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Microengineered platforms for characterizing the contractile function of in vitro cardiac models

Microsystems & Nanoengineering 2022年第1期8卷 29-50页

作者： Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes Yu Sun Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Program in Molecular Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Biochemistry University of TorontoTorontoON M5S 1A8Canada Institute of Robotics and Automatic Information System and the Tianjin Key Laboratory of Intelligent Robotics Nankai UniversityTianjin 300350China School of Mechanical&Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444China Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Translational Biology&Engineering Program Ted Rogers Centre for Heart ResearchTorontoON M5G 1M1Canada Department of Anesthesiology and Pain Medicine University of TorontoTorontoON M5S 1A8Canada Department of Anesthesia and Pain Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Electrical and Computer Engineering University of TorontoTorontoON M5S 3G4Canada Department of Computer Science University of TorontoTorontoON M5T 3A1Canada

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic *** still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue *** to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive *** new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac *** this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac *** characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and *** addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease ***,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed.

关键词： cardiac contractile regularity

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Optimisation of a siamese neural network for real-time energy efficient object tracking

TechRxiv

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TechRxiv 2020年

作者： Przewlocka, Dominika Wasala, Mateusz Szolc, Hubert Blachut, Krzysztof Kryjak, Tomasz Embedded Vision Systems Group Computer Vision Laboratory Department of Automatic Control and Robotics AGH University of Science and Technology Krakow Poland

In this paper the research on optimisation of visual object tracking using a Siamese neural network for embedded vision systems is presented. It was assumed that the solution shall operate in real-time, preferably for a high resolution video stream, with the lowest possible energy consumption. To meet these requirements, techniques such as the reduction of computational precision and pruning were considered. Brevitas, a tool dedicated for optimisation and quantisation of neural networks for FPGA implementation, was used. A number of training scenarios were tested with varying levels of optimisations – from integer uniform quantisation with 16 bits to ternary and binary networks. Next, the influence of these optimisations on the tracking performance was evaluated. It was possible to reduce the size of the convolutional filters up to 10 times in relation to the original network. The obtained results indicate that using quantisation can significantly reduce the memory and computational complexity of the proposed network while still enabling precise tracking, thus allow to use it in embedded vision systems. Moreover, quantisation of weights positively affects the network training by decreasing overfitting. © 2020, CC BY-NC-SA.

关键词： Field programmable gate arrays (FPGA)

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Optimisation of a siamese neural network for real-time energy efficient object tracking

arXiv

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arXiv 2020年

In this paper the research on optimisation of visual object tracking using a Siamese neural network for embedded vision systems is presented. It was assumed that the solution shall operate in real-time, preferably for a high resolution video stream, with the lowest possible energy consumption. To meet these requirements, techniques such as the reduction of computational precision and pruning were considered. Brevitas, a tool dedicated for optimisation and quantisation of neural networks for FPGA implementation, was used. A number of training scenarios were tested with varying levels of optimisations - from integer uniform quantisation with 16 bits to ternary and binary networks. Next, the influence of these optimisations on the tracking performance was evaluated. It was possible to reduce the size of the convolutional filters up to 10 times in relation to the original network. The obtained results indicate that using quantisation can significantly reduce the memory and computational complexity of the proposed network while still enabling precise tracking, thus allow to use it in embedded vision systems. Moreover, quantisation of weights positively affects the network training by decreasing overfitting. Copyright © 2020, The Authors. All rights reserved.

