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Progression subtypes in Parkinson's disease: Results of an AI-based multi-cohort analysis

Clinical Neurophysiology 2024年 159卷 e39-e39页

作者： Hähnel, T. Raschka, T. Sapienza, S. Klucken, J. Glaab, E. Corvol, J. Falkenburger, B. Fröhlich, H. Department of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus TUD Dresden University of Technology Dresden Germany Department of Bioinformatics Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Sankt Augustin Germany Bonn-Aachen International Center for IT University of Bonn Bonn Germany Biomedical Data Science Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg Esch-sur-Alzette Luxembourg Luxembourg Institute of Health (LIH) Strassen Luxembourg Centre Hospitalier de Luxembourg (CHL) Luxembourg Sorbonne Université Paris Brain Institute – ICM Inserm CNRS Assistance Publique Hôpitaux de Paris Pitié-Salpêtrière Hospital Department of Neurology Paris France German Center for Neurodegenerative Diseases (DZNE) Tatzberg 41 01307 Dresden Germany

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Informed machine learning - A taxonomy and survey of integrating prior knowledge into learning systems

arXiv

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arXiv 2019年

作者： von Rueden, Laura Mayer, Sebastian Beckh, Katharina Georgiev, Bogdan Giesselbach, Sven Heese, Raoul Kirsch, Birgit Pfrommer, Julius Pick, Annika Ramamurthy, Rajkumar Walczak, Michal Garcke, Jochen Bauckhage, Christian Schuecker, Jannis The Fraunhofer IAIS Institute for Intelligent Analysis and Information Systems Sankt Augustin53757 Germany The Fraunhofer SCAI Institute for Algorithms and Scientific Computing Sankt Augustin53757 Germany The Fraunhofer ITWM Institute for Industrial Mathematics Kaiserslautern67663 Germany The Fraunhofer IOSB Institute for Optronics System Technologies and Image Exploitation Karlsruhe76131 Germany

Despite its great success, machine learning can have its limits when dealing with insufficient training data. A potential solution is the additional integration of prior knowledge into the training process which leads to the notion of informed machine learning. In this paper, we present a structured overview of various approaches in this field. We provide a definition and propose a concept for informed machine learning which illustrates its building blocks and distinguishes it from conventional machine learning. We introduce a taxonomy that serves as a classification framework for informed machine learning approaches. It considers the source of knowledge, its representation, and its integration into the machine learning pipeline. Based on this taxonomy, we survey related research and describe how different knowledge representations such as algebraic equations, logic rules, or simulation results can be used in learning systems. This evaluation of numerous papers on the basis of our taxonomy uncovers key methods in the field of informed machine learning. © 2019, CC BY.

关键词： Surveys

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Redefining pandemic preparedness:Multidisciplinary insights from the CERP modelling workshop in infectious diseases,workshop report

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Infectious Disease Modelling 2024年第2期9卷 501-518页

