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Biomechanical characteristics of self-expanding sinus stents during crimping and deployment_A comparison between different biomaterials

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Journal of the Mechanical Behavior of Biomedical materials 2023年 138卷 105669页

作者： Lu, Yung-Chang Hsu, Lin-I Lin, Chih-Feng Hsu, Chi-Pin Chang, Ting-Kuo Cheng, Chung-Chih Huang, Chang-Hung Biomechanics Research Laboratory Department of Medical Research MacKay Memorial Hospital Taiwan Department of Medicine MacKay Medical College Taipei Taiwan Department of Physical Therapy and Assistive Technology National Yang Ming Chiao Tung University Taipei Taiwan Department of Otolaryngology National Taiwan University Hospital Taipei Taiwan High Speed 3D Printing Research Center National Taiwan University of Science and Technology Taipei Taiwan Medical and Pharmaceutical Industry Technology and Development Center New Taipei City Taiwan School of Dentistry National Yang Ming Chiao Tung University Taipei Taiwan

Self-expanding sinus stents are often used in functional endoscopic sinus surgery to treat inflamed sinuses. The PROPEL self-expanding sinus stent offers mechanical support to the sinus cavity to prevent restenosis. The stent is made of a bioabsorbable material (PLGA) that disappears after wound healing. However, complications such as foreign body sensation and severe stent migration/expulsion have been reported after implantation. Little is known about the contact characteristics of self-expanding sinus stents from when the stent is crimped into the insertion device through to deployment into the sinus cavity. This current study developed a test platform to analyze the biomechanical behavior of the stent during this process. Three common bioabsorbable materials, PLGA, PCL and Mg alloy, were evaluated to understand how the choice of material affects the biomechanical characteristics of self-expanding sinus stents. The results showed that the material can have a considerable influence on the contact characteristics during crimping and deployment. When crimped, the PLGA and Mg alloy stents showed much higher plastic strain and contact stress than the PCL stent. When deployed, the PCL stent had the largest contact area (4.3 mm2) and the lowest contact pressure (0.1 MPa) on the inner surface of the sinus canal. The results indicate that PCL could be a suitable choice for self-expanding sinus stents. This current study provides a method for observing the biomechanical characteristics of sinus stents during stent crimping and deployment. © 2023 Elsevier Ltd

关键词： Finite element method

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damage Anisotropy of 3d-Printed Concrete Exposed to Sulfate Attack

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SSRN 2022年

作者： Ma, Guowei Rui, Aoyu Li, Rong Wang, Li School of Civil and Transportation Engineering Hebei University of Technology Tianjin300401 China Yaobai Special Cement R&D Co. Ltd Shanxi Xi’an710100 China Engineering Research Center on Construction 3D Printing of Hebei Tianjin300401 China

3d concrete printing (3dCP) technology has grown substantially in recent years and expanded from use in the development of architectural landscapes to the manufacture of load-bearing structures. The durability performance of 3d-printed concrete materials is crucial for the application of 3dCP in engineering structures. In this study, polypropylene (PP) fibre-reinforced sulfoaluminate cement-based composites were prepared for 3d printing, and their mechanical and durability performances after exposed to a sulfate-attack environment were experimentally assessed. The surface damage, mass loss, dynamic modulus, and residual strength of the prepared 3d-printed concrete were quantified during 150 cycles of sulfate attacks. The damage anisotropy of 3dCP exposed to sulfate attacks was introduced and elucidated from both the meso- and microscales. The pore characteristics of the matrix and interfaces were investigated through computerised tomography (CT) scanning and scanning electron microscopy (SEM) to uncover the influence of interfaces on the sulfate resistant performances. The results indicate that the damage anisotropy of 3dCP after exposed to sulfate attack was reduced due to the self-healing properties of sulfoaluminate cementitious composites. © 2022, The Authors. All rights reserved.

关键词： Computerized tomography

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Ultrahigh d31 Anti-Chiral Negative Poisson's Ratio Batio3 Ceramics Fabricated by Vat Photopolymerization 3d printing

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SSRN 2022年

作者： Zhao, Chunyang Zeng, Yong Yao, Haihua Chen, Jimin Faculty of Materials and Manufacturing Beijing University of Technology Beijing100124 China Beijing Engineering Research Center of 3D Printing for Digital Medical Health Beijing100124 China Key Laboratory of Trans-scale Laser Manufacturing Technology Ministry of Education Beijing100124 China

