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Large-scale analysis of neural activity and connectivity from high-density electroencephalographic data

Computers in Biology and Medicine 2024年 178卷 108704-108704页

作者： Taberna, Gaia Amaranta Samogin, Jessica Zhao, Mingqi Marino, Marco Guarnieri, Roberto Cuartas Morales, Ernesto Ganzetti, Marco Liu, Quanying Mantini, Dante Movement Control and Neuroplasticity Research Group KU Leuven Leuven3001 Belgium Gansu Provincial Key Laboratory of Wearable Computing School of Information Science and Engineering Lanzhou University Lanzhou730000 China Department of General Psychology University of Padova Padova35131 Italy Dirección Académica Universidad Nacional de Colombia Sede de La Paz La Paz202017 Colombia pRED Data & Analytics Roche Innovation Center Basel F. Hoffmann–La Roche Ltd Basel4070 Switzerland Department of Biomedical Engineering Southern University of Science and Technology Shenzhen518055 China KU Leuven Brain Institute KU Leuven Leuven3000 Belgium

Introduction: High-density electroencephalography (hdEEG) is a technique used for the characterization of the neural activity and connectivity in the human brain. The analysis of EEG data involves several steps, including signal pre-processing, head modelling, source localization and activity/connectivity quantification. Visual check of the analysis steps is often necessary, making the process time- and resource-consuming and, therefore, not feasible for large datasets. Findings: Here we present the Noninvasive Electrophysiology Toolbox (NET), an open-source software for large-scale analysis of hdEEG data, running on the cross-platform MATLAB environment. NET combines all the tools required for a complete hdEEG analysis workflow, from raw signals to final measured values. By relying on reconstructed neural signals in the brain, NET can perform traditional analyses of time-locked neural responses, as well as more advanced functional connectivity and brain mapping analyses. The extracted quantitative neural data can be exported to provide broad compatibility with other software. Conclusions: NET is freely available (https://***/bind-group-kul/net) under the GNU public license for non-commercial use and open-source development, together with a graphical user interface (GUI) and a user tutorial. While NET can be used interactively with the GUI, it is primarily aimed at unsupervised automation to process large hdEEG datasets efficiently. Its implementation creates indeed a highly customizable program suitable for analysis automation and tight integration into existing workflows. © 2024

关键词： Electroencephalography

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FusionTC: Encrypted App Traffic Classification Using Decision-Level Multimodal Fusion Learning of Flow Sequence

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Wireless Communications and Mobile computing 2023年第1期2023卷

作者： Li, Shengbao Huang, Yuchuan Gao, Tianye Yang, Lanqi Chen, Yige Pan, Quanbo Zang, Tianning Chen, Fei Institute of Information Engineering Chinese Academy of Sciences Beijing100045 China School of Cyber Security University of Chinese Academy of Sciences Beijing101408 China National Computer Network Emergency Response Technical Team/Coordination Center of China Shandong Branch Jinan250004 China Ministry of Emergency Management Big Data Center Beijing100010 China Anhui Provincial Key Laboratory of Network and Information Security Anhui Normal University Anhui Wuhu240002 China College of Computer Science and Artificial Intelligence Wenzhou University Wenzhou325000 China National Computer Network Emergency Response Technical Team/Coordination Center of China Xinjiang Branch Urumqi830000 China

In recent years, an increasing number of mobile platforms and applications have adopted traffic encryption protocol technology to ensure privacy and security. Existing researches on encrypted traffic identification approaches often rely on a single-modal feature pattern (such as packet sequence and statistical features), which cannot fully represent the detail information of complex traffic features, and so their predictions are susceptible to anomalies. In order to improve the effect of classification on encrypted app traffic, we propose FusionTC, a novel app traffic classification framework based on feature fusion of flow sequence. FusionTC consists of two-level subclassifiers, which are used to perform decision-level fusion of multimodal features by an upgraded stacking method. The comprehensive capture and fusion of multimodal traffic details, coupled with the refined processing and segmentation of traffic, enables FusionTC to significantly promote classification accuracy and enhance robustness in challenging situations. Based on our self-built app traffic dataset, FusionTC improves the accuracy by at least 3.2% over the state-of-the-art approaches. © 2023 Shengbao Li et al.

