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Stimuli-responsive gyroid Scaffolds: hierarchical architecture and electric stimulation promote bone regeneration

Materials Today 2025年

作者： Rafael R.A. Silva Frederico Barbosa Guilherme Ferreira Carlos Ureña Eduardo H. Backes José M. Inácio José A. Belo Rui Igreja João C. Silva Luiz H.C. Mattoso Elvira Fortunato Henrique M.V. Almeida Rodrigo Martins Caio G. Otoni Graduate Program in Materials Science and Engineering (PPGCEM) Federal University of São Carlos (UFSCar) Rod. Washington Luís km 235 13565-905 São Carlos SP Brazil Nanotechnology National Laboratory for Agriculture (LNNA) Embrapa Instrumentation 13560-970 São Carlos SP Brazil CENIMAT/i3N Department of Materials Science NOVA School of Science and Technology NOVA University Lisbon (NOVA FCT) and CEMOP/UNINOVA Campus de Caparica 2829-516 Caparica Portugal Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences Instituto Superior Técnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal Associate Laboratory i4HB – Institute for Health and Bioeconomy Instituto Superior Técnico Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisboa Portugal Stem Cells and Development Laboratory iNOVA4Health NOVA Medical School Faculdade de Ciências Médicas Universidade NOVA de Lisboa 1169-056 Lisbon Portugal Department of Mechanical and Aerospace Engineering and PolitoBIOMed Lab Politecnico di Torino Corso Duca Degli Abruzzi 24 Turin 10129 Italy Institute of Chemistry University of Campinas (UNICAMP) Campinas SP Brazil

Osteoporotic fractures in older adults place a significant burden on healthcare systems due to prolonged healing times and escalating costs. Innovative approaches closely mimicking the human bone microenvironment are paramount for advancing bone tissue regeneration. This study leverages a sacrificial template methodology to develop hierarchical 3D porous gelatin-NaNbO 3 @PDMS scaffolds with gyroid structures mimicking cancellous bone architecture, tailored for enhanced stimuli-responsive biological performance. Modulating porosity levels (∼0%, 18 %, and 63 %) enables macro-to-micro pore transitions, highlighting how porosity and zero-curvature surfaces impact critical properties for bioactive scaffold applications. Under simulated physical activity pressures, lower scaffold porosity enhances structural integrity, mechanical stability, and damping capacity, driven by reduced thickness plastic deformation. Corona discharge poling generates electrically charged stimuli-responsive scaffolds, enhancing electric field intensity through charge trapping. Combined with ultrasound stimulation (50 and 250 mW·cm −2 ), it boosts metabolic activity, gene expression, and mineralization, increasing calcium deposition by up to 1200 % compared to unstimulated controls. Finite element analysis reveals that the 63 % porosity scaffolds generate a sixfold stronger electric field than its 18 % counterpart, enhancing stimuli-responsive cell alignment, with ultrasound stimulation boosting it by ∼10 %. These discoveries in zero-curvature geometries and stimuli-responsive systems redefine bone regeneration strategies by mimicking bone anisotropy through electric field stimulation, offering transformative insights for advanced biomaterials in implants and physiotherapy.

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RETRACTION: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Retraction of Vol 32, Pg 76, 2019)

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NATURE BIOTECHNOLOGY 2020年第3期38卷 374-374页

