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Global, regional, and national sex-specific burden and control of the HIV epidemic, 1990–2019, for 204 countries and territories: the Global Burden of Diseases Study 2019

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The Lancet HIV 2021年第10期8卷 e633-e651页

作者： Jahagirdar, Deepa Walters, Magdalene K. Novotney, Amanda Brewer, Edmond D. Frank, Tahvi D. Carter, Austin Biehl, Molly H. Abbastabar, Hedayat Abhilash, E.S. Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Adekanmbi, Victor Adeyinka, Daniel Adedayo Adnani, Qorinah Estiningtyas Sakilah Afzal, Saira Aghababaei, Soodabeh Ahinkorah, Bright Opoku Ahmad, Sajjad Ahmadi, Keivan Ahmadi, Sepideh Ahmadpour, Ehsan Ahmed, Muktar Beshir Rashid, Tarik Ahmed Salih, Yusra Ahmed Aklilu, Addis Akram, Tayyaba Akunna, Chisom Joyqueenet Al Hamad, Hanadi Alahdab, Fares Alanezi, Fahad Mashhour Aleksandrova, Ekaterina A. Alene, Kefyalew Addis Ali, Liaqat Alipour, Vahid Almustanyir, Sami Alvis-Guzman, Nelson Ameyaw, Edward Kwabena Amu, Hubert Andrei, Catalina Liliana Andrei, Tudorel Anvari, Davood Arabloo, Jalal Aremu, Olatunde Arulappan, Judie Atnafu, Desta Debalkie Quintanilla, Beatriz Paulina Ayala Ayza, Muluken Altaye Azari, Samad Darshan, B.B. Banach, Maciej Bärnighausen, Till Winfried Barra, Fabio Barrow, Amadou Basu, Sanjay Bazargan-Hejazi, Shahrzad Belay, Habtamu Gebrehana Berheto, Tezera Moshago Bezabhe, Woldesellassie Mequanint Bezabih, Yihienew Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Nikha Bhardwaj, Pankaj Bhattacharyya, Krittika Bibi, Sadia Bijani, Ali Bisignano, Catherine Bolarinwa, Obasanjo Afolabi Boloor, Archith Boltaev, Azizbek A. Briko, Nikolay Ivanovich Buonsenso, Danilo Burkart, Katrin Butt, Zahid A. Cao, Chao Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Choudhari, Sonali Gajanan Chu, Dinh-Toi Couto, Rosa A.S. Cowden, Richard G. Dachew, Berihun Assefa Dadras, Omid Dagnew, Amare Belachew Dahlawi, Saad M.A. Dai, Xiaochen Dandona, Lalit Dandona, Rakhi das Neves, José Degenhardt, Louisa Demeke, Feleke Mekonnen Desta, Abebaw Alemayehu Deuba, Keshab Dhamnetiya, Deepak Dhungana, Govinda Prasad Dianatinasab, Mostafa Diaz, Daniel Djalalinia, Shirin Doan, Linh Phuong Dorostkar, Fariba Edinur, Hisham Atan Effiong, Andem Eftekharzadeh, Sahar El Sayed Zaki, Maysaa Elayedath, Rajesh Elhadi, Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Division of Allergy and Infectious Diseases University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States School of Social Work University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Vagelos College of Physicians and Surgeones Columbia University Medical Center New York NY United States Division of Data Analytics and Delivery for Impact WHO Geneva Switzerland Advanced Diagnostic and Interventional Radiology Research Centre Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Centre Tehran University of Medical Sciences Tehran Iran School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Paediatric Chronic Kidney Disease Research Centre Tehran University of Medical Sciences Tehran Iran Department of Psychiatry Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Centre Tehran University of Medical Sciences Tehran Iran Sina Trauma and Surgery Research Centre Tehran University of Medical Sciences Tehran Iran Research Centre for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Non-Communicable Diseases Research Centre Tehran University of Medical Sciences Tehran Iran Department of Botany Sree Narayana Guru College Chelannur Kozhikode India Clinical Sciences Department University of Sharjah Sharjah United Arab Emirates Mass Communication Department University of Sharjah Sharjah United Arab Emirates Department of Health-Care Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Department of Population Medicine Ca