作者： Marta C.Nunes Edward Thommes Holger Fröhlich Antoine Flahault Julien Arino Marc Baguelin Matthew Biggerstaff Gaston Bizel-Bizellot Rebecca Borchering Giacomo Cacciapaglia Simon Cauchemez Alex Barbier-Chebbah Carsten Claussen Christine Choirat Monica Cojocaru Catherine Commaille-Chapus Chitin Hon Jude Kong Nicolas Lambert Katharina B.Lauer Thorsten Lehr Cédric Mahe Vincent Marechal Adel Mebarki Seyed Moghadas Rene Niehus Lulla Opatowski Francesco Parino Gery Pruvost Andreas Schuppert Rodolphe Thiébaut Andrea Thomas-Bachli Cecile Viboud Jianhong Wu Pascal Crépey Laurent Coudeville Center of Excellence in Respiratory Pathogens(CERP) Hospices Civils de Lyon(HCL)and Centre International de Recherche en Infectiologie(CIRI)Équipe SantéPubliqueÉpidémiologie etÉcologieÉvolutive des Maladies Infectieuses(PHE3ID)Inserm U1111CNRS UMR5308ENS de LyonUniversitéClaude Bernard Lyon 1LyonFrance South African Medical Research Council Vaccines&Infectious Diseases Analytics Research UnitFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa New Products and Innovation(NPI) Sanofi Vaccines(Global)TorontoOntarioCanada Department of Mathematics and Statistics University of GuelphGuelphOntarioCanada Fraunhofer Institute for Algorithms and Scientific Computing(SCAI) Department of BioinformaticsSchloss BirlinghovenSankt AugustinGermany University of Bonn Bonn-Aachen International Center for IT(b-it)BonnGermany Institute of Global Health Faculty of MedicineUniversity of GenevaGenevaSwitzerland and Swiss School of Public HealthZürichSwitzerland Department of Mathematics University of ManitobaWinnipegManitobaCanada MRC Centre for Global Infectious Disease Analysis School of Public HealthImperial College LondonLondonUK Centre for Mathematical Modelling of Infectious Diseases Department of Infectious Disease EpidemiologyLondon School of Hygiene&Tropical MedicineLondonUK National Center for Immunization and Respiratory Diseases(NCIRD) US Centers for Disease Control and Prevention(CDC)AtlantaGAUSA Departement of Computational Biology Departement of Global HealthInstitut PasteurParisFrance Institut de Physique des Deux Infinis de Lyon(IP2I) UMR5822IN2P3/CNRSUniversitéClaude Bernard Lyon 1VilleurbanneFrance Mathematical Modelling of Infectious Diseases Unit Institut PasteurUniversitéParis CitéUMR2000 CNRSParisFrance Decision and Bayesian Computation Institut PasteurUniversitéParis CitéCNRS UMR 3571France Fraunhofer-Institute for Translational Medicine and Pharmacology HamburgGermany Institute of Global Health Faculty of MedicineUniversity of

In July 2023,the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 *** report summarizes the rich discussions that occurred during the *** workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data,social media,and wastewater *** advancements were noted in the development of predictive models,with examples from various countries showcasing the use of machine learning and artificial intelligence in detecting and monitoring disease *** role of open collaboration between various stakeholders in modelling was stressed,advocating for the continuation of such partnerships beyond the pandemic.A major gap identified was the absence of a common international framework for data sharing,which is crucial for global pandemic ***,the workshop underscored the need for robust,adaptable modelling frameworks and the integration of different data sources and collaboration across sectors,as key elements in enhancing future pandemic response and preparedness.

关键词： Modelling Covid-19 Infectious diseases Pandemic preparedness Workshop

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Evaluating digital device technology in Alzheimer’s disease via artificial intelligence

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Alzheimer's & Dementia 2021年第S6期17卷

作者： Meemansa Sood Robbert Harms Maximilian Bügler Ioannis Tarnanas Neva Coello Holger Fröhlich Bonn-Aachen International Center for IT (b-it) Bonn Germany Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Altoida Inc. Houston TX USA Altoida AG Hirschengraben Lucerne Switzerland Global Brain Health Institute Trinity College Dublin Ireland Hellenic Initiative Against Alzheimer's Disease Johns Hopkins Precision Medicine Center Baltimore MD USA Novartis Basel Switzerland

Background Digital Measures (DMs) derived from mobile devices and smartphone applications have received a strongly increasing attention during the last years, because they could allow for an accurate, quantitative monitoring of disease symptoms, even outside clinics. In addition, DMs may help to diagnose Alzheimer’s Disease (AD) in a pre-symptomatic stage and thus increase the success chances of therapeutic interventions. However, before any use in clinical routine, DMs have to be evaluated carefully by assessing their relationship to established clinical scores and understanding their diagnostic benefit. In this regard the IMI project RADAR-AD ( *** ) has the ambition to evaluate a broad panel of digital technologies with respect to their potential for early disease diagnosis while focusing on functional activities of daily living. Method An example of a panel of digital technology RADAR-AD uses is a smartphone based virtual reality game resulting into an assessment of cognitive impairment. In our work we analyzed connections between digital readouts and cognitive features like MMSE (Mini Mental State Examination) via one of our recently developed Artificial Intelligence (AI) approaches called Variational Autoencoder Modular Bayesian Networks (VAMBN). Going one step further we also tested the possibility to accurately predict MMSE scores from DMs and vice versa via machine learning. Based on this finding we then simulated DMs within the ADNI cohort and re-ran VAMBN. Result Application of VAMBN on the data from virtual reality game resulted into a network comprising DMs, MMSE sub-item scores and demographic features (Figure 1). It thus allowed to disentangle and quantify the relationship between DMs and established clinical scores. The simulation of DM’s and application of VAMBN in the ADNI cohort allowed us to further predict connections of DMs with FAQ (Functional Activity Questionnaire) and even molecular mechanisms. Conclusion Our results indicate t