In this study, BaTiO 3 piezoelectric ceramics fabricated by vat photopolymerization (VPP) 3d printing technology obtained an ultrahigh transverse piezoelectric coefficient d 31 due to their anti-chiral negative Poisson's ratio lattice structure. Here, we performed uniaxial compressive load simulations and electric field-driven lattice in-plane strain response simulations, which showed an in-plane negative Poisson's ratio of -1 for the BaTiO 3 ceramics. Its strain amplification is about 10 times that of BaTiO 3 bulk material. Through the principle of positive and negative piezoelectric effects, we measured equivalent transverse piezoelectric coefficients d 31 for different dimensional parameters. The equivalent transverse piezoelectric coefficient d 31 with a maximum of 599 pm/V was detected at a ligament aspect ratio of 3.6 for the negative Poisson's ratio BaTiO 3 piezoelectric ceramics, which is 7.7 times higher than that of the bulk material. For the prepared hydrophone, test results show that the effective hydrostatic strain constant d h and hydrostatic figure of merit HFOM of BaTiO 3 piezoelectric ceramics with a negative Poisson's ratio structure are 29.6 and 808 times higher than those of bulk BaTiO 3 , respectively. © 2022, The Authors. All rights reserved.

关键词： Fabrication

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Effect of different Sintering Additives Type on Vat Photopolymerization 3d printing of Al2o3 Ceramics

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SSRN 2022年

作者： Chen, Xingfu Zeng, Yong Sun, Lijun Yao, Haihua Chen, Jimin Faculty of Materials and Manufacturing Beijing University of Technology Beijing100124 China Beijing Engineering Research Center of 3D Printing for Digital Medical Health Beijing100124 China Key Laboratory of Trans-scale Laser Manufacturing Technology Ministry of Education Beijing100124 China

The mechanical properties of 3d printed alumina ceramics are degraded due to the micro anisotropy, interlayer interface defects and microporous characteristics. In order to improve its mechanical properties, solid phase sintered, liquid phase sintered and solid-liquid phase sintered alumina (Al 2 O 3 ) ceramics were prepared by Vat photopolymerization 3d printing technology, respectively. In the experiment, Al 2 O 3 was used as the main material to study the effects of TiO 2 solid phase additive, MgO-SiO 2 liquid phase additives and TiO 2 -MgO-SiO 2 solid-liquid phase additives on Al 2 O 3 ceramics sintering behavior and mechanical properties, so as to improve the sintering density and mechanical properties of alumina ceramics. The best composition ratio and sintering temperature were determined by shrinkage, relative density, Raman, XRd and SEM characterization. Thus, nine types of truss structures are prepared to study their mechanical properties. By changing the structure types, the order of compressive strength is FCC >BCC >dLS. By changing the number of units, the order of compressive strength is 3 × 3 × 3 units >2 × 2 × 2 units >1 × 1 × 1 units. The mechanical properties of Al 2 O 3 ceramics prepared by liquid phase sintering are more balanced. It has excellent mechanical compression performance and energy absorption capacity. The FCC structure of 3 × 3 × 3 units can reach 23.2 ± 1.7 MPa compressive strength, 317 ± 34 MPa flexural strength and Vickers hardness up to 1250 ± 102 HV 30 . © 2022, The Authors. All rights reserved.

关键词： 3d printers

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Recent advances and challenges in materials for 3d bioprinting

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Progress in Natural Science:materials International 2020年第5期30卷 618-634页

作者： Hongli Mao Li Yang Haofang Zhu Lihuang Wu Peihong Ji Jiquan Yang Zhongwei Gu College of Materials Science and Engineering Nanjing Tech University Research Institute for Biomaterials Tech Institute for Advanced Materials Nanjing Tech University NJTech-BARTY Joint Research Center for Innovative Medical Technology Nanjing Industry Institute for Advanced Intelligent Equipment Jiangsu Key Lab of 3D Printing Equipment and Manufacturing Nanjing Normal University

3 d bioprinting has been developed as a promising technology in a wide variety of biomedical ***, the successful implementation of bioprinting is still heavily restricted by the relatively narrow range of printable and biocompatible materials. Recently, many comprehensive reviews of the main bioprinting methods,commonly used bioprinting materials and the trending bioprinting applications have been carried out. In this review, we focused on the trends in the development of materials for 3 d bioprinting. The significance and recent advances of ECM-based materials, multi-material and stimuli-responsive materials for bioprinting were summarized successively. Moreover, the challenges in current studies and future perspectives of materials for 3 d bioprinting were discussed.

