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Anti-inflammatory and anabolic biphasic scaffold facilitates osteochondral tissue regeneration in osteoarthritic joints

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Journal of Materials Science & technology 2023年第25期156卷 20-31页

作者： Xiangbo Meng Ling Li Cuishan Huang Keda Shi Qingqiang Zeng Chunyi Wen Sibylle Grad Mauro Alini Ling Qin Xinluan Wang Translational Medicine R&D Center Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China AO Research Institute Davos Clavadelerstrasse 8Davos Platz 7270Switzerland Musculoskeletal Research Laboratory Department of Orthopaedics & TraumatologyThe Chinese University of Hong KongHong Kong SAR 999077China CAS-HK Joint Lab of Biomaterials Joint Laboratory of Chinese Academic of Science and Hong Kong for BiomaterialsTranslational Medicine Research and Development CenterShenzhen Institutes of Advanced Technology of Chinese Academy of Sciences and The Chinese University of Hong KongChina Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

Osteochondral defects (OCD) are common but difficult to heal due to the low intrinsic repair capacity of cartilage and its complex hierarchical structure. In osteoarthritis (OA), OCD become more challenging to repair as both cartilage and subchondral bone regeneration are further impaired due to the arthritic environment. Numerous biomaterials have been developed and tested in osteochondral defects while ignoring the inflammatory environment. To target this challenging underlying pathophysiology, we designed and fabricated a biphasic porous and degradable scaffold incorporating anti-inflammatory and anabolic molecules by low-temperature rapid prototyping technology, and its effects on promoting osteochondral regeneration were evaluated using our well-established OA-OCD rabbit model. The biphasic porous scaffolds consisted of poly lactic-co-glycolic acid (PLGA) with kartogenin (KGN) for cartilage repair and PLGA and β-calcium phosphate (PLGA/β-TCP) with cinnamaldehyde (CIN) for subchondral bone repair. KGN is a molecule for promoting chondrogenesis and CIN is a phytomolecule for enhancing osteogenesis and alleviating inflammation. The biphasic scaffolds PLGA/KGN-PLGA/β-TCP/CIN (PK/PTC) with bio-mimic structure provided stable mechanical properties and exhibited excellent biocompatibility to support cell adhesion, proliferation, migration, and distribution. Furthermore, KGN and CIN within biphasic scaffolds could be released in a controlled and sustained mode, and the biphasic scaffold degraded slowly in vitro . Evaluating the repair of 16-weeks post-implantation into critically sized OA-OCD rabbit models revealed that the biphasic scaffold could promote subchondral bone and cartilage regeneration, as well as reverse subchondral osteosclerosis caused by inflammation in vivo . These findings support the utilization of the PK/PTC scaffold for osteochondral regeneration and provide a promising potential strategy for clinical application for the treatment of patients with

关键词： Biphasic scaffold Osteochondral defect Osteoarthritis Kartogenin Cinnamaldehyde Anti-inflammation

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Recent advances in zinc-based chalcogenides for potassium ion batteries

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Resources Chemicals and Materials 2024年第4期3卷 279-293页

作者： Xijun Xu Tao Yang Fangkun Li Shaomin Ji Jingwei Zhao Yanping Huo Jun Liu School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510641China Research and Development Center Guangzhou Tinci Materials Technology Co.Ltd.Guangzhou510765China

Lithium-ion batteries(LIBs)gradually occupied the energy storage market due to their long cycling life;high working voltage;as well as energy ***;LIBs have high costs due to the limited lithium resource and difficulty to *** ion batteries(PIBs)have aroused extensive attention over the past few years since they possess considerable potassium salt resources while exhibiting similar electrochemical properties to *** electrode material takes on great significance in determining the properties exhibited by the ***-based chalcogenides have served as the most suitable anode materials for their numerous raw material resources;low prices;and environmental ***;the application of Zinc-based chalcogenides has been continuously hindered by sluggish diffusion kinetics;low electrical conductivity;as well as huge volume *** effective strategies have been explored to settle the above matters(e.g.;designing nanostructures;constructing carbon composite structures;as well as doping anions or cations to construct heterojunction).In this review;the recent advance of zinc-based chalcogenides(e.g.;electrochemical mechanisms;challenges;and perspectives)are *** review can provide novel insights into the development of transition metal chalcogenides for PIBs.

