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Functions of nuclear factor Y in nervous system development,function and health

Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

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A sphingolipid message promotes neuronal health across generations

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Neural Regeneration Research 2024年第11期19卷 2325-2326页

作者： Wenyue Wang Roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient *** the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across ***,the molecular mechanisms of regulating such intergenerational effects remain largely unknown.

关键词： mother intestine transferred

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Characterization of a new triaxial nanofiber membrane and osteogenic differentiation capacity of human bone marrow mesenchymal stem cells for bone repair

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Journal of Materials Research 2025年第7期40卷 1117-1134页

作者： Altundag-Erdogan, Özlem Çetinkaya, Hayrullah Çelebi-Saltik, Betül Altun, Belgin Şahin, Mehtap Mağden, Gamze Kara Öteyaka, Mustafa Özgür Department of Stem Cell Sciences Graduate School of Health Sciences and Center for Stem Cell Research and Development Hacettepe University Sihhiye Ankara06100 Turkey Department of Chemical Engineering Eskisehir Osmangazi University Eskişehir26040 Turkey Vocational School Health Services Hacettepe University Sihhiye Ankara06100 Turkey BUGAMED Biotechnology Industry and Trade Inc Eskişehir26380 Turkey Eskişehir Vocational School Electronics and Automation Eskisehir Osmangazi University Mechatronic Program Eskişehir26250 Turkey

A triaxial nanofiber membrane was developed using a custom triaxial nozzle during electrospinning. The membrane consisted of three layers (outer middle (PVA-Collagen Type I-BMP-2), and inner (PVA-nHAP)). TEM revealed the diameters of the outer, middle, and inner layers as 167.5, 142.6, and 119.3 nm, respectively. The triaxial nanofiber membrane exhibited superior tensile strength (36 MPa) and elastic modulus (2.5 GPa), along with a roughness of 359 nm and hydrophilic properties. In addition, it demonstrated a 200% swelling ratio and reduced bacterial colonization by 10.8-fold. Both Calcium deposition and ALP activity were significantly higher and increased expression of BSP (eightfold), OCN (13-fold), and OPN (488-fold) genes were observed in membrane + OST groups (p © The Author(s), under exclusive licence to The Materials Research Society 2025.

关键词： Bone

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The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans

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Small GTPases 2021年第1期12卷 60-66页

作者： Cao, Wei Deng, Shuer Pocock, Roger Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology Monash University Melbourne Australia

During development of the brain, neuronal circuits are formed through the projection of axons and dendrites in response to guidance signals. Rho GTPases (Rac1/RhoA/Cdc42) are major regulators of axo-dendritic outgrowth and guidance due to their role in controlling actin cytoskeletal dynamics, cell adhesion and motility. Functional redundancy of Rho GTPase-regulated pathways in neuronal development can mask the roles of specific GTPases. To examine potential Rho GTPase redundancy, we utilized a recently isolated hypomorphic mutation in a Caenorhabditis elegans Rac1 protein–CED-10(G30E)–which reduces the GTP binding and inhibits axon outgrowth of the PVQ interneurons. Here, we show that the CDC-42-specific guanine nucleotide exchange factor UIG-1 acts in parallel to CED-10/Rac1 to control PVQ axon outgrowth. UIG-1 performs this function in a cell-autonomous manner. Further, we found that transgenic expression of CDC-42 can compensate for aberrant CED-10(G30E)-regulated signalling during PVQ axon outgrowth. Together, our study reveals a previously unappreciated function for CDC-42 in PVQ axon outgrowth in C. elegans. © 2019 Informa UK Limited, trading as Taylor & Francis Group.

关键词： Axon outgrowth CDC-42 guanine nucleotide exchange factor Rac Rho GTPases

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Evaluating the impacts of emerging cancer therapies on ovarian function

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Current Opinion in Endocrine and Metabolic Research 2021年 18卷 15-28页

作者： Alesi, Lauren R. Winship, Amy L. Hutt, Karla J. Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology Monash University Clayton Australia

Ovarian damage, resulting in oocyte death, loss of endocrine function and infertility, is a well-documented side effect of many traditional, cytotoxic cancer therapies. However, the landscape of cancer therapies is rapidly changing. Women are now also receiving new treatments, such as small-molecule inhibitors and immunotherapies, but little is known about the potential consequences of these drug classes for the ovary and reproductive health. This lack of knowledge is because ovarian function and fertility end points are often not included in clinical trials of cancer treatments, and fertility studies on women can take years or decades to complete. Thus, studies defining the impacts of new treatments on the ovary using animal models should be prioritised. Providing patients and clinicians with evidence regarding the potential impacts on future fertility is vital for them to make informed treatment decisions. Here, we critically evaluate the potential for emerging treatments, including small-molecule inhibitors and immunotherapies, to interfere with ovarian function and fertility. We draw on knowledge of ovarian biology and the drug mechanism of action to highlight the potential mechanisms of ovarian damage. © 2021 Elsevier Ltd

