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Strengths, weaknesses, and applications of computational axial lithography in tissue engineering

Bio-Design and Manufacturing 2020年第1期3卷 5-6页

作者： Bin Zhang Lei Gao Qian Xue Zhanfeng Cui Liang Ma Huayong Yang State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China Department of Engineering Science Institute of Biomedical EngineeringUniversity of OxfordOxford OX37DQUK

Recently,Kelly and colleagues[1],inspired by computed tomography(CT),report a“volumetric additive manufacturing”technology via a computed axial lithography(CAL)approach.A related US patent application[2]has also been *** cumulative light exposure solidifies the material in the target area,while the other area remains uncured,resulting in only specific points in the designed 3D objects being *** technology significantly improves the capability of the digital light processing(DLP)***,the lithography approach based on a similar algorithm was already proposed by Xiang Wu in a patent(application ***/CN2016/080097)in 2016[3].

关键词： lithography technique. axial

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Automatic Segmentation Method for Cone-Beam Computed Tomography Image of the Bone Graft Region within Maxillary Sinus Based on the Atrous Spatial Pyramid Convolution Network

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 298-305页

作者： XU Jiangchang HE Shamin YU Dedong WU Yiqun CHEN Xiaojun Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Second Dental Centre Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai200011China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai200240China

Sinus floor elevation with a lateral window approach requires bone graft(BG)to ensure sufficient bone mass,and it is necessary to measure and analyse the BG region for follow-up of postoperative ***,the BG region from cone-beam computed tomography(CBCT)images is connected to the margin of the maxillary sinus,and its boundary is *** segmentation methods are usually performed manually by experienced doctors,and are complicated by challenges such as low efficiency and low *** this study,an auto-segmentation approach was applied to the BG region within the maxillary sinus based on an atrous spatial pyramid convolution(ASPC)*** ASPC module was adopted using residual connections to compose multiple atrous convolutions,which could extract more features on multiple ***,a segmentation network of the BG region with multiple ASPC modules was established,which effectively improved the segmentation *** the training data were insufficient,our networks still achieved good auto-segmentation results,with a dice coefficient(Dice)of 87.13%,an Intersection over Union(Iou)of 78.01%,and a sensitivity of 95.02%.Compared with other methods,our method achieved a better segmentation effect,and effectively reduced the misjudgement of *** method can thus be used to implement automatic segmentation of the BG region and improve doctors’work efficiency,which is of great importance for developing preliminary studies on the measurement of postoperative BG within the maxillary sinus.

关键词： atrous spatial pyramid convolution(ASPC) bone graft(BG)region medical image segmentation residual connection

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Flexible Broadband Compact Antenna Using Hydrogel Material for Noninvasive Medical Diagnostic systems

Flexible Broadband Compact Antenna Using Hydrogel Material f...

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IEEE Asia-Pacific Conference on Antennas and Propagation (APCAP)

作者： Jian Wu Nan Yang Jian Sun Jin Wu School of Electronics and Information Technology and Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and Systems Sun Yat-sen University Guangzhou China College of Biomedical Engineering Army Medical University Chongqing China State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-sen University Guangzhou China

A flexible broadband compact antenna is presented in this paper. To make the antenna compact and flexible, a high-permittivity polyvinyl alcohol organohydrogel is prepared and used. A magnetic coupling feeding method is used to obtain a broadband design, along with lossy material and head loading. The measured impedance bandwidth is larger than 140%, which is useful for imaging and electromagnetic diagnostic systems.

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Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution

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Cellular & Molecular Immunology 2021年第4期18卷 1067-1069页

作者： Huan Qi Ming-liang Ma He-wei Jiang Jian-ya Ling Ling-yun Chen Hai-nan Zhang Dan-yun Lai Yang Li Zi-wen Guo Chuan-sheng Hu Shu-juan Guo Qing-feng Meng Yan Ren Xiao Yang Wei Wang Jie Zhou Xiao-dong Zhao Hua Li Sheng-ce Tao Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Microbial Technology Shandong UniversityQingdaoShandongChina BGI Education Center University of Chinese Academy of SciencesShenzhenGuangdongChina State Key laboratory for Oncogenes and Bio-ID Center School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina BGI-Shenzhen ShenzhenGuangdongChina Foshan Fourth People's Hospital FoshanGuangdongChina Institute of Biophysics Chinese Academy of SciencesBeijingChina

There is a worldwide pandemic of COVID-19 caused by SARS-CoV-2.1 By January 28,2021,more than 100 million cases had been diagnosed,and more than 2 million deaths had been reported(https://***/***).The comprehensive and in-depth elucidation of SARS-CoV-2-specific IgG responses will help us to better understand COVID-19 immunity and facilitate the precise development of neutralizing antibodies and vaccines.

