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Magnesium alloy implant GZ31K with enhanced corrosion resistance promotes fracture healing in vitro and in vivo systems

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Journal of Magnesium and Alloys 2025年

作者： Yusufu, Yalikun Zhang, Yunyang Liu, Xinyun Jiang, Jiahao Shao, Zhiqiang Sun, Minghui Zhang, Xiaobo Jiang, Qing Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Jiangsu Nanjing210008 China State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Jiangsu Nanjing210008 China Branch of National Clinical Research Center for Orthopedics Sports Medicine and Rehabilitation Jiangsu Nanjing210008 China Institue of Medical 3D Printing Nanjing University Jiangsu Nanjing210008 China Jiangsu Engineering Research Center for 3D Bioprinting Jiangsu Nanjing210008 China Centre for Shared Scientific Research Facilities Nanjing University Jiangsu Nanjing210023 China School of Stomatology Xuzhou Medical University Jiangsu Xuzhou221004 China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and Engineering Nanjing Institute of Technology Jiangsu Nanjing211167 China

Magnesium and its alloys have garnered significant attention as promising materials for bone tissue engineering, owing to their bone-like density and elastic modulus, favorable mechanical properties, biodegradability, biocompatibility, and diverse biological activities. However, rapid degradation, subcutaneous gas formation from H2 release, and osteolysis caused by elevated Mg concentrations have limited its widespread clinical application. In this study, Mg-3.0Gd-1Zn-0.4Zr (GZ31K) alloy with desirable uniform degradation and stress corrosion resistance under extruded and drawn condition was used as internal fixation implants for fracture healing, while the commercially available WE43 alloy was used as control. Results revealed that GZ31K alloy exhibited refined grain structure, nanoscale distributed stacking faults and superior corrosion resistance compared to WE43 alloy. The corrosion rate of the extruded GZ31K and WE43 alloys are 0.25 mm/year and 0.35 mm/year, meeting the corrosion tolerance threshold for orthopedic implants ( © 2025

关键词： Corrosion resistant alloys

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Biohybrid-engineered tissue platforms: bridging the gap in tissue engineering

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Trends in Biotechnology 2025年

作者： Uijung Yong Jihwan Kim Jinah Jang Future IT Innovation Laboratory (i-Lab) Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea Department of Convergence IT Engineering Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea Center for 3D Organ Printing and Stem Cells Pohang University of Science and Technology (POSTECH) Pohang Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei University Seoul Republic of Korea

Biohybrid-engineered tissue (BHET) platforms represent a cutting-edge development in tissue engineering by integrating electronic components with engineered biological tissues to enable real-time monitoring, precise modulation, and enhancement of tissue functionality. Recently, biofabrication and biofunctional material advances have facilitated the design of BHET platforms that respond to intricate biological and bioelectrical signals to replicate sophisticated physiological processes. BHET platforms have potential in disease modeling, regenerative medicine, and personalized healthcare applications by bridging the gap between biological and electrical systems. In this review, we classify BHET platforms into three platforms (tissue-sensor, tissue-electromodulator, and tissue-communicator platforms) and explore future directions, including innovations in biofabrication and data-driven platform design alongside optimization to enhance the scalability and functionality of the engineered human tissues.

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Traffic Congestion Prediction using decision Tree, Logistic Regression and Neural Networks

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IFAC-PapersOnLine 2020年第5期53卷 512-517页

作者： Tariku Sinshaw Tamir Gang Xiong Zhishuai Li Hao Tao Zhen Shen Bin Hu Heruye Mulugeta Menkir State Key Laboratory for Management and Control of Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 China Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing Cloud Computing Center Chinese Academy of Sciences Dongguan 523808 China China Ship Development and Design Center Wuhan 430064 China Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Chinese Academy of Sciences Beijing 100190 China Debremarkos University Institute of Technology Debremarkos 269 Ethiopia

Traffic congestion is a serious problem around the world and to a great extent influences urban communities in various manners including increased stress levels, delayed deliveries, fuel wastage, and monetary losses. Therefore, an accurate congestion prediction algorithm to limit these misfortunes is fundamental. This paper presents a comparative study of traffic congestion prediction systems including decision tree, logistic regression, and neural networks. Five days of traffic information (1,231,200 samples) are utilized to drive the prediction model. The TensorFlow and the Clementine machine learning platforms are used for data preprocessing, training, and testing of the model. The confusion matrix clears that decision tree has better prediction performance and leads the other two methods with accuracy (97%), macro-average precision (95%), macro-average recall (96%), and macro-average F1_score (96%) in the python programming environment. Moreover, performance of the three prediction models is verified in Clementine environment and decision tree outperforms all other models with an accuracy of 97.65%.