关键词： Chemotherapy Fertility preservation Immune checkpoint inhibitors Immunotherapy Oncofertility Small-molecule inhibitors

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Role of mentorship, career conceptualization, and leadership in developing women’s physics identity and belonging

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Physical Review Physics Education Research 2024年第1期20卷 010114-010114页

作者： Jessica L. Rosenberg Nancy Holincheck Kathryn Fernández Benjamin W. Dreyfus Fardousa Wardere Stephanie Stehle Tiffany N. Butler Department of Physics and Astronomy George Mason University Fairfax Virginia 22030 USA College of Education and Human Development George Mason University Fairfax Virginia 22030 USA STEM Accelerator Program College of Science George Mason University Fairfax Virginia 22030 USA

The percentage of women receiving bachelor’s degrees in physics (25%) in the U.S. lags well behind that of men, and women leave the major at higher rates. Achieving equity in physics will mean that women stay in physics at the same rates as men, but this will require changes in the culture and support structures. A strong sense of belonging can lead to higher retention rates so interventions meant to increase dimensions of physics identity (interest, recognition, performance, and competence) may increase persistence overall and increase women’s retention differentially. We describe our model in which mentorship, an understanding of career options (career conceptualization), and leadership are inputs into the development of these dimensions of physics identity. This paper includes preliminary results from a qualitative study that aims to better understand how career conceptualization, leadership, and mentorship contribute to the development of physics identity and belonging. We report results from a survey of 15 undergraduate physics students which was followed up by interviews with 5 of those students. The students were from 2 institutions: a small private liberal arts college in the midwest region of the U.S. and a large public university in the southeast region of the U.S. classified as a Hispanic-serving institution (HSI). With respect to mentorship, consistent with the existing literature, we found that it could provide critical support for students’ engagement in the physics community. Leadership experiences have not previously been positioned as an important input into identity, yet we found that they helped women in physics feel more confident, contributing to their recognition of themselves as physics people. While the data on how career conceptualization contributed to the building of identity is limited, there are some connections to recognition and competence, and it will be an interesting avenue of future exploration.

关键词： Diversity & inclusion Student preparation Lower undergraduate students Upper undergraduate students

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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors

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Cellular & Molecular Immunology 2024年第10期21卷 1089-1108页

作者： Lei Peng Giacomo Sferruzza Luojia Yang Liqun Zhou Sidi Chen Department of Genetics Yale University School of MedicineNew HavenCTUSA System Biology Institute Yale UniversityWest HavenCTUSA Combined Program in the Biological and Biomedical Sciences Yale UniversityNew HavenCTUSA Molecular Cell Biology Geneticsand Development ProgramYale UniversityNew HavenCTUSA Immunobiology Program Yale UniversityNew HavenCTUSA Yale Comprehensive Cancer Center Yale University School of MedicineNew HavenCTUSA Department of Neurosurgery Yale University School of MedicineNew HavenCTUSA Yale Stem Cell Center Yale University School of MedicineNew HavenCTUSA Yale Liver Center Yale University School of MedicineNew HavenCTUSA Yale Center for Biomedical Data Science Yale University School of MedicineNew HavenCTUSA Yale Center for RNA Science and Medicine Yale University School of MedicineNew HavenCTUSA

In the past decade,chimeric antigen receptor(CAR)-T cell therapy has emerged as a promising immunotherapeutic approach for combating cancers,demonstrating remarkable efficacy in relapsed/refractory hematological malignancies in both pediatric and adult ***-natural killer(CAR-NK)cell complements CAR-T cell therapy by offering several distinct ***-NK cells do not require HLA compatibility and exhibit low safety ***,CAR-NK cells are conducive to“off-the-shelf”therapeutics,providing significant logistic advantages over CAR-T *** CAR-T and CAR-NK cells have shown consistent and promising results in hematological ***,their efficacy against solid tumors remains limited due to various obstacles including limited tumor trafficking and infiltration,as well as an immuno-suppressive tumor *** this review,we discuss the recent advances and current challenges of CAR-T and CAR-NK cell immunotherapies,with a specific focus on the obstacles to their application in solid *** also analyze in depth the advantages and drawbacks of CAR-NK cells compared to CAR-T cells and highlight CAR-NK CAR ***,we explore future perspectives of these adoptive immunotherapies,highlighting the increasing contribution of cutting-edge biotechnological tools in shaping the next generation of cellular immunotherapy.