关键词： map. precise neutral

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Electrostatic atomization minimum quantity lubrication machining:from mechanism to application

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International Journal of Extreme Manufacturing 2022年第4期4卷 58-100页

作者： Wenhao Xu Changhe Li Yanbin Zhang Hafiz Muhammad Ali Shubham Sharma Runze Li Min Yang Teng Gao Mingzheng Liu Xiaoming Wang Zafar Said Xin Liu Zongming Zhou School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520People's Republic of China State Key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHong KongPeople's Republic of China Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Department of Mechanical Engineering IK Gujral Punjab Technical UniversityPunjab 144603India Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089-1111United States of America College of Engineering University of SharjahSharjah 27272United Arab Emirates School of Mechanical Engineering Dalian University of TechnologyDalian 116024People's Republic of China Hanergy(Qingdao)Lubrication Technology Co.LTD Qingdao 266520People's Republic of China

Metal cutting fluids(MCFs)under flood conditions do not meet the urgent needs of reducing carbon ***-based minimum quantity lubrication(MQL)is an effective alternative to flood ***,pneumatic atomization MQL has poor atomization properties,which is detrimental to occupational ***,electrostatic atomization MQL requires preliminary exploratory ***,systematic reviews are lacking in terms of capturing the current research status and development direction of this *** study aims to provide a comprehensive review and critical assessment of the existing understanding of electrostatic atomization *** research can be used by scientists to gain insights into the action mechanism,theoretical basis,machining performance,and development direction of this ***,the critical equipment,eco-friendly atomization media(biolubricants),and empowering mechanisms of electrostatic atomization MQL are ***,the advanced lubrication and heat transfer mechanisms of biolubricants are revealed by quantitatively comparing MQL with MCF-based wet ***,the distinctive wetting and infiltration mechanisms of electrostatic atomization MQL,combined with its unique empowering mechanism and atomization method,are compared with those of pneumatic atomization *** experiments have shown that electrostatic atomization MQL can reduce tool wear by 42.4%in metal cutting and improve the machined surface Ra by 47%compared with pneumatic atomization ***,future development directions,including the improvement of the coordination parameters and equipment integration aspects,are proposed.

关键词： cutting grinding minimum quantity lubrication electrostatic atomization biolubricant

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Long and Short-Term Constraints Driven Safe Reinforcement Learning for Autonomous Driving

arXiv

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arXiv 2024年

作者： Hu, Xuemin Chen, Pan Wen, Yijun Tang, Bo Chen, Long School of Artificial Intelligence Hubei University Wuhan430062 China Key Laboratory of Intelligent Sensing System and Security Hubei University Ministry of Education Hubei Wuhan430062 China Department of Electrical and Computer Engineering Worcester Polytechnic Institute WorcesterMA01609 United States State Key Laboratory of Multimodal Artificial Intelligence Systems State Key Laboratory of Management and Control for Complex Systems Chinese Academy of Sciences Beijing100190 China WAYTOUS Inc. Beijing100083 China Shenzhen518107 China Institute of Artificial Intelligence and Robotics Xi'an Jiaotong University Xi’an710049 China

Reinforcement learning (RL) has been widely used in decision-making and control tasks, but the risk is very high for the agent in the training process due to the requirements of interaction with the environment, which seriously limits its industrial applications such as autonomous driving systems. Safe RL methods are developed to handle this issue by constraining the expected safety violation costs as a training objective, but the occurring probability of an unsafe state is still high, which is unacceptable in autonomous driving tasks. Moreover, these methods are difficult to achieve a balance between the cost and return expectations, which leads to learning performance degradation for the algorithms. In this paper, we propose a novel algorithm based on the long and short-term constraints (LSTC) for safe RL. The short-term constraint aims to enhance the shortterm state safety that the vehicle explores, while the long-term constraint enhances the overall safety of the vehicle throughout the decision-making process, both of which are jointly used to enhance the vehicle safety in the training process. In addition, we develop a safe RL method with dual-constraint optimization based on the Lagrange multiplier to optimize the training process for end-to-end autonomous driving. Comprehensive experiments were conducted on the MetaDrive simulator. Experimental results demonstrate that the proposed method achieves higher safety in continuous state and action tasks, and exhibits higher exploration performance in long-distance decision-making tasks compared with state-of-the-art methods. Copyright © 2024, The Authors. All rights reserved.