Background: The sustainable development goals (SDGs) aim to end HIV/AIDS as a public health threat by 2030. Understanding the current state of the HIV epidemic and its change over time is essential to this effort. This study assesses the current sex-specific HIV burden in 204 countries and territories and measures progress in the control of the epidemic. Methods: To estimate age-specific and sex-specific trends in 48 of 204 countries, we extended the Estimation and Projection Package Age-Sex Model to also implement the spectrum paediatric model. We used this model in cases where age and sex specific HIV-seroprevalence surveys and antenatal care-clinic sentinel surveillance data were available. For the remaining 156 of 204 locations, we developed a cohort-incidence bias adjustment to derive incidence as a function of cause-of-death data from vital registration systems. The incidence was input to a custom Spectrum model. To assess progress, we measured the percentage change in incident cases and deaths between 2010 and 2019 (threshold >75% decline), the ratio of incident cases to number of people living with HIV (incidence-to-prevalence ratio threshold <0·03), and the ratio of incident cases to deaths (incidence-to-mortality ratio threshold <1·0). Findings: In 2019, there were 36·8 million (95% uncertainty interval [UI] 35·1–38·9) people living with HIV worldwide. There were 0·84 males (95% UI 0·78–0·91) per female living with HIV in 2019, 0·99 male infections (0·91–1·10) for every female infection, and 1·02 male deaths (0·95–1·10) per female death. Global progress in incident cases and deaths between 2010 and 2019 was driven by sub-Saharan Africa (with a 28·52% decrease in incident cases, 95% UI 19·58–35·43, and a 39·66% decrease in deaths, 36·49–42·36). Elsewhere, the incidence remained stable or increased, whereas deaths generally decreased. In 2019, the global incidence-to-prevalence ratio was 0·05 (95% UI 0·05–0·06) and the global incidence-to-mortality ratio was

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

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Nature communications 2023年第1期14卷 3043页

作者： Jianxin Shi Kouya Shiraishi Jiyeon Choi Keitaro Matsuo Tzu-Yu Chen Juncheng Dai Rayjean J Hung Kexin Chen Xiao-Ou Shu Young Tae Kim Maria Teresa Landi Dongxin Lin Wei Zheng Zhihua Yin Baosen Zhou Bao Song Jiucun Wang Wei Jie Seow Lei Song I-Shou Chang Wei Hu Li-Hsin Chien Qiuyin Cai Yun-Chul Hong Hee Nam Kim Yi-Long Wu Maria Pik Wong Brian Douglas Richardson Karen M Funderburk Shilan Li Tongwu Zhang Charles Breeze Zhaoming Wang Batel Blechter Bryan A Bassig Jin Hee Kim Demetrius Albanes Jason Y Y Wong Min-Ho Shin Lap Ping Chung Yang Yang She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young-Chul Kim Neil E Caporaso Jiang Chang James Chung Man Ho Michiaki Kubo Yataro Daigo Minsun Song Yukihide Momozawa Yoichiro Kamatani Masashi Kobayashi Kenichi Okubo Takayuki Honda Dean H Hosgood Hideo Kunitoh Harsh Patel Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Hidehito Horinouchi Masahiro Tsuboi Ryuji Hamamoto Koichi Goto Yuichiro Ohe Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Megumi Hara Yuichiro Nishida Kenji Takeuchi Kenji Wakai Koichi Matsuda Yoshinori Murakami Kimihiro Shimizu Hiroyuki Suzuki Motonobu Saito Yoichi Ohtaki Kazumi Tanaka Tangchun Wu Fusheng Wei Hongji Dai Mitchell J Machiela Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Gee-Chen Chang Ying-Huang Tsai Kuan-Yu Chen Ming-Shyan Huang Wu-Chou Su Yuh-Min Chen Adeline Seow Jae Yong Park Sun-Seog Kweon Kun-Chieh Chen Yu-Tang Gao Biyun Qian Chen Wu Daru Lu Jianjun Liu Ann G Schwartz Richard Houlston Margaret R Spitz Ivan P Gorlov Xifeng Wu Ping Yang Stephen Lam Adonina Tardon Chu Chen Stig E Bojesen Mattias Johansson Angela Risch Heike Bickeböller Bu-Tian Ji H-Erich Wichmann David C Christiani Gadi Rennert Susanne Arnold Paul Brennan James McKay John K Field Sanjay S Shete Loic Le Marchand Geoffrey Liu Angeline Andrew Lambertus A Kiemeney Shan Zienolddiny-Narui Kjell Grankvist Mikael Johansson Angela Cox Fiona Taylor Jian-Min Yuan Philip Lazarus Matthew B Schabath Melinda C Aldrich Hyo-Sung Jeon Shih Sheng Jiang Jae Sook Sung C Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. jianxin.shi@nih.gov. Division of Genome Biology National Cancer Research Institute Tokyo Japan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China. Prosserman Centre for Population Health Research Lunenfeld-Tanenbaum Research Institute Sinai Health Toronto ON Canada. Department of Epidemiology and Biostatistics National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Tianjin China. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Cancer Research Institute Seoul National University College of Medicine Seoul Republic of Korea. Department of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. Department of Epidemiology School of Public Health China Medical University Shenyang China. Department of Clinical Epidemiology and Center of Evidence Based Medicine The First Hospital of China Medical University Shenyang China. Department of Oncology Shandong Cancer Hospital and Institute Shandong Academy of Medical Sciences Jinan China. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China. S

