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α-GalCer-LNP ehanced mRNA delivery and activates natural killer T cells for superior tumor immunotherapy

Materials Today Bio 2025年 32卷 101893页

作者： Zhang, Kexin Xu, Zhen Xiao, Zexiu Cao, Fei Wang, Jing Xu, Yuandong Ma, Winson M.J. Long, Sihui Zha, Gao-Feng Key Laboratory for Green Chemical Process of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Hubei Wuhan430205 China Scientific Research Centre Guangdong Provincial Key Laboratory of Digestive Cancer Research The Seventh Affiliated Hospital Sun Yat-sen University Guangdong Shenzhen518107 China Research and Development Centre Shenzhen MagicRNA Biotech Guangdong Shenzhen518107 China Department of Urology Kidney and Urology Centre Pelvic Floor Disorders Centre The Seventh Affiliated Hospital Sun Yat-sen University Guangdong Shenzhen518107 China Shenzhen Institute of Advanced Technology Guangdong Shenzhen518107 China

Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for cancer immunotherapy;however, challenges remain in optimizing RNA delivery and promoting synergistic immune activation. To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (α-GalCer), a CD1d-binding glycolipid known to activate invariant natural killer T (iNKT) cells. Through structural optimization, we created the α-GalCer-LNP (G-LNP), which offers three primary advantages over conventional four-component LNPs: (1) enhanced mRNA transfection efficiency due to improved endosomal/lysosomal escape, (2) increased capacity for in vivo DC transfection, leading to robust activation of tumor-specific CD8+ T cells via MHC-I and iNKT cells via the CD1d pathway, and (3) reprogramming of the tumor microenvironment, resulting in a 1.5-fold increase in iNKT cell infiltration and sustained elevation of IFN-γ (>24 h) in lymph nodes. In a TC-1 cervical carcinoma model, G-LNP induced complete tumor regression in 100 % of treated mice (compared to 42.85 % for standard LNP) and provided long-term protection against tumor rechallenge (lasting >100 days). Mechanistic studies showed that G-LNP preferentially targets CD11c+ DC in the lymph nodes, facilitating coordinated antigen presentation and innate immune activation. This five-component engineering strategy establishes a versatile platform to enhance the functionality of LNPs for the development of next-generation cancer vaccines. © 2025

关键词： T-cells

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development of Renewable Diesel Production Under Free External H2 Using Hydrogen Donor Solvents: The Effect of Hydrogen Donor Solvents and Ni-Based Catalysts

SSRN

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SSRN 2023年

作者： Hongloi, Nitchakul Prapainainar, Chaiwat Seubsai, Anusorn Sudsakorn, Kandis Kiatkittipong, Worapon Limphirat, Wanwisa Prapainainar, Paweena National Center of Excellence for Petroleum Petrochemicals and Advance Material Department of Chemical Engineering Faculty of Engineering Kasetsart University Bangkok10900 Thailand Department of Chemical Engineering Faculty of Engineering King Mongkut’s University of Technology North Bangkok Bangkok10800 Thailand Research and Development Center for Chemical Unit Operation and Catalyst Design Science and Technology Research Institute King Mongkut’s University of Technology North Bangkok Bangkok10800 Thailand Research Network of NANOTEC KU on NanoCatalysts and NanoMaterials for Sustainable Energy and Environment Bangkok10900 Thailand Department of Chemical Engineering Faculty of Engineering and Industrial Technology Silpakorn University Nakhon Pathom73000 Thailand Nakhon Ratchasima30000 Thailand

Green diesel is composed of C14-C16 alkane similar to petroleum diesel. Typically, the reaction for green diesel production necessitates a large amount and high pressure of external H2, which influences the cost of production. Using in situ H2 is an interesting way to develop the production of green diesel. The purpose of this work was to investigate the effect of hydrogen donor solvents (formic acid, acetic acid, methanol, ethanol, lactic acid, and glycerol) on green diesel production over 10%Ni, 15%Ni, NiCu, NiCo, and NiMo on ZrO2 catalysts. The results from characterization techniques confirmed that the ZrO2 support and all catalysts had been successfully synthesized. The reaction was carried out at 270 °C for 6 h using palmitic acid as a reactant. The palmitic acid conversion was up to 90%. The liquid product composition varied depending on the type of H-donor solvent used. Except for alcohol type, the main product components from all H-donor solvents were C15-C16 alkanes (green diesel). The selectivity of alkyl ester (biodiesel) produced from fatty acids using methanol and ethanol exceeded 83%. The presence of C16 alkane from the hydrodeoxygenation pathway and H2 in gas products confirmed that all the solvents could act as hydrogen donors. © 2023, The Authors. All rights reserved.

