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Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990-2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021

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LANCET INFECTIOUS DISEASES 2025年第5期25卷 519-536页

作者： Kyu, Hmwe Hmwe Vongpradith, Avina Dominguez, Regina-Mae Villanueva Ma, Jianing Albertson, Samuel B. Novotney, Amanda Khalil, Ibrahim A. Troeger, Christopher E. Doxey, Matthew C. Ledesma, Jorge R. Sirota, Sarah Brooke Bender, Rose Grace Swetschinski, Lucien R. Cunningham, Matthew Spearman, Sandra Abate, Yohannes Habtegiorgis Abd Al Magied, Abdallah H. A. Abd ElHafeez, Samar Abdoun, Meriem Abera, Bayeh Abidi, Hassan Aboagye, Richard Gyan Abtew, Yonas Derso Abualruz, Hasan Abu-Gharbieh, Eman Abukhadijah, Hana J. Aburuz, Salahdein Addo, Isaac Yeboah Adekanmbi, Victor Adetunji, Charles Oluwaseun Oluwaseun Adeyeoluwa, Temitayo Esther Adhikary, Ripon Kumar Adnani, Qorinah Estiningtyas Sakilah Adra, Saryia Adzigbli, Leticia Akua Afolabi, Aanuoluwapo Adeyimika Afzal, Muhammad Sohail Afzal, Saira Agampodi, Suneth Buddhika Agide, Feleke Doyore Ahinkorah, Bright Opoku Ahmad, Aqeel Ahmad, Sajjad Ahmed, Ali Ahmed, Ayman Ahmed, Haroon Ahmed, Saeed Akinosoglou, Karolina Akter, Ema Al Awaidy, Salah Alajlani, Muaaz M. Alam, Khurshid Albakri, Almaza Albashtawy, Mohammed Aldhaleei, Wafa A. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Syed Shujait Ali Ali, Waad Alif, Sheikh Mohammad Aljunid, Syed Mohamed Al-Marwani, Sabah Almazan, Joseph Uy Al-Mekhlafi, Hesham M. Almustanyir, Sami Alqahatni, Saleh A. Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Altaf, Awais Altirkawi, Khalid A. Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Alyahya, Mohammad Sharif Ibrahim Al-Zyoud, Walid A. Amugsi, Dickson A. Andrei, Catalina Liliana Antoni, Sebastien Anuoluwa, Boluwatife Stephen Anuoluwa, Iyadunni Adesola Anwari, Saleha Anwar Palwasha Apostol, Geminn Louis Carace Arabloo, Jalal Arafat, Mosab Aravkin, Aleksandr Y. Areda, Demelash Aregawi, Brhane Berhe Aremu, Abdulfatai Arndt, Michael Benjamin Asgedom, Akeza Awealom Ashraf, Tahira Athari, Seyyed Shamsadin Atreya, Alok Ayele, Firayad Azadi, Davood Azhar, Gulrez Shah Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Taghanaki, Pegah Bahrami Bahramian, Saeed Balakrishna Department of Health Metrics Sciences School of Medicine Institute for Health Metrics and Evaluation University of Washington Seattle 98195 WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Center for Biostatistics Ohio State University Columbus OH United States Department of Global Health University of Washington Seattle WA United States Urban Indian Health Institute Seattle Indian Health Board Seattle WA United States School of Medicine Yale University New Haven CT United States Department of Clinical Governance and Quality Improvement Aleta Wondo General Hospital Aleta Wondo Ethiopia College of Pharmacy Ajman University Ajman United Arab Emirates Department of Epidemiology Alexandria University Alexandria Egypt Department of Medicine University of Sétif Algeria Sétif Algeria Department of Health Sétif Algeria Department of Medical Microbiology Bahir Dar University Bahir Dar Ethiopia Department of Biology Ghent University Ghent Belgium Laboratory Technology Sciences Department Yasuj University of Medical Sciences Yasuj Iran Department of Family and Community Health University of Health and Allied Sciences Ho Ghana Department of Biomedical Science Arba Minch University Arba Minch Ethiopia Department of Nursing Al Zaytoonah University of Jordan Amman Jordan Amman Jordan Department of Clinical Sciences Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center-Academic Health System Hamad Medical Corporation Doha Qatar College of Pharmacy University of Jordan Amman Jordan Department of Therapeutics United Arab Emirates University Al Ain United Arab Emirates School of Medicine University of Sydney Sydney NSW Australia Centre for Social Research in Health University of New South Wales Syd

