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CFD modeling of droplet generation process for medical applications using the electrostatic impulse method

Chemical and Process engineering - Inzynieria Chemiczna i Procesowa 2022年第3期43卷 331-355页

作者： Cendrowski, Piotr Kramek-Romanowsk, Katarzyna Lewinska, Dorota Grzeczkowicz, Marcin Korycka, Paulina Krzysztoforski, Jan Warsaw University of Technology Faculty of Chemical and Process Engineering Ludwika Warynskiego 1 Warsaw Poland Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences Ks. Trojdena 4 Warsaw Poland Foundation of Research and Science Development Rydygiera 8 Warsaw01-793 Poland

The electrostatic impulse method is an established method for producing microbeads or capsules. Such particles have found application in biomedical engineering and biotechnology. The geometric properties of the droplets - constituting precursors of microbeads and capsules - can be precisely controlled by adjusting the geometry of the nozzle system, the physical properties and the flow rate of the fluids involved, as well as the parameters of the electrostatic impulse. In this work, a method of mathematical modeling of the droplet generation process using the electrostatic impulse method in a single nozzle system is presented. The developed mathematical model is an extension of the standard Volume of Fluid (VOF) model by addition of the effect of the electric field on the fluid flow. The model was implemented into the OpenFOAM toolkit for computational fluid dynamics (CFD). The performed CFD simulation results showed good agreement with experimental data. As a result, the influence of all process parameters on the droplet generation process was studied. The most significant change in droplet generation was caused by changing the electrostatic impulse strength. The presented modeling method can be used for optimization of process design and for studying the mechanisms of droplet generation. It can be extended to describe multi nozzle systems used for one-step microcapsule production. © 2022. The Author(s).

关键词： Computational fluid dynamics

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Solar-powered miniature robot for on-site oil spill treatment under magnetic steering

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science China(Technological sciences) 2024年第7期67卷 2164-2175页

作者： WANG Ben CHEN YunRui WANG Yun JI FengTong LI HongYuan NIU ShiChao HAN ZhiWu ZHANG YaBin GUO ZhiGuang College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Ministry of Education Key Laboratory of New Processing Technology for Nonferrous Metals and Materialsand School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning 530004China Key Laboratory for Bionic Engineering Ministry of Education Jilin UniversityChangchun 130022China Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei UniversityWuhan 430062China Wellcome Trust/Cancer Research UK Gurdon Institute University of CambridgeCambridge CB21QNUK Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB21QNUK State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBeijing Innovation Center for Engineering Science and Advanced TechnologyCollege of EngineeringPeking UniversityBeijing 100871China

Walking on the water surface is an effective method for miniature robots to transport payloads with dramatically decreased interfacial drag. Current aquatic robots reported are generally actuated by a beam of focused light that can trigger asymmetrical deformation, enabling the directional movement through horizontal momentum transfer of photoinduced actuation force to the water. However, the operations are heavily dependent on manual manipulation of the focused light, making the long-term actuation and application of the aquatic robots in vast scenarios challenging. Herein, we developed a kind of water striderinspired robot that can autonomously manage the motion on the water surface under solar irradiation, with their direction steerable by a magnetic field. The motion of this bioinspired robot on the water surface was achieved by the use of a solar cell panel as a driving module to enable propulsive motion based on the conversion of light-electric-mechanical energies. The superhydrophobic design of its leg surfaces enables the aquatic robots with weight-bearing and drag-reducing abilities. With the assistance of magnetic navigation, the bioinspired robot can continuously and controllably locomote to the oily spill floating on the water body and collect them with high efficiency. For further demonstration, the treatment of oil spills in a campus pool with high efficiency has also been achieved. This on-site oil-spill treating strategy, taking advantage of a home-made bioinspired robot actuated by natural sunlight under magnetic steering, shows great potential applications in water-body remediation.