关键词： Paraffins

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Synthesis and thermal stabilizing effect on polyvinyl chloride of calcium/zinc carboxylate from palm fatty acid distillate: Effect of metal to fatty acid ratio

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AIP Conference Proceedings 2024年第1期3073卷

作者： I. Dewa Gede Arsa Putrawan Nadya Amalia Pratiwi Nento Adli Azharuddin Antonius Indarto Dendy Adityawarman Chemical Engineering Product Design and Development Research Group Institut Teknologi Bandung Indonesia Master Program in Chemical Engineering Institut Teknologi Bandung Indonesia Chemical Reaction Technology and Catalysis Research Group Institut Teknologi Bandung Indonesia Chemical Engineering Process Design and Development Research Group Institut Teknologi Bandung Indonesia

Polyvinyl chloride (PVC) has many applications in construction, such as pipes, floors, roofs, walls, frames, and cables. Since it is easily degraded by heat, a heat stabilizer must be added to the PVC resin before it is molded into final products. Mixed calcium/zinc carboxylate has become a popular PVC thermal stabilizer since it is more friendly than the conventional lead base thermal stabilizers and is relatively inexpensive. This research aims to investigate the synthesis and assess the effectiveness of a mixed calcium/zinc thermal stabilizer in stabilizing PVC. The stabilizer was prepared from palm fatty acid distillate (PFAD), and different metal salt-to-fatty acid molar ratios were employed for the study. The synthesis was carried out by a metathesis method at 10% deficiency, stoichiometric, and 10% excess of metal salt-to-fatty acid molar ratio. The stabilizing effects of the obtained metal carboxylates as mixed metal thermal stabilizers have also been evaluated by standard thermal stability tests. The calcium and zinc carboxylates prepared at a 10% deficiency were found to have high pHs and lower metal contents than those at stoichiometric molar ratios due to the presence of residual sodium soap. Their thermal stabilizing effects on PVC are also worst when prepared at a deficient metal salt-to-fatty acid molar ratio. Increasing the metal-to-fatty acid molar ratio above the stoichiometric requirement lowers the thermal stabilizing effect of zinc carboxylate but has little influence on the thermal stabilizing effect of calcium carboxylate obtained. Synthesis at stoichiometric metal salt-to-fatty acid molar ratios is recommended for preparing calcium and zinc carboxylates as mixed metal PVC thermal stabilizers.

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Efficient Hydrogen Evolution from Dimethylamine Borane, Ammonia Borane and Sodium Borohydride Catalyzed by Ruthenium and Platinum Nanoparticles Stabilized by an Amine Modified Polymer Immobilized Ionic Liquid: A Comparative Study*

SSRN

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SSRN 2024年

作者： Doherty, Simon Alharbi, Adhwa A. Wills, Corinne Dixon, Casey Arca, Elisabetta Chamberlain, Thomas W. Griffiths, Anthony Collins, Sean M. Wu, Kejun Yan, Han Bourne, Richard A. Knight, Julian G. School of Chemistry Newcastle University Bedson Building Newcastle upon TyneNE1 7RU United Kingdom School of Mathematics Statistics and Physics Newcastle University Newcastle upon TyneNE1 7RU United Kingdom Institute of Process Research & Development School of Chemistry School of Chemical and Process Engineering University of Leeds Woodhouse Lane LS2 9JT United Kingdom

