and security attributes. The proposed protocol yields substantial improvements, demonstrating a 40.74% reduction in computation overhead and a 13.03% decrease in communication overhead as compared to related protocols, delivering both enhanced performance and resource efficiency. The analysis demonstrates its capacity to support secure communication in the VCC environment and satisfy desirable security attributes. © 2024 IEEE.

关键词： Authentication

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Cooperative structure of Li/Ni mixing and stacking faults for achieving high-capacity Co-free Li-rich oxides

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Journal of Energy Chemistry 2024年第8期95卷 315-324,I0007页

作者： Zhen Wu Yu-Han Zhang Hao Wang Zewen Liu Xudong Zhang Xin Dai Kunyang Zou Xiaoming Lou Xuechen Hu Lijing Ma Yan Liu Yongning Liu State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101ShandongChina Hefei Advanced Computing Center Operation Management Corp Ltd Hefei 230088AnhuiChina Center for High Performance Computing Network Information CenterXi’an Jiaotong UniversityXi’an 710049ShaanxiChina Wuhan Dongfeng Motor Corporation Ltd Wuhan 430056HubeiChina School of Materials Science and Intelligent Engineering Nanjing UniversitySuzhou 215163JiangsuChina Key Laboratory of MEMS of the Ministry of Education Southeast UniversityNanjing 210096JiangsuChina International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina

Co-free Li-rich layered oxides(LLOs)are emerging as promising cathode materials for Li-ion batteries due to their low cost and high ***,they commonly face severe structural instability and poor electrochemical activity,leading to diminished capacity and voltage ***,we introduce a Co-free LLO,Li_(1.167)Ni_(0.222)Mn_(0.611)O_(2)(Cf-L1),which features a cooperative structure of Li/Ni mixing and stacking *** structure regulates the crystal and electronic structures,resulting in a higher discharge capacity of 300.6 mA h g^(-1)and enhanced rate capability compared to the typical Co-free LLO,Li_(1.2)Ni_(0.2)Mn_(0.6)O_(2)(Cf-Ls).Density functional theory(DFT)indicates that Li/Ni mixing in LLOs leads to increased Li-O-Li configurations and higher anionic redox activities,while stacking faults further optimize the electronic interactions of transition metal(TM)3d and non-bonding O 2p ***,stacking faults accommodate lattice strain,improving electrochemical reversibility during charge/discharge cycles,as demonstrated by the in situ XRD of Cf-L1 showing less lattice evolution than *** study offers a structured approach to developing Co-free LLOs with enhanced capacity,voltage,rate capability,and cyclability,significantly impacting the advancement of the next-generation Li-ion batteries.

关键词： Co-free Li-rich oxides Li/Ni mixing Stacking faults Electronic structure

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Meta-Path Based Social Relation Reasoning in a Deep and Robust Way 28th

Meta-Path Based Social Relation Reasoning in a Deep and R...

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28th International Conference on database Systems for Advanced Applications, DASFAA 2023

作者： Jiang, Xuhui Shen, Yinghan Wang, Yuanzhuo Shen, Huawei Xu, Chengjin Ma, Shengjie Data Intelligent System Research Center Institute of Computing Technology Chinese Academy of Sciences Beijing China School of Computer Science and Technology UCAS Gloucester United Kingdom Big Data Academy Zhongke Zhengzhou China International Digital Economy Academy Shenzhen China Gaoling School of Artificial Intelligence Renmin University of China Beijing China

ISBN: (纸本)9783031306747

Social relation reasoning in heterogeneous social networks (HSNs) should not only infer whether people are connected, but also why they know each other and what their relationship is. This task is challenging because the heterogeneous social network is non-trivial to leverage and the collected data is always noisy and incomplete, which leads that the existing rule-based and representation methods cannot efficiently and accurately reason social relations. To reason social relations in noisy and incomplete HSNs, we shift from simply inferring meta-path based social relations by rule-based methods to reasoning by social relation learning. Then, we present an inductive model named Heterogeneous Graph Variational AutoEncoders (HGVAE) towards robust social relation learning on noisy and incomplete HSN data. In HGVAE, the well-designed heterogeneous graph encoder, multi-signal decoder, and variational inference mechanism bring prominent robustness and significant performance improvement. Extensive experiments are conducted to compare our methods against a set of the most representative baseline methods. The efficiency analysis, robust analysis and ablation studies confirm the value of our proposed approach for modelling meta-path based social relations buried in various HSNs. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Learning systems

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Geometry Problem Solving Based on Counter-Factual Evolutionary Reasoning 19

Geometry Problem Solving Based on Counter-Factual Evolutiona...