Background Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021. Methods We used the Cause of Death Ensemble modelling strategy to analyse vital registration data, verbal autopsy data, mortality surveillance data, and minimally invasive tissue sampling data. We used DisMod-MR (version 2.1), a Bayesian meta-regression tool, to analyse incidence and prevalence data identified via systematic reviews, population-based surveys, and claims and inpatient data. We calculated diarrhoeal disability-adjusted life-years (DALYs) as the sum of years of life lost (YLLs) and years lived with disability (YLDs) for each location, year, and age-sex group. For aetiology estimation, we used a counterfactual approach to quantify population-attributable fractions (PAFs). Additionally, we estimated the diarrhoeal disease burden attributable to the independent effects of risk factors using the comparative risk assessment framework. Findings In 2021, diarrhoeal diseases caused an estimated 1.17 million (95% uncertainty interval 0.793-1.62) deaths globally, representing a 60.3% (50.6-69.0) decrease since 1990 (2.93 million [2.31-3.73] deaths). The most pronounced decline was in children younger than 5 years, with a 79.2% (72.4-84.6) decrease in diarrhoeal deaths. Global YLLs also decreased substantially, from 186 million (147-221) in 1990 to 51.4 million (39.9-65.9) in 2021. In 2021, an esti

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A Robust Ensemble Algorithm for Ischemic Stroke Lesion Segmentation: Generalizability and Clinical Utility Beyond the ISLES Challenge

arXiv

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arXiv 2024年

作者： de la Rosa, Ezequiel Reyes, Mauricio Liew, Sook-Lei Hutton, Alexandre Wiest, Roland Kaesmacher, Johannes Hanning, Uta Hakim, Arsany Zubal, Richard Valenzuela, Waldo Robben, David Sima, Diana M. Anania, Vincenzo Brys, Arne Meakin, James A. Mickan, Anne Broocks, Gabriel Heitkamp, Christian Gao, Shengbo Liang, Kongming Zhang, Ziji Siddiquee, Md Mahfuzur Rahman Myronenko, Andriy Ashtari, Pooya Van Huffel, Sabine Jeong, Hyun-Su Yoon, Chi-Ho Kim, Chulhong Huo, Jiayu Ourselin, Sebastien Sparks, Rachel Clèrigues, Albert Oliver, Arnau Lladó, Xavier Chalcroft, Liam Pappas, Ioannis Bertels, Jeroen Heylen, Ewout Moreau, Juliette Hatami, Nima Frindel, Carole Qayyum, Abdul Mazher, Moona Puig, Domenec Lin, Shao-Chieh Juan, Chun-Jung Hu, Tianxi Boone, Lyndon Goubran, Maged Liu, Yi-Jui Wegener, Susanne Kofler, Florian Ezhov, Ivan Shit, Suprosanna Hernandez Petzsche, Moritz R. Menze, Bjoern Kirschke, Jan S. Wiestler, Benedikt Department of Quantitative Biomedicine University of Zurich Zurich Switzerland Department of Informatics Technical University Munich Germany Icometrix Leuven Belgium ARTORG Center for Biomedical Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Switzerland University of Bern Bern Switzerland Chan Division of Occupational Science and Occupational Therapy University of Southern California Los AngelesCA United States Stevens Neuroimaging and Informatics Institute Department of Neurology Keck School of Medicine University of Southern California United States University Institute of Diagnostic and Interventional Neuroradiology Inselspital Bern Switzerland University Institute of Diagnostic and Interventional Neuroradiology University Hospital Bern Inselspital University of Bern Bern Switzerland Department of Diagnostic and Interventional neuroradiology University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Medical Imaging Radboud University Medical Center Institute for Health Sciences Nijmegen Netherlands Deepwise AI Lab Beijing China Beijing University of Posts and Telecommunications Bejing China School of Computing and Augmented Intelligence Arizona State University TempeAZ United States NVIDIA Santa ClaraCA United States STADIUS Center for Dynamical Systems Signal Processing and Data Analytics KU Leuven Leuven Belgium Pohang Korea Republic of School of Biomedical Engineering & Imaging Sciences King’s College London United Kingdom Institute of Computer Vision and Robotics University of Girona Spain Wellcome Centre for Human Neuroimaging University College London London United Kingdom Laboratory of Neuro Imaging Stevens Institute for Neuroimaging and Informatics Keck School of Medicine University of Southern California Los Angeles United States KU Leuven Leuven Belgium CREATIS Université Lyon1 CNRS UMR5220 INSERM U1206 INSA-Lyon Villeurbanne696