关键词： CAR-T CAR-NK Cell therapy Cancer immunotherapy Solid tumor

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Quantum Science and Technologies in K-12: Supporting Teachers to Integrate Quantum in stem Classrooms

arXiv

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arXiv 2024年

作者： Holincheck, Nancy Rosenberg, Jessica L. Zhang, Xiaolu Butler, Tiffany N. Colandene, Michele Dreyfus, Benjamin W. College of Education and Human Development George Mason University FairfaxVA22030 United States Department of Physics and Astronomy George Mason University FairfaxVA22030 United States STEM Accelerator Program George Mason University FairfaxVA22030 United States

Quantum science and computing represent a vital intersection between science and technology, gaining increasing importance in modern society. There is a pressing need to incorporate these concepts into the K-12 curriculum, equipping new generations with the tools to navigate and thrive in an evolving technological landscape. This study explores the professional learning of K-12 teachers (n = 49) related to quantum concepts and pedagogy. We used open-ended surveys, field notes, workshop artifacts, and interviews to examine teachers’ perceptions of quantum and how they made connections between quantum and their curriculum. Our data reveal that most teachers were excited and interested in teaching quantum but were aware of potential barriers and concerns that might get in the way of teaching quantum. We found that teachers readily identified connections to math and science in their curriculum, but only a few made connections to computing. Enthusiasm for teaching quantum concepts was found in both elementary and secondary educators, suggesting a widespread recognition of its importance in preparing students for a future where quantum technology is a fundamental aspect of their lives and careers. © 2024, CC BY.

关键词： Teaching

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Role of Mentorship, Career Conceptualization, and Leadership in Developing Women's Physics Identity and Belonging

arXiv

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arXiv 2024年

作者： Rosenberg, Jessica L. Holincheck, Nancy Fernández, Kathryn Dreyfus, Benjamin W. Wardere, Fardousa Stehle, Stephanie Butler, Tiffany N. Department of Physics and Astronomy George Mason University FairfaxVA22030 United States College of Education and Human Development George Mason University FairfaxVA22030 United States STEM Accelerator Program College of Science George Mason University FairfaxVA22030 United States

The percentage of women receiving bachelor’s degrees in physics (25%) in the U.S. lags well behind that of men, and women leave the major at higher rates. Achieving equity in physics will mean that women stay in physics at the same rates as men, but this will require changes in the culture and support structures. A strong sense of belonging can lead to higher retention rates so interventions meant to increase dimensions of physics identity (interest, recognition, performance, and competence) may increase persistence overall and increase women’s retention differentially. We describe our model in which mentorship, an understanding of career options (career conceptualization), and leadership are inputs into the development of these dimensions of physics identity. This paper includes preliminary results from a qualitative study that aims to better understand how career conceptualization, leadership, and mentorship contribute to the development of physics identity and belonging. We report results from a survey of 15 undergraduate physics students which was followed up by interviews with 5 of those students. The students were from 2 institutions: a small private liberal arts college in the Midwest region of the U.S. and a large public university in the southeast region of the U.S. classified as a Hispanic-serving institution (HSI). With respect to mentorship, consistent with the existing literature, we found that it could provide critical support for students' engagement in the physics community. Leadership experiences have not previously been positioned as an important input into identity, yet we found that they helped women in physics feel more confident, contributing to their recognition of themselves as physics people. While the data on how career conceptualization contributed to the building of identity is limited, there are some connections to recognition and competence, and it will be an interesting avenue of future exploration. © 2024, CC BY-NC-ND.

关键词： Students

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Rab3a, a small GTP-binding protein, is required for the stabilization of the murine leukaemia virus Gag protein

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Small GTPases 2022年第1期13卷 162-182页

作者： Izumida, Mai Kakoki, Katsura Hayashi, Hideki Matsuyama, Toshifumi Kubo, Yoshinao Department of Clinical Medicine Institute of Tropical Medicine Nagasaki University Nagasaki Japan Department of Molecular Microbiology and Immunology Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan Japan Association for Development of Community Medicine Urology Department Omura Municipal Hospital Nagasaki Japan Medical University Research Administrator Nagasaki University School of Medicine Nagasaki Japan Department of Cancer Stem Cell Institute of Biomedical Sciences Nagasaki University Nagasaki Japan Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan

We recently identified a CD63-interacting protein to understand the role of CD63 in virion production of the human immunodeficiency virus type 1, and we have found that Rab3a forms a complex with CD63. In this study, we analysed the effect of Rab3a on virion production of the murine leukaemia virus (MLV), which is another member of the retrovirus family. We found that Rab3a silencing induced lysosomal degradation of the MLV Gag protein, and recovery of the Rab3a expression restored the level of the Gag protein through a complex formation of MLV Gag and Rab3a, indicating that Rab3a is required for MLV Gag protein expression. In contrast, CD63 silencing decreased the infectivity of released virions but had no effect on virion production, indicating that CD63 facilitates the infectivity of released MLV particles. Although Rab3a induced CD63 degradation in uninfected cells, the complex of MLV Gag and Rab3a suppressed the Rab3a-mediated CD63 degradation in MLV-infected cells. Finally, we found that the MLV Gag protein interacts with Rab3a to stabilize its own protein and CD63 that facilitates the infectivity of released MLV particles. Considering the involvement of Rab3a in lysosome trafficking to the plasma membrane, it may also induce cell surface transport of the MLV Gag protein. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

关键词： CD63 gag protein Murine leukaemia virus Rab3a

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