关键词： Lagrange multipliers

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Mode-degeneracy lifting in exceptional points of a coupled spaser-dielectric waveguide system

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Physical Review A 2023年第6期108卷 063513-063513页

作者： Anton V. Hlushchenko Vitalii I. Shcherbinin Oksana L. Andrieieva Viktor I. Tkachenko Vladimir R. Tuz State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering International Center of Future Science Jilin University 2699 Qianjin St. Changchun 130012 China and School of Radiophysics Biomedical Electronics and Computer Systems V. N. Karazin Kharkiv National University 4 Svobody Sq. Kharkiv 61022 Ukraine

One of the main requirements for advanced optical systems is controllability, which can be greatly improved by introducing gain elements into a guiding system. In this study, we consider a coupled photonic-plasmonic system composed of a dielectric waveguide and a three-layer (dielectric-metal-dielectric) waveguide spaser with loss and gain. Conditions of mode degeneracy in this system are revealed. A classification of waveguide and surface plasmon modes is used to find parameters of the formation of exceptional points (EPs) of the coupled system with loss and gain. It is shown that at these points the lifting of the mode degeneracy occurs. In addition, the response of the coupled system to illumination is investigated for incident Gaussian beams of two orthogonal polarizations. It is demonstrated that the control of the incident beam polarization makes it possible to excite different modes. The revealed operation conditions of the optical system with two-stage control (control of the EP parameters plus control of wave polarization) can widen the application range of coupled spaser-dielectric waveguide systems.

关键词： Beam optics Photonics Plasmonics Surface plasmons Laser systems Optical fibers Waveguides Polarization Laser-beam impact phenomena

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Polycationic Nanoparticles for Cascaded Antibiosis and Lps- Detoxifying Via Co-Delivery of Antibiotics and Tlr Sirna in Bacterial Infected Diseases Treatment

SSRN

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SSRN 2025年

作者： Zhang, Yufeng Huangfu, Yini Xu, Ling Zhao, Zhezhe Su, Qi Li, Hui Zhang, Yumin Zhang, Chuangnian Huang, Pingsheng Dong, Anjie Feng, Zujian Wang, Weiwei Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin300072 China State Key Laboratory of Advanced Medical Materials and Devices Institute of Biomedical Engineering Chinese Academy of Medical Sciences Peking Union Medical College Tianjin300192 China State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin300071 China State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Tianjin Institutes of Health Science Institute of Radiation Medicine Chinese Academy of Medical Sciences Peking Union Medical College Tianjin300192 China Department of Periodontology School and Hospital of Stomatology Tianjin Medical University Tianjin300070 China Department of Respiratory Critical Care Medicine Binzhou Medical University Hospital China Tianjin Key Laboratory of Biomaterial Research China

Antimicrobial-resistant (AMR) Gram-negative bacteria emerge due to the overuse of antibiotics. Moreover, current bactericidal drugs or materials inevitably associate with the immunologic risks from the lipopolysaccharide (LPS) released by dead bacteria, which initiates and exacerbates chronic tissue-destructive hyperinflammation, leading to treatment failure. In this study, we describe an orchestrated pH-sensitive cationic polymer nanoparticle encapsulated with rifampicin and toll-like receptor (TLR) siRNA (RNP/siRNA) that exhibits antibacterial and LPS-detoxifying characteristics for treating infected diseases. Under acidic conditions, RNP/siRNA nanoparticle releases rifampicin and cationic polymers displaying synergistically inhibitory activity against AMR bacteria by disrupting bacterial membranes, and facilitating the entry of antibiotics. Furthermore, RNP/siRNA nanoparticle exhibits high cellular uptake and TLR knockdown efficiency, thereby detoxifying the etiological LPS in M1-type macrophages polarization and reducing proinflammatory cytokines. In a mouse pneumonia model, RNP/siRNA nanoparticle treatment inhibits bacterial growth, suppresses inflammation and reduces leukocyte recruitment. In a rat periodontitis model, the administration of RNP/siRNA downregulates proinflammatory cytokines expression and inhibits bone resorption. This work highlights the elevated LPS release is an early trigger of hyperinflammation during the antibacterial process of currently established antimicrobials. The RNP/siRNA nanoparticle represents a promising strategy by integrating antibiosis and immunomodulation in a cascading manner for the treatment of bacterial infections. © 2025, The Authors. All rights reserved.

