In order to solve the problem that it is difficult to guarantee the overall benefit maximization under the stepwise clearing of electric energy and reserve, a generation plan generation method based on joint clearing ...
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In 2011, 68 archived beluga whale (Delphinapterus leucas) liver samples collected from Cook Inlet and the eastern Chukchi Sea from 1989 to 2006 were characterized for 12 per- and polyfluoroalkyl substances (PFAS) usin...
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The aim of this paper is to gain evidence of the scalability of flexibility trading mechanisms by executing large scale simulations for day-ahead trading of flexibility. The objective is to allow the quantification of...
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Lattice-strain engineering has demonstrated its capability to influence the electronic structure and catalytic performance of ***,we present a facile method for inducing thermal strain in cobalt/molybdenum nitride rod...
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Lattice-strain engineering has demonstrated its capability to influence the electronic structure and catalytic performance of ***,we present a facile method for inducing thermal strain in cobalt/molybdenum nitride rod-shaped structures(denoted Co/Mo_(2)N)via ammonia-assisted reduction,which effectively modulating the HER *** optimized Co/Mo_(2)N-500,characterized by 3%tensile lattice strain,demonstrates exceptional HER activity with lower overpotentials of140 mV and 184 mV at high current density of 1000 mA cm^(-2)in alkaline freshwater and seawater electrolytes,***/Mo_(2)N also exhibits excellent long-term durability even at a high current density of 300 mA cm^(-2),surpassing its counterparts and benchmark Pt/C *** functional theory calculations validate that the tensile strain optimizes the d-band states,water dissociation,and hydrogen adsorption kinetics of the strained Mo_(2)N in Co/Mo_(2)N,thereby improving its catalytic *** work provides valuable insights into controlling lattice strain to develop highly efficient electrocatalysts towards advanced electrocatalytic applications.
Poultry farms face challenges in solid waste management, environmental protection, and human health due to massive feather waste generation, necessitating the development of economical treatment techniques. In this st...
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The Cenozoic geological hallmark of Western Yunnan is the characteristic voluminous Late Cretaceous-Eocene granites;however, their geological background and petrogenesis have not been well constrained and elucidated. ...
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The Cenozoic geological hallmark of Western Yunnan is the characteristic voluminous Late Cretaceous-Eocene granites;however, their geological background and petrogenesis have not been well constrained and elucidated. In this study, we present new zircon U-Pb dating, along with geochemical and Sr-Nd-Hf isotopic data for granites from the Tengchong–Lianghe granitoid belt(as abbreviated to Tengliang belt) and West Yingjiang batholiths from the Tengchong block. The mineralogical and geochemical features of the Tengliang granites and the West Yingjiang batholiths are ascribed to aluminous S-type granites and weak peraluminous I-type, respectively. Zircon U-Pb analyses yielded consistent ages ranging from 67.5 Ma, 68.4 Ma and 66.2 Ma from the Tengliang granitoid belt and 50.4 Ma to 60.8 Ma for three samples from the west Yingjiang batholiths. The Tengliang granites were emplaced during the Late Cretaceous(68-66 Ma) and demonstrate negative ε_(Hf)(t) values(-24 to-4) and initial ~(87)Sr/~(86)Sr ratios of 0.7101–0.7139 and significant negative ε_(Nd)(t) values from-8.91 to-13.2, indicating a Proterozoic sedimentary source or enriched components. The hornblende-bearing I-type granites from West Yingjiang are characterized by lower initial ~(87)Sr/~(86)Sr ratios of 0.7076–0.7106, compared to Tengliang granite and negative whole-rock ε_(Nd)(t) values from-4.0 to-11.9. The early Eocene west Yingjiang gneissic granites show wide ranges of ε_(Hf)(t) values from +7.4 to-8.5 and T_(2DM) of 1.30–0.65 Ga, indicating partial melting of ancient crust with contributions of depleted mantle materials. In combination with the regional background and previous studies, we propose that such a spatio-temporal distribution of the Tengchong granitoid belt might be related to the rollback or angleswitching of the Neo-Tethyan subducting slab. This study sheds new light on the evolutionary history of the Tengchong block.
Advanced biliary tract cancer(BTC)and pancreatic ductal adenocarcinoma(PDAC)have poor prognoses and limited treatment ***,we conducted thisfirst-in-class phase II study to evaluate the efficacy and safety of SHR-1701,...
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Advanced biliary tract cancer(BTC)and pancreatic ductal adenocarcinoma(PDAC)have poor prognoses and limited treatment ***,we conducted thisfirst-in-class phase II study to evaluate the efficacy and safety of SHR-1701,a bifunctional fusion protein targeting programmed death-ligand 1(PD-L1)and transforming growth factor-beta(TGF-β),combined with famitinib,a multi-targeted receptor tyrosine kinase inhibitor,in patients with advanced BTC or PDAC who failed previous standard treatment(trial registration:ChiCTR2000037927).Among 51 enrolled patients,the BTC cohort showed an objective response rate(ORR)of 28%(including 2 complete responses)and a disease control rate(DCR)of 80%,with a median progression-free survival(mPFS)of 5.1 months and a median overall survival(mOS)of 16.0 *** the PDAC cohort,the ORR was 15%(2 complete responses),with a DCR of 60%,and the mPFS and mOS were 2.1 months and 5.3 months,*** 3 or 4 treatment-related adverse events(TRAEs)occurred in 29.4%of patients,with no grade 5 TRAEs *** analyses revealed that primary tumor resection history,peripheral blood immunophenotype changes,and distinct immune-metabolic profiles were associated with treatment *** immune/metabolism score integrating the features of six genes was developed as a predictive biomarker for immunotherapy response in multiple cohorts,allowing for the selection of patients most likely to experience positive outcomes from this therapy *** conclusion,our study provides proof-of-concept data supporting the potential of SHR-1701 plus famitinib as an effective and safe subsequent-line therapy for refractory BTC and PDAC,highlighting the promise of targeting PDL1,TGF-β,and angiogenesis pathways simultaneously.
The molybdenum is one of the most important refractory metals used in aerospace industry. The main disadvantage of Mo is low oxidation resistance at elevated temperature and the using of protective coatings is necessa...
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A number of suggestions are made based on the improved evolutionary algorithm and using the polishing parameter optimization of an industrial robot as an example to optimize the industrial process parameter control. B...
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