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Assessment of RMTs for Discriminating Stages of Alzheimer’s Disease

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Alzheimer's & Dementia 2023年第S22期19卷

作者： Manuel Lentzen Srinivasan Vairavan Jelena Curcic Alankar Atreya Chris Hinds Marijn Muurling Pauline Conde Margarita Grammatikopoulou Ioulietta Lazarou Spiros Nikolopoulos Neva Coello Casper de Boer Dag Aarsland Anna-Katharine Brem Holger Fröhlich RADAR-AD Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Bonn-Aachen International Center for IT (b-it) Bonn Germany Janssen Research and Development LLC Titusville NJ USA Novartis Institutes for BioMedical Research Basel Switzerland University of Oxford Oxford United Kingdom VU University Medical Center Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Amsterdam Neuroscience Neurodegeneration Amsterdam Netherlands King’s College London London United Kingdom Centre for Research & Technology Hellas Thessaloniki Greece Amsterdam Neuroscience Neurodegeneration Amsterdam Noord-Holland Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands

Background RADAR-AD is a European project in the context of the Innovative Medicine Initiative (IMI) focusing on the earlier identification of patients at risk for developing Alzheimer’s Disease (AD) via a panel of remote monitoring technologies (RMTs), including smartphone apps and wearable devices. Method We examined the ability of 6 RMTs (Altoida, Axivity, Banking app, Fitbit, Physilog, and Mezurio) to distinguish between healthy controls (HC) and disease stages of preclinical (PreAD), prodromal (ProAD), and mild to moderate Alzheimer’s disease (MildAD) based on 175 patients (interim analysis). We trained three machine learning classifiers (Logistic Regression, Random Forest, and XGBoost) in a pairwise setting (HC vs. PreAD, HC vs. ProAD, HC vs. MildAD, PreAD vs. ProAD, and ProAD vs. MildAD). Since the interim dataset is still limited, we performed repeated, stratified nested cross-validation to get a robust performance estimate. Each classifier was trained with the features of the different devices and a set of baseline variables. The latter include a patient’s gender, age, years of education, and body mass index (BMI) when physical conditions might play a role (Axivitiy, Fitbit, Physilog). In addition, we checked whether specific patterns of the study groups allowed discrimination of the different study groups based on the baseline variables alone. Therefore, we trained one Logistic Regression model with these variables and compared the performance of the other three models with this baseline. The models trained with the baseline and questionnaire-based data served as the reference value in our benchmark that represents how well the discrimination of the different groups works with clinical tests. Result Our preliminary data show that RMTs can identify patients already in a prodromal disease stage (AUC ∼69%, Figure 1). Furthermore, the pairwise combination of data from a banking app and an app monitoring functional cognitive abilities via an augmented reality g

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Pseudoentropic derivation of the regularized lattice Boltzmann method

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Physical Review E 2019年第2期100卷 023302-023302页

作者： Andreas Krämer Dominik Wilde Knut Küllmer Dirk Reith Holger Foysi Institute of Technology Resource and Energy-efficient Engineering (TREE) Bonn-Rhein-Sieg University of Applied Sciences Grantham-Allee 20 53757 Sankt Augustin Germany National Heart Lung and Blood Institute National Institutes of Health Bethesda Maryland 20892 United States Department of Mechanical Engineering University of Siegen Paul-Bonatz-Straße 9-11 57076 Siegen-Weidenau Germany Fraunhofer Institute for Algorithms and Scientific Computing (SCAI) Schloss Birlinghoven 53754 Sankt Augustin Germany

