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RVPD: An Automated System for Calculating the Tortuosity and Bifurcation Angles of Retinal Vessels to Predict Diseases

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RVPD: An Automated System for Calculating the Tortuosity and...

IEEE International Symposium on Biomedical Imaging

作者： Guangzhengao Yang Xingyu Luo Jie Zhao Fangfang Fan Haoshen Li Bin Dong Li Zhang Yan Zhang Center for Data Science Peking University China Department of Cardiology Peking University First Hospital China National Engineering Laboratory for Big Data Analysis and Applications Peking University China Peking University Changsha Institute for Computing and Digital Economy China Beijing International Center for Mathematical Research Peking University China Center for Machine Learning Research Peking University China National Biomedical Imaging Center Peking University China

ISBN: (数字)9798331520526

ISBN: (纸本)9798331520533

Hypertension and diabetes are known to potentially cause morphological changes in the retinal capillary system, yet quantifying these changes presents significant challenges. This research addresses this issue by designing and developing an automated system capable of analyzing retinal images to detect and measure these changes. Our system automatically segments vessels and the optic disc, calculates tortuosity and bifurcation angles, and performs disease prediction based on these measurements along with clinical features. For tortuosity calculation, we adopted a novel curve fitting method, which provides more stable convergence compared to traditional discrete numerical methods. The system integrates clinical data and conducts prediction experiments on hypertensive and diabetic patients with varying sample sizes. Our results demonstrate the system's strong performance and scalability: in the hypertension group, the AUC reached a maximum of 0.814 ± 0.023, with an ACC of 0.735 ± 0.033, while in the diabetes group, the AUC reached a maximum of 0.710 ± 0.043, with an ACC of 0.641 ± 0.052. These findings suggest that our automated system could serve as a valuable tool for early detection and risk assessment of hypertension and diabetes, potentially improving patient outcomes through timely intervention.

关键词： Hypertension Image segmentation Scalability Bifurcation Optical variables measurement Optical imaging Retinal vessels Diabetes Risk management Diseases

On Error Bounds of Inequalities in Asplund Spaces

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arXiv 2023年

Error bounds are central objects in optimization theory and its applications. They were for a long time restricted only to the theory before becoming over the course of time a field of itself. This paper is devoted to the study of error bounds of a general inequality defined by a proper lower semicontinuous function on an Asplund space. Even though the results of the dual characterization on the error bounds of a general inequality (if one drops the convexity assumption) may not be valid, several necessary dual conditions are still obtained in terms of Fréchet/Mordukhovich subdifferentials of the concerned function at points in the solution set. Moreover, for an inequality defined by a composite-convex function that is to say by a function which is the composition of a convex function with a smooth mapping, such dual conditions also turn out to be sufficient to have the error bound property. Our work is an extension of results on dual characterizations of convex inequalities to the possibly non-convex case. © 2023, CC0.

关键词： Site selection

Time Series Domain Adaptation via Latent Invariant Causal Mechanism

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arXiv 2025年

作者： Cai, Ruichu Huang, Junxian Yang, Zhenhui Li, Zijian Eldele, Emadeldeen Wu, Min Sun, Fuchun School of Computer Science Guangdong University of Technology Guangzhou510006 China Peng Cheng Laboratory Shenzhen518066 China School of Computing Guangdong University of Technology Guangzhou510006 China Machine Learning Department Mohamed bin Zayed University of Artificial Intelligence Abu Dhabi United Arab Emirates Institute for Infocomm Research A*STAR Singapore Centre for Frontier AI Research A*STAR Singapore Department of Computer Science and Technology Tsinghua University Beijing China

Time series domain adaptation aims to transfer the complex temporal dependence from the labeled source domain to the unlabeled target domain. Recent advances leverage the stable causal mechanism over observed variables to model the domain-invariant temporal dependence. However, modeling precise causal structures in high-dimensional data, such as videos, remains challenging. Additionally, direct causal edges may not exist among observed variables (e.g., pixels). These limitations hinder the applicability of existing approaches to real-world scenarios. To address these challenges, we find that the high-dimension time series data are generated from the low-dimension latent variables, which motivates us to model the causal mechanisms of the temporal latent process. Based on this intuition, we propose a latent causal mechanism identification framework that guarantees the uniqueness of the reconstructed latent causal structures. Specifically, we first identify latent variables by utilizing sufficient changes in historical information. Moreover, by enforcing the sparsity of the relationships of latent variables, we can achieve identifiable latent causal structures. Built on the theoretical results, we develop the Latent Causality Alignment (LCA) model that leverages variational inference, which incorporates an intradomain latent sparsity constraint for latent structure reconstruction and an inter-domain latent sparsity constraint for domain-invariant structure reconstruction. Experiment results on eight benchmarks show a general improvement in the domain-adaptive time series classification and forecasting tasks, highlighting the effectiveness of our method in real-world scenarios. Codes are available at https: //***/DMIRLAB-Group/LCA. Copyright © 2025, The Authors. All rights reserved.