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19th IEEE International Conference on Automation Science and Engineering, CASE 2023

作者： Song, Bing Xiong, Gang Shen, Zhen Zhu, Fenghua Lv, Yisheng Ye, Peijun Institute of Automation Chinese Academy of Sciences The State Key Laboratory of Management and Control for Complex Systems Beijing China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing100049 China Institute of Automation Chinese Academy of Sciences The Beijing Engineering Research Center of Intelligent Systems and Technology China Chinese Academy of Sciences The Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing The Cloud Computing Center Dongguan523808 China Qingdao Academy of Intelligent Industries Intelligent Manufacturing Center Qingdao266000 China

ISBN: (纸本)9798350320695

As a representative topic in natural language processing and automated theorem proving, geometry problem solving requires an abstract problem understanding and symbolic reasoning. A major challenge here is to find a feasible reasoning sequence that is consistent with given axioms and the theorems already proved. Most recent methods have exploited neural network-based techniques to automatically discover eligible solving steps. Such a kind of methods, however, is greatly impacted by the expert solutions for training. To improve the accuracy, this paper proposes a new method called counterfactual evolutionary reasoning, which uses a generative adversarial network to generate initial reasoning sequences and then introduces counterfactual reasoning to explore potential solutions. By directly exploring theorem candidates rather than the neural network selection, the new method can sufficiently extend the searching space to get a more appropriate reasoning step. Through comparative experiments on the recent proposed Geometry3k, the largest geometry problem solving dataset, our method generally achieves a higher accuracy than most previous methods, bringing an overall improvement about 4.4% compared with the transformer models. © 2023 IEEE.

关键词： Geometry

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Real-time In-situ Defect Detection in 3D Printing of Continuous Fiber-Reinforced Composites 4

Real-time In-situ Defect Detection in 3D Printing of Continu...

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4th IEEE International Conference on Digital Twins and Parallel Intelligence, DTPI 2024

作者： Yue, Zhijian Shen, Zhen Dong, Xiangyang Fang, Qihang Wang, Weixing Dong, Xisong Xiong, Gang Wang, Fei-Yue University of Chinese Academy of Sciences School of Artificial Intelligence Beijing100049 China Chinese Academy of Sciences State Key Laboratory of Multimodal Artificial Intelligence Systems Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Beijing100190 China Qingdao Academy of Intelligent Industries Intelligent Manufacturing Center Qingdao266109 China Chinese Academy of Sciences Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing Cloud Computing Center Dongguan523808 China Chinese Academy of Sciences State Key Laboratory for Management and Control for Complex Systems Institute of Automation Beijing100190 China

ISBN: (纸本)9798350349252

With the development of continuous fiber-reinforced composites (CFRCs) 3D printing technology, timely, efficient and accurate detection of fiber path defects is essential for ensuring product quality and performance. However, challenges still need to be addressed in this field, such as inadequate training data coverage and the complexity of fiber path structures. These factors hinder the capability of traditional methods to accurately assess the status of printed products. Therefore, developing accurate and robust fiber path defect detection techniques is crucial for CFRCs 3D printing technology. In this paper, we propose a precise detection method for fiber path defects in CFRCs 3D printing using the YOLOv7 object detection model combined with a Squeeze-and-Excitation (SE) attention mechanism. By introducing the SE attention mechanism, we enhance the perception capability of the YOLOv7 model for crucial features, thereby improving the accuracy of fiber path defect detection. The experimental results show that the YOLOv7 model, when augmented with an attention mechanism, achieves an average accuracy of 93.9% in identifying fiber path defects during the printing process. Compared to models without this attention mechanism, the results show that there is 10.7% increase, with a notably enhanced learning capacity during the training phase, which substantiates the efficacy and practicality of the proposed approach. © 2024 IEEE.

关键词： Fiber reinforced plastics

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Enhancing Medical Image Report Generation Through Regional and Global Feature Interaction 2nd

Enhancing Medical Image Report Generation Through Regional a...

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2nd International Conference on Applied Intelligence, ICAI 2024

作者： Teng, Pengrui Yang, Hongyu Zhang, Qinhu Ningbo Institute of Digital Twin Eastern Institute of Technology Tongxin Road No. 568 Zhuangshi Street Zhejiang Ningbo315201 China Big Data and Intelligent Computing Research Center Guangxi Academy of Science Nanning530007 China University of Science and Technology of China No. 96 Jinzhai Road Baohe District Anhui Hefei230022 China

ISBN: (纸本)9789819619061

Medical image report generation has gained significant attention as an essential task in automated diagnosis, aiming to reduce the workload of physicians and expedite the diagnostic process. However, existing methods predominantly rely on coarse-grained global features, neglecting the fine-grained regional analysis. This limitation potentially leads to the loss of crucial diagnostic information. To address this challenge, we propose the Regional-Global Interaction Network (RGI), an innovative architecture designed to provide more granular information to the model. The RGI introduces two key components: (1) a region selection agent that precisely locates and selects relevant image patches based on input regional word embeddings, and (2) a bidirectional cross-attention mechanism that fuses the selected regional features with global features. This approach enables the model to capture local details while retaining global context. Extensive experiments on the IU X-Ray dataset demonstrate that our RGI architecture significantly improves the accuracy of medical image analysis and report generation. The proposed method outperforms existing state-of-the-art models across multiple evaluation metrics, including BLEU and ROUGE scores. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Distribution transformers