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

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Author Correction: National identity predicts public health support during a global pandemic

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Nature communications 2022年第1期13卷 1949页

作者： Jay J Van Bavel Aleksandra Cichocka Valerio Capraro Hallgeir Sjåstad John B Nezlek Tomislav Pavlović Mark Alfano Michele J Gelfand Flavio Azevedo Michèle D Birtel Aleksandra Cislak Patricia L Lockwood Robert Malcolm Ross Koen Abts Elena Agadullina John Jamir Benzon Aruta Sahba Nomvula Besharati Alexander Bor Becky L Choma Charles David Crabtree William A Cunningham Koustav De Waqas Ejaz Christian T Elbaek Andrej Findor Daniel Flichtentrei Renata Franc Biljana Gjoneska June Gruber Estrella Gualda Yusaku Horiuchi Toan Luu Duc Huynh Agustin Ibanez Mostak Ahamed Imran Jacob Israelashvili Katarzyna Jasko Jaroslaw Kantorowicz Elena Kantorowicz-Reznichenko André Krouwel Michael Laakasuo Claus Lamm Caroline Leygue Ming-Jen Lin Mohammad Sabbir Mansoor Antoine Marie Lewend Mayiwar Honorata Mazepus Cillian McHugh John Paul Minda Panagiotis Mitkidis Andreas Olsson Tobias Otterbring Dominic J Packer Anat Perry Michael Bang Petersen Arathy Puthillam Julián C Riaño-Moreno Tobias Rothmund Hernando Santamaría-García Petra C Schmid Drozdstoy Stoyanov Shruti Tewari Bojan Todosijević Manos Tsakiris Hans H Tung Radu G Umbreș Edmunds Vanags Madalina Vlasceanu Andrew Vonasch Meltem Yucel Yucheng Zhang Mohcine Abad Eli Adler Narin Akrawi Hamza Alaoui Mdarhri Hanane Amara David M Amodio Benedict G Antazo Matthew Apps F Ceren Ay Mouhamadou Hady Ba Sergio Barbosa Brock Bastian Anton Berg Maria P Bernal-Zárate Michael Bernstein Michał Białek Ennio Bilancini Natalia Bogatyreva Leonardo Boncinelli Jonathan E Booth Sylvie Borau Ondrej Buchel C Daryl Cameron Chrissie F Carvalho Tatiana Celadin Chiara Cerami Hom Nath Chalise Xiaojun Cheng Luca Cian Kate Cockcroft Jane Conway Mateo Andres Córdoba-Delgado Chiara Crespi Marie Crouzevialle Jo Cutler Marzena Cypryańska Justyna Dabrowska Michael A Daniels Victoria H Davis Pamala N Dayley Sylvain Delouvee Ognjan Denkovski Guillaume Dezecache Nathan A Dhaliwal Alelie B Diato Roberto Di Paolo Marianna Drosinou Uwe Dulleck Jānis Ekmanis Arhan S Ertan Tom W Etienne Hapsa Hossain Farhana Fahima Farkhari Har Department of Psychology and Neural Science New York University New York NY USA. jay.vanbavel@nyu.edu. School of Psychology University of Kent Canterbury England. Department of Economics Middlesex University London London England. Department of Strategy and Management Norwegian School of Economics Bergen Norway. SWPS University of Social Sciences and Humanities Poznań Poland. Department of Psychological Sciences College of William and Mary Williamsburg VA USA. Institute of Social Sciences Ivo Pilar Zagreb Croatia. Department of Philosophy Macquarie University Sydney NSW Australia. Stanford Graduate School of Business Stanford University Stanford CA USA. Institute of Communication Science Friedrich-Schiller University Jena Jena Germany. flavio.azevedo@uni-jena.de. School of Human Sciences Institute for Lifecourse Development University of Greenwich London England. Department of Experimental Psychology University of Oxford Oxford England. Center for Human Brain Health School of Psychology University of Birmingham Birmingham England. Department of Psychology Macquarie University Sydney NSW Australia. KU Leuven Leuven Belgium. National Research University Higher School of Economics (HSE) Moscow Russia. De La Salle University Manila Philippines. Department of Psychology University of the Witwatersrand Johannesburg South Africa. Department of Political Science Aarhus University Aarhus Denmark. X University Toronto ON Canada. Department of Government Dartmouth College Hanover NH USA. Department of Psychology University of Toronto Toronto ON Canada. Gatton College of Business and Economics University of Kentucky Lexington KY USA. Department of Mass Communication National University of Science and Technology (NUST) Islamabad Pakistan. Department of Management Aarhus University Aarhus Denmark. Faculty of Social and Economic Sciences Comenius University Bratislava Slovakia. IntraMed Buenos Aires Argentina. Macedonian Academy of Sciences and

