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Identification of microbial metabolites that accelerate the ubiquitindependent degradation of c-Myc

Oncology research 2023年第5期31卷 655-666页

作者： ZIYU LIU AKIKO OKANO EMIKO SANADA YUSHI FUTAMURA TOSHIHIKO NOGAWA KOSUKE ISHIKAWA KENTARO SEMBA JIANG LI XIAOMENG LI HIROYUKI OSADA NOBUMOTO WATANABE Bioprobe Application Research Unit RIKEN CSRSSaitama351-0198Japan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental UniversityTokyo113-8510Japan Chemical Biology Research Group RIKEN CSRSSaitama351-0198Japan Chemical Resource Development Research Unit RIKEN CSRSSaitama351-0198Japan Molecular Structure Characterization Unit RIKEN CSRSSaitama351-0198Japan Japan Biological Informatics Consortium(JBIC) Tokyo135-8073Japan Department of Life Science and Medical Bioscience School of Advanced Science and EngineeringWaseda UniversityTokyo162-8480Japan Medical-Industrial Translational Research Center Fukushima Medical UniversityFukushima960-1295Japan Guangdong Engineering Research Center of Oral Restoration and Reconstruction Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhouChina KingMed School of Laboratory Medicine Guangzhou Medical UniversityGuangzhouChina Department of Pharmaceutical Sciences University of ShizuokaShizuoka422-8526Japan

Myc belongs to a family of proto-oncogenes that encode transcription *** overexpression of c-Myc causes many types of ***,we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical *** specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be *** this study,we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces ***19-A0402 strongly inhibits c-Myc transcriptional *** purification of the hit broth,we identified compounds closely related to the aglycone of cytovaricin and had a structure similar to that of oligomycin *** to oligomycin A,the hit compounds inhibited mitochondrial complex *** mitochondria dysfunction caused by the compounds induced the production of reactive oxygen species(ROS),and the ROS activated GSK3α/βthat phosphorylated c-Myc for *** study provides a successful screening strategy for identifying natural products as potential c-Myc inhibitors as potential anticancer agents.

关键词： High-throughput screening Phosphorylation Reactive oxygen species

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Exploring uncommon Fe-oxides in non-metallic inclusions in ultra-high-strength steel

Results in Materials

引用

Results in Materials 2024年 23卷

作者： Rani, Ekta Gupta, Vandna K. Gyakwaa, Francis Kharbach, Mourad Singh, Harishchandra Alatarvas, Tuomas Martinelli, Anna Fabritius, Timo Huttula, Marko Nano and Molecular Systems Research Unit University of Oulu Department of Chemistry and Chemical Engineering Chalmers University of Technology Process Metallurgy Research Unit University of Oulu Circular Economy/Sustainable Solutions LAB University of Applied Sciences

Investigating non-metallic inclusions within ultra-high-strength-steel via conventional methods is a known: however, the challenge is to obtain chemical information of such inclusions at the sub-micrometer level. In this context, probing Fe-based oxide in inclusions is a vital aspect for guiding steel’ performance. The vibrational properties of sub micrometer size Fe-based oxides were investigated by Raman mapping along with chemometric analysis with the aim of probing their chemical composition. Highly contrasted Raman spectra were recorded from several inclusions embedded at different spatial locations. The observed spectral features were identified as specific markers of hematite (α-Fe₂O₃) and magnetite (Fe₃O₄). Principal Component Analysis was used to confirm the presence of these markers and potentially revealing additional patterns. Their unambiguous assignment has been inferred by comparing our experimental findings with the literature data recorded either in single crystals of iron oxides or oxyhydroxides. Micro-Raman spectroscopy is proven to be a reliable, cost-effective, and non-invasive tool for the unambiguous identification of subsurface regions of steel. © 2024

关键词： Fe-based oxides Low carbon steel Non-metallic inclusion Principal component analysis Raman mapping

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Formulation of Lithium Ion-Sieve by Surfactant Assisted Non-Solvent Induced Phase Separation

SSRN

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SSRN 2024年

作者： Liu, Ping Zhou, Mingchi Ma, Jiayu Chen, Zhen Qin, Yuanhang Yang, Li He, Dongshen Zhou, Junfeng Engineering Research Center of Phosphorus Resources Development and Utilization Ministry of Education Key Laboratory of Green Chemical Process of Ministry of Education Key Laboratory of Novel Reactor and Green Chemical Technology of Hubei Province School of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan430205 China Xingfa School of Mining Engineering Wuhan Institute of Technology Wuhan430074 China