作者： Baeyens, Luc Lemper, Marie Leuckx, Gunter De Groef, Sofie Bonfanti, Paola Stange, Geert Shemer, Ruth Nord, Christoffer Scheel, David W. Pan, Fong C. Ahlgren, Ulf Gu, Guoqiang Stoffers, Doris A. Dor, Yuval Ferrer, Jorge Gradwohl, Gerard Wright, Christopher V. E. Van de Casteele, Mark German, Michael S. Bouwens, Luc Heimberg, Harry Diabetes Research Center Vrije Universiteit Brussel Brussels Belgium. Diabetes Center California Institute for Regenerative Medicine (CIRM) University of California San Francisco San Francisco California USA. The Institute for Medical Research Israel-Canada The Hebrew University Jerusalem Israel. Umeå Center for Molecular Medicine Umeå University Umeå Sweden. Department of Cell and Developmental Biology Vanderbilt University Program in Developmental Biology Vanderbilt University Medical Center Nashville Tennessee USA. Institute for Diabetes Obesity and Metabolism University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA. Institut d'Investigacions Biomediques August Pi i Sunyer Hospital Clinic de Barcelona Barcelona Spain. Imperial College London London UK. Development and Stem Cells Program Institute of Genetics and Molecular and Cellular Biology (IGBMC) Illkirch France. Diabetes Research Center Vrije Universiteit Brussel Brussels Belgium. lucbo@expa.vub.ac.be. Diabetes Research Center Vrije Universiteit Brussel Brussels Belgium. Harry.Heimberg@vub.ac.be.

This article has been retracted; see accompanying Retraction Note, which can be accessed via a link at the top of the paper.

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Publisher Correction: Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

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Nature 2025年 2025 May 22页

作者： Xueqian Zhuang Qing Wang Simon Joost Alexander Ferrena David T Humphreys Zhuxuan Li Melissa Blum Klavdija Krause Selena Ding Yuna Landais Yingqian Zhan Yang Zhao Ronan Chaligne Joo-Hyeon Lee Sebastian E Carrasco Umeshkumar K Bhanot Richard P Koche Matthew J Bott Pekka Katajisto Yadira M Soto-Feliciano Thomas Pisanic Tiffany Thomas Deyou Zheng Emily S Wong Tuomas Tammela Cancer Biology and Genetics Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. Victor Chang Cardiac Research Institute Sydney New South Wales Australia. Institute for Clinical and Translational Research Albert Einstein College of Medicine New York NY USA. Weill Cornell Graduate School of Medical Science Weill Cornell Medicine New York NY USA. Center for Epigenetics Research Memorial Sloan Kettering Cancer Center New York NY USA. Department of Biomedical Engineering Johns Hopkins University Baltimore MD USA. Computational and Systems Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York NY USA. Wellcome-MRC Cambridge Stem Cell Institute Jeffrey Cheah Biomedical Centre University of Cambridge Cambridge UK. Department of Physiology Development and Neuroscience University of Cambridge Cambridge UK. Laboratory of Comparative Pathology Weill Cornell Medicine Memorial Sloan Kettering Cancer Center and Rockefeller University New York NY USA. Pathology Core Facility Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA. Institute of Biotechnology HiLIFE University of Helsinki Helsinki Finland. Department of Cell and Molecular Biology Karolinska Institute Stockholm Sweden. Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland. David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA USA. Department of Biology Massachusetts Institute of Technology Cambridge MA USA. Institute for NanoBioTechnology Department of Oncology-Cancer Genetics and Epigenetics Johns Hopkins University Baltimore MD USA. Department of Pathology and Cell Biology Columbia University College of Physicians and Surgeons New York NY USA. Departments of Genetics Neurology and Neuroscience Albert Einstein College of Medicine New York NY USA. School of Biotechnology and Biomolecular Sciences UNSW Sy

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Erratum. WNT signalling in the normal human adult testis and in male germ cell neoplasms

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Human reproduction (Oxford, England) 2020年第11期35卷 2639页

作者： Julia C Young Genevieve Kerr Diana Micati John E Nielsen Ewa Rajpert-De Meyts Helen E Abud Kate L Loveland Department of Anatomy and Developmental Biology Biomedicine Discovery Institute Monash University 3800 Australia. Centre for Reproductive Health Hudson Institute of Medical Research Clayton 3168 Australia. Department of Growth and Reproduction Rigshospitalet University of Copenhagen Denmark. Development and Stem Cells Program Monash Biomedicine Discovery Institute Monash University 3800 Australia. Department of Molecular and Translational Science School of Clinical Sciences Monash University 3168 Australia.