Diffusion-weighted MRI (DWI) is essential for stroke diagnosis, treatment decisions, and prognosis. However, image and disease variability hinder the development of generalizable AI algorithms with clinical value. We address this gap by presenting a novel ensemble algorithm derived from the 2022 Ischemic Stroke Lesion Segmentation (ISLES) challenge. ISLES’22 provided 400 patient scans with ischemic stroke from various medical centers, facilitating the development of a wide range of cutting-edge segmentation algorithms by the research community. By assessing them against a hidden test set, we identified strengths, weaknesses, and potential biases. Through collaboration with leading teams, we combined top-performing algorithms into an ensemble model that overcomes the limitations of individual solutions. Our ensemble model combines the individual algorithms’ strengths and achieved superior ischemic lesion detection and segmentation accuracy (median Dice score: 0.82, median lesion-wise F1 score: 0.86) on our internal test set compared to individual algorithms. This accuracy generalized well across diverse image and disease variables. Furthermore, the model excelled in extracting clinical biomarkers like lesion types and affected vascular territories. Notably, in a Turing-like test, neuroradiologists consistently preferred the algorithm’s segmentations over manual expert efforts, highlighting increased comprehensiveness and precision. Validation using a real-world external dataset (N=1686) confirmed the model’s generalizability (median Dice score: 0.82, median lesion-wise F1 score: 0.86). The algorithm’s outputs also demonstrated strong correlations with clinical scores (admission NIHSS and 90-day mRS) on par with or exceeding expert-derived results, underlining its clinical relevance. This study offers two key findings. First, we present an ensemble algorithm that detects and segments ischemic stroke lesions on DWI across diverse scenarios on par with expert (neuro)rad

关键词： Diagnosis

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A novel 7-level SCMLI with selective harmonic elimination via war strategy optimization

Results in Engineering

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Results in Engineering 2025年 27卷

作者： Ankit Singh Vibhu Jately Peeyush Kala Jyoti Joshi Nitin Kumar Saxena Shashank Mishra Pavan Khetrapal Brian Azzopardi Department of Electrical and Electronics Engineering University of Petroleum and Energy Studies Dehradun 248007 India Senior Project Associate R & D Electrical Research and Development Association (ERDA) Makarpura GIDC Road Vadodara Gujarat 390010 India Department of Computer Science and Engineering Graphic Era Hill University Dehradun 248002 India Teerthanker Mahaveer University Moradabad India ABES College of Engineering Ghaziabad India The Foundation for Innovation and Research–Malta BKR 4012 Birkirkara Malta MCAST Energy Research Group Institute of Engineering and Transport Malta College of Arts Science and Technology (MCAST) Main Campus PLA 9032 Paola Malta Department of Systems and Control Faculty of Engineering University of Malta MSD 2080 Msida Malta Azzopardi & Associates BKR 2012 Birkirkara Malta

This paper introduces a seven-level switched capacitor multilevel inverter that achieves triple voltage gain while reducing the number of components, employing a single DC source, two switched capacitors, and ten semiconductor switches. The War Strategy Optimization (WSO) algorithm is employed for selective harmonic elimination (SHE), enhancing switching angles with swift convergence and reducing total harmonic distortion (THD) to around 11 %. The inverter features built-in self-voltage balancing with zero voltage and zero current switchings (ZVS/ZCS), eliminating additional balancing circuits and minimizing inrush currents. The test results for 48 V input generates a maximum output voltage of 144 V at 50 Hz, under dynamic load and modulation conditions, validating the robustness of the design. Analysis indicates that the suggested SCMLI features a reduced peak inverse voltage (PIV) and necessitates fewer components, rendering it a more cost-effective option for high-power and renewable energy applications.

关键词： Switched capacitor MLI Total harmonic distortion War strategy optimization Selective harmonic elimination

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Data Cleaning Based on Multi-sensor Spatiotemporal Correlation 4th

Data Cleaning Based on Multi-sensor Spatiotemporal Correlati...

