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Pharmaceutical Fronts 2022年第1期4卷 E30-E39页

作者： Isaac, Johnson Ajeh Daburi, Aisha Ifeanyi, Benneth Ben-Umeh, Kenechukwu Chijioke Adedokun, Abiodun Abigail Builders, Philip Department of Pharmaceutical Technology and Raw Materials Development National Institute for Pharmaceutical Research and Development (NIPRD) Department of Pharmacology and Toxicology National Institute for Pharmaceutical Research and Development (NIPRD)

Senna podocarpa (SP) leaves are used in folk medicines for treatment of burns and wounds as poultices on wound surface. However, to the best of our knowledge, the wound healing ability of this plant has not been scientifically evaluated. This work aimed to determine the wound healing potential of the crude extract of SP leaves, and to evaluate the benefit of its preparation as an emulgel. In this study, the formulations of 2.5% of SP emulgel (F1) and 7.5% of SP emulgel (F2) were prepared by mixing the emulsion phase with the gel phase in a ratio of 1:1, and then physical appearance, globule size, pH, viscosity, swelling, water activity, extrudability, occlusion, spreadability, stability, and wound healing ability were determined. Phytochemical screening showed the presence of alkaloids, saponins, tannins, cardiac glycosides, flavonoids, anthraquinones, and phenols within the hydro-ethanolic extract of SP leaves, and high flavonoid content is believed to be responsible for its healing attributes. Our formulations showed acceptable physical properties. Hematoxylin-eosin and Verhoeff Van Gieson stain showed that F2 could induce the accumulation of fibroblasts, fibrocytes, inflammatory cells, gland cells, epidermal cells, adipocytes, and collagen n the process of wound healing in mice injured with hydrochloric acid. Encouragingly, the percent of wound contractions in mice treated with F1, F2, and SP leaf poultice were 64, 87, and 50, respectively, suggesting the superior healing properties exhibited by SP emulgel over SP leaf poultice, and this may due to the occlusive property of emulgels. In conclusion, F2 of crude extract of SP leaves has better pharmacological effects on burn and wound healing, and may represent a preferred choice to treat burn wounds in the future. © 2022. The Author(s).

关键词： burn emulgel hematoxylin-eosin Senna podocarpa Verhoeff-Van Gieson wound healing

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The investigation on the influence of key parameters on turbulence response characteristics of helicopter

The investigation on the influence of key parameters on turb...

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第34届中国控制与决策会议

作者： Shanyong Zhao Ke Lu Yujie Ma Hongyuan Tian Science & Technology on Rotorcraft Aeromechanics Laboratory China Helicopter Research and Development Institute

In this paper,the influence of key parameters on helicopter flight dynamic response characteristics in turbulent environment is *** view of the characteristics of helicopter flying near earth,it is often disturbed by atmospheric *** the helicopter flight dynamics model coupled with turbulent environment is established and *** this basis,the simulation of helicopter turbulence response is carried *** influence of different helicopter parameters on turbulence response is studied,which provides a theoretical basis for anti-turbulence design of helicopter.

关键词： Helicopter Parameter Flight Dynamics Turbulence Response

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Proteomic and phosphoproteomic analysis reveal threonine deficiency increases hepatic lipid deposition in Pekin ducks via reducing STAT phosphorylation

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Animal Nutrition 2023年第2期13卷 249-260页

作者： Yong Jiang Zhong Zhuang Wenqia Jia Zhiguo Wen Ming Xie Hao Bai Yulin Bi Zhixiu Wang Guobin Chang Shuisheng Hou Guohong Chen College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China State Key Laboratory of Animal Nutrition Key Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaInstitutes of Agricultural Science and Technology DevelopmentYangzhou UniversityYangzhou 225009China Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs Institute of Feed ResearchChinese Academy of Agricultural SciencesBeijing 100081China