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Allogeneic ABCB5⁺ Mesenchymal stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial

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JID Innovations 2022年第1期2卷 100067-100067页

作者： Kerstan, Andreas Dieter, Kathrin Niebergall-Roth, Elke Dachtler, Ann-Kathrin Kraft, Korinna Stücker, Markus Daeschlein, Georg Jünger, Michael Görge, Tobias Meyer-Pannwitt, Ulrich Erfurt-Berge, Cornelia von Engelhardt, Charlotte Klare, Andreas Pfeiffer, Christiane Esterlechner, Jasmina Schröder, Hannes M. Gasser, Martin Waaga-Gasser, Ana M. Goebeler, Matthias Ballikaya, Seda Sadeghi, Samar Murphy, George F. Orgill, Dennis P. Frank, Natasha Y. Ganss, Christoph Scharffetter-Kochanek, Karin Frank, Markus H. Kluth, Mark A. Department of Dermatology Venereology and Allergology University Hospital Würzburg Würzburg Germany RHEACELL Heidelberg Germany TICEBA Heidelberg Germany Department of Dermatology St. Josef Hospital Catholic Clinic Bochum Ruhr University Bochum Bochum Germany Department of Dermatology University Hospital Greifswald Greifswald Germany Clinic of Dermatology Immunology and Allergology Medical University Brandenburg “Theodor Fontane” Medical Center Dessau Dessau Germany Department of Dermatology University Hospital Münster Münster Germany pro scientia med at the Department of Clinical Research and Development MARE Clinic Kiel Germany Department of Dermatology University Hospital Erlangen Erlangen Germany Klinische Forschung Schwerin Schwerin Germany Klinische Forschung Hamburg Hamburg Germany Department of Dermatology and Allergic Diseases University Hospital Ulm Germany Department of Surgery University Hospital Würzburg Würzburg Germany Division of Renal (Kidney) Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts United States Department of Dermatology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts United States Division of Plastic Surgery Brigham and Women's Hospital Harvard Medical School Boston Massachusetts United States Department of Medicine VA Boston Healthcare System Boston Massachusetts United States Division of Genetics Brigham and Women's Hospital Harvard Medical School Boston Massachusetts United States Transplant Research Program Boston Children's Hospital Harvard Medical School Boston Massachusetts United States Harvard Stem Cell Institute Harvard University Cambridge Massachusetts United States School of Medical and Health Sciences Edith Cowan University Perth Australia

A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5+ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in ... 详细信息

A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5⁺ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in chronic wounds. On the basis of their wound healing‒facilitating effects in a mouse CVU model and an autologous first-in-human study, ABCB5⁺ mesenchymal stem cells have emerged as a potential candidate for cell-based advanced therapy of nonhealing CVUs. In this interventional, multicenter, single-arm, phase I/IIa clinical trial, subjects whose CVUs had emerged as standard therapy resistant received one or two topical applications of 1 × 10⁶ allogeneic ABCB5⁺ mesenchymal stem cells per cm² wound area, in addition to standard treatment. Of 83 treatment-emergent adverse events, only three were judged related to the cell product;they were mild or moderate and recovered without sequelae. Wound size markedly decreased from baseline to week 12, resulting in a median wound size reduction of 76% (full analysis set, n = 31), 78% (per-protocol set, n = 27), and 87% (subset of responders, n = 21). In conclusion, the study treatment was well-tolerated and safe. The treatment elicited a profound wound size reduction within 12 weeks, identifying ABCB5⁺ mesenchymal stem cells as a potential candidate for adjunctive therapy of otherwise incurable CVUs. These results justify the conduct of a larger, randomized, controlled trial to confirm clinical efficacy. © 2021 The Authors

关键词： CVU chronic venous ulcer FAS full analysis set IQR interquartile range MSC mesenchymal stem cell PP per-protocol set TEAE treatment-emergent adverse event