关键词： Confusion matrix data preprocessing Python TensorFlow Clementine environment ITS

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Additive manufacturing of hydroxyapatite and its composite materials: A review

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Journal of Micromechanics and Molecular Physics 2020年第3期5卷

作者： Yan, Chunze Ma, Gao Chen, Annan Chen, Ying Wu, Jiamin Wang, Wei Yang, Shoufeng Shi, Yusheng State Key Laboratory of Material Processing and Die & Mould Technology School of Material Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministry of Education Wuhan 430074 China Zhejiang Huake 3D Technology Co.Ltd Wenzhou 325004 China Department of Mechanical Engineering KU Leuven (University of Leuven) Leuven 3001 Belgium

Hydroxyapatite (HA) is a promising biomaterial for tissue engineering scaffolds due to its similar performance and composition to natural bone. However, the brittleness and poor toughness of pure HA limit its clinical application. Therefore, a lot of HA composites have been prepared to improve their mechanical performance. Fabricating complex and customized tissue engineering HA scaffolds have a very high requirement for manufacturing processes. It is difficult to fabricate ideal HA porous structures for artificial bone implants using traditional manufacturing processes, such as plasma spraying–sintering, and injection forming. Additive manufacturing (AM) could make three-dimensional physical parts with complex structures directly from computer-aided-design (CAd) models in a layer-by-layer way, and therefore show unique advantages in fabricating bone tissue engineering scaffolds with complex external shape and internal microporous structures. This paper reviews the state of the art for the preparation and AM process of HA and its composite materials, and raises the prospects for this research field. © World Scientific. All rights reserved.

关键词： Additive manufacturing Biomaterial HA composite materials Hydroxyapatite Tissue engineering scaffold

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Multi-Nozzle Pneumatic Extrusion Based Additive Manufacturing System for Fabricating a Sandwich Structure with Soft and Hard material

Multi-Nozzle Pneumatic Extrusion Based Additive Manufacturin...

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International Conference on Machine Learning and Cybernetics (ICMLC)

作者： Kai-Wei Chen Ming-Jong Tsai Institute of Automation and Control National Taiwan University of Science and Technology Taipei Taiwan High Speed 3D Printing Research Center National Taiwan University of Science and Technology Taipei Taiwan

ISBN: (纸本)9781728128177

The additive manufacturing is an intelligent manufacturing technology that can quickly build a variety of complex objects with single or different functional materials. If additive manufacturing technology can be used to print mechanical structure with sensing or electronic feature, it will be able to break through the development bottleneck of a smart gripper and achieve the goal of rapid industrial development. In this study, a multi-nozzle pneumatic extrusion additive manufacturing system for printing soft and hard material structure was developed. The structure is made of a multi-material polymer which can be fabricated by using 3d printing machine. The liquid material is extruded through a tiny nozzle and then cured by a UV lighting source. The system architecture includes a CNC controller, which controls the nozzle through two stepping motors, both positive and negative pressures and curing light source are also manipulated with peripheral I/Os. A dA controller is also applied to flexibly control the air pressure for requirement of different injected flow speed. The program part is automatically executed with a numerical control software in CNC and PLC. different pressures were set for extrusion nozzles with different materials. The G-code data was processed by Python Language and sent to the multi-nozzle pneumatic extrusion additive manufacturing system. This paper successfully printed a sandwich pad with soft and hard material structure, including double-layer material pad and three-layer material pad. A finer printing performance than a traditional FdM machine is achieved.