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Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn VanderHeide, John D. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagirdar, Deepa Schaeffer, Lauren E. Serfes, Audrey L. LeGrand, Kate E. Abbastabar, Hedayat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred Mario Kokou Adebayo, Oladimeji M. Adegbosin, Adeyinka Emmanuel Adekanmbi, Victor Adetokunboh, Olatunji O. Adeyinka, Daniel Adedayo Ahinkorah, Bright Opoku Ahmadi, Keivan Ahmed, Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Oladapo Akinyemi, Rufus Olusola Aklilu, Addis Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Noore Alamneh, Alehegn Aderaw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid Amini, Saeed Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, Davood Anwer, Razique Appiah, Seth Christopher Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabadi, Mohammad Asmare, Wondwossen Niguse Atnafu, Desta Debalkie Atout, Maha Moh'd Wahbi Atreya, Alok Ausloos, Marcel Awedew, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared Asmare Ayza, Muluken Altaye Azari, Samad Azene, Zelalem Nigussie Babar, Zaheer-Ud-Din Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried Basu, Sanjay Bayati, Mohsen Bedi, Neeraj Bekuma, Tariku Tesfaye Bezabhe, Woldesellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sadia Bikbov, Boris Birhan, Tsegaye Adane Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brady, Oliver J. Bragazzi, Nicola Luigi Briko, Andrey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid A. Cárdenas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowden, Richard G. Culquichicon, Carlos Dagnew, Baye Dahlawi, Saad M.A. D Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique,

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Predicted temperature-increase-induced global health burden and its regional variability

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ENVIRONMENT INTERNATIONAL 2019年 131卷 105027-000页