The lattice Boltzmann method (LBM) facilitates efficient simulations of fluid turbulence based on advection and collision of local particle distribution functions. To ensure stable simulations on underresolved grids, the collision operator must prevent drastic deviations from local equilibrium. This can be achieved by various methods, such as the multirelaxation time, entropic, quasiequilibrium, regularized, and cumulant schemes. Complementing a part of a unified theoretical framework of these schemes, the present work presents a derivation of the regularized lattice Boltzmann method (RLBM), which follows a recently introduced entropic multirelaxation time LBM by Karlin, Bösch, and Chikatamarla (KBC). It is shown that both methods can be derived by locally maximizing a quadratic Taylor expansion of the entropy function. While KBC expands around the local equilibrium distribution, the RLBM is recovered by expanding entropy around a global equilibrium. Numerical tests were performed to elucidate the role of pseudoentropy maximization in these models. Simulations of a two-dimensional shear layer show that the RLBM successfully reproduces the largest eddies even on a 16×16 grid, while the conventional LBM becomes unstable for grid resolutions of 128×128 and lower. The RLBM suppresses spurious vortices more effectively than KBC. In contrast, simulations of the three-dimensional Taylor-Green and Kida vortices show that KBC performs better in resolving small scale vortices, outperforming the RLBM by a factor of 1.8 in terms of the effective Reynolds number.

关键词： Flow instability Shear flows Turbulence

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Motor-cognitive dual tasking in the clinical setting: a sensitive measure of functional impairment in early Alzheimer’s disease

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Anna-Katharine Brem Gaetano Scebba Jelena Curcic Marijn Muurling Casper de Boer Neva Coello Alankar Atreya Pauline Conde Holger Fröhlich Margarita Grammatikopoulou Chris Hinds Ioulietta Lazarou Manuel Lentzen Vaibhav A Narayan Rouba Kozak Spiros Nikolopoulos Srinivasan Vairavan Pieter Jelle Visser Gayle Wittenberg Dag Aarsland RADAR-AD Consortium University Hospital of Old Age Psychiatry University of Bern Bern Switzerland King’s College London London United Kingdom Correspondece Novartis Institutes for BioMedical Research Basel Switzerland Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands University of Oxford Oxford United Kingdom Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Centre for Research & Technology Hellas Thessaloniki Greece Davos Alzheimers Collaborative Wayne PA USA Novartis Cambridge MA USA Janssen Research and Development LLC Titusville NJ USA Alzheimer Center Amsterdam Department of Neurology Amsterdam University Medical Center Amsterdam Netherlands Maastricht University Maastricht Netherlands Stavanger University Hospital Stavanger Norway

Background Gait is a complex everyday activity that depends upon supraspinal activity and a host of cognitive functions such as attention and executive functions. As cognition declines in neurodegenerative diseases, the interaction and competition for neuronal resources during motor-cognitive dual-tasking (e.g., walking while talking) might be a sensitive measure of subtle functional impairments in early Alzheimer’s disease (AD). Here, we aim to identify gait deficits due to neuronal competition across the AD spectrum. Method This investigation is part of the ongoing Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD) study. We attached three inertial measurement units (accelerometer and gyroscope) to both feet and one hip to assess dual task effects (DTE) assessing gait performance with/without concurrent serial subtraction-by-1 task in four groups: 1) amyloid negative healthy controls (HC, N = 59); and 2) amyloid positive preclinical AD (PreAD, N = 30); 3) prodromal AD (ProAD, N = 51); and 4) mild-to-moderate AD dementia (MildAD, N = 44) (Table 1). We furthermore investigated associations of DTE with observer-reported cognition. Result Group comparisons showed that dual-tasking induced lower cadence and increased stance, which were significantly different between HC and ProAD. Several DTE measures of variability differed significantly between PreAD and MildAD, with variability in the path length separating best between PreAD and ProAD (Table 2, Figure 1). DTE measures were associated with observer-rated divided attention only in the MildAD group. Conclusion Neuronal competition as assessed with motor-cognitive dual-tasking, specifically the DTE variability, might reflect functional deficits already in early AD, and could be a valuable additional measure to detect early impairments not captured by cognitive or motor tests alone. Future studies should implement an adaptive cognitive load to improve sensitivity/specificity in early AD stages and

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Ten new insights in climate science 2024