关键词： 3d bioprinting ECM-based materials Multi-material Composite and hybrid materials Stimuli-responsive materials

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development and Evaluation of Multiscale Fiber-reinforced Composite Powders for Powder-bed Fusion Process

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2023年第2期2卷 43-53页

作者： Zhihao Wang Meixin Zhou Heye Xiao Shangqin Yuan Institute of Intelligence Material and Structure Unmanned System Research InstituteNorthwestern Polytechnical UniversityXi’an710072China State IJR Center of Aerospace Design and Additive Manufacturing School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’an710072China Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

The development of multiscale fiber-reinforced composite powders is an effective way to improve the mechanical properties and functionality of additively manufactured ***,a novel thermally induced precipitation process is proposed for preparing multiscale fiber-reinforced powders.A systematic evaluation was conducted to explore the main factors influencing powder morphology,powder flow,and *** the powder-forming mechanism,the polymer matrix is coated on the microfiber,and a film of carbon nanotubes covers the powder surface,which is promoted by heterogeneous *** composite powders comprised polyamide 12,carbon fiber(CF),and carbon nanotubes,which have been successfully applied in powder bed fusion processes including selective laser sintering(SLS).Smooth flow and powder deposition were observed,and the composite components obtained via SLS were well-fabricated using the optimized process parameters.A CF loading ratio of up to 66.7 wt%and homogeneous fiber distribution within the matrix were successfully achieved.

关键词： Fiber-reinforced composite powder Multi-scale fibers Powder bed fusion Selective laser sintering

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Real-time In-situ defect detection in 3d printing of Continuous Fiber-Reinforced Composites

Real-time In-situ Defect Detection in 3D Printing of Continu...

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digital Twins and Parallel Intelligence (dTPI), IEEE International Conference on

作者： Zhijian Yue Zhen Shen Xiangyang dong Qihang Fang Weixing Wang Xisong dong Gang Xiong Fei-Yue Wang School of Artificial Intelligence University of Chinese Academy of Sciences Beijing China State Key Laboratory of Multimodal Artificial Intelligence Systems Beijing Engineering Research Center of Intelligent Systems and Technology Institute of Automation Chinese Academy of Sciences Beijing China Intelligent Manufacturing Center Qingdao Academy of Intelligent Industries Qingdao China Guangdong Engineering Research Center of 3D Printing and Intelligent Manufacturing Cloud Computing Center Chinese Academy of Sciences Dongguan China State Key Laboratory for Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China

ISBN: (数字)9798350349252

ISBN: (纸本)9798350349269

With the development of continuous fiber-reinforced composites (CFRCs) 3d printing technology, timely, efficient and accurate detection of fiber path defects is essential for ensuring product quality and performance. However, challenges still need to be addressed in this field, such as inadequate training data coverage and the complexity of fiber path structures. These factors hinder the capability of traditional methods to accurately assess the status of printed products. Therefore, developing accurate and robust fiber path defect detection techniques is crucial for CFRCs 3d printing technology. In this paper, we propose a precise detection method for fiber path defects in CFRCs 3d printing using the YOLOv7 object detection model combined with a Squeeze-and-Excitation (SE) attention mechanism. By introducing the SE attention mechanism, we enhance the perception capability of the YOLOv7 model for crucial features, thereby improving the accuracy of fiber path defect detection. The experimental results show that the YOLOv7 model, when augmented with an attention mechanism, achieves an average accuracy of 93.9% in identifying fiber path defects during the printing process. Compared to models without this attention mechanism, the results show that there is 10.7% increase, with a notably enhanced learning capacity during the training phase, which substantiates the efficacy and practicality of the proposed approach.

关键词： Training Solid modeling Accuracy Attention mechanisms Training data Three-dimensional printing Real-time systems Quality assessment Optical fiber testing defect detection

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Generating 3d-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3386-3389页

作者： Ye Sun Qiang Wu Kerong dai Yongqing You Wenbo Jiang Department of Orthopaedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Clinical and Translational Research Center for 3D Printing Technology Shanghai Key Laboratory of Orthopaedic ImplantsDepartment of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Nephrology Affiliated Hospital of Nanjing Medical UniversityNorth District of Suzhou Municipal HospitalSuzhouChina

dear Editor,Human cell-based and personalized in vitro cartilage models are urgently needed for osteoarthritis treatment in pre-clinical regenerative medicine *** self-assemblies and condensations of the appropriate stem cells could initiate the formation of transient tissue structures programmed for specific organogenesis processes.1 This recapitulation of developmental events has previously been demonstrated for the formation of cardiac,epithelial and liver ***,there has been very limited progress in the development of human cartilage organoids for osteoarthritis(OA).2 Here,we describe the fabrication of functional bioengineered cartilage organoid suitable for OA ***,agarose microwell inserts for formation of a high number of synovial mesenchymal stromal cell(SMSC)organoids with homogeneous size distribution were created as previously described by Leijten et al.33d-cultured SMSC organoids were generated and phenotypically analyzed for potential applications in OA modeling and treatment(Fig.1a).