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The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and development of Immunofluoresence Imaging Methods

arXiv

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arXiv 2024年

作者： Yaniv, Ziv Anidi, Ifeanyichukwu U. Arakkal, Leanne Arroyo-Mejías, Armando J. Beuschel, Rebecca T. Börner, Katy Chu, Colin J. Clark, Beatrice Clatworthy, Menna R. Colautti, Jake Coscia, Fabian Croteau, Joshua Denha, Saven Dever, Rose Dutra, Walderez O. Fritzsche, Sonja Fullam, Spencer Gerner, Michael Y. Gola, Anita Gollob, Kenneth J. Hernandez, Jonathan M. Hor, Jyh Liang Ichise, Hiroshi Jing, Zhixin Jonigk, Danny Kandov, Evelyn Kastenmüller, Wolfgang Koenig, Joshua F.E. Kothurkar, Aanandita Kortekaas, Rosa K. Kreins, Alexandra Y. Lamborn, Ian T. Lin, Yuri Morais, Katia Luciano Pereira Lunich, Aleksandra Luz, Jean C.S. MacDonald, Ryan B. Makranz, Chen Maltez, Vivien I. McDonough, John E. Moriarty, Ryan V. Ocampo-Godinez, Juan M. Olyntho, Vitoria M. Oxenius, Annette Padhan, Kartika Remmert, Kirsten Richoz, Nathan Schrom, Edward C. Shang, Wanjing Shi, Lihong Shih, Rochelle M. Speranza, Emily Stierli, Salome Teichmann, Sarah A. Veres, Tibor Z. Vierhout, Megan Wachter, Brianna T. Williams, Margaret Zangger, Nathan Germain, Ronald N. Radtke, Andrea J. Bioinformatics and Computational Bioscience Branch National Institute of Allergy and Infectious Diseases National Institutes of Health BethesdaMD United States Critical Care Medicine and Pulmonary Branch National Heart Lung and Blood Institute National Institutes of Health BethesdaMD United States Lymphocyte Biology Section Laboratory of Immune System Biology NIAID NIH BethesdaMD United States Department of Intelligent Systems Engineering Indiana University BloomingtonIN United States UCL Institute of Ophthalmology NIHR Moorfields Biomedical Research Centre London United Kingdom Cambridge Institute for Therapeutic Immunology and Infectious Diseases University of Cambridge Department of Medicine Molecular Immunity Unit Laboratory of Molecular Biology Cambridge United Kingdom McMaster Immunology Research Centre Schroeder Allergy and Immunology Research Institute Department of Medicine Faculty of Health Sciences McMaster University HamiltonON Canada Spatial Proteomics Group Berlin Germany Department of Business Development BioLegend Inc. San DiegoCA United States Functional Immunogenomics Unit National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health BethesdaMD United States Laboratory of Cell-Cell Interactions Department of Morphology Institute of Biological Sciences Universidade Federal de Minas Gerais MG Belo Horizonte Brazil Division of Rheumatology Rush University Medical Center ChicagoIL United States Department of Immunology University of Washington School of Medicine SeattleWA United States Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development The Rockefeller University New YorkNY United States Hospital Israelita Albert Einstein SP Sao Paulo Brazil Surgical Oncology Program National Cancer Institute National Institutes of Health BethesdaMD United States Institute of Pathology Aachen Medical University RWTH Aachen Aachen Germany Hannover Germany Würzburg Institute

The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled after efforts in the open-source software community and includes three facets: a development platform (GitHub), static website, and service for data archiving. The Knowledge-Base facilitates the practice of open science throughout the research life cycle by providing validation data for recommended and non-recommended reagents, e.g., primary and secondary antibodies. In addition to reporting negative data, the Knowledge-Base empowers method adoption and evolution by providing a venue for sharing protocols, videos, datasets, software, and publications. A dedicated discussion forum fosters a sense of community among researchers while addressing questions not covered in published manuscripts. Together, scientists from around the world are advancing scientific discovery at a faster pace, reducing wasted time and effort, and instilling greater confidence in the resulting data. © 2024, CC BY.