One Earth

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One Earth 2025年第6期8卷 None页

作者： Schaeffer, Roberto Schipper, E. Lisa F. Ospina, Daniel Mirazo, Paula Alencar, Ane Anvari, Mehrnaz Artaxo, Paulo Biresselioglu, Mehmet Efe Blome, Tanja Boeckmann, Melanie Brink, Ebba Broadgate, Wendy Bustamante, Mercedes Cai, Wenju Canadell, Josep G. Cardinale, Roberto Chidichimo, Maria Paz Ditlevsen, Peter Eicker, Ursula Feron, Sarah Fikru, Mahelet G. Fuss, Sabine Gaye, Amadou T. Gustafsson, Örjan Harring, Niklas He, Cheng Hebden, Sophie Heilemann, Adrian Hirota, Marina Janardhanan, Nandakumar Juhola, Sirkku Jung, Tae Yong Kejun, Jiang Kilkiș, Şiir Kumarasinghe, Nilushi Lapola, David Lee, June-Yi Levis, Carolina Lusambili, Adelaide Maasakkers, Joannes D. MacIntosh, Claire Mahmood, Jemilah Mankin, Justin S. Marchegiani, Pía Martin, Maria Mukherji, Aditi Muñoz-Erickson, Tischa A. Niazi, Zeenat Nyangon, Joseph Pandipati, Santosh Perera, Amarasinghage T.D. Persad, Geeta Persson, Åsa Redman, Aaron Riipinen, Ilona Rockström, Johan Roffe, Sarah Roy, Joyashree Sakschewski, Boris Samset, Bjørn H. Schlosser, Peter Sharifi, Ayyoob Shih, Wan-Yu Sioen, Giles B. Sokona, Youba Stammer, Detlef Suk, Sunhee Thiam, Djiby Thompson, Vikki Tullos, Erin van Westen, René M. Vargas Falla, Ana Maria Vecellio, Daniel J. Worden, John Wu, Henry C. Xu, Chi Yang, Yang Zachariah, Mariam Zhang, Zhen Ziervogel, Gina Federal University of Rio de Janeiro Rio de Janeiro Brazil University of Bonn Bonn Germany Future Earth Secretariat Stockholm Sweden Arizona State University Tempe AZ United States Amazon Environmental Research Institute (IPAM) Brasilia Brazil Fraunhofer Institute for Algorithms and Scientific Computing SCAI St. Augustin Germany Potsdam Institute for Climate Impact Research (PIK) Potsdam Germany University of São Paulo São Paulo Brazil İzmir University of Economics İzmir Turkey Climate Service Center Germany (GERICS) Helmholtz-Zentrum Hereon Hamburg Germany University of Bremen Bremen Germany Lund University Lund Sweden University of Brasilia Brasilia Brazil Ocean University of China Qingdao China Xiamen University Xiamen China Commonwealth Scientific and Industrial Research Organisation (CSIRO) Environment Canberra ACT Australia University College London London United Kingdom National Scientific and Technical Research Council (CONICET) Buenos Aires Argentina National University of San Martin Buenos Aires Argentina University of Copenhagen Copenhagen Denmark Concordia University Montreal QC Canada University of Groningen Groningen Netherlands Missouri University of Science and Technology Rolla MO United States Mercator Research Institute on Global Commons and Climate Change (MCC) Berlin Germany Humboldt-University of Berlin Berlin Germany Cheikh Anta Diop University Dakar Senegal Stockholm University Stockholm Sweden University of Gothenburg Gothenburg Sweden Institute of Epidemiology Helmholtz Zentrum München—German Research Center for Environmental Health (GmbH) Neuherberg Germany European Space Agency (ESA) - European Centre for Space Applications and Telecommunications (ECSAT) Oxford United Kingdom Federal University of Santa Catarina Florianopolis Brazil Institute for Global Environmental Strategies (IGES) Hayama Japan University of Helsinki Helsinki Finland Yonsei University Graduate Seoul South Korea Chinese Academy of Macroeconomic

The years 2023 and 2024 were characterized by unprecedented warming across the globe, underscoring the urgency of climate action. Robust science advice for decision makers on subjects as complex as climate change requires deep cross- and interdisciplinary understanding. However, navigating the ever-expanding and diverse peer-reviewed literature on climate change is enormously challenging for individual researchers. We elicited expert input through an online questionnaire (188 respondents from 45 countries) and prioritized 10 key advances in climate-change research with high policy relevance. The insights span a wide range of areas, from changes in methane and aerosol emissions to the factors shaping citizens’ acceptance of climate policies. This synthesis and communications effort forms the basis for a science-policy report distributed to party delegations ahead of the 29th session of the Conference of the Parties (COP29) to inform their positions and arguments on critical issues, including heat-adaptation planning, comprehensive mitigation strategies, and strengthened governance in energy-transition minerals value chains. © 2025 The Authors