作者： Lee, Jae Young Kim, Ho Gasparrini, Antonio Armstrong, Ben Bell, Michelle L. Sera, Francesco Lavigne, Eric Abrutzky, Rosana Tong, Shilu Zanotti Stagliorio Coelho, Micheline de Sousa Nascimento Saldiva, Paulo Hilario Correa, Patricia Matus Ortega, Nicolas Valdes Kan, Haidong Garcia, Samuel Osorio Kysely, Jan Urban, Ales Orru, Hans Indermitte, Ene Jaakkola, Jouni J. K. Ryti, Niilo R. I. Pascal, Mathilde Goodman, Patrick G. Zeka, Ariana Michelozzi, Paola Scortichini, Matteo Hashizume, Masahiro Honda, Yasushi Hurtado, Magali Cruz, Julio Seposo, Xerxes Nunes, Baltazar Teixeira, Joao Paulo Tobias, Aurelio Iniguez, Carmen Forsberg, Bertil Astrom, Christofer Vicedo-Cabrera, Ana Maria Ragettli, Martina S. Guo, Yue-Liang Leon Chen, Bing-Yu Zanobetti, Antonella Schwartz, Joel Tran Ngoc Dang, Oal Dung Do Van, Oal Mayvaneh, Fetemeh Overcenco, Ala Li, Shanshan Guo, Yuming [a]Graduate School of Public Health Institute of Health and Environment Seoul National University Seoul Republic of Korea [b]Department of Social and Environmental Health Research London School of Hygiene & Tropical Medicine London UK [c]School of Forestry and Environmental Studies Yale University New Haven CT USA [d]Air Health Science Division Health Canada Ottawa ON Canada [e]School of Epidemiology & Public Health University of Ottawa Ottawa ON Canada [f]Universidad de Buenos Aires Facultad de Ciencias Sociales Instituto de Investigaciones Gino Germani Buenos Aires Argentina [g]School of Public Health Institute of Environment and Human Health Anhui Medical University Hefei China [h]Shanghai Children's Medical Centre Shanghi Jiao-Tong University Shanghai China [i]School of Public Health and Social Work Queensland University of Technology Brisbane QLD Australia [j]Institute of Advanced Studies of the University of São Paulo São Paulo Brazil [k]Climate Change Cluster Faculty of Sciences University of Technology–Sydney Sydney Australia [l]Department of Public Health Universidad de los Andes Santiago Chile [m]School of Public Health Key Lab of Public Health Safety of the Ministry of Education Key Lab of Health Technology Assessment of the Ministry of Health Fudan University Shanghai China [n]Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3) Fudan University Shanghai China [o]Hospital Vista Hermosa Bogotá Colombia [p]Institute of Atmospheric Physics Czech Academy of Sciences Prague Czech Republic [q]Faculty of Environmental Sciences Czech University of Life Sciences Prague Czech Republic [r]Institute of Family Medicine and Public Health University of Tartu Tartu Estonia [s]Department of Public Health and Clinical Medicine Umeå University Umeå Sweden [t]Center for Environmental and Respiratory Health Research University of Oulu Oulu Finland [u]Santé Publique France French National Public Health Agency Saint Maurice Fra

An increase in the global health burden of temperature was projected for 459 locations in 28 countries worldwide under four representative concentration pathway scenarios until 2099. We determined that the amount of temperature increase for each 100 ppm increase in global CO2 concentrations is nearly constant, regardless of climate scenarios. The overall average temperature increase during 2010-2099 is largest in Canada (1.16 degrees C/100 ppm) and Finland (1.14 degrees C/100 ppm), while it is smallest in Ireland (0.62 degrees C/100 ppm) and Argentina (0.63 degrees C/100 ppm). In addition, for each 1 degrees C temperature increase, the amount of excess mortality is increased largely in tropical countries such as Vietnam (10.34%p degrees C) and the Philippines (8.18%p degrees C), while it is decreased in Ireland (-0.92%p degrees C) and Australia (-0.32%p degrees C). To understand the regional variability in temperature increase and mortality, we performed a regression-based modeling. We observed that the projected temperature increase is highly correlated with daily temperature range at the location and vulnerability to temperature increase is affected by health expenditure, and proportions of obese and elderly population.

关键词： Projection Mortality Climate change Regional variation Vulnerability

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Advances in understanding high-mass X-ray binaries with INTEGRAL and Future Directions

