Drugs and other substances with psychoactive substances have the potential to alter body functioning and structure when ingested either for medical or recreational purposes. The study investigated the effects of ethan...
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ISBN:
(数字)9798350358155
ISBN:
(纸本)9798350358162
Drugs and other substances with psychoactive substances have the potential to alter body functioning and structure when ingested either for medical or recreational purposes. The study investigated the effects of ethanol with Nicotiana tabacum and Cannabis sativa on markers of brain function and hematological parameters through both an experimental and docking predictive approach. Thirty-five female Wistar rats with an average weight of 180 ± 0.5 g were randomly assigned to seven treatment groups of five rats each: ethanol, Nicotiana tabacum, Cannabis sativa, ethanol + Nicotiana tabacum, ethanol + Cannabis sativa, and ethanol + Nicotiana tabacum + Cannabis sativa. The dosage of the substance administered in each group includes 30 ml/kg body weight (BW) of 40% ethanol, 13.44 g/kg BW of Nicotiana tabacum, and 6.72 g/kg BW of Cannabis sativa. Smoke from Nicotiana tabacum and Cannabis sativa sativa was inhaled for five minutes while ethanol was given orally. At the end of the 28-day treatment, the rats were euthanized. Brain homogenates underwent biochemical assays and blood parameters were examined. There was a significant decrease (p<0.05) in malondialdehyde (MDA) concentration in the ethanol group in comparison to the treated groups and the control group. On the contrary, the groups exposed to Nicotiana tabacum and Cannabis sativa smoke, as well as the control group showed a significant increase (p<0.05) in total protein concentration compared to the ethanol group. There was a significant decrease (p<0.05) in catalase activity in the ethanol group compared to the treated groups and the control group. Furthermore, there was a significant increase (p<0.05) in HGB and RDW in groups exposed to Nicotiana tabacum and Cannabis sativa smoke respectively, and in the control group in comparison to the ethanol group. When compared to ethanol and nicotine, delt-9-tetrahydrocannabinol had the highest binding energy across receptor proteins. Ethanol, nicotine, and delt-9- tetrahydr
ABACUS (Atomic-orbital Based Ab-initio Computation at USTC) is an open-source software for first-principles electronic structure calculations and molecular dynamics simulations. It mainly features density functional t...
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One-dimensional(1D)metal halide perovskite nanowire(NW)arrays with high absorption efficiency,emission yield and dielectric constants,as well as anisotropic optoelectronic properties have found applications in energy ...
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One-dimensional(1D)metal halide perovskite nanowire(NW)arrays with high absorption efficiency,emission yield and dielectric constants,as well as anisotropic optoelectronic properties have found applications in energy harvesting,flexible electronics,and biomedical imaging ***,a modified two-step solvothermal method is developed for the synthesis of self-assembled cubic CsPbBr_(3) NW *** method provides facile access to continuous and uniform ultrafine perovskite NWs and well-aligned pure perovskite NW arrayed *** excitation at 365 nm,the CsPbBr_(3) NWs give a strong blue emission observable to the naked *** CsPbBr_(3) NWs also exhibit strong two-photon excited luminescence under the irradiation with an 800 nm pulse *** rotating the polarization angle of the 800 nm laser,strong polarization dependence with a polarization degree up to~0.49 is demonstrated in the selfassembled CsPbBr_(3) NW array,although the CsPbBr_(3) NWs have an isotropic cubic *** on density functional theory(DFT)calculations,this polarization-dependent emission is correlated with the anisotropic charge density distribution of the perovskite *** findings suggest that the ultrafine CsPbBr_(3) NWs with a well-defined self-assembled architecture could be applied as next-generation polarizationsensitive photoelectronic detection materials.
An improved quantum trajectory Monte Carlo method including the Stark shift of the initial state, Coulomb potential, and multielectron polarization-induced dipole potential is adopted to revisit the origin of the low-...
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An improved quantum trajectory Monte Carlo method including the Stark shift of the initial state, Coulomb potential, and multielectron polarization-induced dipole potential is adopted to revisit the origin of the low-energy interference structure in the photoelectron momentum distribution of the xenon atom subjected to an intense laser field, and resolve the different contributions of these three effects. We found that the Stark shift plays an essential role on the low-energy interference structure, which moves the ringlike constructive interference structure to the lower momentum region. The formation of the low-energy interference structure is a result of the combined effects of Stark shift, laser, and Coulomb fields, while the multielectron polarization mainly enhance the probability of the low energy photoelectron spectrum. Our finding provides insight into the electron dynamics of atoms and molecules when driven by the intense laser fields.