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Predicting Response to Patients with Gastric Cancer Via a Dynamic-Aware Model with Longitudinal Liquid Biopsy Data

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SSRN

SSRN 2024年

作者： Chen, Zifan Zhao, Jie Li, Yanyan Li, Yilin Liu, Huimin Feng, Xujiao Nan, Xinyu Dong, Bin Shen, Lin Chen, Yang Zhang, Li Center for Data Science Peking University Beijing China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Peking University Cancer Hospital and Institute Beijing China National Engineering Laboratory for Big Data Analysis and Applications Peking University Beijing China Guangzhou Medical University Guangzhou China Peking University Beijing China Center for Machine Learning Research Peking University Beijing China Peking University Changsha Institute for Computing and Digital Economy Changsha China

Gastric cancer (GC) presents challenges in predicting treatment responses due to its patient-specific heterogeneity. Recently, liquid biopsies have become recognized as a valuable data modality, offering essential cellular and molecular insights and enabling the capture of time-sensitive information. This study aimed to harness artificial intelligence (AI) technology to analyze longitudinal liquid biopsy data. We collected a dataset from longitudinal liquid biopsies of 91 patients at Peking Cancer Hospital, spanning from July 2019 to April 2022, which included 1,895 tumor-related cellular images and 1,698 tumor marker indices. Subsequently, we introduced the Dynamic-Aware Model (DAM) to predict GC treatment responses. DAM incorporates the dynamic data through AI-engineered components, enabling an in-depth longitudinal analysis. Utilizing three-fold cross-validation, DAM exhibited superior performance over traditional cell-counting-based methods, achieving an AUC of 0.807 in predicting GC treatment responses. In the test set, DAM maintained stable efficacy with an AUC of 0.802. Besides, DAM showed the capability to accurately predict treatment responses from early treatment data. Moreover, DAM's visual analysis of attention mechanisms identified six dynamic focus-area-related visual features and their strong association with treatment response. These findings represent a pioneering effort in applying AI technology for interpreting longitudinal liquid biopsy data and employ visual analytics in GC, offering a promising avenue toward precise response prediction and tailored treatment strategies for patients with ***: This work was supported by the National Natural Science Foundation of China (81801778 to Li Zhang., 82203881 to Yang Chen, U22A20327 to Lin Shen, 12090022 to Bin Dong), Beijing Natural Science Foundation (7222021 to Yang Chen), Beijing Hospitals Authority Youth Programme (QML20231115 to Yang Chen), Clinical Medicine Plus X-Young Scholars Project of P

关键词： Diseases

Improving Generative Model-based Unfolding with Schrödinger Bridges

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arXiv 2023年

作者： Diefenbacher, Sascha Liu, Guan-Horng Mikuni, Vinicius Nachman, Benjamin Nie, Weili Physics Division Lawrence Berkeley National Laboratory BerkeleyCA94720 United States Autonomous Control and Decision Systems Laboratory Georgia Institute of Technology AtlantaGA30332 United States National Energy Research Scientific Computing Center Berkeley Lab BerkeleyCA94720 United States Berkeley Institute for Data Science University of California BerkeleyCA94720 United States Machine Learning Research Group NVIDIA Research United States

machine learning-based unfolding has enabled unbinned and high-dimensional differential cross section measurements. Two main approaches have emerged in this research area: one based on discriminative models and one based on generative models. The main advantage of discriminative models is that they learn a small correction to a starting simulation while generative models scale better to regions of phase space with little data. We propose to use Schrödinger Bridges and diffusion models to create SBUnfold, an unfolding approach that combines the strengths of both discriminative and generative models. The key feature of SBUnfold is that its generative model maps one set of events into another without having to go through a known probability density as is the case for normalizing flows and standard diffusion models. We show that SBUnfold achieves excellent performance compared to state of the art methods on a synthetic Z+jets dataset. © 2023, CC BY.

关键词： Phase space methods

Primal Characterizations of Stability of Error Bounds for Semi-infinite Convex Constraint Systems in Banach Spaces

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arXiv 2023年

作者： Wei, Zhou Théra, Michel Yao, Jen-Chih Hebei Key Laboratory of Machine Learning and Computational Intelligence College of Mathematics and Information Science Hebei University Baoding071002 China XLIM UMR CNRS 7252 Université de Limoges Limoges France Federation University Australia Ballarat Australia Research Center for Interneural Computing China Medical University Hospital China Medical University Taichung Taiwan

This article is devoted to the stability of error bounds (local and global) for semi-infinite convex constraint systems in Banach spaces. We provide primal characterizations of the stability of local and global error bounds when systems are subject to small perturbations. These characterizations are given in terms of the directional derivatives of the functions that enter into the definition of these systems. It is proved that the stability of error bounds is essentially equivalent to verifying that the optimal values of several minimax problems, defined in terms of the directional derivatives of the functions defining these systems, are outside of some neighborhood of zero. Moreover, such stability only requires that all component functions entering the system have the same linear perturbation. When these stability results are applied to the sensitivity analysis of Hoffman’s constants for semi-infinite linear systems, primal criteria for Hoffman’s constants to be uniformly bounded under perturbations of the problem data are *** Codes 90C31, 90C25, 49J52, 46B20 © 2023, CC0.