arXiv

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arXiv 2020年

作者： Kretschmar, Peter Fürst, Felix Sidoli, Lara Bozzo, Enrico Alfonso-Garzón, Julia Bodaghee, Arash Chaty, Sylvain Chernyakova, Masha Ferrigno, Carlo Manousakis, Antonios Negueruela, Ignacio Postnov, Konstantin Paizis, Adamantia Reig, Pablo Rodes-Roca, José Joaquín Tsygankov, Sergey Bird, Antony J. né Kühnel, Matthias Bissinger Blay, Pere Caballero, Isabel Coe, Malcolm J. Domingo, Albert Doroshenko, Victor Ducci, Lorenzo Falanga, Maurizio Grebenev, Sergei A. Grinberg, Victoria Hemphill, Paul Kreykenbohm, Ingo née Fritz, Sonja Kreykenbohm Li, Jian Lutovinov, Alexander A. Martínez-Núñez, Silvia Mas-Hesse, J. Miguel Masetti, Nicola McBride, Vanessa A. Neronov, Andrii Pottschmidt, Katja Rodriguez, Jérôme Romano, Patrizia Rothschild, Richard E. Santangelo, Andrea Sguera, Vito Staubert, Rüdiger Tomsick, John A. Torrejón, José Miguel Torres, Diego F. Walter, Roland Wilms, Jörn Wilson-Hodge, Colleen A. Zhang, Shu E-28692 Spain E-28692 Spain INAF - IASF Istituto di Astrofisica Spaziale e Fisica Cosmica Via A. Corti 12 MilanoI-20133 Italy Department of Astronomy ISDC University of Geneva Chemin d'Ecogia 16 VersoixCH-1290 Switzerland E-28692 Spain Department of Chemistry Physics and Astronomy Georgia College and State University MilledgevilleGA31061 United States AIM CEA CNRS Université Paris-Saclay Université de Paris Gif-sur-YvetteF-91191 France Université de Paris CNRS Astroparticule et Cosmologie ParisF-75006 France School of Physical Sciences and CfAR Dublin City University Dublin 9 Ireland Dublin Institute for Advanced Studies 31 Fitzwilliam Place Dublin 2 Ireland Department of Applied Physics & Astronomy University of Sharjah Sharjah United Arab Emirates Sharjah United Arab Emirates Department of Applied Physics University of Alicante AlicanteE-03080 Spain Sternberg Astronomical Institute Moscow State University Moscow119234 Russia Kazan Federal University Kazan Russia Institute of Astrophysics Foundation for Research and Technology-Hellas Heraklion Crete71110 Greece University of Crete Physics Department Institute of Theoretical & Computational Physics Heraklion Crete70013 Greece Department of Physics Systems Engineering and Signal Theory University of Alicante AlicanteE-03690 Spain University Institute of Physics Applied to Sciences and Technologies University of Alicante AlicanteE-03690 Spain Department of Physics and Astronomy University of Turku FI-20014 Finland Space Research Institute The Russian Academy of Sciences Profsoyuznaya Str. 84/32 Moscow117997 Russia School of Physics and Astronomy Faculty of Physical Sciences and Engineering University of Southampton SouthamptonSO17 1BJ United Kingdom Erwin-Rommel-Strae 1 Erlangen91058 Germany Universidad Internacional de Valencia - VIU C/Pintor Sorolla 21 Valencia46002 Spain E-28692 Spain Institut für Astronomie und Astrophysik Universität Tübingen Sand 1 Tübingen

High mass X-ray binaries are among the brightest X-ray sources in the Milky Way, as well as in nearby Galaxies. Thanks to their highly variable emissions and complex phenomenology, they have attracted the interest of the high energy astrophysical community since the dawn of X-ray Astronomy. In more recent years, they have challenged our comprehension of physical processes in many more energy bands, ranging from the infrared to very high energies. In this review, we provide a broad but concise summary of the physical processes dominating the emission from high mass X-ray binaries across virtually the whole electromagnetic spectrum. These comprise the interaction of stellar winds with the high gravitational and magnetic fields of compact objects, the behaviour of matter under extreme magnetic and gravity conditions, and the perturbation of the massive star evolutionary processes by presence in a binary system. We highlight the role of the INTEGRAL mission in the discovery of many of the most interesting objects in the high mass X-ray binary class and its contribution in reviving the interest for these sources over the past two decades. We show how the INTEGRAL discoveries have not only contributed to significantly increase the number of high mass X-ray binaries known, thus advancing our understanding of the population as a whole, but also have opened new windows of investigation that stimulated the multi-wavelength approach nowadays common in most astrophysical research fields. We conclude the review by providing an overview of future facilities being planned from the X-ray to the very high energy domain that will hopefully help us in finding an answer to the many questions left open after more than 18 years of INTEGRAL scientific observations. Copyright © 2020, The Authors. All rights reserved.

关键词： Galaxies

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Application of a new modelling tool for simulating the continuous casting of steel: Steel sim 6

Application of a new modelling tool for simulating the conti...

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6th International Congress on the science and technology of Steelmaking, ICS 2015

作者： Ruvalcaba, Démian Li, Hongxiang Mortensen, Dag Van Der Plas, Dirk Zhuang, Lin Fjaer, Hallvard Research and Development Tata Steel IJmuiden1970 CA Netherlands State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing100083 China Computational Materials Processing Department Institute for Energy Technology KjellerN-2027 Norway

An FEM (Finite Element Method) model, called SteelSim, was developed in order to study the influence of casting parameters and roll alignment on the local deformation of a slab during continuous casting of steel. The model is applied to study Liquid Core Reduction in a thin slab caster. The results presented here show that the model is capable in determining the local distribution of stresses, influenced by roll alignment, which affect the deformation of the narrow face of the slab. Eventually, the model can be utilized for determining the optimal roll configuration and casting conditions (such as: casting speed, cooling, etc.) for a given steel, in order to avoid the formation of casting defects, such as: excessive bulging, segregation, cracking etc., which may lead to bad product quality or even to a catastrophic event such as a breakout.