关键词： Zn-based chalcogenides Anode Potassium ion batteries Nanostructuring Carbon modify

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Multifunction integration within magnetic CNT-bridged MXene/CoNi based phase change materials

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eScience 2024年第6期4卷 108-117页

作者： Yan Gao Xiao Chen Xu Jin Chenjun Zhang Xi Zhang Xiaodan Liu Yinhui Li Yang Li Jinjie Lin Hongyi Gao Ge Wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China School of Physics and Astronomy Beijing Normal UniversityBeijing 100875China Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China Micro-Nano System Research Center College of Information and Optical EngineeringTaiyuan University of TechnologyTaiyuanShanxi 030024China Shunde Graduate School University of Science and Technology BeijingShunde 528399China

Developing advanced nanocomposite phase change materials(PCMs)integrating zero-energy thermal management,microwave absorption,photothermal therapy and electrical signal detection can promote the leapfrog development of flexible wearable electronic *** this goal,we propose a multidimensional collaborative strategy combining two-dimensional(2D)MXene nanosheets with metal-organic framework-derived onedimensional(1D)carbon nanotubes(CNTs)and zero-dimensional(0D)metal *** encapsulating paraffin wax(PW)in three-dimensional(3D)networked multidimensional MXene/CoNi-C,the resulting composite PCMs exhibit excellent thermal energy storage capacity and long-term thermally reliable *** from the synergistically enhanced photothermal effects of CNTs,Co/Ni nanoparticles and MXene,PW@MXene/CoNi-C can capture photons efficiently and transfer phonons quickly,yielding an ultrahigh photothermal conversion and storage efficiency of 97.5%.Additionally,PW@MXene/CoNi-C composite PCMs exhibit high microwave absorption with a minimum reflection loss of -49.3 dB at 8.03 GHz in heat-related electronic application *** attractively,the corresponding flexible phase change film can simultaneously achieve thermal management and electromagnetic shielding of electronic devices,as well as photothermal therapy and electrical signal detection for *** functional integration design provides an important reference for developing advanced flexible multifunctional wearable materials and devices.

关键词： Phase change materials Metal-organic frameworks Two-dimensional MXene Photothermal conversion Thermal energy storage Microwave absorption

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Consistency Check for Multimodal Transportation Data: A Case Study of Vision and LiDARA 9

Consistency Check for Multimodal Transportation Data: A Case...

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9th International Conference on Information Management and technology, ICIMTech 2024

作者： Liu, Zhengyu Chen, Zhenwu Yang, Xiangmin Peng, Lei Software Engineering Institute University of Science and Technology of China HeFei230026 China Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Research Center for Automotive Electronics ShenZhen518055 China Shenzhen Urban Transport Planning Center Co. Ltd. Innovation Center for ITS ShenZhen518063 China Shenzhen Shenzhentong Co. Ltd. Dept. Research and Development ShenZhen518131 China

ISBN: (纸本)9798350390025

This study proposes a novel consistency verification method for multimodal transportation data, targeting spatial feature issues caused by multisource heterogeneous data in the transportation field. We unify different sources of data and point cloud data into a single 3D space through image data dimensionality increase and point cloud registration, addressing data inconsistencies caused by perspective differences. Through the application of data dimensionality augmentation and point cloud registration, our method effectively resolves spatial feature discrepancies between various data sources, significantly improving the accuracy of consistency verification. Experimental results indicate that the model trained with our method exhibits superior precision in consistency verification of multisource heterogeneous data compared to traditional approaches. © 2024 IEEE.

关键词： Spatio-temporal data

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F3FAD: Fast 3D Facial Avatar Digitization With XR Cloud Service 24

F3FAD: Fast 3D Facial Avatar Digitization With XR Cloud Serv...