关键词： Controlled drug delivery

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Fully Robotized 3D Ultrasound Image Acquisition for Artery

Fully Robotized 3D Ultrasound Image Acquisition for Artery

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IEEE International Conference on robotics and Automation (ICRA)

作者： Mingcong Chen Yuanrui Huang Jian Chen Tongxi Zhou Jiuan Chen Hongbin Liu State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing China Centre for Artificial Intelligence and Robotics Hong Kong Institute of Science and Innovation Chinese Academy of Sciences Hong Kong School of Artificial Intelligence University of Chinese Academy of Sciences Beijing China School of Biomedical Engineering and Imaging Sciences King's College London London UK

Current imaging of the artery relies primarily on computed tomography angiography (CTA), which requires contrast injections and exposure to radiation. In this paper, we present a method for fully autonomous artery 3D image acquisition using a linear ultrasound (US) probe and a 6 DoFs robot arm with a 3D camera. Robotic vessel acquisition can minimize tissue deformation and permit the reproduction of scans. Additionally, the robotic-based acquisition can provide more precise vessel position data that can be utilized for 3D reconstruction as a preoperative image. The first scanning point is determined by the 3D camera using a neural network for leg area estimation. A visual servo algorithm adjusts the in-plane motions using a cross-sectional vessel segmentation produced by a neural network with a UNet structure, while a US confidence map regulates the in-plane rotation. The robot is equipped with impedance control to maintain a constant and safe scan. Experiments on a leg phantom and a volunteer indicate that the robot can follow the vessel and modify its position to provide a sharper US image. The average error of phantom scanning in y-axis and z-axis are 0.2536mm and 0.2928mm, respectively, while the root means square error (RMSE) of contact force in the volunteer experiment is 0.2664N. In addition, a 3D vessel reconstruction demonstrates the possibility of robotic US acquisition as a preoperative image.

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Visual pinwheel centers act as geometric saliency detectors 24

Visual pinwheel centers act as geometric saliency detectors

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Proceedings of the 38th International Conference on Neural Information Processing systems

作者： Haixin Zhong Mingyi Huang Wei P. Dai Haoyu Wang Anna Wang Roe Yuguo Yu Research Institute of Intelligent Complex Systems Fudan University and State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Fudan University Research Institute of Intelligent Complex Systems Fudan University and Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Research Institute of Intelligent Complex Systems Fudan University and Shanghai Artificial Intelligence Laboratory Institute of Science and Technology for Brain-Inspired Intelligence Fudan University MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain Medicine Key Laboratory of Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument Science Zhejiang University Research Institute of Intelligent Complex Systems Fudan University and State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Fudan University and Institute of Science and Technology for Brain-Inspired Intelligence Fudan University and Shanghai Artificial Intelligence Laboratory

ISBN: (纸本)9798331314385

During natural evolution, the primary visual cortex (V1) of lower mammals typically forms salt-and-pepper organizations, while higher mammals and primates develop pinwheel structures with distinct topological properties. Despite the general belief that V1 neurons primarily serve as edge detectors, the functional advantages of pinwheel structures over salt-and-peppers are not well recognized. To this end, we propose a two-dimensional self-evolving spiking neural network that integrates Hebbian-like plasticity and empirical morphological data. Through extensive exposure to image data, our network evolves from salt-and-peppers to pinwheel structures, with neurons becoming localized bandpass filters responsive to various orientations. This transformation is accompanied by an increase in visual field overlap. Our findings indicate that neurons in pinwheel centers (PCs) respond more effectively to complex spatial textures in natural images, exhibiting quicker responses than those in salt-and-pepper organizations. PCs act as first-order stage processors with heightened sensitivity and reduced latency to intricate contours, while adjacent iso-orientation domains serve as second-order stage processors that refine edge representations for clearer perception. This study presents the first theoretical evidence that pinwheel structures function as crucial detectors of spatial contour saliency in the visual cortex.

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