关键词： Field programmable gate arrays (FPGA)

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THE BLESSINGS OF MULTIPLE TREATMENTS AND OUTCOMES IN TREATMENT EFFECT ESTIMATION

arXiv

引用

arXiv 2023年

作者： Wu, Yong Liu, Mingzhou Yan, Jing Fu, Yanwei Wang, Shouyan Wang, Yizhou Sun, Xinwei Institute of Science and Technology for Brain-Inspired Intelligence Fudan University China Computer Science Department Peking University China School of Data Science Fudan University China Key Laboratory of Computational Neuroscience Brain-Inspired Intelligence China MOE Frontiers Center for Brain Science Fudan University China Zhangjiang Fudan International Innovation Center China Engineering Research Center of AI & Robotics Ministry of Education Fudan University China

Assessing causal effects in the presence of unobserved confounding is a challenging problem. Existing studies leveraged proxy variables or multiple treatments to adjust for the confounding bias. In particular, the latter approach attributes the impact on a single outcome to multiple treatments, allowing estimating latent variables for confounding control. Nevertheless, these methods primarily focus on a single outcome, whereas in many real-world scenarios, there is greater interest in studying the effects on multiple outcomes. Besides, these outcomes are often coupled with multiple treatments. Examples include the intensive care unit (ICU), where health providers evaluate the effectiveness of therapies on multiple health indicators. To accommodate these scenarios, we consider a new setting dubbed as multiple treatments and multiple outcomes. We then show that parallel studies of multiple outcomes involved in this setting can assist each other in causal identification, in the sense that we can exploit other treatments and outcomes as proxies for each treatment effect under study. We proceed with a causal discovery method that can effectively identify such proxies for causal estimation. The utility of our method is demonstrated in synthetic data and sepsis disease. Copyright © 2023, The Authors. All rights reserved.

关键词： Intensive care units

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Rank-Based Filter Pruning for Real-Time Deep Uav Trackers

SSRN

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SSRN 2022年

作者： Wang, Xucheng Zeng, Dan Zhao, Qijun Li, Shuiwang Guangxi Key Laboratory of Embedded Technology and Intelligent System Guilin University of Technology Guilin541001 China Research Institute of Trustworthy Autonomous Systems Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen518000 China Sichuan University Chengdu610000 China

UAV tracking is an emerging task and has wide potential applications in such as agriculture, navigation, entertainment and public security. However, the limitations of computing resources, battery capacity, and maximum load of UAV hinder the deployment of DL-based tracking algorithms on UAV. In contrast to deep learning trackers, discriminative correlation filters (DCF)-based trackers stand out in the UAV tracking community because of their high efficiency. However, their precision is usually much lower than trackers based on deep learning. Model compression is a promising way to narrow the gap (i.e., effciency, precision) between DCF- and deep learning- based trackers, which has not caught much attention in UAV tracking community. In this paper, We propose the P-SiamFC++ tracker, which is the first to use rank-based filter pruning to compress the SiamFC++ model, achieving a remarkable balance between efficiency and precision. Our method is general and may encourage further studies on UAV tracking with model compression in the future. Extensive experiments on four UAV benchmarks, including UAV123@10fps, DTB70, UAVDT and Vistrone2018, show that P-SiamFC++ tracker significantly outperforms state-of-the-art UAV tracking methods. © 2022, The Authors. All rights reserved.

关键词： Unmanned aerial vehicles (UAV)

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Exploiting Rank-Based Filter Pruning for Real-Time Uav Tracking

SSRN

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SSRN 2022年

作者： Wang, Xucheng Zeng, Dan Zhao, Qijun Li, Shuiwang Guangxi Key Laboratory of Embedded Technology and Intelligent System Guilin University of Technology Guilin541001 China Research Institute of Trustworthy Autonomous Systems Department of computer science and engineering Southern University of Science and Technology Shenzhen518000 China Sichuan University Chengdu610000 China

关键词： Unmanned aerial vehicles (UAV)

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Optimal Landing of Tilt-rotor Aircraft after Engine Failure Considering Pilot Inherent Limitations

Optimal Landing of Tilt-rotor Aircraft after Engine Failure ...