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Lightweight Authenticated Key Agreement Protocol for Smart Power Grid Systems Using PUF

IEEE Open Journal of the Communications Society

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IEEE Open Journal of the Communications Society 2024年 5卷 3568-3580页

作者： Zahoor, Amina Mahmood, Khalid Saleem, Muhammad Asad Badar, Hafiz Muhammad Sanaullah Le, Tuan-Vinh Das, Ashok Kumar Department of Computer Science Sahiwal57000 Pakistan National Yunlin University of Science and Technology Graduate School of Intelligent Data Science Douliu64002 Taiwan University of Electronic Science and Technology of China School of Computer Science and Engineering Chengdu611731 China Emerson University Multan Department of Emerging Computing Technologies Multan61000 Pakistan Fu Jen Catholic University Bachelor's Program of Artificial Intelligence and Information Security New Taipei City24206 Taiwan International Institute of Information Technology Hyderabad Center for Security Theory and Algorithmic Research Hyderabad500032 India

The Smart Power Grid (SPG) is pivotal in orchestrating and managing demand response in contemporary smart cities, leveraging the prowess of Information and Communication Technologies (ICTs). Within the immersive SPG environment, the ubiquitous deployment of smart meters stands as a testament to their paramount importance in the realm of vigilant monitoring and oversight. These smart meters are installed on high-tension electricity lines and transmit information about electricity outages and other issues to the utility center. To access services from utility centers, smart meters need to communicate securely over a public channel, even though the network itself is insecure. However, potential attacks from adversaries ( Ad) can exploit this communication. Therefore, protecting this communication is of utmost importance. Several privacy-preserving authentication protocols designed for SPG have been introduced in the literature. Nevertheless, a significant number of these protocols exhibit vulnerabilities to diverse security attacks. This article introduces a lightweight and anonymous authentication protocol specifically designed to address these concerns in the SPG environment. Our protocol ensures both security and efficiency, surpassing other comparable protocols in terms of its lightweight nature. By employing both formal and informal analysis, we showcase the robustness of our protocol against significant attacks while remaining lightweight. The proposed protocol provides added security features and incurs 23.8879% lower computation cost than related protocols. Consequently, our protocol is highly suitable for implementation in the SPG system. © 2020 IEEE.

关键词： Hash functions

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A Robust Key Exchange and Tamper-Resistant Protocol for HAN and NAN Networks in Smart Grids

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IEEE Internet of Things Journal 2025年第12期12卷 21394-21403页

作者： Ayub, Muhammad Faizan Li, Xiong Mahmood, Khalid Shamshad, Salman Das, Ashok Kumar Wang, Guijuan University of Electronic Science and Technology of China School of Computer Science and Engineering Sichuan Chengdu611731 China National Yunlin University of Science and Technology Graduate School of Intelligent Data Science Yunlin Douliu64002 Taiwan The University of Lahore Department of Software Engineering Lahore54590 Pakistan International Institute of Information Technology Center for Security Theory and Algorithmic Research Hyderabad500 032 India Korea University College of Informatics Department of Computer Science and Engineering Anam-ro Seoul145 Korea Republic of Qilu University of Technology Shandong Academy of Sciences Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center Jinan250353 China Shandong Fundamental Research Center for Computer Science Shandong Provincial Key Laboratory of Industrial Network and Information System Security Jinan250353 China

Smart Grids (SG) rely on Home Area Networks (HAN) and Neighborhood Area Networks (NAN) to ensure efficient power distribution, real-time monitoring, and seamless communication between smart devices. Despite these advantages, the use of public communication channels in HAN and NAN networks introduces critical challenges, such as vulnerability to impersonation, physical tampering, and scalability issues in resource-constrained environments. These issues compromise the stability, reliability, and security of SG environments. Existing protocols often fail to adequately address these challenges, particularly in ensuring resistance to physical tampering of supply lines and impersonation attacks. Additionally, they struggle to minimize the computation, communication, and energy costs associated with securing a resource-constrained SG environment. Therefore, we propose a robust key exchange and tamper-resistant protocol for HAN and NAN networks to address these limitations. The proposed protocol leverages the Physical Unclonable Function (PUF) mechanism to offer physical tampering resistance to smart meters. We validate our protocol formally using the Random or Real (RoR) model, which confirms its security robustness. Additionally, our informal security analysis highlights the protocol's resilience against impersonation, physical tampering attacks, etc. We analyze and compare the performance of the proposed protocol, which further demonstrates our protocol's effectiveness and security compared to competing protocols. Moreover, the proposed protocol achieves resource efficiency with 45.99% and 58.85% substantial reductions in computation overhead and energy overhead, respectively, compared to competing protocols. These results showcase the protocol's enhanced security and practicality for resource-constrained SG environments. © 2014 IEEE.

关键词： Authentication Protocol

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