Platinum and ruthenium nanoparticles stabilised by an amine modified polymer immobilised ionic liquid (MNP@NH2-PEGPIILS, M = Pt, Ru) catalyse the hydrolytic liberation of hydrogen from dimethylamine borane (DMAB), amine borane (AB) and NaBH4 under mild conditions. While RuNP@NH2-PEGPIILS and PtNP@NH2-PEGPIILS catalyse the hydrolytic evolution of hydrogen from NaBH4 with comparable initial TOFs of 6,200 and 5,900 ***-1, respectively, RuNP@NH2-PEGPIILS is a markedly more efficient catalyst for the dehydrogenation of DMAB and AB than its platinum counterpart, as RuNP@NH2-PEGPIILS gave initial TOFs of 8,050 ***-1 and 21,200 ***-1, respectively, compared with 3,050 ***-1 and 8,500 ***-1, respectively, for PtNP@NH2-PEGPIILS. Gratifyingly, for each substrate tested RuNP@NH2-PEGPIILS and PtNP@NH2-PEGPIILS were markedly more active than commercial 5wt % Ru/C and 5wt% Pt/C, respectively. The apparent activation energies of 55.7 kJ mol-1 and 27.9 kJ mol-1 for the catalytic hydrolysis of DMAB and AB, respectively, with RuNP@NH2-PEGPIILS are significantly lower than the respective activation energies of 74.6 kJ mol-1 and 35.7 kJ mol-1 for its platinum counterpart, commensurate with the markedly higher initial rates obtained with the RuNPs. In comparison, the apparent activation energies of 44.1 kJ mol-1 and 46.5 kJ mol-1, for the hydrolysis NaBH4 reflect the similar initial TOFs obtained for both catalysts. The difference in apparent activation energies for the hydrolysis of DMAB compared with AB also reflect the higher rates of hydrolysis for the latter. Further kinetic studies revealed that the hydrolysis of DMAB, AB and NaBH4 are each first order in catalyst and substrate. Primary kinetic isotope effects for the hydrolytic dehydrogenation of DMAB, AB and NaBH4 using RuNP@NH2-PEGPIILS or PtNP@NH2-PEGPIILS as catalysts varied between 2.5 and 4.0 and support a mechanism involving rate limiting a

关键词： Hydrolysis

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Green synthesis of magnetic type Zeolites 4A as catalyst for the elimination of quinoline yellow by the Fenton process: Optimization and kinetic investigation

Hybrid Advances

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Hybrid Advances 2025年 9卷

作者： Foko, Roland Urselin Noumsi Fotsop, Cyrille Ghislain Tchuifon, Donald Raoul Tchuifon Banenzoué, Charles Azebaze, Anatole Guy Blaise Department of Chemistry Faculty of Science University of Douala PO Box: 24157 Douala Cameroon Institute of Chemistry Faculty of Process and Systems Engineering Universitat Splatz 2 Magdeburg 39106 Germany Department of Process Engineering Laboratory of Chemical Engineering and industrial bio-processes National Higher Polytechnic School of Douala University of Douala P.O. Box 2701 Douala Cameroon Department of Chemistry Research Unit of Noxious Chemistry and Environmental Engineering Faculty of Science University of Dschang P.O. Box 67 Dschang Cameroon

This work describes the hydrothermal synthesis and characterization of zeolite 4A (Zeo-4A) and magnetite zeolite (Zeo-4A@Fe3O4) from Cameroonian raw kaolin. The study also explores the efficiency of Zeo-4A@Fe3O4 for t... 详细信息

This work describes the hydrothermal synthesis and characterization of zeolite 4A (Zeo-4A) and magnetite zeolite (Zeo-4A@Fe₃O₄) from Cameroonian raw kaolin. The study also explores the efficiency of Zeo-4A@Fe₃O₄ for the removal of quinoline yellow (E104) via Fenton process. XRD, FTIR, SEM, EDX, NMR-MAS and TGA-DSC characterizations show that Zeo-4A is crystalline with cubic morphology, while Zeo-4A@Fe₃O₄ exhibits a bonding interaction between zeolite and Fe₃O₄ nanoparticle leading to morphological structural changes. The degradation of quinoline yellow by heterogeneous Fenton process was carried out by varying several parameters, namely solution pH (3–7), H₂O₂ concentration (0.5–1.5 mol/L), quinoline yellow concentration (50–100 mg/L), and catalyst mass (50–100 mg). The results of catalytic performance tests reveal that the degradation efficiency of synthetic Zeo-4A, Zeo-4A@Fe₃O₄ and Fe₃O₄ were 1.71 %, 93.60 % and 92.65 %, respectively, after 60 min. Confirmatory tests were carried out by response surface methodology based on the Box-Behnken design, and a degradation rate of 98.81 % was obtained under optimum conditions of pH 3.84, 50.14 mg/L, 100 mg, and 1.5 g/L;which is well in line with the model predictions. A significant quadratic regression model R² = 91.35 % and the adjusted coefficient of determination value (adjusted R² = 82.04 %) were observed using the analysis of the variance. The study of catalyst recovery and reusability shows that the catalysts remain stable with a degradation rate greater than 66 % after five cycles. The kinetics results show that the degradation of E104 follows first and second order kinetic models, influenced by pH and catalyst mass, with optimum efficiency at pH 3. The characterization results of the material after degradation show that it maintains its stru