Piezo-photocatalysis of ZnO nanostructures had recently well attracted due to their exceptional potential in degrading the antibiotics and scalable hydrogen production. Here, we have synthesized the Ce3+ doped ZnO nan...
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Surface and grain boundary defects in halide perovskite solar cells are highly detrimental,reducing efficiencies and *** halide anion and organic cation defects usually aggravate ion diffusion and material degradation...
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Surface and grain boundary defects in halide perovskite solar cells are highly detrimental,reducing efficiencies and *** halide anion and organic cation defects usually aggravate ion diffusion and material degradation on the surfaces and at the grain boundaries of perovskite *** this study,we employ an in-situ green method utilizing nontoxic cetyltrimethylammonium chloride(CTAC)and isopropanol(IPA)as anti-solvents to effectively passivate both surface and grain boundary defects in hybrid *** vacancies can be readily passivated by the chloride group due to its high electronegativity,and cation defects can be synchronously passivated by the more stable cetyltrimethylammonium *** results show that the charge trap density was significantly reduced,while the carrier recombination lifetime was markedly *** a result,the power conversion efficiency of the cell can reach 23.4%with this in-situ green *** addition,the device retains 85%of its original power conversion efficiency after 600 h of operation under illumination,showing that the stability of perovskite solar cells is improved with this in-situ passivation *** work may provide a green and effective route to improve both the stability and efficiency of perovskite solar cells.
Background: Monoclonal antibodies (mAbs) as biopharmaceuticals take a pivotal role in the current therapeutic applications. Generally mammalian cell lines, such as those derived from Chinese hamster ovaries (CHO), are...
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Background: Monoclonal antibodies (mAbs) as biopharmaceuticals take a pivotal role in the current therapeutic applications. Generally mammalian cell lines, such as those derived from Chinese hamster ovaries (CHO), are used to produce the recombinant antibody. However, there are still concerns about the high cost and the risk of pathogenic contamination when using mammalian cells. Aspergillus oryzae, a filamentous fungus recognized as a GRAS (Generally Regarded As Safe) organism, has an ability to secrete a large amount of proteins into the culture supernatant, and thus the fungus has been used as one of the cost-effective microbial hosts for heterologous protein production. Pursuing this strategy the human anti-TNFα antibody adalimumab, one of the world's best-selling antibodies for the treatment of immune-mediated inflammatory diseases including rheumatoid arthritis, was chosen to produce the full length of mAbs by A. oryzae. Generally, N-glycosylation of the antibody affects immune effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) via binding to the Fc receptor (FcγR) on immune cells. The CRISPR/Cas9 system was used to first delete the Aooch1 gene encoding a key enzyme for the hyper-mannosylation process in fungi to investigate the binding ability of antibody with FcγRIIIa. Results: Adalimumab was expressed in A. oryzae by the fusion protein system with α-amylase AmyB. The full-length adalimumab consisting of two heavy and two light chains was successfully produced in the culture supernatants. Among the producing strains, the highest amount of antibody was obtained from the ten-protease deletion strain (39.7 mg/L). Two-step purifications by Protein A and size-exclusion chromatography were applied to obtain the high purity sample for further analysis. The antigen-binding and TNFα neutralizing activities of the adalimumab produced by A. oryzae were comparable with those of a commercial product Humira®. No apparent binding wit
Valence transition could induce structural, insulator-metal, nonmagnetic-magnetic and superconducting transitions in rare-earth metals and compounds, while the underlying physics remains unclear due to the complex int...
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Valence transition could induce structural, insulator-metal, nonmagnetic-magnetic and superconducting transitions in rare-earth metals and compounds, while the underlying physics remains unclear due to the complex interaction of localized 4f electrons as well as their coupling with itinerant electrons. The valence transition in the elemental metal europium (Eu) still has remained as a matter of debate. Using resonant x-ray emission scattering and x-ray diffraction, we pressurize the states of 4f electrons in Eu and study its valence and structure transitions up to 160 GPa. We provide compelling evidence for a valence transition around 80 GPa, which coincides with a structural transition from a monoclinic (C2/c) to an orthorhombic phase (Pnma). We show that the valence transition occurs when the pressure-dependent energy gap between 4f and 5d electrons approaches the Coulomb interaction. Our discovery is critical for understanding the electrodynamics of Eu, including magnetism and high-pressure superconductivity.
This research aims to prepare amorphous gallium oxide (α-Ga2O3) films for use in flexible deep ultraviolet photodetectors. The films are deposited using high-speed spatial atomic layer deposition (SALD) at different ...
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