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24th IEEE International Conference on High Performance Computing and Communications, 8th IEEE International Conference on Data Science and Systems, 20th IEEE International Conference on Smart City and 8th IEEE International Conference on Dependability in Sensor, Cloud and Big Data Systems and Application, HPCC/DSS/SmartCity/DependSys 2022

作者： Yang, Qing Zhang, Hua Beijing Engineering Research Center of Mixed Reality and Advanced Display Beijing Institute of Technology China Intel China Research Center Ltd. China Intel Asia-Pacific Research and Development Ltd. China

ISBN: (纸本)9798350319934

As 3D Facial Avatar Digitization has become an increasingly important and popular feature for Extended Reality (XR), a high-fidelity and specially customized face avatar can greatly improve immersive experience for users who have been engaged in the virtual space. In this paper, we propose Fast 3D Facial Avatar Digitization (F3FAD), a novel end-to-end deep learning method for digitizing highly detailed 3D faces from a single image. There are four advantages of the F3FAD. Unlike previous works, F3FAD can infer both 3D mesh surface and color texture for overall human head model from a single view. There would be no need for sophisticated 3D scanning devices, multi-view stereo algorithms, or tedious capture procedures of hand-hold devices. It merely takes a single picture to digitize an entire face in the 3D world. Next, face attributes of the avatar can be freely manipulated according to user's preference. Thirdly, the avatar can be physically driven by multiple modalities of message inputs. At last, we have designed a novel AI computing framework to intelligently arrange the workload of F3FAD pipeline on a server-client system. In addition, we demonstrate the F3FAD technology with a speech-driven talking avatar, to showcase the advantages of our technology and system design in the real-world scenario. © 2022 IEEE.

关键词： Deep learning

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Life cycle assessment and economic analysis of HFC-134a production from natural gas compared with oil-based and coal-based production

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1713-1725页

作者： Suisui Zhang Gang Li Boyang Bai Luyao Qiang Xiaoxun Ma Jingying Li School of Chemical Engineering Northwest UniversityXi’an 710069China Chemical Engineering Research Center of the Ministry of Education(MOE)for Advanced Use Technology of Shanbei Energy Xi’an 710069China Shaanxi Research Center of Engineering Technology for Clean Coal Conversion Xi’an 710069China Collaborative Innovation Center for Development of Energy and Chemical Industry in Northern Shaanxi Xi’an 710069China International Scientific and Technological Cooperation Base of the Ministry of Science and Technology(MOST)for Clean Utilization of Hydrocarbon Resources Xi’an 710069China Longdong University Qingyang 745000China

China is the largest producer and consumer of HFC-134a(1,1,1,2-tetrafluoroethane)in the ***-based route is mainly adopted to produce HFC-134a,which suffers from large waste and CO_(2) *** gas is a low-carbon and clean energy resource,and no research has been found on the environment and economy of producing HFC-134a from natural *** this study,CML 2001 method was used to carry out the life cycle assessment of natural gas(partial oxidation)-based and natural gas(plasma cracking)-based routes(abbreviated as gas(O)-based and gas(P)-based routes,respectively),and their environmental performances were compared with coal-based and oil-based ***,considering that China is vigorously promoting the transformation of energy structure,and the application of electric heating equipment to replace fossil-based heating equipment in industrial field,which has a great impact on the environmental performance of the production processes,the authors conducted a scenario *** results showed that the gas(O)-based route had the most favourable environmental ***,the gas(P)-based route had the highest potential for reducing environmental burdens,and its environmental benefit was the most favourable in scenario ***,the economic performance of the gas(P)-based route was significantly better than that of gas(O)-based and coal-based routes.

关键词： life cycle assessment economic performance HFC-134a natural gas oil coal

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Runx2 controls the osteogenic fate of growth plate chondrocytes

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Genes & Diseases 2025年第3期12卷 1-3页

作者： Daofu Zeng Jiamin Yu Ke Lu Dan Yi Zhidao Xia Ling Qin Guozhi Xiao Xiao Yang Liping Tong Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Faculty of Pharmaceutical Sciences Shenzhen University of Advanced TechnologyShenzhenGuangdong 518055China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institute of Life Science Swansea University Medical SchoolSwanseaSA28PPUK Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial&Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 518172China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China State Key Laboratory of Proteomics Genetic Laboratory of Development and DiseasesInstitute of BiotechnologyBeijing 100071China

The origin of bone marrow osteoblasts is not totally *** findings demonstrated that bone marrow osteoblasts could be derived from a subpopulation of hypertrophic Col2^(+)/Col10^(+)chondrocytes which migrate from the growth plate into the bone marrow cavity underneath the growth plate and dedifferentiate into mesenchymal progenitor cells and then differentiate into mature osteoblasts.1 This process is called chondrocyte-osteoblast *** type of osteoblast participates in bone formation and is involved in maintaining bone remodeling,especially in the epiphyseal and diaphyseal regions of long *** growth factors,such as Ihh,PTH,and Wnt signaling molecules have been demonstrated to play a critical role in the regulation of chondrocyte-osteoblast transdifferentiation2;however,the role of Runx2,the key transcription factor controlling skeletal development,3 in chondrocyte-osteoblast transdifferentiation has not been fully defined.