Manganese-based lithium ion-sieve are a widely researched lithium adsorbent for the extraction of lithium from liquid resources. However, practical applications face challenges such as severe pressure drop, significant adsorbent loss, poor flowability, and difficulty in recovery, which urgently require the development of effective molding techniques. Based on previous work, this paper employs a non-solvent induced phase separation method to prepare spherical lithium ion-sieve precursor particles PLMO with N,N-dimethylformamide as a solvent, deionized water as a solvent extractant, and polyvinyl chloride as a binder. The surface morphology and hydrophilicity of the particles are controlled by the surfactant sodium dodecyl sulfate (SDS). After acid treatment, spherical lithium ion-sieve particles PHMO are obtained. The results show that PVC is physically uniformly mixed with the powder, and the particles have a stable structure with a porous outer layer and finger-like support layers. Compared to without surfactant, the addition of 5% SDS increases the PLMO particle porosity from 0.190 cm3/g to 0.196 cm3/g, and the PHMO adsorption capacity from 12.73 mg/g to 14.66 mg/g. The adsorption process follows the Langmuir and pseudo-second-order kinetic models, and it exhibits high selectivity for Li+ in a lithium-containing waste solution. Therefore, the surfactant assisted molding technology proposed in this paper holds promise for industrial application. © 2024, The Authors. All rights reserved.

关键词： Adsorption

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AFM Evaluation of Different-Sized Active Materials and Interface of All-Solid-State Lithium-Ion Batteries

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 574-575页

作者： Iida, Eiji Kogure, Akinori Miyamoto, Takeshi Nakajima, Hideo Macey, Christopher J. Mukohara, Hyosuke Morimoto, Naoki Yamasaki, Ryoya Yamada, Hirotoshi Analytical & Measuring Instruments Division Shimadzu Corporation Kawasaki Kanagawa Japan Analytical & Measuring Instruments Division Shimadzu Corporation X-ray/Surface Business Unit Kyoto Japan Shimadzu Scientific Instruments Inc. Columbia MD United States Research & Business Development Department Research & Development Division Sakai Chemical Industry Co. Ltd. Sakai Osaka Japan Graduate School of Engineering Nagasaki University Nagasaki Japan

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Anthropogenic land use substantially increases riverine CO_(2) emissions

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Journal of Environmental Sciences 2022年第8期34卷 158-170页

作者： Shijie Gu Siyue Li Isaac R.Santos School of River and Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Key Laboratory of Reservoir Aquatic Environment Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China Chongqing School University of Chinese Academy of SciencesChongqing 400714China Research Center for Environmental Ecology and Engineering Institute of Changjiang Water Environment and Ecological SecuritySchool of Environmental Ecology and Biological EngineeringKey Laboratory for Green Chemical Process of Ministry of EducationKey Laboratory of Novel Reactor and Green Chemical Technology of Hubei ProvinceEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationWuhan Institute of TechnologyWuhan 430205China Department of Marine Sciences University of GothenburgGothenburg 41296Sweden National Marine Science Centre Southern Cross UniversityCoffs HarbourNSW 2450Australia

Carbon dioxide(CO_(2)) emissions from inland waters to the atmosphere are a pivotal component of the global carbon budget. Anthropogenic land use can influence riverine CO_(2) emissions, but empirical data exploring cause-effect relationships remain limited. Here, we investigated CO_(2) partial pressures(pCO_(2)) and degassing in a monsoonal river(Yue River)within the Han River draining to the Yangtze in China. Almost 90% of river samples were supersaturated in CO_(2) with a mean ± standard deviation of 1474 ± 1614 μatm, leading to emissions of 557-971 mmol/m^(2)/day from river water to the atmosphere. Annual CO_(2) emissions were 1.6-2.8 times greater than the longitudinal exports of riverine dissolved inorganic and organic carbon. pCO_(2) was positively correlated to anthropogenic land use(urban and farmland), and negatively correlated to forest cover. p CO_(2) also had significant and positive relationships with total dissolved nitrogen and total dissolved phosphorus. Stepwise multiple regression models were developed to predict p CO_(2) . Farmland and urban land released nutrients and organic matter to the river system, driving riverine p CO_(2) enrichment due to enhanced respiration in these heterotrophic rivers. Overall, we show the crucial role of land use driving riverine pCO_(2) , which should be considered in future large-scale estimates of CO_(2) emissions from streams. Land use change can thus modify the carbon balance of urban-river systems by enhancing river emissions, and reforestation helps carbon neutral in rivers.