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4th International Conference on Machine Learning and Intelligent Communications, MLICOM 2019

作者： Shao, Baozhu Song, Chunhe Wang, Zhongfeng Li, Zhexi Yu, Shimao Zeng, Peng Liaoning Electric Power Research Institute State Grid Liaoning Electric Power Co. Ltd. 110000 Shenyang China Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences Shenyang110016 China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang110016 China Shenyang Power Supply Company State Grid Liaoning Electric Power Co. Ltd. 110000 Shenyang China

ISBN: (纸本)9783030323875

Sensor-based condition monitoring systems are becoming an important part of modern industry. However, the data collected from sensor nodes are usually unreliable and inaccurate. It is very critical to clean the sensor data before using them to detect actual events occurred in the physical world. Popular data cleaning methods, such as moving average and stacked denoise autoencoder, cannot meet the requirements of accuracy, energy efficiency or computation limitation in many sensor related applications. In this paper, we propose a data cleaning method based on multi-sensor spatiotemporal correlation. Specifically, we find out and repair the abnormal data according to the correlation of sensor data in adjacent time and adjacent space. Real data based simulation shows the effectiveness of our proposed method. © 2019, ICST institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

关键词： Sensor nodes

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Distributed Functional Safety for Modular Process Plants

Distributed Functional Safety for Modular Process Plants

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International Conference on Emerging Technologies and Factory Automation (ETFA)

作者： Anselm Klose Florian Pelzer Mike Barth Rainer Drath Rainer Oehlert Silvia Vélez León Alexander Horch Christoph Kotsch Jochen Knab Bernhard Gut Hartmut Manske Leon Urbas Process Control Systems & Process Systems Engineering TU Dresden Dresden Germany Research Training Group 2323 TU Dresden Dresden Germany IoS³ - Institute of Smart Systems and Services Pforzheim University Pforzheim Germany Retired Process Engineering & Automation The Dow Chemical Company Stade Germany Dept. Global Consulting HIMA Paul Hildebrandt GmbH Brühl Germany R. D. & Product Management HIMA Paul Hildebrandt GmbH Brühl Germany Control Systems Technology BASF SE Ludwigshafen Germany Engineering Services Merck KGaA Darmstadt Germany Retired Electrical Engineering for Process Automation Endress+Hauser Germany Automation and Robotics Merck KGaA Darmstadt Germany

ISBN: (数字)9781728189567

ISBN: (纸本)9781728189574

Modular process plants enable the process industry to adapt to volatile and fluctuating markets. The preferred process technology concept for these market scenarios is realized through combining pre-engineered process equipment assemblies (PEA) from different manufacturers with standardized interfaces. While the flexibility gain for this type of plants is high, the design of the safety systems of these modular plants in terms of exchangeability and compatibility is challenging. One solution could be the development of a safety-interface for PEAs to create flexible and scalable safety systems. The principles of modular basic process control are analyzed and requirements with respect to safety design are discussed. The authors provide a differentiation of the intramodular safety concept of a single PEA from the intermodular safety concept of a complete modular plant. A concept for safe and modular interaction of PEAs in a modular plant is developed and additionally validated on a basic demonstrator. Finally, from these findings, standardization requirements are provided and aspects for further research are pointed out.

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Economic analysis of solar energy development in North Africa

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Global Energy Interconnection 2018年第1期1卷 53-62页

作者： Liang Zhao Wei Wang Lingzhi Zhu Yang Liu Andreas Dubios China Electrical Power Research Institute State Key Laboratory of Operation and Control of Renewable Energy & Storage Systems China Electric Power Research Institute Global Energy Interconnection of Development and Cooperation Organization Intec-GOPA International Energy Consultants GmbH

The economic analysis of solar energy development is the basis of promoting the solar energy planning in north Africa and realizing the clean energy power transmission among continents. In this paper, the cost development trend of photovoltaic(PV) power and concentrating solar power(CSP) generation is analyzed, and the levelized cost of energy(LCOE) of solar power generation is forecasted. Then, taking the development of Tunisian solar energy as an example in the context of transcontinental transmission, PV power with energy storage and PV-CSP power generation are given as two kinds of development plan respectively. The installed capacity configurations of the two schemes are given with production simulation method, and comprehensive LCOE are calculated. The studies show that based on the LCOE forecast value, the LCOE of PV-CSP combined power generation will decrease when the annual utilization hours of transmission channel is increased. It can be chosen as one of important mode of the North Africa solar energy development.

