检索结果-内蒙古大学图书馆

The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we... 详细信息

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Biclustering Method to Capture the Spatial Pattern and to Identify the Causes of Social Vulnerability in Indonesia: A New Recommendation for Disaster Mitigation Policy

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Procedia Computer Science 2019年 157卷 31-37页

作者： Puspita Anggraini Kaban Robert Kurniawan Rezzy Eko Caraka Bens Pardamean Budi Yuniarto Sukim Computational Statistics Department Polytechnic of Statistics - STIS Jakarta 13330 Indonesia Bioinformatics and Data Science Research Center Bina Nusantara University Indonesia College of Informatics Chaoyang University of Technology Taichung City 41349 Taiwan (R.O.C.) Computer Science Department BINUS Graduate Program Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480

Geographically, Indonesia is a meeting point of three continental plates. Scilicet, the Eurasian Plate, the Indo-Australian Plate, and the Pacific Plate. Therefore, Indonesia is part of the infamous volcanic zone call... 详细信息

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Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis

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The Lancet. Microbe 2025年 101103页

作者： Raianna F Fantin Jordan J Clark Hallie Cohn Deepika Jaiswal Bailey Bozarth Vishal Rao Alesandro Civljak Igor Lobo Jessica R Nardulli Komal Srivastava Jeremy S Yong Robert Andreata-Santos Kaitlyn Bushfield Edward S Lee Gagandeep Singh Steven H Kleinstein Florian Krammer Viviana Simon Goran Bajic Camila H Coelho Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY USA Center for Vaccine Research and Pandemic Preparedness Icahn School of Medicine at Mount Sinai New York NY USA. Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY USA. Center for Vaccine Research and Pandemic Preparedness Icahn School of Medicine at Mount Sinai New York NY USA Graduate School of Biomedical Sciences Icahn School of Medicine at Mount Sinai New York NY USA. Retrovirology Laboratory Department of Microbiology Immunology and Parasitology Paulista School of Medicine Federal University of São Paulo São Paulo Brazil. Department of Laboratory Medicine Yale School of Medicine New Haven CT USA Department of Pathology Yale School of Medicine New Haven CT USA. Department of Pathology Yale School of Medicine New Haven CT USA Program in Computational Biology and Biomedical Informatics Yale University New Haven CT USA Department of Immunobiology Yale School of Medicine New Haven CT USA Department of Biomedical Informatics and Data Science Yale School of Medicine New Haven CT USA. Department of Pathology Molecular and Cell-Based Medicine Icahn School of Medicine at Mount Sinai New York NY USA Ignaz Semmelweis Institute Interuniversity Institute for Infection Research Medical University of Vienna Vienna Austria. The Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount Sinai New York NY USA Division of Infectious Diseases Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA. Program in Computational Biology and Biomedical Informatics Yale University New Haven CT USA. Electronic address: goran.bajic@mssm.edu. Precision Immunology Institute Icahn School of Medicine at Mount Sinai New York NY USA. Electronic address: camila.coelho@mssm.edu.

BACKGROUND:The rapid emergence of highly transmissible and immune-evasive SARS-CoV-2 variants has required the reformulation of COVID-19 vaccines to target these evolving threats. Although previous infections and booster vaccinations can boost variant neutralisation, it remains uncertain whether monovalent vaccines-delivered via mRNA or protein-based platforms-can trigger novel B-cell responses specific to omicron XBB.1.5 variants. We sought to address this uncertainty by characterising the antibody repertoire of individuals receiving a monovalent booster vaccine. METHODS:In this observational study, we analysed the genetic antibody repertoire of 603 individual plasmablasts from five individuals (recruited at the Icahn School of Medicine at Mount Sinai, New York, NY, USA, from STUDY-16-01215/IRB-16-00971 and STUDY-20-00442/IRB-20-03374) vaccinated with a monovalent XBB.1.5 vaccine, either through mRNA (Moderna or Pfizer-BioNTech; participants 1, 2, and 3) or adjuvanted protein (Novavax; participants 4 and 5) platforms. Before XBB.1.5 booster vaccination, all participants received mRNA-based priming and booster vaccine with ancestral SARS-CoV-2 and four of the five participants had a breakthrough omicron variant infection. We expressed 100 human monoclonal antibodies (mAbs; 50 from participants 1, 2, and 3, and 50 from participants 4 and 5) and evaluated their binding and neutralisation against various SARS-CoV-2 variants, including JN.1. We then selected four mAbs for in-vivo protection experiments by passive immunisation and viral challenge, and cryo-electron microscopy with two selected mAbs complexed with the XBB.1.5 spike (S) protein to determine their structures and binding interactions. FINDINGS:Between October and November, 2023, we enrolled three male and two female participants (mean age 46 years) all of whom were White. We identified 21 binding mAbs and tested their neutralisation capacity against ancestral SARS-CoV-2, XBB.1.5, and JN.1. From the six neutr

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Precision probiotics supplement strategy in aging population based on gut microbiome composition

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Briefings in bioinformatics 2024年第4期25卷 bbae351页

作者： Yi-Fang Chuang Kang-Chen Fan Yin-Yuan Su Ming-Fong Wu Yen-Ling Chiu Yi-Chien Liu Chen-Ching Lin School of Medicine National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City 112304 Taiwan. Institute of Public Health National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City 112304 Taiwan. Department of Psychiatry Far Eastern Memorial Hospital No. 21 Sec. 2 Nanya S. Rd. Banqiao Dist. New Taipei City 220216 Taiwan. Institute of Biomedical Informatics National Yang Ming Chiao Tung University No. 155 Sec. 2 Linong St. Beitou Dist. Taipei City 112304 Taiwan. Department of Medical Research Far Eastern Memorial Hospital No. 21 Sec. 2 Nanya S. Rd. Banqiao Dist. New Taipei City 220216 Taiwan. Graduate Program in Biomedical Informatics and Graduate Institute of Medicine Yuan Ze University No. 135 Yuandong Rd. Zhongli Dist. Taoyuan City 320315 Taiwan. Graduate Institute of Clinical Medicine National Taiwan University No. 1 Sec. 4 Roosevelt Rd. Taipei City 106319 Taiwan. Department of Neurology Cardinal Tien Hospital No. 362 Zhongzheng Rd. Xindian Dist. New Taipei City 231009 Taiwan.

With the increasing prevalence of age-related chronic diseases burdening healthcare systems, there is a pressing need for innovative management strategies. Our study focuses on the gut microbiota, essential for metabo... 详细信息

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Community-based intervention in reducing flood impacts in Gambia

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IOP Conference Series: Earth and Environmental Science 2021年第1期711卷

作者： A Jonga E Meilianda Nizamuddin Graduate Program School of Disaster Science Universitas Syiah Kuala Banda Aceh 23111 Indonesia Tsunami and Disaster Mitigation Research Centre (TDMRC) Universitas Syiah Kuala Banda Aceh 23111 Indonesia Civil Engineering Department Engineering Faculty Universitas Syiah Kuala Banda Aceh 23111 Indonesia Informatics Department Mathematics and Natural Science Faculty Universitas Syiah Kuala Banda Aceh 23111 Indonesia

Flood has caused significant damage to the agricultural sector, which results in low productivity and causes famine in Kaba-kama community of Basse in the Upper river region of the Gambia. This study analyses the pote...

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