关键词： Cryptography

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One for Multiple: Physics-informed Synthetic data Boosts Generalizable Deep Learning for Fast MRI Reconstruction

arXiv

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arXiv 2023年

作者： Wang, Zi Yu, Xiaotong Wang, Chengyan Chen, Weibo Wang, Jiazheng Chu, Ying-Hua Sun, Hongwei Li, Rushuai Li, Peiyong Yang, Fan Han, Haiwei Kang, Taishan Lin, Jianzhong Yang, Chen Chang, Shufu Shi, Zhang Hua, Sha Li, Yan Hu, Juan Zhu, Liuhong Zhou, Jianjun Lin, Meijing Guo, Jiefeng Cai, Congbo Chen, Zhong Guo, Di Yang, Guang Qu, Xiaobo Department of Electronic Science Intelligent Medical Imaging R&D Center Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance National Institute for Data Science in Health and Medicine Xiamen University China Human Phenome Institute Fudan University China Philips Healthcare China Siemens Healthineers Ltd. China United Imaging Research Institute of Intelligent Imaging China Department of Nuclear Medicine Nanjing First Hospital China Shandong Aoxin Medical Technology Company China Department of Radiology The First Affiliated Hospital of Xiamen University China Department of Radiology Zhongshan Hospital Affiliated to Xiamen University China China Department of Cardiology Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University China Department of Radiology Zhongshan Hospital Fudan University China Department of Cardiovascular Medicine Heart Failure Center Ruijin Hospital Lu Wan Branch Shanghai Jiaotong University School of Medicine China Department of Radiology Ruijin Hospital Shanghai Jiaotong University School of Medicine China Medical Imaging Department The First Affiliated Hospital of Kunming Medical University China Xiamen Key Laboratory of Clinical Transformation of Imaging Big Data and Artificial Intelligence China Department of Applied Marine Physics and Engineering Xiamen University China Department of Microelectronics and Integrated Circuit Xiamen University China School of Computer and Information Engineering Xiamen University of Technology China Department of Bioengineering Imperial College London United Kingdom

Magnetic resonance imaging (MRI) is a widely used radiological modality renowned for its radiation-free, comprehensive insights into the human body, facilitating medical diagnoses. However, the drawback of prolonged scan times hinders its accessibility. The k-space undersampling offers a solution, yet the resultant artifacts necessitate meticulous removal during image reconstruction. Although Deep Learning (DL) has proven effective for fast MRI image reconstruction, its broader applicability across various imaging scenarios has been constrained. Challenges include the high cost and privacy restrictions associated with acquiring large-scale, diverse training data, coupled with the inherent difficulty of addressing mismatches between training and target data in existing DL methodologies. Here, we present a novel Physics-Informed Synthetic data learning framework for Fast MRI, called PISF. PISF marks a breakthrough by enabling generalized DL for multi-scenario MRI reconstruction through a single trained model. Our approach separates the reconstruction of a 2D image into many 1D basic problems, commencing with 1D data synthesis to facilitate generalization. We demonstrate that training DL models on synthetic data, coupled with enhanced learning techniques, yields in vivo MRI reconstructions comparable to or surpassing those of models trained on matched realistic datasets, reducing the reliance on real-world MRI data by up to 96%. Additionally, PISF exhibits remarkable generalizability across multiple vendors and imaging centers. Its adaptability to diverse patient populations has been validated through evaluations by ten experienced medical professionals. PISF presents a feasible and cost-effective way to significantly boost the widespread adoption of DL in various fast MRI applications. Importantly, it alleviates the ethical and practical challenges associated with in vivo human data acquisitions, opening new horizons for advancing fast MRI technologies. Copyright © 20