关键词： North Africa Photovoltaic power generation Concentrating solar power Energy storage Technical and economic

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Integrating Static Code Analysis Toolchains

Integrating Static Code Analysis Toolchains

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IEEE Annual International Computer Software and Applications Conference (COMPSAC)

作者： Matthias Kern Ferhat Erata Markus Iser Carsten Sinz Frederic Loiret Stefan Otten Eric Sax FZI Research Center for Information Technology Karlsruhe Germany UNIT Information Technologies Research & Development Izmir Turkey KTH Royal Institute of Technology Embedded Control Systems Stockholm Sweden Karlsruhe Institute of Technology Institut für Theoretische Informatik Karlsruhe Germany

This paper proposes an approach for a tool-agnostic and heterogeneous static code analysis toolchain in combination with an exchange format. This approach enhances both traceability and comparability of analysis results. State of the art toolchains support features for either test execution and build automation or traceability between tests, requirements and design information. Our approach combines all those features and extends traceability to the source code level, incorporating static code analysis. As part of our approach we introduce the "ASSUME Static Code Analysis tool exchange format" that facilitates the comparability of different static code analysis results. We demonstrate how this approach enhances the usability and efficiency of static code analysis in a development process. On the one hand, our approach enables the exchange of results and evaluations between static code analysis tools. On the other hand, it enables a complete traceability between requirements, designs, implementation, and the results of static code analysis. Within our approach we also propose an OSLC specification for static code analysis tools and an OSLC communication framework.

关键词： Tools Static analysis Computer bugs Standards Software Computer languages Collaboration

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

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Nature 2024年第8003期627卷 347-357页

作者： Ken Suzuki Konstantinos Hatzikotoulas Lorraine Southam Henry J Taylor Xianyong Yin Kim M Lorenz Ravi Mandla Alicia Huerta-Chagoya Giorgio E M Melloni Stavroula Kanoni Nigel W Rayner Ozvan Bocher Ana Luiza Arruda Kyuto Sonehara Shinichi Namba Simon S K Lee Michael H Preuss Lauren E Petty Philip Schroeder Brett Vanderwerff Mart Kals Fiona Bragg Kuang Lin Xiuqing Guo Weihua Zhang Jie Yao Young Jin Kim Mariaelisa Graff Fumihiko Takeuchi Jana Nano Amel Lamri Masahiro Nakatochi Sanghoon Moon Robert A Scott James P Cook Jung-Jin Lee Ian Pan Daniel Taliun Esteban J Parra Jin-Fang Chai Lawrence F Bielak Yasuharu Tabara Yang Hai Gudmar Thorleifsson Niels Grarup Tamar Sofer Matthias Wuttke Chloé Sarnowski Christian Gieger Darryl Nousome Stella Trompet Soo-Heon Kwak Jirong Long Meng Sun Lin Tong Wei-Min Chen Suraj S Nongmaithem Raymond Noordam Victor J Y Lim Claudia H T Tam Yoonjung Yoonie Joo Chien-Hsiun Chen Laura M Raffield Bram Peter Prins Aude Nicolas Lisa R Yanek Guanjie Chen Jennifer A Brody Edmond Kabagambe Ping An Anny H Xiang Hyeok Sun Choi Brian E Cade Jingyi Tan K Alaine Broadaway Alice Williamson Zoha Kamali Jinrui Cui Manonanthini Thangam Linda S Adair Adebowale Adeyemo Carlos A Aguilar-Salinas Tarunveer S Ahluwalia Sonia S Anand Alain Bertoni Jette Bork-Jensen Ivan Brandslund Thomas A Buchanan Charles F Burant Adam S Butterworth Mickaël Canouil Juliana C N Chan Li-Ching Chang Miao-Li Chee Ji Chen Shyh-Huei Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Mary Cushman John Danesh Swapan K Das H Janaka de Silva George Dedoussis Latchezar Dimitrov Ayo P Doumatey Shufa Du Qing Duan Kai-Uwe Eckardt Leslie S Emery Daniel S Evans Michele K Evans Krista Fischer James S Floyd Ian Ford Oscar H Franco Timothy M Frayling Barry I Freedman Pauline Genter Hertzel C Gerstein Vilmantas Giedraitis Clicerio González-Villalpando Maria Elena González-Villalpando Penny Gordon-Larsen Myron Gross Lindsay A Guare Sophie Hackinger Liisa Hakaste Sohee Han Andrew T Hattersley Christian Herder Momoko Horikoshi Annie-Green Howard Willa Centre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research Division of Musculoskeletal and Dermatological Sciences University of Manchester Manchester UK. Department of Diabetes and Metabolic Diseases Graduate School of Medicine University of Tokyo Tokyo Japan. Department of Statistical Genetics Osaka University Graduate School of Medicine Suita Japan. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. konstantinos.hatzikotoulas@helmholtz-munich.de. Institute of Translational Genomics Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany. Center for Precision Health Research National Human Genome Research Institute National Institutes of Health Bethesda MD USA. British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK. Heart and Lung Research Institute University of Cambridge Cambridge UK. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA. Corporal Michael J. Crescenz VA Medical Center Philadelphia PA USA. Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA. Programs in Metabolism and Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge MA USA. Diabetes Unit and Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. TIMI Study Group Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London L