Dietary threonine(Thr)deficiency enhances triglyceride(TG)deposition in the liver of Pekin ducks,which injures hepatic function and impairs growth ***,the underlying molecular mechanisms remain *** the present study,we investigated the effects of dietary Thr deficiency on the expressions of proteins and phosphoproteins in liver of Pekin ducks,to identify the underlying molecular changes.A total of 300 one-day-old ducklings were divided into 3 groups with 10 replicates of 10 *** ducks were fed corn-wheat-peanut meal diets containing 0.46%,0.71%,and 0.96%Thr,respectively,from 1 to 21 days of *** performance,serum parameters,hepatic TG content,and expression of genes involved in lipid metabolism of Pekin ducks were determined.A Thr deficiency group(Thr-D,0.46%Thr)and a Thr sufficiency group(Thr-S,0.71%Thr)were selected for subsequent proteomic and phosphoproteomic *** results showed that Thr-D reduced the growth performance(P<0.001),and increased the plasma concentrations of cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and hepatic TG(P<0.05).Thr-D increased gene expression related to fatty acid and TG synthesis(P<0.05).A total of 176 proteins and 259 phosphosites(containing 198 phosphoproteins)were observed to be differentially expressed as a result of *** upregulated proteins were enriched in the pathway related to amino acid metabolism,*** down-regulated proteins were enriched in linolenic and arachidonic acid metabolism,and the Janus kinase-signal transducer and activator of transcription(JAK-STAT)signaling *** upregulated phos-phoproteins were enriched in the pathways related to fatty acid biosynthesis,fructose and mannose metabolism,and glycolysis/***-D reduced the phosphorylation of STAT1 at S729 and STAT3 at S728,and expression of *** contrast,Thr-D increased non-receptor tyrosine-protein kinase(TYK2)expression and STAT1 phosphoryla

关键词： Threonine deficiency Triglyceride accumulation Proteomic Phosphoproteomic Pekin duck

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Simultaneous biomethane and hydrochar recovery from washed elephant dung:The effects of inoculum source,substrate to inoculum ratio,and hydrothermal temperature

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Carbon Resources Conversion 2025年第1期8卷 26-34页

作者： Chayanon Sawatdeenarunat Boonya Charnnok Rojapun Nirunsin Sumate Chaiprapat Chen-Yeon Chu Asian Development College for Community Economy and Technology Chiang Mai Rajabhat UniversityChiang Mai 50300Thailand Energy Technology Program Department of Interdisciplinary EngineeringFaculty of EngineeringPrince of Songkla UniversityHat Yai DistrictSongkhla Province 90110Thailand School of Renewable Energy Maejo UniversityChiang Mai 50290Thailand Department of Civil and Environment Engineering PSU Energy Systems Research Institute(PERIN)Faculty of EngineeringPrince of Songkla UniversitySongkla 90002Thailand Institute of Green Products Feng Chia UniversityTaichung 40724TaiwanChina

This research aims to develop the appropriate biorefinery process integrating anaerobic digestion(AD)and hydrothermal carbonization(HTC)to recover the highest energy from the pretreated elephant ***,the raw elephant dung was physically processed by washing with water to generate the liquid waste,i.e.,washing water(WW),and solid waste,i.e.,washed fiber(WF).The appropriate substrate-to-inoculum ratio(SIR)and the inoculum source of the AD of WW were determined and the HTC temperature of WF was also *** results indicated that the AD of WW with the SIR of 1:2 and anaerobically digested swine manure as the inoculum presented the highest methane and energy yields of 412.3±9.9 N mL/g VS added and 2,220.1±53.03 MJ/ton dry wt.,*** HTC of WF,the optimum condition was the hydrothermal temperature of 170℃ at the residence time of 60 *** highest hydrochar and energy yields were 76.8%±1.9%dry *** 12,067.0±452.1 MJ/ton dry wt.,***,this biorefinery process could simultaneously treat elephant campderived waste and produce clean energy.

关键词： Elephant dung Biorefinery Anaerobic digestion Hydrothermal carbonization Lignocellulosic biomass

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Labelling of Annotated Condition Monitoring Data Through Technical Language Processing 15

Labelling of Annotated Condition Monitoring Data Through Tec...