关键词： Magnetic resonance imaging

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Generative Modelling of the Ageing Heart with Cross-Sectional Imaging and Clinical data

arXiv

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arXiv 2022年

作者： Qiao, Mengyun Basaran, Berke Doga Qiu, Huaqi Wang, Shuo Guo, Yi Wang, Yuanyuan Matthews, Paul M. Rueckert, Daniel Bai, Wenjia Department of Computing Imperial College London London United Kingdom Data Science Institute Imperial College London London United Kingdom Department of Brain Sciences Imperial College London London United Kingdom Uk Dementia Research Institute Imperial College London London United Kingdom Klinikum Rechts der Isar Technical University of Munich Munich Germany Department of Electronic Engineering Fudan University Shanghai China Digital Medical Research Center School of Basic Medical Sciences Fudan University Shanghai China Shanghai Key Laboratory of Miccai Shanghai China

Cardiovascular disease, the leading cause of death globally, is an age-related disease. Understanding the morphological and functional changes of the heart during ageing is a key scientific question, the answer to which will help us define important risk factors of cardiovascular disease and monitor disease progression. In this work, we propose a novel conditional generative model to describe the changes of 3D anatomy of the heart during ageing. The proposed model is flexible and allows integration of multiple clinical factors (e.g. age, gender) into the generating process. We train the model on a large-scale cross-sectional dataset of cardiac anatomies and evaluate on both cross-sectional and longitudinal datasets. The model demonstrates excellent performance in predicting the longitudinal evolution of the ageing heart and modelling its data distribution. The codes are available at https://***/MengyunQ/AgeHeart. © 2022, CC BY-NC-ND.

关键词： Heart

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Rockburst prediction using artificial intelligence techniques:A review

岩石力学通报（英文）

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岩石力学通报（英文） 2024年第3期3卷 1-13页

作者： Yu Zhang Kongyi Fang Manchao He Dongqiao Liu Junchao Wang Zhengjia Guo School of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China Beijing Key Laboratory of Intelligent Processing for Building Big Data Beijing University of Civil Engineering and ArchitectureBeijing100044China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing100083China School of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing100044China Beijing Key Laboratory of Intelligent Processing for Building Big Data Beijing University of Civil Engineering and ArchitectureBeijing100044China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing100083China Thomas Lord Department of Computer Science University of Southern CaliforniaLos Angeles90007CAUSA

Rockburst is a phenomenon where sudden,catastrophic failure of the rock mass occurs in underground deep regions or areas with high tectonic stress during the excavation *** disasters endanger the safety of people's lives and property,national energy security,and social interests,so it is very important to accurately predict *** rockburst prediction has not been able to find an effective prediction method,and the study of the rockburst mechanism is facing a *** the development of artificial intelligence(AI)techniques in recent years,more and more experts and scholars have begun to introduce AI techniques into the study of the rockburst *** previous research,several scholars have attempted to summarize the application of AI techniques in rockburst ***,these studies either are not specifically focused on reviews of the application of AI techniques in rockburst prediction,or they do not provide a comprehensive *** on the advantages of extensive interdisciplinary research and a deep understanding of AI techniques,this paper conducts a comprehensive review of rockburst prediction methods leveraging AI ***,pertinent definitions of rockburst and its associated hazards are ***,the applications of both traditional prediction methods and those rooted in AI techniques for rockburst prediction are summarized,with emphasis placed on the respective advantages and disadvantages of each ***,the strengths and weaknesses of prediction methods leveraging AI are summarized,alongside forecasting future research trends to address existing challenges,while simultaneously proposing directions for improvement to advance the field and meet emerging demands effectively.

关键词： Rockburst Rockburst prediction Artificial intelligence techniques

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Two Efficient Beamforming Methods for Hybrid IRS-aided AF Relay Wireless Networks

arXiv

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arXiv 2023年

作者： Wang, Xuehui Shu, Feng Huang, Mengxing Zhou, Fuhui Chen, Riqing Pan, Cunhua Wu, Yongpeng Wang, Jiangzhou The School of Information and Communication Engineering Hainan University Haikou570228 China The School of Information and Communication Engineering and Collaborative Innovation Center of Information Technology Hainan University Haikou570228 China The School of Electronic and Optical Engineering Nanjing University of Science and Technology Nanjing210094 China The College of Electronic and Information Engineering Nanjing University of Aeronautics and Astronautics Nanjing210000 China The Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Nanjing University of Aeronautics and Astronautics Nanjing210000 China The Ministry of Industry and Information Technology Nanjing211106 China The Digital Fujian Institute of Big Data for Agriculture Fujian Agriculture and Forestry University Fuzhou350002 China National Mobile Communications Research Laboratory Southeast University Nanjing211111 China The Shanghai Key Laboratory of Navigation and Location Based Services Shanghai Jiao Tong University Minhang200240 China The School of Engineering University of Kent CanterburyCT2 7NT United Kingdom