关键词： Continuous casting

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26th Annual computational Neuroscience Meeting (CNS*2017) of the Organization for computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROscience 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT

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Journal of Structural and Functional Genomics 2015年第2期16卷 55-65页

作者： Tochio, Naoya Umehara, Takashi Nakabayashi, Kazuhiko Yoneyama, Misao Tsuda, Kengo Shirouzu, Mikako Koshiba, Seizo Watanabe, Satoru Kigawa, Takanori Sasazuki, Takehiko Shirasawa, Senji Yokoyama, Shigeyuki RIKEN Systems and Structural Biology Center 1-7-22 Suehiro-cho Tsurumi Yokohama 230-0045 Japan Department of Mathematical and Life Sciences Research Center for the Mathematics on Chromatin Live Dynamics Graduate School of Science Hiroshima University 1-3-1 Kagamiyama Higashi-Hiroshima 739-8530 Japan RIKEN Center for Life Science Technologies 1-7-22 Suehiro-cho Tsurumi Yokohama 230-0045 Japan PRESTO Japan Science and Technology Agency (JST) 1-7-22 Suehiro-cho Tsurumi Yokohama 230-0045 Japan Department of Maternal-Fetal Biology National Research Institute for Child Health and Development Tokyo 157-8535 Japan Department of Integrative Genomics Tohoku Medical Megabank Organization Tohoku University 2-1 Seiryo-machi Aoba-ku Sendai 980-8573 Japan RIKEN Quantitative Biology Center 1-7-22 Suehiro-cho Tsurumi Yokohama 230-0045 Japan Department of Computational Intelligence and Systems Science Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology 4259 Nagatsuta-cho Midori Yokohama 226-8502 Japan Institute for Advanced Studies Kyushu University 6-10-1 Hakozaki Higashi-ku Fukuoka 812-8582 Japan Department of Cell Biology Faculty of Medicine Fukuoka University Fukuoka 814-0180 Japan Center for Advanced Molecular Medicine Fukuoka University Fukuoka 814-0180 Japan RIKEN Structural Biology Laboratory 1-7-22 Suehiro-cho Tsurumi Yokohama 230-0045 Japan

ZFAT is a transcriptional regulator, containing eighteen C2H2-type zinc-fingers and one AT-hook, involved in autoimmune thyroid disease, apoptosis, and immune-related cell survival. We determined the solution structur... 详细信息

ZFAT is a transcriptional regulator, containing eighteen C₂H₂-type zinc-fingers and one AT-hook, involved in autoimmune thyroid disease, apoptosis, and immune-related cell survival. We determined the solution structures of the thirteen individual ZFAT zinc-fingers (ZF) and the tandemly arrayed zinc-fingers in the regions from ZF2 to ZF5, by NMR spectroscopy. ZFAT has eight uncommon bulged-out helix-containing zinc-fingers, and six of their structures (ZF4, ZF5, ZF6, ZF10, ZF11, and ZF13) were determined. The distribution patterns of the putative DNA-binding surface residues are different among the ZFAT zinc-fingers, suggesting the distinct DNA sequence preferences of the N-terminal and C-terminal zinc-fingers. Since ZFAT has three to five consecutive tandem zinc-fingers, which may cooperatively function as a unit, we also determined two tandemly arrayed zinc-finger structures, between ZF2 to ZF4 and ZF3 to ZF5. Our NMR spectroscopic analysis detected the interaction between ZF4 and ZF5, which are connected by an uncommon linker sequence, KKIK. The ZF4–ZF5 linker restrained the relative structural space between the two zinc-fingers in solution, unlike the other linker regions with determined structures, suggesting the involvement of the ZF4–ZF5 interfinger linker in the regulation of ZFAT function. © 2015, The Author(s).