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15th Annual Conference of the Prognostics and Health Management Society, PHM 2023

作者： Löwenmark, Karl Taal, Cees Vurgaft, Amit Nivre, Joakim Liwicki, Marcus Sandin, Fredrik Luleå University of Technology Luleå971 87 Sweden SKF Research & Technology Development Meidoornkade 14 Houten3992 AE Netherlands P.O. Box 2350 Nieuwegein3430 DT Netherlands RISE Research Institutes of Sweden Isafjordsgatan 22 Kista164 40 Sweden P.O. Box 857 Borås501 15 Sweden

ISBN: (纸本)9781936263059

We propose a novel approach, technical language labelling, to facilitate supervised intelligent fault diagnosis on unlabelled but annotated industry datasets using technical language processing. Condition monitoring (CM) is vital for high safety and resource efficiency in the green transition and digital transformation of the process industry. Computerised maintenance systems are required to facilitate CM scalability, and learning-based Intelligent Fault Diagnosis (IFD) methods are required to automate maintenance decisions and improve support for human analysts. A major challenge is the lack of labelled datasets from industry and the difficulty of transferring features from labelled lab datasets to unlabelled industry datasets. In this study, we investigate how the fault description annotations and maintenance work orders present in many CM datasets can be understood and used for IFD through Technical Language Processing, based on insights from recent advances in Natural Language Supervision joint pre-training of images and captions. We identify two distinct pipelines, one based on pre-training on large datasets, and one based on a human-centric approach and unsupervised clustering methods to transform annotations into labels, aided by insights from dimensionality reduction and visualisation techniques. Finally, we showcase one example of the small-data fault classification implementation on a CM industry dataset with a Sentence BERT model and conventional signal processing methods. Sets of features are used to overcome data imbalance and label misalignment, and we show that our model can separate sets of cable and sensor fault recordings from sets of bearing-related fault recordings with an F1-score of 92.6%. To our knowledge, this is the first system to create labels for CM data through pre-trained language models without requiring pre-defined taxonomies. © 2023 Prognostics and Health Management Society. All rights reserved.

关键词： Condition monitoring

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Study on Grid Control Methods Based on Three-Phase Current Source Type 5-Level Converters

Study on Grid Control Methods Based on Three-Phase Current S...

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Annual Conference of Industrial Electronics Society

作者： Jianyu Bao Cheng Yan Nannan Gu Liu Yang School of Electronic and Information Engineering Ningbo University of Technology Ningbo China Research and Development Department Ningbo Deye Inverter Technology Co. Ltd Ningbo China Research Institute of Interdisciplinary Intelligent Science Ningbo University of Technology Ningbo China

ISBN: (数字)9781665464543

ISBN: (纸本)9781665464550

Against the backdrop of global energy transition and climate change, enhancing the grid integration efficiency and quality of renewable energy sources is pivotal for achieving sustainable development goals. This paper introduces a three-phase current source type 5-level grid-connected inverter and its control method, designed to offer a system with adjustable power factor for high-quality stable grid operation. This system is particularly suitable for grid integration of renewable energy generation, effectively suppressing the resonance of the CL filter and reducing harmonic distortion in grid current. Detailed simulations of the system demonstrate that the design maintains exceptional performance under various conditions, particularly showing outstanding adaptability and stability in response to grid voltage fluctuations and load changes.

关键词： Reactive power Renewable energy sources Power system stability Inverters Stability analysis Resonance Harmonic distortion Voltage control Phase locked loops Power harmonic filters

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Soft Label Coding for end-to-end Sound Source Localization with ad-hoc Microphone Arrays

Soft Label Coding for end-to-end Sound Source Localization w...

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： Linfeng Feng Yijun Gong Xiao-Lei Zhang School of Marine Science and Technology Northwestern Polytechnical University China Research & Development Institute of Northwestern Polytechnical University in Shenzhen China

Recently, an end-to-end two-dimensional sound source localization algorithm with ad-hoc microphone arrays formulates the sound source localization problem as a classification problem. The algorithm divides the target indoor space into a set of local areas, and predicts the local area where the speaker locates. However, the local areas are encoded by one-hot code, which may lose the connections between the local areas due to quantization errors. In this paper, we propose a new soft label coding method, named label smoothing, for the classification-based two-dimensional sound source location with ad-hoc microphone arrays. The core idea is to take the geometric connection between the classes into the label coding process. The first one is named static soft label coding (SSLC), which modifies the one-hot codes into soft codes based on the distances between the local areas. Because SSLC is handcrafted which may not be optimal, the second one, named dynamic soft label coding (DSLC), further rectifies SSLC, by learning the soft codes according to the statistics of the predictions produced by the classification-based localization model in the training stage. Experimental results show that the proposed methods can effectively improve the localization accuracy.

关键词： Location awareness Training Codes Smoothing methods Signal processing algorithms Prediction algorithms Encoding

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Enhanced Drug-Drug Interaction Prediction with Graph Neural Networks and SVM

Enhanced Drug-Drug Interaction Prediction with Graph Neural ...