Due to the "double fading" effect caused by conventional passive intelligent reflecting surface (IRS), the signal via the reflection link is weak. To enhance the received signal, active elements with the ability to amplify the reflected signal are introduced to the passive IRS forming hybrid IRS. In this paper, we propose a hybrid IRS-aided amplify-and-forward (AF) relay wireless network, where an optimization problem is formulated, which is subject to the constraints of transmit power budgets at the source/AF relay/hybrid IRS and that of unit modulus for passive IRS elements. By alternately designing the beamforming matrix at AF relay and the reflecting coefficient matrices at IRS, signal-to-noise ratio can be maximized. To achieve high rate performance and extend the coverage range, a high-performance method based on semidefinite relaxation and fractional programming (HP-SDR-FP) algorithm is presented. Due to its extremely high complexity, a low-complexity method based on whitening filter, general power iterative and generalized Rayleigh-Ritz (WF-GPI-GRR) is proposed, which is different from HP-SDR-FP method. It is assumed that the amplifying coefficient of each active IRS element is equal, and the corresponding analytical solution of the amplifying coefficient can be obtained according to the transmit powers at AF relay and hybrid IRS. Simulation results show that the proposed two methods can greatly improve the rate performance compared to the existing networks, such as the passive IRS-aided AF relay and only AF relay network. In particular, a 50.0% rate gain over the existing networks is approximately achieved in the high power budget region of hybrid IRS. Moreover, it is verified that the proposed HP-SDR-FP method perform better than WF-GPI-GRR method in terms of rate performance. Copyright © 2023, The Authors. All rights reserved.

关键词： Wireless networks

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Revisiting Cloud Migration: Strategies and Methods

引用

Journal of Physics: Conference Series 2020年第1期1575卷

作者： Zhixiao Wang Wenyao Yan Wendong Wang School of Computer Science and Engineering Xi'an University of Technology Xi'an 710048 China Shaanxi Key Laboratory Xi'an of Network Computing and Security Technology China School of Data Science and Computer Xi'an innovation college of Yan'an University Xi'an 710100 China Yan'an University Xi'an 716000 China

Cloud computing attracts users with its advantage of unlimited resource supply where resources can be elastically expanded on demand and balanced-load at the same time. This means that the application in the cloud environment should run in the way of elastic expansion cluster. At present, most of the elastic expansion and load balancing technologies provided by IaaS level are oriented to virtual machines (VM), with little consideration of application level, which does not fundamentally meet the needs of users. Based on this, starting from the motivation of cloud migration, we first analyse the cloud migration technology from three aspects: migration object, migration means and migration objectives, then explore the cloud migration criteria and four cloud migration strategies at the application level in the cloud environment, and point out that cloud migration should be optimized and maintained in terms of elastic expansion, load balancing, security, etc.

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Accelerated MRI reconstruction with separable and enhanced low-rank Hankel regularization

arXiv

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arXiv 2021年

作者： Zhang, Xinlin Lu, Hengfa Guo, Di Lai, Zongying Ye, Huihui Peng, Xi Zhao, Bo Qu, Xiaobo Biomedical Intelligent Cloud R&D Center Department of Electronic Science National Institute for Data Science in Health and Medicine Xiamen University Xiamen361105 China The Department of Biomedical Engineering University of Texas at Austin AustinTX78712 United States The School of Computer and Information Engineering Xiamen University of Technology Xiamen361021 China The School of Information Engineering Jimei University Xiamen361024 China The State of Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou310058 China The Department of Radiology Mayo Clinic RochesterMN55902 United States The Department of Biomedical Engineering Oden Institute for Computational Engineering and Sciences University of Texas at Austin AustinTX78712 United States