关键词： RUNX mesenchymal progenitor cells chondrocyte osteoblast transdifferentiation hypertrophic chondrocytes growth plate bone marrow bone marrow osteoblasts

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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei Chen Jingyi Wang Jing Liu Jianbang Lin Yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical Research Institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural ***,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and *** addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral ***,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque *** data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

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Broadband Perpendicular Permittivity Measurements up to 220 GHz Using a Balanced-Type Circular Disk Resonator Without Air Gap Errors

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IEEE Transactions on Instrumentation and Measurement 2025年 74卷

作者： Kato, Yuto Arakawa, Tomonori National Institute of Advanced Industrial Science and Technology National Metrology Institute of Japan Tsukuba305-8563 Japan National Institute of Advanced Industrial Science and Technology Global Research and Development Center for Business by Quantum-AI technology Tsukuba305-8560 Japan

This paper presents broadband perpendicular permittivity measurements at frequencies up to 220 GHz by using a balanced-type circular disk resonator (BCDR). To achieve this, we develop a BCDR excited by 0.6-mm coaxial lines. The developed resonator is designed to be connectable to a commercially available ultra-broadband vector network analyzer system with 0.6-mm coaxial interfaces, and provides broadband characterization of low-loss substrate materials owing to its mode-selective behavior. Moreover, we propose a new sample configuration for the BCDR method involving dielectric sheets metallized on both sides to eliminate air gaps between the sample and the resonator, which lead to measurement inaccuracies. The developed BCDR and proposed sample configuration are experimentally demonstrated up to 220 GHz by measuring three ceramic samples: fused silica, aluminum nitride, and alumina. The measured perpendicular permittivity results are in good agreement with those obtained using the split-cylinder resonator method and previously reported literature values. We also observe that conventional BCDR measurements using bare samples, without metallization on either side, underestimate the relative permittivity by 1.5 %, 5.5 %, and 4.9 % for fused silica, aluminum nitride, and alumina samples, respectively, owing to the air gap errors. Accurate perpendicular permittivity measurements using the improved BCDR method are expected to contribute to the development of advanced materials for 6G applications. © 1963-2012 IEEE.

关键词： Permittivity measurement

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Design,synthesis,and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

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Chinese Chemical Letters 2024年第3期35卷 326-331页

作者： Yu Wen Shichun Lun Yuxue Jiao Wei Zhang Tianyu Hu Ting Liu Fan Yang Jie Tang Bing Zhang William R.Bishai Li-Fang Yu Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Center for Tuberculosis Research Department of MedicineDivision of Infectious DiseaseJohns Hopkins School of MedicineBaltimoreMD21231-1044United States Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China

Inhibition of mycobacterial membrane protein large 3(MmpL3)thereby affecting the mycolic acid biosynthetic pathway has been proven to be an effective strategy for developing antitubercular *** on the X-ray crystal structure of MmpL3 inhibitor complexes,a series of novel 1,2,4-triazole derivatives were designed,synthesized and evaluated antitubercular activity against Mtb strain *** structure–activity relationship exploration resulted in the identification of compounds 21 and 28,which possess potent antitubercular activity against Mtb strain H37Rv[minimum inhibitory concentration(MIC)=0.03–0.13μg/mL]and the clinical isolates of multidrug resistance(MDR)and extensive drug resistance(XDR)tuberculosis(MIC=0.06–1.0μg/mL).Moreover,compounds 21 and 28 showed neglectable cytotoxicity(IC_(50)≥32μg/mL)to the mammalian Vero cells and favorable physicochemical and pharmacokinetic properties according to the in silico absorption,distribution,metabolism and excretion(ADME)***,the potential target of representative 1,2,4-triazole 28 was identified to be MmpL3 using a microscale thermophoresis(MST)assay.

关键词： Tuberculosis MDR and XDR-TB MmpL3 inhibitor 1 2 4-Triazole Structure-based drug design

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