关键词： Additive manufacturing Pneumatic extrusion system Multi-material Smart sensing component printing, Three-dimensional Additive manufacturing sandwich structures FLEXIBLE Pneumatic extrusion Manufacturing systems program part Air Pressure nozzles materials Computer numerical control STRUCTURES(BY material) Manufacturing technology Functional materials

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Microstructural evolution and mechanical instability of Mar-M509 superalloy fabricated by laser powder bed fusion under short-term thermal exposure

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materials Science and Engineering: A 2025年 940卷

作者： Cao, Tingwei Chen, Chaoyue Wei, daixiu Zhao, Ruixin Hou, Yuyang Lu, Lin Yang, Tao Ke, Linda Gong, Wu Kawasaki, Takuro Harjo, Stefanus Shi, Lei Lei, Liming Wang, Jiang Ren, Zhongming State Key Laboratory of Advanced Special Steels School of Materials Science and Engineering Shanghai University Shanghai200444 China Jiangsu Belight Laboratory State Key Laboratory of Advanced Casting Technologies Nanjing University of Science and Technology Nanjing210094 China Shanghai Engineering Research Center of 3D Printing Materials Shanghai Research Institute of Materials Co. Ltd Shanghai200437 China Department of Materials Science and Engineering City University of Hong Kong China Shanghai Engineering Technology Research Center for Near-net Forming of Metal Materials Shanghai Aerospace Precision Machinery Institute Shanghai200444 China J-PARC Center Japan Atomic Energy Agency 2-4 Shirakata Tokai Naka-gun Ibaraki319-1195 Japan AECC Shanghai Commercial Aircraft Engine Manufacturing Co. Ltd. Shanghai201306 China TaiHang Laboratory Chengdu610213 China

The thermal stability of microstructure and mechanical performance is crucial for the industrial application of laser powder bed fusion (LPBF) superalloy components in gas turbines and jet engines. This work investigated the microstructural evolution and strengthening mechanism of LPBF Mar-M509 cobalt-based superalloy before and after thermal exposure at 1200 °C using multi-scale microstructural characterization and in situ neutron diffraction tensile testing. The as-built Mar-M509 superalloy exhibited a heterogeneous microstructural features with coarse columnar and fine equiaxed grains, both containing dendritic and cellular substructures enriched with nanoscale carbides and high-density dislocations. The ultra high strength (1504 ± 4 MPa) of the as-built sample was primarily attributed to dislocation-precipitation synergistic strengthening. After thermal exposure at 1200 °C for 4 h, the dendritic and cellular substructures disappeared and the dislocation density decreased significantly. Meanwhile, Cr, Ta, and other solute elements segregated along fast diffusion channels such as dislocations, stacking faults, and grain boundaries, and combined with the liberated carbon to re-precipitate as coarse M23C6 and MC carbides. The precipitation of microscale M23C6 carbides at the grain boundaries not only weakened the Orowan strengthening mechanism but also reduced the grain boundary strength, resulting in a decrease in the tensile strength to 1192 ± 8 MPa. High-temperature stress rupture testing further revealed microstructural instability in the as-built sample, which adversely affected its stress rupture life. Although the elongation of the sample after thermal exposure decreased from 25.9 % to 10.64 %, its stress rupture life increased from 119:01 h:min to 331 h. This study reveals the microstructural evolution and instability of LPBF Mar-M509 superalloy under high-temperature exposure and the impacts on mechanical properties, which provides critical support for the

关键词： Tensile testing

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Medical Additive Manufacturing: From a Frontier technology to the research and development of Products

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Engineering 2020年第11期6卷 1217-1221页

作者： Guixing Qiu Wenjiang ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu du Jimin Chen Mo Elbestawi Zhongwei Gu dichen Li Wei Sun Yuanjin Zhao Jie He dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong dewei Zhao dingjun Hao Yingfang Ao Xuliang deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Science 8 Peking Union Medical CollegeBejjing 100730.China National Engineering Research Center of Light Alloys Net Forming&State Key Laboratony of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Notional Engineering Research Center of Mg Materials and Applicarions and School of Materials Science 8r Engineering.Shanghai Jlao Tong University Shanghai 200240China Department of Spine Surgery Beijing Jishuitan HospitalBeijing 100035China Center for Troanslational Medicine Research and Development Institute of Biomedical and Health EngineeringShenzhen Insitute of Advanced Technology.Chinese Academy of SciencesShenzhen 518055China Guangdong Engineering Laboratony of Biomaterials Additive Manufacturing Guangdong 518055China Musculoskeletal Research Laboratory of the Department of Orthopedics 8 Traumatology and Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Center for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstiuteShenzhen 518057.China Hong Kong Branch of National Precious Metals Material Engineering Research Center Department of Material Science and EngineeringCity Untiversity of Hong KongHong Kong 999077.China Department of Mechanical Engineering ity Untiversity of Hong Kong.Hong Kong 9977 China School of Pharmacy.Shanghai Jiao Tong University Shanghai 200240China China State Instute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical IndustryShonghai 201203China Shanghai Innovation Instinute for Materials Shanghai 200444.China State Key Laboratory of High-Performance Ceramies and Superfine Microstructure Shanghai Institute of CeramicsChinese Acadermy 0f SciencesShanghai 200050Ch

*** and development(R&d)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3d)*** and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common *** example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of *** most widely used materials in biomedicine are *** homogeneous and non-homogeneous composites are also available for 3d printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3d printing is particularly challenging.