关键词： miniature robot superhydrophobic water strider interfacial friction magnetic actuation

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Application of functional near-infrared spectroscopy(fNIRS) for studying the influence of capsaicin stimulation on brain perception

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Food science and Human Wellness 2025年

作者： Ran Tao Hang Liang Huiting Qiao Xin Liu Na Xu Ling Wang Xinglian Xu Lingqi Li Yujia Yang Peng Wang State Key Laboratory of Meat Quality Control and Cultured Meat Development， Ministry of Education China， Jiangsu Collaborative Innovation Center of Meat Production and Processing， Quality and Safety Control， College of Food Science and Technology， Nanjing Agricultural University Danyang SuHuichuang Brain Scientific Research Center School of Biological Science and Medical Engineering， Beihang University College of Computer Science， Sichuan Normal University

Spicy taste have been utilized in the food industry as appetizers， stomachics， and beverages and in the health sector to alleviate high cholesterol and hypertension. However， an understanding of neural mechanisms and cognitive processes associated with spicy diets remains limited due to the lack of instruments that directly monitoring the brain’s reaction to spicy sensations. This study aimed to examine the neural responses of participants to oral capsaicin solutions through functional near-infrared spectroscopy and reveal distinct neural activation patterns associated with spiciness induction and relief phases. Results showed that the perception of spiciness is a dynamic process， and significant differences in sensory intensity and emotion were observed between the phases. The prefrontal regions of the brain were activated during spicy flavor perception and presented clear lateralization effects. Further spatial localization results indicated that the orbitofrontal， dorsolateral prefrontal， and ventral lateral prefrontal cortices were the main causes of difference in activation among the phases. In addition， correlational analyses indicated that spicy flavor perception activated cortical areas related to emotion and reward processing. Overall， this research enhances our understanding of the neural mechanisms underlying addiction to spicy food and may be useful in the development of food on the basis of consumers’ preferences and behavioral responses.

关键词： Taste Capsaicin fNIRS Prefrontal cortex Oral irritation

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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food science and Human Wellness 2025年第1期14卷 307-331页

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao RPaul Ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 K8AFIreland Teagasc Food Research Centre Cork P61 C996Ireland Nutrition and Metabolism Research Division Innovation CenterHeilongjiang Feihe Dairy Co.Ltd.Beijing 100015China PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development Beijing 100083China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c *** BALB/c mice were assigned to the control group(administration saline)and the CCFM1078 group(administration *** CCFM1078,3×10^(9) CFU/day)in 3-,4-,and 5-week *** the groups have male and female *** findings demonstrate that *** CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites(hexadecanamide,linoleoyl ethanolamide,and palmitoyl ethanolamide),the genes and proteins expression related to the growth hormone(GH)/insulin-like growth factors-1(IGF-1)axis and Gs/PKA/CREB signaling pathways,as well as downstream osteogenic and osteoclastic differentiation *** effects of *** CCFM1078 were different with age and gender *** finding suggests *** CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

关键词： Bifidobacterium breve Bone development Gut microbiota GH/IGF-1 axis Gs/PKA/CREB signaling pathway

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Investigation on Structures of Axial Gap Type Magnetic Multiple Spur Gear for In-Wheel Motor System of Electric Vehicle

Investigation on Structures of Axial Gap Type Magnetic Multi...

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2023 IEEE Transportation Electrification Conference and Expo, Asia-Pacific, ITEC Asia-Pacific 2023

作者： Kamijo, Taiga Aiso, Kohei Akatsu, Kan Aoyama, Yasuaki Shibaura Institute of Technology Electrical Engineering and Computer Science Tokyo Japan Shibaura Institute of Technology Department of Electrical Engineering Tokyo Japan Yokohama National University Division of Intelligent Systems Engineering Department of Faculty of Engineering Yokohama Japan Center for Technology Innovation - Materials Hitachi Ltd. Research & Development Group Ibaraki Japan

ISBN: (纸本)9798350314274

A novel drive system using Magnetic Multiple Spur Gear (MMSG) and multiple high-speed motors is characterized by small size, lightweight, and high efficiency even at high-speed region, it is expected to apply to in-wheel motor systems. However, there is a risk of contact between the rotors when applied to in-wheel motor system. In this study, a novel axial-gap MMSG is proposed to solve this problem, stabilize the air gap between the high-speed and low-speed rotors, and effectively utilize the magnets, and its performance is evaluated by finite element analysis. © 2023 IEEE.