关键词： River carbon Inland waters Greenhouse gases Climate change Water quality Headwater streams

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Sulfur-doped g-C_(3)N_(4)/g-C_(3)N_(4) isotype step-scheme heterojunction for photocatalytic H_(2) evolution

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Journal of Materials Science & Technology 2022年第23期118卷 15-24页

作者： Jizhou Jiang Zhiguo Xiong Haitao Wang Guodong Liao Saishuai Bai Jing Zou Pingxiu Wu Peng Zhang Xin Li School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Rare Mineral Ministry of Natural ResourcesGeological Experimental Testing Center of Hubei ProvinceWuhan 430034China Semiconductor Electronic Special Gas of Hubei Engineering Research Center Jingzhou 434000China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China State Centre for International Cooperation on Designer Low-Carbon&Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The rational fabrication of an efficient heterojunction is critical to the enhancement of photocatalytic hydrogen(H_(2)) evolution ***,a new-fashioned graphitic-carbon nitride(g-C_(3) N_(4)) based isotype step-scheme(S-scheme) heterojunction composed of sulfur-doped and sulfur-free active sites is developed by liquid sulfur-mediation of exfoliated g-C_(3) N_(4).Particularly,the liquid sulfur not only contributes to the full contact between sulfur species and exfoliated g-C_(3) N_(4),but also creates sulfur-doping and abundant pores,since self-gas foaming effect of sulfur ***,the S-doped and S-free active sites located in the structural unit of C_(3) N_(4) jointly construct a typical sulfur-doped g-C_(3) N_(4)/g-C_(3) N_(4) isotype step-scheme heterojunction,which endows highly efficient photocatalytic reaction ***,the optimal sample possesses remarkable photocatalytic H_(2) evolution activity(5548.1 μmol g^(-1) h^(-1)) and robust *** importantly,the investigation will open up a new path for the exploration of other carbon-based isotype S-scheme heterojunctions.

关键词： Liquid sulfur S-doping g-C_(3)N_(4) Isotype S-scheme heterojunction Photocatalytic H_(2) evolution

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Direct Sputtered Copper Seed Layer Formation on Low Dielectric Resin to Reduce Transmission Loss

Direct Sputtered Copper Seed Layer Formation on Low Dielectr...

引用

IEEE International Conference on 3D System Integration, 3DIC

作者： Akihiro Shimizu Kazuhiro Fukada Shinichi Endo Mitsuru Abe Akiko Matsui Technology & Engineering Department 1 Photon Process Division Ushio Inc. Hyogo Himeji Japan Research and Development Department Shibaura Machine Co Ltd. Research & Development Center Kanagawa Zama Japan Photon Process Division Photon Process GBU Ushio Inc.Osaka Osaka Japan Assembly Solution Business Unit Assembly Technology Division NTT Devices Cross Technologies Corporation Kanagawa Kawasaki Japan

ISBN: (数字)9798331516505

ISBN: (纸本)9798331516512

We developed a method to form a copper seed layer directly on resins with excellent dielectric properties using sputtering (referred to as the direct sputtering method). One of the key challenges to implementing 6G wireless communication systems that use millimeter waves is minimizing high-frequency transmission losses, as the transmission loss is affected by the dielectric (resin substrate) and the conductor (copper wiring) used to fabricate the transmission line. We compared our direct sputtering method for fabricating transmission circuits with the electroless copper plating method by evaluating the characteristics of their high-frequency transmission up to 100 GHz. Our direct sputtering method has several advantages over the electroless copper plating method, including a streamlined fabrication process for the transmission circuit. The direct sputtering method reduces the usage of chemicals and the high-frequency transmission loss in the transmission circuit. Thus, our direct sputtering method is beneficial to the fabrication of transmission circuits for 6G wireless communications.

关键词： Wireless communication 6G mobile communication Fabrication Dielectric losses Plating Propagation losses Copper Resins Millimeter wave communication Sputtering

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Lignin Solvent Fractionation with Pure Solvents and Their Water Solutions

SSRN

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SSRN 2022年

作者： Romakkaniemi, Idamaria Pinja Pauliina Ahola, Juha Panula-Perälä, Johanna Mikola, Marja Pyörälä, Juuso Tanskanen, Juha Chemical Process Engineering Research Unit University of Oulu P.O. Box 4300 Oulu90014 Finland

Lignin fractionation aims at dividing the original lignin material into fractions which have the qualities desired for further processing of the material. Kraft, organosolv and hydrolysis lignins were fractionated using multiple solvents and their water solutions. The single-stage fractionation process produced a soluble and an insoluble fraction, which were analysed for their molecular size distribution and phenolic hydroxyl group content. Soluble fractions were discovered with desirable qualities, including a narrow size distribution and accumulation of phenolic hydroxyl groups. In addition, three fractionation solvents were found to produce solvent-specific soluble fractions which had relatively identical, characteristic Mw, Mn and PDI values regardless of the initial lignin material: pure isopropanol and ethanol as well as 30% γ-valerolactone. © 2022, The Authors. All rights reserved.