关键词： Degradation Fenton process Quinoline yellow Zeolite 4A

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Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

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Burns & Trauma 2023年第1期11卷 32-45页

作者： Kevin H.-Y.Tsai Huaikai Shi Roxanne J.Parungao Sina Naficy Xiaotong Ding Xiaofeng Ding Jonathan J.Hew Xiaosuo Wang Wojciech Chrzanowski Gareth G.Lavery Zhe Li Andrea C.Issler-Fisher Jun Chen Qian Tan Peter K.Maitz Mark S.Cooper Yiwei Wang Adrenal Steroid Group ANZAC Research InstituteConcord HospitalThe University of SydneySydneyNSW 2137Australia Burns and Reconstructive Surgery Research Group ANZAC Research InstituteConcord HospitalThe Uni-versity of SydneySydneyNSW 2137Australia School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW 2006Australia Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application Nanjing University of Chinese MedicineNanjingJiangsu210023China Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsu210008China Heart Research Institute The University of SydneySydneyNSW 2006Australia Sydney Nano Institute Sydney Pharmacy SchoolFaculty of Medicine and HealthThe University of SydneySydneyNSW2006Australia Department of Biosciences Centre for Healthy Ageing and Understanding DiseaseNottingham Trent UniversityNG14BUUK Burns and Reconstructive Surgery Unit Concord Repatriation General HospitalSydneyNSW 2137Australia

Background:Excessive scarring and fibrosis are the most severe and common complications of burn *** exposure to high levels of glucocorticoids detrimentally impacts on skin,leading to skin thinning and impaired wound *** can generate active glucocorticoids locally through expression and activity of the 11β-hydroxysteroid dehydrogenase type 1 enzyme(11β-HSD1).We hypothesised that burn injury would induce 11β-HSD1 expression and local glucocorticoid metabolism,which would have important impacts on wound healing,fibrosis and *** additionally proposed that pharmacological manipulation of this system could improve aspects of post-burn ***:Skin 11β-HSD1 expression in burns patients and mice was *** impacts of 11β-HSD1 mediating glucocorticoid metabolism on burn wound healing,scar formation and scar elas-ticity and quality were additionally examined using a murine 11β-HSD1 genetic knockout ***-release scaffolds containing therapeutic agents,including active and inactive glucocorticoids,were developed and pre-clinically tested in mice with burn ***:We demonstrate that 11β-HSD1 expression levels increased substantially in both human and mouse skin after burn injury.11β-HSD1 knockout mice experienced faster wound healing than wild type mice but the healed wounds manifested significantly more collagen deposition,tensile strength and stiffness,features characteristic of excessive *** of slow-release prednisone,an inactive glucocorticoid,slowed the initial rate of wound closure but significantly reduced post-burn scarring via reductions in inflammation,myofibroblast generation,collagen production and scar ***:Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn *** of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics po

关键词： Wound healing Burn injury Scarring Skin 11β-HSD1 11β-HSD1 knockout Glucocorticoid metabolism Polycaprolactone scaffold Drug delivery

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Microalgae cultivation using nutrients in fish farm effluent for biodiesel production

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South African Journal of chemical engineering 2021年 37卷 46-52页