关键词： Electric vehicles

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A reliability analysis framework coupled with statistical uncertainty characterization for geotechnical engineering

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Geoscience Frontiers 2024年第6期15卷 336-347页

作者： Liang Han Wengang Zhang Lin Wang Jia Fu Liang Xu Yu Wang School of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011China School of Civil Engineering Chongqing UniversityChongqing 400045China Department of Architecture and Civil Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina School of National Safety and Emergency Management Beijing Normal UniversityZhuhai 519087China National Engineering Research Center of Gas Hydrate Exploration and Development Guangzhou Marine Geological SurveyGuangzhou 511458China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China Center of International Cooperation and Innovation for the Digital Economics Chongqing University of Posts and TelecommunicationsChongqing 400065China

Reliability analysis plays an important role in the risk management of geotechnical *** the random field-based method,it is expected that the uncertainty characterization of geo-material parameters and the realization of random field can be integrated ***,as the increase in measured data size is generally difficult in the field investigation of geotechnical engineering due to limitation of budget and time etc.,the statistical uncertainty resulting from sparse data should be paid great ***,taking the determination of hyper-parameters for Bayesian-based conditional random field as the breakthrough,this study proposed a reliability analysis framework to achieve the expectation *** this proposed reliability analysis framework,the present characterization method of statistical uncertainty is improved by setting the lognormal distribution as the prior distribution of scale of fluctuation(SOF).Subsequently,the performance of statistical uncertainty characterization method is tested by a set of unconfined compressive strength(UCS)database about ***,a case study about the stability analysis of slope is employed to demonstrate the beneficial effect of the proposed reliability analysis *** is found that the uncertainty in both the realization of random field and the reliability analysis results can be significantly mitigated by the proposed reliability analysis framework.

关键词： Reliability analysis Statistical uncertainty Bayesian inference Conditional random field Geotechnical engineering

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The sudden ocean warming and its potential influences on earlyfrozen landfast ice in the Prydz Bay, East Antarctica

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Acta Oceanologica Sinica 2024年第5期43卷 65-77页

作者： Haihan Hu Jiechen Zhao Jingkai Ma Igor Bashmachnikov Natalia Gnatiuk Bo Xu Fengming Hui School of Geospatial Engineering and Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Qingdao Innovation and Development Base(Centre)of Harbin Engineering University Qingdao 266500China Key Laboratory for Polar Acoustics and Application of Ministry of Education(Harbin Engineering University) Harbin 150001China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CentreBeijing 100081China Nansen International Environmental and Remote Sensing Centre St.Petersburg 199034Russia Saint Petersburg State University St.Petersburg 199034Russia Antarctic Great Wall Ecology National Observation and Research Station Polar Research Institute of ChinaShanghai 201209China

The ocean conditions beneath the ice cover play a key role in understanding the sea ice mass balance in the polar *** integrated high-frequency ice-ocean observation system,including Acoustic Doppler Velocimeter,Conductivity-Temperature-Depth Sensor,and Sea Ice Mass Balance Array(SIMBA),was deployed in the landfast ice region close to the Chinese Zhongshan Station in Antarctica.A sudden ocean warming of 0.14℃(p<0.01)was observed beneath early-frozen landfast ice,from(−1.60±0.03)℃during April 16-19 to(−1.46±0.07)℃during April 20-23,2021,which is the only significant warming event in the nearly 8-month *** sudden ocean warming brought a double rise in oceanic heat flux,from(21.7±11.1)W/m^(2) during April 16-19 to(44.8±21.3)W/m^(2) during April 20-23,2021,which shifted the original growth phase at the ice bottom,leading to a 2 cm melting,as shown from SIMBA and borehole ***,the slowdown of ice bottom freezing decreased salt rejection,and the daily trend of observed ocean salinity changed from+0.02 d^(-1) during April 16-19,2021 to+0.003 d^(-1) during April 20-23,*** potential reasons are increased air temperature due to the transit cyclones and the weakened vertical ocean mixing due to the tide phase transformation from semi-diurnal to *** high-frequency observations within the ice-ocean boundary layer enhance the comprehensive investigation of the ocean’s influence on ice evolution at a daily scale.

关键词： sudden ocean warming oceanic heat flux landfast ice Zhongshan Station in-situ observation

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Green pathway to 14.51% efficiency in all-small-molecule organic solar cells: apigenin-mediated morphology control with halogen-free processing

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Journal of Energy Chemistry 2025年 108卷 819-826页

作者： Sun, Lingya Zou, Wentao Zhang, Xu Liu, Shizhao Zu, Meiyuan Wang, Xunchang Yang, Renqiang Zou, Xianshao Geng, Longlong Xie, Hua Xu, Huajun Kan, Yuanyuan Sun, Yanna Gao, Ke Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Science Center for Material Creation and Energy Conversion Institute of Frontier Chemistry School of Chemistry and Chemical Engineering Shandong University Shandong Qingdao266237 China Qingdao Innovation and Development Center Harbin Engineering University Shandong Qingdao266000 China School of Optoelectronic Materials & Technology Jianghan University Hubei Wuhan430056 China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical Engineering Dezhou University Shandong Dezhou253023 China Suzhou Research Institute Shandong University Jiangsu Suzhou215123 China