关键词： Lignin

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XPS Characterization of Ag-Sn Backside Metallization

XPS Characterization of Ag-Sn Backside Metallization

引用

International Symposium on Physical & Failure Analysis of Integrated Circuits

作者： Yen Min Chew Tatt Wai Wan Huat Chye Lim Kuan Yew Cheong Unit Process Development Infineon Technologies Kulim Kulim Hi-Tech Park Kulim Kedah Malaysia Electronic Materials Research Group School of Materials & Mineral Resources Engineering Engineering Campus Universiti Sains Malaysia Nibong Tebal Penang Malaysia

ISBN: (数字)9798350360608

ISBN: (纸本)9798350360615

X-ray Photoelectron Spectroscopy (XPS) was used to characterize Ag-Sn bilayer structure crucial for backside metallization (BSM) in power device. 1000 nm Sn layer followed by a 140 nm Ag layer was deposited using sputter deposition at 200°C. The XPS depth profile confirmed a 5 nm oxide layer at the surface and showcased Ag diffusion into Sn. Core-level binding energies and oxidation states of O 1s, C 1s, Sn 3d5/2, and Ag 3d species were analyzed through narrow scan XPS spectra, including depth profiling at the surface (cycle 0), 5 nm depth (cycle 1), and 40 nm depth (cycle 8). At cycle 0, a combination of pure Ag, pure Ag3Sn, pure Sn, and other species was observed, with atomic concentrations of 1.29%, 4.21%, 5.56%, and 88.94%, respectively. The atomic concentrations of pure Ag, pure Ag3Sn, and pure Sn were 28.69%, 19.64%, and 51.68% respectively at cycle 1, and 38.02%, 13.16%, and 48.82% respectively at cycle 8. The lower concentration of AgO (17.86%) compared to SnO (31.84%) at cycle 0 and the consistent lower concentration of Ag than Sn at cycles 0, 1, and 8 suggested that complete Ag diffusion into Sn, concurrent with Ag3Sn intermetallic compound formation. The study highlights the role of XPS in understanding Ag-Sn bilayer thin films and illustrate the contribution of interdiffusion mechanism to Ag3Sn intermetallic compound formation.

关键词： Integrated circuits Spectroscopy Three-dimensional displays Metallization Lattices Oxidation Intermetallic Compounds Surface treatment Sputtering

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Phase Change Nanocapsules Filled Separator for Wide Temperature Range Performance Enhancement of Li-Ion Battery

SSRN

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SSRN 2024年

作者： Wang, Miao Mou, Chen Wang, Kai Wang, Wenjun Jiang, Shanzhu Key laboratory for Green Chemical Process of Ministry of Education Hubei Key Laboratory of Novel Reactor & Green Chemical Technology College of Chemical Engineering and Pharmacy Wuhan Institute of Technology Wuhan430073 China Hubei Three Gorges Laboratory Phosphogypsum Comprehensive Utilization Research and Development Center Hubei Yichang443007 China

The rapid development of electrical vehicle urgently requires high-performance Li-ion battery in wide temperature range. Herein, disodium hydrogen phosphate dodecahydrate encapsulated with silica was embedded to polyvinylidene fluoride as a DHPD@SiO2/PVDF (DSP) membrane. The DSP based cell exhibited superior discharge performance under mild temperature as the silica surrounded nanocapsules could enhance electrolyte affinity, separator porosity and mechanical strength, thus to reduce interfacial resistance reduction and increase Li-ion conductivity. More importantly, the phase change DSP membrane is leakage-proof with a comparable latent heat due to porous silica shell and hydrophobic PVDF encapsulation. When battery discharged in cold environment, heat release from hydrate salt solidification could mitigate the damage from chilling temperature and alleviate performance degradation by 70%. The present design of separator integrating electrochemical properties promotion and low-temperature thermal management provides a novel and efficient strategy to enhance wide temperature range performance of Li-ion battery. © 2024, The Authors. All rights reserved.

关键词： Nanocapsules

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