作者： Enwereuzoh, Uzochukwu Harding, Kevin Low, Michelle Industrial and Mining Water Research Unit (IMWaRU) School of Chemical and Metallurgical Engineering University of the Witwatersrand Johannesburg South Africa Centre in Water Research and Development (CiWaRD) University of the Witwatersrand Johannesburg South Africa Department of Environmental Management Federal University of Technology Owerri P.M.B. 1526 Owerri Nigeria

This article contributes to research on the composition of microalgae grown in fish farm wastewater (FFW), particularly for use in biodiesel production. In this research, Tetradesmus obliquus, Heterochlorella luteoviridis, and Chlamydomonas reinhardtii, cultivated in unmodified-and modified FFW, and the standard growth media, Tris-Acetate-Phosphate (TAP), were studied. The following parameters of the algae species were investigated: specific growth rate, biomass yield, biomass productivity, lipid content and carbohydrate content. Additionally, lipids and carbohydrate productivities were calculated, and the rate of CO₂ uptake was determined. This study showed that the nutrients in FFW were suitable for algae biomass cultivation for biodiesel production. Chlamydomonas reinhardtii, in unmodified FFW, had the highest lipid and carbohydrate composition of 44.08% and 35.04%, respectively, and was most suited for biodiesel production as well as nutrient removal. The modified FFW only had the extra benefit of near-complete nutrient removal, but a comparable yield and biochemical composition with samples in unmodified FFW. A similar effect of CO₂ concentration was observed in both the unmodified and modified FFW. © 2021

关键词： Biomass yield Carbohydrate content Carbon content CO2 removal Lipid content

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Anaerobic co-digestion of glycerol waste and distillery wastewater for bio-hythane production: Performance and ADM-1 based kinetics

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Carbon Resources Conversion 2025年

作者： Sani, Khaliyah O-Thong, Sompong Jariyaboon, Rattana Reungsang, Alissara Yasui, Hidenari Kongjan, Prawit Pattani Muang94000 Thailand Pattani Muang94000 Thailand Biofuel and Biocatalysis Innovation Research Unit Nakhonsawan Campus Mahidol University Nakhonsawan60130 Thailand Department of Biotechnology Faculty of Technology Khon Kaen University Khon Kaen40002 Thailand Research Group for Development of Microbial Hydrogen Production Process from Biomass Khon Kaen University Khon Kaen40002 Thailand Faculty of Environmental Engineering The University of Kitakyushu 1-1 Hibkino Wakamatsu Fukuoka Kitakyushu808-0135 Japan

Glycerol waste (GW), with its high carbon content, was co-digested with nitrogen-rich distillery wastewater (DW) in this experiment to evaluate hydrogen and methane production in a two-stage anaerobic digestion (AD) system. Bio-hydrogen potential (BHP) and methane potential (BMP) were conducted under thermophilic conditions (55°C) for the co-digestion of GW and acetone-butanol-ethanol distillery wastewater (ABE-DW) at various mixing ratios of 0:100, 20:80, 40:60, 50:50, 60:40, 80:20, and 100:0 (%VS) to determine the optimal mixing ratio. The highest BHP of 147 mL-H2/g-VS and BMP of 650 mL-CH4/g-VS were achieved at a GW to ABE-DW mixing ratio 50:50. Then. the process proceded with the continuous two-stage anaerobic process which was later implemented with the continuously stirred tank reactor (CSTR) for hydrogen production and the up-flow anaerobic sludge blanket (UASB) reactor for methane production in order to assess system performance. A mixture of GW and DW from commercial ethanol production (ethanol-DW) at a 50:50 mixing ratio was fed into the CSTR at a 4-day HRT, and the CSTR effluent was subsequently fed into the UASB at 21-day and 18-day HRTs. The CSTR achieved a hydrogen yield of 83.6 mL-H2/g-VS, while methane yields in the UASB were 367 mL-CH4/g-VS at a 21-day HRT and 440 mL-CH4/g-VS at an 18-day HRT. Additionally, the original ADM-1 was modified to describe the two-stage anaerobic co-digestion of GW and DW. This enhanced model effectively predicts the performance of the two-stage anaerobic process for co-digesting GW and DW. © 2025 The Authors

关键词： Anaerobic digestion

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Three-dimensional MXenes heterostructures and their applications

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Science China Materials 2022年第11期65卷 2895-2910页