引用

IEEE International Conference on robotics and Biomimetics

作者： Xufei Yan Renliang Chen Shiqiang Zhu Anhuan Xie Jason Gu Research Center for Intelligent Robotics Zhejiang Lab Hangzhou 311100 China. Zhejiang Engineering Research Center for Intelligent Robotics Hangzhou China National Key Laboratory of Science and Technology on Rotorcraft Aeromechanics College of Aeronautics Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu China Intelligent Robot Research Center Zhejiang Lab Hangzhou Zhejiang China Department of Electrical and Computer Engineering Dalhousie University Halifax NS Canada

ISBN: (纸本)9781665481106

An augmented longitudinal rigid-body model is developed with a set of algebra equations describing the controls in the cockpit and the differential equations describing the pilot inherent limitations. The landing procedure after one engine failure is formulated into a nonlinear optimal control problem. XV-15 tilt-rotor aircraft is taken as the sample for the demonstration of landing in one engine failure during short takeoff. The results show that the total power required, thrust coefficient, longitudinal flapping angle and optimal controls are more relatively gentle than the solutions without considering the pilot inherent limitations. Compared with the basic longitudinal rigid-body model, the optimal solutions involve more control information.

关键词： Atmospheric modeling Optimal control Rotors Mathematical models History Aircraft propulsion Aircraft

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A Lightweight Flexible Semi-Cylindrical Valve for Seamless Integration in Soft Robots Based on the Giant Electrorheological Fluid

SSRN

引用

SSRN 2022年

作者： Huang, Tiantian Xu, Denan Zhang, Hang Bai, Ou Aravelli, Aparna Zhou, Xiaoxiao Han, Bin School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan430070 China Human Cyber-Physical Systems Laboratory The Department of Electrical and Computer Engineering Florida International University Florida33174 United States Applied Research Center Florida International University Florida33174 United States Guangdong Intelligent Robotics Institute Dongguan523808 China

Complete compliance of soft robots is a trending research topic. One significant aspect is the control element. In the current work, a flexible electro-rheological (ER) valve development is chosen due to the advantage of its dynamic power density, convenient electronic control mode and no mechanical moving parts. These properties enable the ER valve to be miniaturized and easily integrated into a fluid-driven soft robot. However, the integration effect of the existing flexible ER valve configuration in soft robots is not ideal. In this study, a novel concentric semi-cylindrical flexible giant ER (GER) valve with a dual flowing direction is proposed for a soft robot to enable a larger deformation bending motion with multiple motion modes. The resulting valve has an overall volume of 50 mm 3 , a mass of 0.88 g, and a maximum controlling pressure of 84 kPa with a pressure change rate of 13.9, which is suitable for most soft robot applications. The pressure difference calculation method for the concentric semi-cylindrical GER valve is discussed. The effects of size, voltages, and flow rates on the valve’s static and dynamic performances, as well as the characteristics of the two pressure regulation modes, are investigated through simulations and experiments. The seamless integration and flexibility of the proposed valve are demonstrated by controlling a typical network actuator with six motion modes. Finally, a soft robot composed of two actuators is fabricated and realized the grasping of multiple everyday objects using different motion modes. © 2022, The Authors. All rights reserved.

关键词： Nanofluidics

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Bacteria Flagella-Mimicking Polymer Multilayer Magnetic Microrobots

SSRN

引用

SSRN 2024年

作者： Wu, Zhiguang Lu, Liang Bai, Shuang Shi, Jiaqi Zhang, Zhuotao Pan, Yunlu Wang, Wei Wu, Wenfeng Sun, Shoubin Li, Xu Hou, Gang Huang, Tianyun Jia, Yuxin Zuo, Kaiwen Granovsky, Alexander Wu, He Nikolai, Perov School of Medicine and Health Harbin Institute of Technology Harbin China State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin China The First Affiliated Hospital of Harbin Medical University Harbin China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and Multimorbidity National Clinical Research Center for Respiratory Diseases Institute of Respiratory Medicine Chinese Academy of Medical Sciences Department of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China-Japan Friendship Hospital Beijing China College of Science Sichuan Agricultural University Chengdu China The Fourth Affiliated Hospital of Harbin Medical University Harbin China Department of Ophthalmology The Second Hospital Jilin University Changchun China Department of Advanced Manufacturing and Robotics College of Engineering State Key Laboratory for Turbulence and Complex Systems Peking University Beijing China Department of Mathematics Imperial College London United Kingdom Department of Computer Science University of Warwick Coventry United Kingdom Magnetism Department Faculty of Physics Lomonosov Moscow State University Moscow Russia Harbin Medical University China