All-small-molecule organic solar cells (ASM OSCs) have emerged as promising photovoltaic technologies due to their excellent batch-to-batch reproducibility and potential for scalable manufacturing. However, the development of eco-friendly processing protocols using halogen-free solvents combined with sustainable solid additives remains unexplored, despite being crucial for realizing green and efficient ASM OSC production. Herein, we demonstrate the first successful integration of plant-extracted apigenin (AP) as a green solid additive with tetrahydrofuran (THF), a non-halogenated processing solvent, in ASM OSC fabrication. Systematic investigations reveal that AP establishes hydrogen-bonding interactions with the acceptor molecules, thereby promoting tighter molecular packing and enhancing crystallinity. Simultaneously, the additive modulates donor–acceptor miscibility to optimize phase-separated domain sizes. These synergistic effects generate a well-interconnected nanomorphology with balanced charge transport pathways, effectively facilitating exciton dissociation while suppressing charge recombination. The resultant devices obtain a remarkable power conversion efficiency (PCE) of 14.51%, representing one of the highest performances among halogen-free processed binary ASM OSCs reported to date. This pioneering work establishes a viable pathway toward sustainable OSC manufacturing by demonstrating that eco-friendly additives can synergistically cooperate with non-halogenated solvents to simultaneously enhance device performance and process sustainability. © 2025 science Press and Dalian Institute of Chemical Physics, Chinese Academy of sciences.

关键词： Hydrogen bonds

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Pathogenic analysis of coxsackievirus A10 in rhesus macaques

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Virologica Sinica 2022年第4期37卷 610-618页

作者： Suqin Duan Fengmei Yang Yanyan Li Yuan Zhao Li Shi Meng Qin Quan Liu Weihua Jin Junbin Wang Lixiong Chen Wei Zhang Yongjie Li Ying Zhang Jingjing Zhang Shaohui Ma Zhanlong He Qihan Li Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research Development on Severe Infectious DiseaseKunming650118China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China

Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and *** people,particularly young children,may have different immunological responses to *** CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this *** characteristics of CV-A10 infection,replication,and shedding in humans remain *** this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in *** clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in *** inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and *** the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery *** addition,there were no significant differences between respiratory and digestive tract infected ***,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies.

关键词： Coxsackievirus A10(CV-A10) Hand Foot and mouth disease(HFMD) Non-human primate model Rhesus macaque Pathogenic analysis

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GIS data support technique for forest fire management and decision support system: A Sebangau National Park, Kalimantan case 6

GIS data support technique for forest fire management and de...

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6th International Conference on Information and Communications Technology, ICOIACT 2023

作者： Yuana, Kumara Ari Kusrini, Kusrini Setyanto, Arief Laksito, Arif Dwi Maruf, Zauvik Rizaldi Johari, Muhammad Zuhdi Fikri Adninda, Gardyas Bidari Kartikakirana, Renindya Azizza Nucifera, Fitria Widayani, Wiwi Orphanoudakis, Theofanis Universitas Amikom Yogyakarta Faculty of Computer Science Yogyakarta Indonesia Universitas Amikom Yogyakarta Magister of Informatic Engineering Yogyakarta Indonesia Universitas Amikom Yogyakarta Faculty of Science and Technology Yogyakarta Indonesia Netcompany-Intrasoft A. Research & Innovation Development Unit L1253 Luxembourg

ISBN: (纸本)9798350315639

Numerous science and engineering fields are involved when handling forest fire disasters. Social sciences contribute to analyze the human behavior behind the forest fire phenomena, while science and engineering principles can be applied to investigate the physical and environment variables involved. The use of a Geographic Information System (GIS) as a computer system that manages the comprehensive variables influence on the forest fire is proposed is proposed. Capturing, processing and displaying the data generating valuable information related to specific locations is possible through satellite and computer utilities, which turn into powerful assistants for forest fire management with the aid of a decision support system. Data fusion from different sources with different formats and the relevant processing requirements with a large variety of complexities are the challenges that are addressed in the present work. Our proposed method results in a specific informative map with specific characteristics of variables of the forest. These maps are very useful for mitigating forest fire disaster as well as for making informed decisions about optimal resources allocation. © 2023 IEEE.

关键词： Data acquisition

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