作者： Jizhou Jiang Fangyi Li Jing Zou Song Liu Jiamei Wang Yilun Zou Kun Xiang Han Zhang Guoyin Zhu Yizhou Zhang Xianzhu Fu Jyh-Ping Hsu School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationWuhan Institute of TechnologyWuhan 430205 Key Laboratory of Rare Mineral Ministry of Natural ResourcesGeological Experimental Testing Center of Hubei ProvinceWuhan 430034 Institute of Chemical Biology and Nanomedicine(ICBN) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 College of Materials Science and Engineering Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics and Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060 Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science&TechnologyNanjing 210044 Department of Chemical Engineering “National”Taiwan UniversityTaipei 10617

Due to their unique surface chemistry,highly adjustable metal components,hydrophilicity,and high carrier concentrations,MXenes are applied in a variety of *** to other two-dimensional(2D)materials,building heterostructures with additional materials to form a 3D porous architecture for MXenes can significantly enhance their functionality and ***,the open structures and well-defined pathways of these 3D structured MXenes can improve ionic and electronic transport,thereby promoting their applications in electrochemical energy storage,sensing,catalysis,and *** this review,the recent efforts made on preparing 3D porous MXenes with heterostructures,focusing on MXenes/C,MXenes/inorganics,and MXenes/polymers were *** discussion covers aspects ranging from the design to synthesis of 3D porous MXenes,and their applications in photocatalysis,environmental monitoring and electrochemical energy *** review is concluded by presenting the prospects and insights on exploring the relationships between the porosity formation mechanisms,properties and applications of the 3D porous MXenes *** review can provide meaningful guidance for the design,fabrication and application of 3D porous MXenes in high-performance materials and devices.

关键词： 3D porous MXenes MXenes heterostructures photocatalysis environmental monitoring electrochemical energy storage

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A Novel Anaerobic Digestion (Ad) System Driven By Iron-Based Metal-Organic Framework (Fe-Mof) Towards Expediting the Direct Interspecies Electron Transfer (Diet): Insights into Electron Transfer and Metabolic Pathways

SSRN

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SSRN 2023年

作者： Geng, Mengqi Zhang, Yichu Ma, Rui Wu, Di Zhang, Yifeng Qian, Jin Research & Development Institute in Shenzhen School of Chemistry and Chemical Engineering Northwestern Polytechnical University China Centre for Environmental and Engineering Research Ghent University Global Campus Incheon Korea Republic of Department of Green Chemistry and Technology Ghent Centre for Advanced Process Technology for Urban Resource Recovery [CAPTURE Ghent9000 Belgium Department of Environmental and Resource Engineering Technical University of Denmark Miljoevej B113 Kgs LyngbyDK 2800 Denmark

The inadequate methane production and substandard hydrolysis-acidification activity have impeded the practical application of anaerobic digestion (AD) of waste activated sludge (WAS). Recently, metal-organic framework (MOF) materials have shown the promising capability of controlling proton/electron transfer in AD processes. This study uses a typical iron-based MOF, MIL-88A(Fe), synthesized via a one-step hydrothermal method to improve the methanogenic potential for the WAS treatment. The findings indicate that adding 150 mg MIL-88A(Fe)/g WAS VS resulted in a 57.23% increase in accumulated methane production and a 43.84% increase in daily maximum methane production. The methane production rate (Rmax) also increased from 22.25 to 29.14 mL/g VS/d. MIL-88A(Fe) enhanced the electron transfer capacity, accelerated the hydrolysis of WAS, boosted acetate generation, and mitigated the accumulation of volatile fatty acids. The significant enrichment of Methanobacterium and Methanosaeta and the up-regulation of key methanogenesis enzyme-encoding genes suggested that the CO2 reduction and acetoclastic methanation were strengthened. Moreover, MIL-88A(Fe) stimulated the production of c-type cytochrome and e-pili, facilitating direct interspecies electron transfer (DIET) between norank-f-SC-I-84 and Methanobacterium. This study provides new solutions for improving methane production and offers insights into the mechanism of enhanced methanogenesis of AD in the presence of MIL-88A(Fe). © 2023, The Authors. All rights reserved.

关键词： Anaerobic digestion

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