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Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

SSRN

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SSRN 2020年

作者： Gonzalez-Teran, Barbara Pittman, Maureen Felix, Franco Richmond-Buccola, Desmond Thomas, Reuben Choudhary, Krishna Moroni, Elisabetta Colombo, Giorgio Alexanian, Michael Cole, Bonnie Samse-Knapp, Kaitlen McGregor, Michael Gifford, Casey A. Huttenhain, Ruth Gelb, Bruce D. Conklin, Bruce R. Black, Brian L. Bruneau, Benoit G. Krogan, Nevan J. Pollard, Katherine S. Srivastava, Deepak Gladstone Institutes San FranciscoCA United States SCITEC-CNR Milano Italy University of Pavia Department of Chemistry Pavia Italy Developmental and Stem Cell Biology PhD Program University of California San FranciscoCA United States Department of Cellular and Molecular Pharmacology University of California San Francisco San FranciscoCA United States Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New YorkNY United States Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai New YorkNY United States Department of Pediatrics Icahn School of Medicine at Mount Sinai New YorkNY United States Cardiovascular Research Institute University of California San FranciscoCA United States Department of Pediatrics UCSF School of Medicine San FranciscoCA United States Roddenberry Center for Stem Cell Biology and Medicine at Gladstone San FranciscoCA United States University of California San Francisco San FranciscoCA United States Chan Zuckerberg Biohub San FranciscoCA United States Department of Epidemiology & Biostatistics Institute for Computational Health Sciences Institute for Human Genetics University of California San FranciscoCA United States Department of Biochemistry and Biophysics University of California San FranciscoCA United States Gladstone Institutes 1650 Owens St San FranciscoCA94158 United States

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains a challenge despite large-scale genomic sequencing efforts. We hypothesized that genetic determinants for CHDs may lie in protein interactomes of GATA4 and TBX5, two transcription factors that cause CHDs. Defining their interactomes in human cardiac progenitors via affinity purification-mass spectrometry and integrating results with genetic data from the Pediatric Cardiac Genomic Consortium revealed an enrichment of de novo variants among proteins that interact with GATA4 or TBX5. A consolidative score that prioritized interactome members based on variant, gene, and proband features identified likely CHD-causing genes, including the epigenetic reader GLYR1. GLYR1 and GATA4 widely co-occupied cardiac developmental genes, resulting in co-activation, and the GLYR1 missense variant associated with CHD disrupted interaction with GATA4. This integrative proteomic and genetic approach provides a framework for prioritizing and interrogating the contribution of genetic variants in disease. © 2020, The Authors. All rights reserved.

关键词： Proteins

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From fly to mammal:targeting ion channels in brain tumor

From fly to mammal:targeting ion channels in brain tumor

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全球华人生物学家大会暨第十六届美洲华人生物科学学会学术研讨会

作者： Xi Huang Development & Stem Cell Biology Program Arthur and Sonia Labatt Brain Tumour Research CentreThe Hospital for Sick Children

As transmembrane proteins thatregulate ion flow across cell membrane,ion channels are accessible for pharmacological intervention and comprise a large class of drug ***,the role of ion channels in brain tumor is largely *** group uses multi-disciplinary approaches including Drosophilaand mouse genetics,xenograft modeling,cell biology

关键词： From fly to mammal:targeting ion channels in brain tumor

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Mastery of Transferrable Skills by Doctoral Scholars: Visualization using Digital Micro-credentialing

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Change 2018年第5期50卷 38-45页

作者： Ambika Mathur Mary E Wood Annmarie Cano Associate Provost Office of Scientific Training Workforce Development and Diversity and Dean Graduate School and Professor of Pediatrics at Wayne State University (WSU). She served as Associate Dean the first director of the WSU M.D./Ph.D. program first director of the Office of Postdoctoral Affairs founding director of Wayne Med Direct program and is P.I. of both the NIH-funded WSU-BEST Program and the NIH-funded ReBUILDetroit Program that supports underrepresented students who seek to pursue careers in biomedical research. the Program Director for the Office of Scientific Training Workforce Development and Diversity at WSU. In this role she identifies potential external funding opportunities for workforce development and diversity. This includes preparing grants for submission to key federal agencies and working closely with faculty key university executives and department chairs to identify opportunities strengths and potential focus areas for training initiatives. Professor of Psychology and Associate Dean in the Graduate School at WSU. She oversees graduate enrollment management efforts including recruitment admissions and competency-based professional development with micro-credentialing. She is the Wayne State co-PI of the NSF-funded Michigan Alliance for Graduate Education and the Professoriate to support women and underrepresented graduate students in STEM and the Social and Behavioral Sciences.