The combination of the sparse sampling and the low-rank structured matrix reconstruction has shown promising performance, enabling a significant reduction of the magnetic resonance imaging data acquisition time. However, the low-rank structured approaches demand considerable memory consumption and are time-consuming due to a noticeable number of matrix operations performed on the huge-size block Hankel-like matrix. In this work, we proposed a novel framework to utilize the low-rank property but meanwhile to achieve faster reconstructions and promising results. The framework allows us to enforce the low-rankness of Hankel matrices constructing from 1D vectors instead of 2D matrices from 1D vectors and thus avoid the construction of huge block Hankel matrix for 2D k-space matrices. Moreover, under this framework, we can easily incorporate other information, such as the smooth phase of the image and the low-rankness in the parameter dimension, to further improve the image quality. We built and validated two models for parallel and parameter magnetic resonance imaging experiments, respectively. Our retrospective in-vivo results indicate that the proposed approaches enable faster reconstructions than the state-of-the-art approaches, e.g., about 8× faster than STDLR-SPIRiT, and faithful removal of undersampling artifacts. Copyright © 2021, The Authors. All rights reserved.

关键词： Image reconstruction

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Abnormal Scanning Patterns Based on Eye Movement Entropy in Early Psychosis

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Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2024年

作者： Zhang, Dan Ma, Chunyan Xu, Lihua Liu, Xu Cui, Huiru Wei, Yanyan Zheng, Wensi Hong, Yawen Xie, Yuou Qian, Zhenying Hu, Yegang Tang, Yingying Li, Chunbo Liu, Zhi Chen, Tao Liu, Haichun Zhang, Tianhong Wang, Jijun Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine People's Republic of China Shanghai China First Clinical Medical College of Nanjing Medical University People's Republic of China Nanjing China Shanghai Institute for Advanced Communication and Data Science Shanghai University People's Republic of China Shanghai China School of Communication and Information Engineering Shanghai University People's Republic of China Shanghai China Labor and Worklife Program Harvard University Cambridge Massachusetts United States Big Data Research Laboratory University of Waterloo Waterloo ON Canada Niacin (Shanghai) Technology Co. Ltd. People's Republic of China Shanghai China Department of Automation Shanghai Jiao Tong University People's Republic of China Shanghai China Shanghai Mental Health Center Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention Shanghai Key Laboratory of Psychotic Disorders Shanghai Jiaotong University School of Medicine People's Republic of China Shanghai China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences People's Republic of China Shanghai China Institute of Psychology and Behavioral Science Shanghai Jiao Tong University People's Republic of China Shanghai China

Background: Restricted scan path mode is hypothesized to explain abnormal scanning patterns in patients with schizophrenia. Here, we calculated entropy scores (drawing on gaze data to measure the statistical randomness of eye movements) to quantify how strategical and random participants were when processing image stimuli. Methods: Eighty-six patients with first-episode schizophrenia (FES), 124 individuals at clinical high risk (CHR) for psychosis, and 115 healthy control participants (HCs) completed an eye-tracking examination while freely viewing 35 static images (each presented for 10 seconds) and cognitive assessments. We compared group differences in the overall entropy score, as well as entropy scores under various conditions. We also investigated the correlations between entropy scores and symptoms and cognitive function. Results: Increased overall entropy scores were noted in the FES and CHR groups compared with the HC group, and these differences were already apparent within 0 to 2.5 seconds. In addition, the CHR group exhibited higher entropy than the HC group when viewing low-meaning images. Moreover, the entropy within 0 to 2.5 seconds showed significant correlations with negative symptoms in the FES group, attention/vigilance scores in the CHR group, and speed of processing and attention/vigilance scores across all 3 groups. Conclusions: The results indicate that individuals with FES and those at CHR scanned pictures more randomly and less strategically than HCs. These patterns also correlated with clinical symptoms and neurocognition. The current study highlights the potential of the eye movement entropy measure as a neurophysiological marker for early psychosis. © 2024 Society of Biological Psychiatry

关键词： Biomarker Clinical high risk for psychosis Cognitive impairments Early psychosis Eye movement Schizophrenia