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.

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Flatness-Based Feed-Forward control Design for Solenoid Actuators Considering Eddy Currents

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IFAC-PapersOnLine 2019年第15期52卷 567-572页

作者： Tristan Braun Johannes Reuter Joachim Rudolph ZF Friedrichshafen AG Corporate Research & Development 88038 Friedrichshafen Germany Institute of System Dynamics Konstanz University of Applied Sciences 78462 Konstanz Germany Chair of Systems Theory and Control Engineering Saarland University Campus A5 1 66123 Saarbrücken Germany

Flatness-based feed-forward control of solenoid actuators is considered. For precise motion planning and accurate steering of conventional solenoids, eddy currents cannot be neglected. The system of ordinary differential equations including eddy currents, that describes the nonlinear dynamics of such actuators, is not differentially flat. Thus, a distributed parameter approach based on a diffusion equation is considered, that enables the parametrization of the eddy current by the armature position and its time derivatives. In order to design the feedforward control, the distributed parameter model of the eddy current subsystem is combined with a typical nonlinear lumped parameter model for the electrical and mechanical subsystems of the solenoid. The control design and its application are illustrated by numerical and practical results for an industrial solenoid actuator.

关键词： differential flatness feed-forward control motion planning distributed parameter systems diffusion equation eddy currents solenoid valves

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Measurement-induced boolean dynamics and controllability for quantum networks

arXiv

引用

arXiv 2019年

作者： Qi, Hongsheng Muy, Biqiang Petersenz, Ian R. Shix, Guodong Key Laboratory of Systems and Control Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing100190 China Research School of Electrical Energy and Materials Engineering Australian National University Canberra0200 Australia Australian Center for Field Robotics School of Aerospace Mechanical and Mechatronic Engineering University of Sydney NSW2008 Australia

In this paper, we study dynamical quantum networks which evolve according to Schrodinger equations but subject to sequential local or global quantum measurements. A network of qubits forms a composite quantum system whose state undergoes unitary evolution in between periodic measurements, leading to hybrid quantum dynamics with random jumps at discrete time instances along a continuous orbit. The measurements either act on the entire network of qubits, or only a subset of qubits. First of all, we reveal that this type of hybrid quantum dynamics induces probabilistic Boolean recursions representing the measurement outcomes. With global measurements, it is shown that such resulting Boolean recursions define Markov chains whose state-transitions are fully determined by the network Hamiltonian and the measurement observables. Particularly, we establish an explicit and algebraic representation of the underlying recursive random mapping driving such induced Markov chains. Next, with local measurements, the resulting probabilistic Boolean dynamics is shown to be no longer Markovian. The state transition probability at any given time becomes dependent on the entire history of the sample path, for which we establish a recursive way of computing such non-Markovian probability transitions. Finally, we adopt the classical bilinear control model for the continuous Schrodinger evolution, and show how the measurements affect the controllability of the quantum networks. Copyright © 2019, The Authors. All rights reserved.

关键词： Quantum optics

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