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Knowledge Engineering and Communication Systems (ICKECS), International Conference on

作者： A G Gnanabaskaran K Tamil Bharathi S P Nandakumar B Sanjay R Praveen Computer Science and Engineering K. S. Rangasamy College of Technology Tiruchengode India Research & Development ICU Medical India LLP Chennai India

ISBN: (数字)9798350359688

ISBN: (纸本)9798350359695

Predicting drug-drug interactions (DDIs) is crucial for medication safety and efficacy. Traditional methods often face challenges in capturing complex interactions within large-scale drug networks. In this study, we propose an enhanced approach leveraging Graph Neural Networks (GNNs) and Support Vector Machines (SVM) to improve DDI prediction accuracy. Our method integrates graph representation learning with SVM-based classification, effectively capturing intricate relationships between drugs and their interactions. Through extensive experimentation on benchmark datasets, we demonstrate superior performance compared to existing methods, achieving higher prediction accuracy of ${9 7 \%}$ and f1 measure of ${9 8 \%}$. Moreover, our approach offers interpretability, enabling insights into underlying interaction mechanisms. Overall, our study highlights the potential of combining GNNs and SVM for advancing drug interaction prediction, with implications for enhancing medication safety and clinical decision-making.

关键词： Support vector machines Drugs Representation learning Knowledge engineering Accuracy Decision making Predictive models

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Microstructural and thermal properties of coal measure sandstone subjected to high temperatures

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2909-2921页

作者： Weijing Xiao Dongming Zhang Shujian Li Mingyang Wu School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang330013China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China Yunnan Phosphate Chemical Group Co. Ltd.Kunming650600China National Engineering and Technology Research Center for Development and Utilization of Phosphate Resources Kunming650600China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

To study the microscopic structure,thermal and mechanical properties of sandstones under the influence of temperature,coal measure sandstones from Southwest China are adopted as the research object to carry out high-temperature tests at 25℃-1000℃.The microscopic images of sandstone after thermal treatment are obtained by means of polarizing microscopy and scanning electron microscopy(SEM).Based on thermogravimetric(TG)analysis and differential scanning calorimetric(DSC)analysis,the model function of coal measure sandstone is explored through thermal analysis kinetics(TAK)theory,and the kinetic parameters of thermal decomposition and the thermal decomposition reaction rate of rock are *** the uniaxial compression experiments,the stress‒strain curves and strength characteristics of sandstone under the influence of temperature are *** results show that the temperature has a significant effect on the microstructure,mineral composition and mechanical properties of *** particular,when the temperature exceeds 400℃,the thermal fracture phenomenon of rock is obvious,the activity of activated molecules is significantly enhanced,and the kinetic phenomenon of the thermal decomposition reaction of rock appears *** mechanical properties of rock are weakened under the influence of rock thermal fracture and mineral thermal *** research results can provide a reference for the analysis of surrounding rock stability and the control of disasters caused by thermal damage in areas such as underground coal gasification(UCG)channels and rock masses subjected to mine fires.

关键词： Rock mechanics Coal measure sandstone Micromorphology Thermal damage

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The challenge of defining rare genetic programs by single-cell RNA sequencing:Insights from phloem studies

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Molecular Plant 2024年第1期17卷 22-25页

作者： Xiaomin Liu Pawel Roszak YkäHelariutta State Key Laboratory of Tree Genetics and Breeding College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083China The Sainsbury Laboratory University of CambridgeCB21TN CambridgeUK Wood Development Group University of Helsinki00100 HelsinkiFinland Organismal and Evolutionary Biology Research Programme Faculty of Biological and Environmental Sciences and Viikki Plant Science CentreUniversity of Helsinki00100 HelsinkiFinland

Single-cell RNA sequencing technology provides unprecedented opportunities to capture the spatiotemporal aspects of genetic programs that drive cell *** is a subtype of vascular tissue that is crucial for transporting sugars,proteins,and other organic *** critical role in the redistribution of carbon between photosynthetically active“source”organs(leaves,shoots)and“sink”tissues/organs incapable of fixing carbon(wood,storage organs,root system,etc.)has made phloem development and its transcriptional regulation a prime research focus.

关键词： organs sugar rare

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