关键词： clinical treatment organo

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Magnesium alloy implant GZ31K with enhanced corrosion resistance promotes fracture healing in vitro and in vivo systems

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Journal of Magnesium and Alloys 2025年

作者： Yusufu, Yalikun Zhang, Yunyang Liu, Xinyun Jiang, Jiahao Shao, Zhiqiang Sun, Minghui Zhang, Xiaobo Jiang, Qing Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Jiangsu Nanjing210008 China State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Jiangsu Nanjing210008 China Branch of National Clinical Research Center for Orthopedics Sports Medicine and Rehabilitation Jiangsu Nanjing210008 China Institue of Medical 3D Printing Nanjing University Jiangsu Nanjing210008 China Jiangsu Engineering Research Center for 3D Bioprinting Jiangsu Nanjing210008 China Centre for Shared Scientific Research Facilities Nanjing University Jiangsu Nanjing210023 China School of Stomatology Xuzhou Medical University Jiangsu Xuzhou221004 China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and Engineering Nanjing Institute of Technology Jiangsu Nanjing211167 China

Magnesium and its alloys have garnered significant attention as promising materials for bone tissue engineering, owing to their bone-like density and elastic modulus, favorable mechanical properties, biodegradability, biocompatibility, and diverse biological activities. However, rapid degradation, subcutaneous gas formation from H2 release, and osteolysis caused by elevated Mg concentrations have limited its widespread clinical application. In this study, Mg-3.0Gd-1Zn-0.4Zr (GZ31K) alloy with desirable uniform degradation and stress corrosion resistance under extruded and drawn condition was used as internal fixation implants for fracture healing, while the commercially available WE43 alloy was used as control. Results revealed that GZ31K alloy exhibited refined grain structure, nanoscale distributed stacking faults and superior corrosion resistance compared to WE43 alloy. The corrosion rate of the extruded GZ31K and WE43 alloys are 0.25 mm/year and 0.35 mm/year, meeting the corrosion tolerance threshold for orthopedic implants ( © 2025

关键词： Corrosion resistant alloys

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Additive Manufacturing-Enabled Advanced design and Process Strategies for Multi-Functional Lattice Structures

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materials 2024年第14期17卷 3398页

作者： Bhat, Chinmai Prajapati, Mayur Jiyalal Kumar, Ajeet Jeng, Jeng-Ywan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology No. 1 Section 3 Zhongxiao East Road Taipei106 Taiwan Taiwan High Speed 3D Printing Research Center National Taiwan University of Science and Technology No. 43 Sec. 4 Keelung Rd Taipei106 Taiwan Department of Mechanical Engineering National Taiwan University of Science and Technology No. 43 Sec. 4 Keelung Rd Taipei106 Taiwan Lab Department of Design Indian Institute of Technology Guwahati Assam Guwahati781039 India Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University No. 1 Dasyue Rd East District Tainan701 Taiwan Department of Design Indian Institute of Technology Guwahati Assam Guwahati781039 India Prague252 41 Czech Republic

The properties of each lattice structure are a function of four basic lattice factors, namely the morphology of the unit cell, its tessellation, relative density, and the material properties. The recent advancements in additive manufacturing (AM) have facilitated the easy manipulation of these factors to obtain desired functionalities. This review attempts to expound on several such strategies to manipulate these lattice factors. Several design-based grading strategies, such as functional grading, with respect to size and density manipulation, multi-morphology, and spatial arrangement strategies, have been discussed and their link to the natural occurrences are highlighted. Furthermore, special emphasis is given to the recently designed tessellation strategies to deliver multi-functional lattice responses. Each tessellation on its own acts as a novel material, thereby tuning the required properties. The subsequent section explores various material processing techniques with respect to multi-material AM to achieve multi-functional properties. The sequential combination of multiple materials generates novel properties that a single material cannot achieve. The last section explores the scope for combining the design and process strategies to obtain unique lattice structures capable of catering to advanced requirements. In addition, the future role of artificial intelligence and machine learning in developing function-specific lattice properties is highlighted. © 2024 by the authors.

关键词： 3d printing

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