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The IBEX Knowledge-Base: Achieving more together with open science

arXiv

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arXiv 2024年

作者： Radtke, Andrea J. Anidi, Ifeanyichukwu Arakkal, Leanne Arroyo-Mejias, Armando Beuschel, Rebecca T. Börner, Katy Chu, Colin J. Clark, Beatrice Clatworthy, Menna R. Colautti, Jake Croteau, Joshua Denha, Saven Dever, Rose Dutra, Walderez O. Fritzsche, Sonja Fullam, Spencer Gerner, Michael Y. Gola, Anita Gollob, Kenneth J. Hernandez, Jonathan M. Hor, Jyh Liang Ichise, Hiroshi Jing, Zhixin Jonigk, Danny Kandov, Evelyn Kastenmüller, Wolfgang Koenig, Joshua F.E. Kothurkar, Aanandita Kreins, Alexandra Y. Lamborn, Ian Lin, Yuri Morais, Katia Luciano Pereira Lunich, Aleksandra Luz, Jean C.S. MacDonald, Ryan B. Makranz, Chen Maltez, Vivien I. Moriaty, Ryan V. Ocampo-Godinez, Juan M. Olyntho, Vitoria M. Padhan, Kartika Remmert, Kirsten Richoz, Nathan Schrom, Edward C. Shang, Wanjing Shi, Lihong Shih, Rochelle M. Speranza, Emily Stierli, Salome Teichmann, Sarah A. Veres, Tibor Z. Vierhout, Megan Wachter, Brianna T. Wade-Vallance, Adam K. Williams, Margaret Zangger, Nathan Germain, Ronald N. Yaniv, Ziv Lymphocyte Biology Section Center for Advanced Tissue Imaging Laboratory of Immune System Biology National Institute of Allergy and Infectious Diseases National Institutes of Health BethesdaMD United States Critical Care Medicine and Pulmonary Branch National Heart Lung and Blood Institute National Institutes of Health BethesdaMD United States Lymphocyte Biology Section Laboratory of Immune System Biology National Institute of Allergy and Infectious Diseases National Institutes of Health BethesdaMD United States Department of Intelligent Systems Engineering Indiana University BloomingtonIN United States UCL Institute of Ophthalmology NIHR Moorfields Biomedical Research Centre London United Kingdom Cambridge Institute for Therapeutic Immunology and Infectious Diseases University of Cambridge Department of Medicine Molecular Immunity Unit Laboratory of Molecular Biology Cambridge United Kingdom McMaster Immunology Research Centre Schroeder Allergy and Immunology Research Institute Department of Medicine Faculty of Health Sciences McMaster University HamiltonON Canada Department of Business Development BioLegend Inc. San DiegoCA United States Functional Immunogenomics Unit National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health BethesdaMD United States Laboratory of Cell-Cell Interactions Department of Morphology Institute of Biological Sciences Universidade Federal de Minas Gerais MG Belo Horizonte Brazil Spatial Proteomics Group Berlin Germany Division of Rheumatology Rush University Medical Center ChicagoIL United States Department of Immunology University of Washington School of Medicine SeattleWA United States Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development The Rockefeller University New YorkNY United States Hospital Israelita Albert Einstein SP Sao Paulo Brazil Surgical Oncology Program National Cancer Institute National Institutes of Health BethesdaMD United St

Iterative Bleaching Extends multipleXity (IBEX) is a versatile method for highly multiplexed imaging of diverse tissues. Based on open science principles, we created the IBEX Knowledge-Base, a resource for reagents, p... 详细信息

关键词： Cleaning

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