Learning from natural bacteria flagellum, we demonstrate a magnetic polymer multilayer conical microrobot that bestow the controllable propulsion upon external rotating magnetic field with uniform intensity. The magnetic microrobots were constructed by template-assisted Layer-by-Layer technique technique and subsequent functionalization of magnetic particle onto the big opening of the microrobots. Geometric variables of the polymer microrobots, such as the diameter and wall thickness, can be controlled by selection of porous template and layers of assembly. The microrobots perform controllable propulsion through the manipulation of magnetic field. The comparative analysis of the movement behavior reveals that the deformation of microrobots may attributed to the propulsion upon rotating magnetic field, which is similar as that of natural bacteria. The influence of actuation frequencies and frequencies on the velocity of the microrobots is studied. Such use of polymer polymer multilayer tubular micro/nanoarchitectures results in significant savings in the processing costs and provides a simple and cost-effective fabrication route for the mass production of magnetic polymer microrobots. © 2024, The Authors. All rights reserved.

关键词： Bacteria

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DPER: Diffusion Prior Driven Neural Representation for Limited Angle and Sparse View CT Reconstruction

arXiv

引用

arXiv 2024年

作者： Du, Chenhe Lin, Xiyue Wu, Qing Tian, Xuanyu Su, Ying Luo, Zhe Zheng, Rui Chen, Yang Wei, Hongjiang Zhou, S. Kevin Yu, Jingyi Zhang, Yuyao The School of Information Science and Technology ShanghaiTech University Shanghai China The Department of Critical Care Medicine Zhongshan Hospital Fudan University Shanghai China The Laboratory of Image Science and Technology The School of Computer Science and Engineering The Key Laboratory of New Generation Artificial Intelligence Technology and Its Interdisciplinary Applications Southeast University Ministry of Education Nanjing210096 China The School of Biomedical Engineering Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China School of Biomedical Engineering Suzhou Institute for Advanced Research University of Science and Technology of China Suzhou215123 China Institute of Computing Technology CAS Beijing100190 China

Limited-angle and sparse-view computed tomography (LACT and SVCT) are crucial for expanding the scope of X-ray CT applications. However, they face challenges due to incomplete data acquisition, resulting in diverse artifacts in the reconstructed CT images. Emerging implicit neural representation (INR) techniques, such as NeRF, NeAT, and NeRP, have shown promise in under-determined CT imaging reconstruction tasks. However, the unsupervised nature of INR architecture imposes limited constraints on the solution space, particularly for the highly ill-posed reconstruction task posed by LACT and ultra-SVCT. In this study, we introduce the Diffusion Prior Driven Neural Representation (DPER), an advanced unsupervised framework designed to address the exceptionally ill-posed CT reconstruction inverse problems. DPER adopts the Half Quadratic Splitting (HQS) algorithm to decompose the inverse problem into data fidelity and distribution prior sub-problems. The two sub-problems are respectively addressed by INR reconstruction scheme and pre-trained score-based diffusion model. This combination first injects the implicit image local consistency prior from INR. Additionally, it effectively augments the feasibility of the solution space for the inverse problem through the generative diffusion model, resulting in increased stability and precision in the solutions. We conduct comprehensive experiments to evaluate the performance of DPER on LACT and ultra-SVCT reconstruction with two public datasets (AAPM and LIDC), an in-house clinical COVID-19 dataset and a public raw projection dataset created by Mayo Clinic. The results show that our method outperforms the state-of-the-art reconstruction methods on in-domain datasets, while achieving significant performance improvements on out-of-domain (OOD) datasets. Copyright © 2024, The Authors. All rights reserved.

关键词： Inverse problems

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