关键词： Gene expression NMR Transcription Zinc-finger

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Highlights from the 11th ISCB Student Council Symposium 2015. Dublin, Ireland. 10 July 2015

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BMC bioinformatics 2016年第3期17 Suppl 3卷 95页

作者： Katie Wilkins Mehedi Hassan Margherita Francescatto Jakob Jespersen R. Gonzalo Parra Bart Cuypers Dan DeBlasio Alexander Junge Anupama Jigisha Farzana Rahman Griet Laenen Sander Willems Lieven Thorrez Yves Moreau Nagarajan Raju Sonia Pankaj Chothani C. Ramakrishnan Masakazu Sekijima M. Michael Gromiha Paddy J Slator Nigel J Burroughs Przemysław Szałaj Zhonghui Tang Paul Michalski Oskar Luo Xingwang Li Yijun Ruan Dariusz Plewczynski Giulia Fiscon Emanuel Weitschek Massimo Ciccozzi Paola Bertolazzi Giovanni Felici Pieter Meysman Manu Vanaerschot Maya Berg Hideo Imamura Jean-Claude Dujardin Kris Laukens Westa Domanova James R. Krycer Rima Chaudhuri Pengyi Yang Fatemeh Vafaee Daniel J. Fazakerley Sean J. Humphrey David E. James Zdenka Kuncic Plant Pathology and Plant-Microbe Biology Section School of Integrative Plant Science Cornell University Ithaca USA Graduate Field of Computational Biology Cornell University Ithaca USA School of Computing & Mathematics University of South Wales Cardiff UK Department of Genome Biology for Neurodegenerative Diseases German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz Association ᅟ Germany Department of Surgery Massachusetts General Hospital The Broad Institute of MIT and Harvard Boston USA Department of Systems Biology Technical University of Denmark Kemitorvet Denmark Protein Physiology Lab Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Molecular Parasitology Unit (MPU) Institute of Tropical Medicine Antwerp Belgium Advanced Database Research and Modeling (ADReM) research group University of Antwerp Antwerpen Belgium Department of Computer Science University of Arizona Tucson USA Department of Veterinary Clinical and Animal Sciences Center for non-coding RNA in Technology and Health University of Copenhagen Copenhagen Denmark University College Dublin Dublin Ireland Department of Electrical Engineering (ESAT) STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Minds Medical IT Department Leuven Belgium Scientific Institute of Public Health (WIV-ISP) Platform of Biotechnology and Molecular Biology (PBB) Brussels Belgium Department of Development and Regeneration @ Kulak KU Leuven Kortrijk Belgium Department of Biotechnology Bhupat and Jyoti Metha School of Biosciences Indian Institute of Technology Madras Chennai India Philips Research North America Briarcliff Manor USA Global Scientific Information and Computing Center (GSIC) Tokyo Institute of Technology Tokyo Japan Systems Biology Centre University of Warwick Senate House Coventry UK Systems Biology Doctoral Training Centre University of Warwick Senate House Coventry UK Center for B

A1 Highlights from the eleventh ISCB Student Council Symposium 2015 Katie Wilkins, Mehedi Hassan, Margherita Francescatto, Jakob Jespersen, R. Gonzalo Parra, Bart Cuypers, Dan DeBlasio, Alexander Junge, Anupama Jigisha, Farzana Rahman O1 Prioritizing a drug’s targets using both gene expression and structural similarity Griet Laenen, Sander Willems, Lieven Thorrez, Yves Moreau O2 Organism specific protein-RNA recognition: A computational analysis of protein-RNA complex structures from different organisms Nagarajan Raju, Sonia Pankaj Chothani, C. Ramakrishnan, Masakazu Sekijima; M. Michael Gromiha O3 Detection of Heterogeneity in Single Particle Tracking Trajectories Paddy J Slator, Nigel J Burroughs O4 3D-NOME: 3D NucleOme Multiscale Engine for data-driven modeling of three-dimensional genome architecture Przemysław Szałaj, Zhonghui Tang, Paul Michalski, Oskar Luo, Xingwang Li, Yijun Ruan, Dariusz Plewczynski O5 A novel feature selection method to extract multiple adjacent solutions for viral genomic sequences classification Giulia Fiscon, Emanuel Weitschek, Massimo Ciccozzi, Paola Bertolazzi, Giovanni Felici O6 A Systems Biology Compendium for Leishmania donovani Bart Cuypers, Pieter Meysman, Manu Vanaerschot, Maya Berg, Hideo Imamura, Jean-Claude Dujardin, Kris Laukens O7 Unravelling signal coordination from large scale phosphorylation kinetic data Westa Domanova, James R. Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J. Fazakerley, Sean J. Humphrey, David E. James, Zdenka Kuncic

关键词： Visceral Leishmaniasis Feature Selection Method Frequent Itemset Mining Leishmania Donovani Student Council

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