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From FAIR to CURE: Guidelines for Computational Models of Biological Systems

arXiv

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arXiv 2025年

作者： Sauro, Herbert M. Agmon, Eran Blinov, Michael L. Gennari, John H. Hellerstein, Joe Heydarabadipour, Adel Hunter, Peter Jardine, Bartholomew E. May, Elebeoba Nickerson, David P. Smith, Lucian P. Bader, Gary D. Bergmann, Frank Boyle, Patrick M. Dräger, Andreas Faeder, James R. Feng, Song Freire, Juliana Fröhlich, Fabian Glazier, James A. Gorochowski, Thomas E. Helikar, Tomas Hoops, Stefan Imoukhuede, Princess Keating, Sarah M. Konig, Matthias Laubenbacher, Reinhard Loew, Leslie M. Lopez, Carlos F. Lytton, William W. McCulloch, Andrew Mendes, Pedro Myers, Chris J. Myers, Jerry G. Mulugeta, Lealem Niarakis, Anna van Niekerk, David D. Olivier, Brett G. Patrie, Alexander A. Quardokus, Ellen M. Radde, Nicole Rohwer, Johann M. Sahle, Sven Schaff, James C. Sego, T.J. Shin, Janis Snoep, Jacky L. Vadigepalli, Rajanikanth Wiley, H. Steve Waltemath, Dagmar Moraru, Ion Department of Bioengineering University of Washington SeattleWA98195-5061 United States Intelligent Systems Engineering and Biocomplexity Institute Indiana University Street BloomingtonIN47408 United States Center for Cardiovascular Biology University of Washington SeattleWA98195-5061 United States eScience Institute University of Washington SeattleWA98195-5061 United States Institute for Stem Cell and Regenerative Medicine University of Washington SeattleWA98195-5061 United States School of Biological Sciences University of Bristol 24 Tyndall Avenue BristolBS8 1TQ United Kingdom Departments of Physiology & Pharmacology Neurology Downstate Health Science University BrooklynNY11203 United States Department of Neurology Kings County Hospital BrooklynNY11203 United States NASA-John H. Glenn Research Center MS 110-3 21000 Brookpark Road ClevelandOH44135 United States Center for Cell Analysis and Modeling UConn Health 263 Farmington Avenue FarmingtonCT06030-6406 United States Amsterdam Institute for Life and Environment Vrije Universiteit Amsterdam De Boelelaan 1108 Amsterdam1081 HZ Netherlands Department of Pathology and Genomic Medicine Thomas Jefferson University 1020 Locust St PhiladelphiaPA19107 United States Biological Sciences Division Pacific Northwest National Laboratory 902 Battelle Blvd RichlandWA99354 United States Auckland Bioengineering Institute University of Auckland Auckland1010 New Zealand Center of Integrative Biology University of Toulouse III-Paul Sabatier 165 Rue Marianne Grunberg-Manago Toulouse31400 France Lifeware Group Inria Building Alan Turing 1 Rue Honoré d’Estienne d’Orves Palaiseau91120 France Multiscale Modeling Group Altos Labs Redwood CityCA94065 United States partner site Tübingen Tübingen Germany Ottfried-Müller-Str. 37 Tübingen72076 Germany 06120 Germany Department of Computer Science Center for Data Science New York University New YorkNY11201 United States Department of Bi

Guidelines for managing scientific data have been established under the FAIR principles requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data and models are key to progress. For this reason, and recognizing that such models are a very special type of "data", we argue that computational models, especially mechanistic models prevalent in medicine, physiology and systems biology, deserve a complementary set of guidelines. We propose the CURE principles, emphasizing that models should be Credible, Understandable, Reproducible, and Extensible. We delve into each principle, discussing verification, validation, and uncertainty quantification for model credibility;the clarity of model descriptions and annotations for understandability;adherence to standards and open science practices for reproducibility;and the use of open standards and modular code for extensibility and reuse. We outline recommended and baseline requirements for each aspect of CURE, aiming to enhance the impact and trustworthiness of computational models, particularly in biomedical applications where credibility is paramount. Our perspective underscores the need for a more disciplined approach to modeling, aligning with emerging trends such as Digital Twins and emphasizing the importance of data and modeling standards for interoperability and reuse. Finally, we emphasize that given the non-trivial effort required to implement the guidelines, the community moves to automate as many of the guidelines as possible. © 2025, CC BY.

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