关键词： adaptation climate policy climate science governance just transition mitigation resilience science policy

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App-based augmented reality to assess cognitive impairment in early Alzheimer’s disease

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Alzheimer's & Dementia 2023年第S14期19卷

作者： Anna-Katharine Brem Marijn Muurling Casper de Boer Jelena Curcic Alankar Atreya Neva Coello Pauline Conde Holger Fröhlich Margarita Grammatikopoulou Chris Hinds Ioulietta Lazarou Manuel Lentzen Robbert Harms Maximilian Bügler Vaibhav A Narayan Rouba Kozak Spiros Nikolopoulos Srinivasan Vairavan Pieter Jelle Visser Gayle Wittenberg Dag Aarsland RADAR-AD Consortium King’s College London London United Kingdom University Hospital of Old Age Psychiatry University of Bern Bern Switzerland Correspondece Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Netherlands Alzheimer Center Amsterdam Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam Noord-Holland Netherlands Novartis Institutes for BioMedical Research Basel Switzerland University of Oxford Oxford United Kingdom Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany Centre for Research & Technology Hellas Thessaloniki Greece Altoida Inc. Washington DC USA Davos Alzheimers Collaborative Wayne PA USA Novartis Cambridge MA USA Janssen Research and Development LLC Titusville NJ USA Alzheimer Center Amsterdam Department of Neurology Amsterdam University Medical Center Amsterdam Netherlands Maastricht University Maastricht Netherlands Stavanger University Hospital Stavanger Norway

Background Augmented reality apps merge real world with virtual experiences and can be used to remotely assess complex instrumental activities of daily living (iADL) that are affected early in Alzheimer’s disease (AD). Our aim was to compare standard clinical measures with an augmented reality app to assess iADL that are related to memory and spatial navigation in early AD and its feasibility in the home-setting. Method We administered an augmented reality app (Altoida Inc., Washington DC, USA) in an on-going cross-sectional study (RADAR-AD: Remote Assessment of Disease and Relapse – Alzheimer’s Disease) in three groups: 1) amyloid negative healthy controls (HC, N = 49); and amyloid positive 2) preclinical AD (PreAD, N = 17); and 3) prodromal AD (ProAD, N = 29) (Table 1). Altoida’s research algorithm DNS-MCI (Digital Neuro Signature) produces the outcome of a machine learning model trained to identify cognitively normal individuals from those with cognitive impairment). DNS-MCI reflects performance in app-based tasks assessing memory and visuo-spatial function (placing and finding virtual objects, fire drill simulation) further including attention and motor performance (reaction time, finger tapping, navigational trajectory). At baseline, app-based tasks were performed in the clinic together with a standard neuropsychological assessment and iADL questionnaires (Figure 1). Participants were furthermore given the option of using Altoida in the home environment. Result The DNS-MCI score could significantly distinguish HC and PreAD participants from the ProAD group and was correlated with all neuropsychological tests and iADL questionnaires (Figures 1 and 2). Participants used the app on average 3-4 times at home (Table 1). Baseline in-clinic assessments were strongly correlated with at-home assessments (r = 0.53, p <.001). Conclusion App-based augmented reality tasks are applicable in the home setting and successful in capturing cognitive impairment in early AD. Future

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A representer theorem for deep kernel learning

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The Journal of Machine Learning Research 2019年第1期20卷

作者： Bastian Bohn Christian Rieger Michael Griebel Institute for Numerical Simulation University of Bonn Bonn Germany Institute for Numerical Simulation University of Bonn Bonn Germany and Fraunhofer Center for Machine Learning Fraunhofer Institute for Algorithms and Scientific Computing SCAI Sankt Augustin Germany

In this paper we provide a finite-sample and an infinite-sample representer theorem for the concatenation of (linear combinations of) kernel functions of reproducing kernel Hilbert spaces. These results serve as mathematical foundation for the analysis of machine learning algorithms based on compositions of functions. As a direct consequence in the finite-sample case, the corresponding infinite-dimensional minimization problems can be recast into (nonlinear) finite-dimensional minimization problems, which can be tackled with nonlinear optimization algorithms. Moreover, we show how concatenated machine learning problems can be reformulated as neural networks and how our representer theorem applies to a broad class of state-of-the-art deep learning methods.

关键词： artificial neural networks deep kernel learning multilayer kernel regularized least-squares regression representer theorem

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