关键词： Sensitivity analysis

Subtransversality and Strong CHIP of Closed Sets in Asplund Spaces

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arXiv 2023年

In this paper, we mainly study subtransversality and two types of strong CHIP (given via Fréchet and limiting normal cones) for a collection of finitely many closed sets. We first prove characterizations of Asplund spaces in terms of subtransversality and intersection formulae of Fréchet normal cones. Several necessary conditions for subtransversality of closed sets are obtained via Fréchet/limiting normal cones in Asplund spaces. Then, we consider subtransversality for some special closed sets in convex-composite optimization. In this frame we prove an equivalence result on subtransversality, strong Fréchet CHIP and property (G) so as to extend a duality characterization of subtransversality of finitely many closed convex sets via strong CHIP and property (G) to the possibly non-convex case. As applications, we use these results on subtransversality and strong CHIP to study error bounds of inequality systems and give several dual criteria for error bounds via Fréchet normal cones and subdifferentials. © 2023, CC0.

关键词： Convex optimization

GSLB: The Graph Structure learning Benchmark 37

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GSLB: The Graph Structure Learning Benchmark

37th Conference on Neural Information Processing Systems, NeurIPS 2023

作者： Li, Zhixun Wang, Liang Sun, Xin Luo, Yifan Zhu, Yanqiao Chen, Dingshuo Luo, Yingtao Zhou, Xiangxin Liu, Qiang Wu, Shu Yu, Jeffrey Xu Department of Systems Engineering and Engineering Management The Chinese University of Hong Kong Hong Kong Center for Research on Intelligent Perception and Computing State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences China School of Artificial Intelligence University of Chinese Academy of Sciences China Department of Automation University of Science and Technology of China China School of Cyberspace Security Beijing University of Posts and Telecommunications China Department of Computer Science University of California Los Angeles United States Heinz College of Information Systems and Public Policy Machine Learning Department School of Computer Science Carnegie Mellon University United States

ISBN: (纸本)9781713899921

Graph Structure learning (GSL) has recently garnered considerable attention due to its ability to optimize both the parameters of Graph Neural Networks (GNNs) and the computation graph structure simultaneously. Despite the proliferation of GSL methods developed in recent years, there is no standard experimental setting or fair comparison for performance evaluation, which creates a great obstacle to understanding the progress in this field. To fill this gap, we systematically analyze the performance of GSL in different scenarios and develop a comprehensive Graph Structure learning Benchmark (GSLB) curated from 20 diverse graph datasets and 16 distinct GSL algorithms. Specifically, GSLB systematically investigates the characteristics of GSL in terms of three dimensions: effectiveness, robustness, and complexity. We comprehensively evaluate state-of-the-art GSL algorithms in node- and graph-level tasks, and analyze their performance in robust learning and model complexity. Further, to facilitate reproducible research, we have developed an easy-to-use library for training, evaluating, and visualizing different GSL methods. Empirical results of our extensive experiments demonstrate the ability of GSL and reveal its potential benefits on various downstream tasks, offering insights and opportunities for future research. The code of GSLB is available at: https://***/GSL-Benchmark/GSLB. © 2023 Neural information processing systems foundation. All rights reserved.

关键词： Graphic methods

Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant

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Medicine Plus

Medicine Plus 2024年第2期1卷 102-124页

作者： Mingze Yuan Peng Bao Jiajia Yuan Yunhao Shen Zifan Chen Yi Xie Jie Zhao Quanzheng Li Yang Chen Li Zhang Lin Shen Bin Dong Center for Data Science Peking UniversityBeijing 100871China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and Institute Beijing 100142China National Engineering Laboratory for Big Data Analysis and Applications Peking UniversityBeijing 100871China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871China Center for Machine Learning Research Peking University Beijing 100871China National Biomedical Imaging Center Peking UniversityBeijing 100871China Peking University Changsha Institute for Computing and Digital Economy Changsha 410205China Massachusetts General Hospital Boston MA 02114-2696USA Harvard Medical School BostonMA 02115USA

With the rapid development of artificial intelligence,large language models(LLMs)have shown promising capabilities in mimicking human-level language comprehen-sion and *** has sparked significant interest in applying LLMs to enhance various aspects of healthcare,ranging from medical education to clinical decision ***,medicine involves multifaceted data modalities and nuanced reasoning skills,presenting challenges for integrating *** review introduces the fundamental applications of general-purpose and specialized LLMs,demon-strating their utilities in knowledge retrieval,research support,clinical workflow automation,and diagnostic *** the inherent multimodality of medicine,the review emphasizes the multimodal LLMs and discusses their ability to process diverse data types like medical imaging and electronic health records to augment diagnostic *** address LLMs'limitations regarding personalization and complex clinical reasoning,the review further explores the emerging develop-ment of LLM-powered autonomous agents for ***,it summarizes the evaluation methodologies for assessing LLMs'reliability and safety in medical *** have transformative potential in medicine;however,there is a pivotal need for continuous optimizations and ethical oversight before these models can be effectively integrated into clinical practice.

关键词： Large language models Artificial intelligence Medicine Healthcare assistant Prompt engineering In-context learning