关键词： composites printing additive

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A versatile and double cross-linked hydrogel with potent antibacterial and immunomodulatory Zn@Met nanocomplexes for enhanced diabetic-infected wound healing

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Chemical Engineering Journal 2025年 516卷

作者： Chen, Tinglong Zhang, Xueliang Zhou, Shengzhe Fang, dong Luo, dinghao Ran, Zhaoyang Liu, Yingchun Xu, Cheng Cao, Jinhao Li, Xiaodong Hao, Yongqiaong Wang, Xiaoqing deng, Liang Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai200011 China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai200240 China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 200011 China Department of Orthopedic Surgery Luan People's Hospital Luan Hospital Affiliated of Anhui Medical University Anhui Luan237001 China Department of Nephrology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai200233 China School of Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai200240 China Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine Clinical and Translational Research Center for 3D Printing Technology Shanghai200011 China

Persistent infections, oxidative stress, and vascular damage in diabetic wounds require multifunctional dressings tailored to complex wound healing process. Herein, a coordination nanocomplexes of Zn@Met were synthesized by chelating Zn2+ with metformin (Met). These coordination nanocomplexes were subsequently integrated into an injectable self-healing hydrogel comprising methacrylic anhydride-modified gelatin (GelMA) and oxidized konjac glucomannan (OKGM). Through free-radical polymerization as well as hydrogen and schiff base bonds formation, we fabricated an pH-responsive composite hydrogel, named GO@ZM, which exhibited remarkable antibacterial efficacy, antioxidant capabilities, and potent modulation of inflammatory responses. In the final stages of wound healing, the composite hydrogel significantly enhanced macrophage polarization, angiogenesis, and collagen deposition, expediting the wound site's re-epithelialization process. Collectively, this study introduces a pioneering hydrogel for the treatment of infected diabetic wounds and holds the potential to spark fresh perspectives on the development of high-performance hydrogels for diverse biomedical applications. © 2025

关键词： Free radical polymerization

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Corrigendum to“Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone”[***.10C(April 2022)32-47]

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Bioactive materials 2023年第2期20卷 165-165页

作者： Wenhao Wang Jie Shen Yuan Meng Miaoman Ye Shaozhang Lin Qi Zhao Le Wang Kenneth M.C.Cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul K.Chu Kelvin W.K.Yeung Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong Kong999077Hong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China Ministry of Education Key Laboratory for Advanced Ceramics and Machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Materials Science and Engineering City University of Hong Kong999077Hong KongChina

The authors regret a mistake of funding numbers in the Acknowledgment Section failed to be corrected during proof *** is the corrected funding statement in Acknowledgment SECTION This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.81902189,81772354,82002303,31570980),Clinical Innovation research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR0201002),National Key research and development Plan(2018YFC1105103).

关键词： NSFC statement enriched

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Mechanical Properties of GH4169 superalloy Prepared by Selective Laser Melting

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IOP Conference Series: materials Science and Engineering 2019年第2期631卷

作者： Guohui Zhang Shaoqing Guo Shuai Huang Biao Zhou Taiqi Yan Bingqing Chen Xuejun Zhang 3D Printing Research Engineering Technology Center Beijing Institute of Aeronautical Materials Beijing 100095 China

Using selective laser melting technique, 3 sets of GH4169 samples were formed by various laser power and scanning speed to prepare mechanical properties test specimens. The defects and porosity of the samples were measured by CT inspection. The tensile test was carried out at room temperature. The fracture morphology of the tensile samples was observed by SEM and the fracture mechanism was analyzed. The results show that some samples have pores with largest size of 100μm, which have no effect on the subsequent tensile properties test. The tensile strength does not change significantly with the varying process parameters, and the highest strength could reach 1480MPa. The elongation and the reduction of area decrease gradually as the scanning speed increases, indicating that the plasticity of the material is descending. The fracture mechanism of the three sets specimens are ductile fractures, and the microscopic morphology shows distribution of equiaxed dimples.

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