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Highly Selective Biomimetic Flexible Tactile Sensor for Neuroprosthetics

Research 2020年第1期2020卷 1648-1658页

作者： Yue Li Zhiguang Cao Tie Li Fuqin Sun Yuanyuan Bai Qifeng Lu Shuqi Wang Xianqing Yang Manzhao Hao Ning Lan Ting Zhang i-Lab Key Laboratory of Multifunctional Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)398 Ruoshui RoadSuzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of China96 Jinzhai RoadHefeiAnhui 230026China Laboratory of Neurorehabilitation Engineering School of Biomedical Engineering and Institute of Medical RoboticsShanghai Jiao Tong University1954 Huashan RoadShanghai 20030China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Biomimetic flexible tactile sensors endow prosthetics with the ability to manipulate objects,similar to human ***,it is still a great challenge to selectively respond to static and sliding friction forces,which is crucial tactile information relevant to the perception of weight and slippage during ***,inspired by the structure of fingerprints and the selective response of Ruffini endings to friction forces,we developed a biomimetic flexible capacitive sensor to selectively detect static and sliding friction *** sensor is designed as a novel plane-parallel capacitor,in which silver nanowire-3D polydimethylsiloxane(PDMS)electrodes are placed in a spiral configuration and set perpendicular to the *** nanowires are uniformly distributed on the surfaces of 3D polydimethylsiloxane microcolumns,and silicon rubber(Ecoflex^(■))acts as the dielectric *** capacitance of the sensor remains nearly constant under different applied normal forces but increases with the static friction force and decreases when sliding ***,aiming at the slippage perception of neuroprosthetics,a custom-designed signal encoding circuit was designed to transform the capacitance signal into a bionic pulsed signal modulated by the applied sliding friction *** results demonstrate the great potential of the novel biomimetic flexible sensors with directional and dynamic sensitivity of haptic force for smart neuroprosthetics.

关键词： friction capacitance Highly

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CCA-Net: Zero-shot SSVEP classification via an integration of canonical correlation analysis and deep neural network

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IEEE Transactions on Instrumentation and Measurement 2025年 74卷

作者： Deng, Yang Ji, Zhiwei Wang, Yijun Zhou, S. Kevin Harbin Institute of Technology School of Life Science and Technology Heilongjiang Harbin 150001 China University of Science and Technology of China Division of Life Sciences and Medicine School of Biomedical Engineering Anhui Hefei 230026 China University of Science and Technology of China Center for Medical Imaging Robotics Analytic Computing & Learning (MIRACLE) Suzhou Institute for Advanced Research Jiangsu Suzhou 215123 China Nanjing Agricultural University College of Artificial Intelligence Jiangsu Nanjing 210095 China Chinese Academy of Sciences State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Beijing 100083 China University of Science and Technology of China Key Laboratory of Precision and Intelligent Chemistry Anhui Hefei 230026 China Chinese Academy of Sciences Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences Institute of Computing Technology Beijing 100190 China

Accurate decoding of electroencephalographic (EEG) signals is a crucial foundation for brain-computer interface (BCI) applications. Among various decoding approaches, those that do not require calibration are particularly significant for advancing BCI technologies into everyday life, as they alleviate user fatigue by eliminating the need for user-specific training. In this study, we integrate a deep neural network with canonical correlation analysis (CCA) to form the CCA-Net approach for decoding steady-state visually evoked potential (SSVEP) based BCI without user-specific calibration, i.e., at the zero-shot scenario. The CCA-Net aims to reduce the cross-subject domain gap for better transfer learning and make full use of the testing signal itself. Specifically, it adapts the cross-subject dual-domain fusion network (CSDuDoFN) by transferring the global multi-reference least-squares transformation coefficient from source subjects to both source and target data to reduce the cross-subject domain gap. In addition, CCA-Net enhances the transfer template-based canonical correlation analysis (tt-CCA) by introducing a subject-specific template to replace the sine-cosine reference template and adding an extra CCA coefficient to make full use of the testing signal itself, resulting in the Modified tt-CCA. Finally, the features extracted by CSDuDoFN and Modified tt-CCA are integrated to produce the final decoding result. Our approach leverages the strengths of both data-driven and model-driven methods and achieves state-of-the-art performance on three publicly available datasets, thus holding the potential to facilitate everyday BCI applications based on SSVEP. The reproducibility code is available at: https://***/Sungden/Zero-shot-SSVEP-classification. © 1963-2012 IEEE.

关键词： Brain-computer interface (BCI) canonical correlation analysis (CCA) deep neural network (DNN) steady-state visual evoked potential (SSVEP) zero-shot learning

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USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

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Protein & Cell 2020年第2期11卷 138-143页

作者： Beiqing Pan Yi Yang Jian Li Yu Wang Chuantao Fang Fa-Xing Yu Yanhui Xu Fudan University Shanghai Cancer Center Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringKey Laboratory of Medical Epigenetics and MetabolismShanghai Medical College of Fudan UniversityShanghai 200032China Children's Hospital and Institutes of Biomedical Sciences Key Laboratory of Medical Epigenetics and MetabolismFudan UniversityShanghai 200032China Key Laboratory of Molecular Medicine Ministry of EducationDepartment of Systems Biology for MedicineSchool of Basic Medical SciencesShanghai Medical College of Fudan UniversityShanghai 200032China Collaborative Innovation Center of Genetics and Development School of Life SciencesFudan UniversityShanghai 200433China CAS Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031China

Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and ***-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;Yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;Yu etal.,2015).

关键词： al. colorectal intestine

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Real-Time Human Lower Limbs Motion Estimation and Feedback for Potential Applications in Robotic Gait Aid and Training

Real-Time Human Lower Limbs Motion Estimation and Feedback f...

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IEEE International Conference on robotics and Automation (ICRA)

作者： Lei Wang Qingguo Li Jingang Yi Jinyuan Zhang Tao Liu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang University Hangzhou China Queen’s University Kingston Canada Rutgers University NJ USA Weldon School of Biomedical Engineering Purdue University West Lafayette IN USA

Real-time lower limbs motion or gait measurement is an important part in human-robotic interaction for the control of robotic walkers and rehabilitation devices. Laser range finder or infrared sensor that is mounted on the device has been widely used in applications. Although these sensors can provide accurate horizontal motion information of lower limbs during human walking, it is still difficult to measure the angular motion of lower limbs due to their functional principles. Using inertial measurement units (IMU) can measure the angular motion of lower limbs, but it requires a large amount of IMU units for measurements of all lower limb segments. In this study, a novel method is developed for real-time monitoring lower limbs (shanks and thighs) motion in human walking using just two shank-mounted IMUs. A pose prediction model based on multiple linear regression and Kalman filter is proposed. The root-mean-square error (RMSE) of the thigh orientation and the knee joint angle estimation in sagittal plane are 6.1 ± 1.3 and 6.8 ± 1.4 degs, respectively. The RMSE of the ankle, knee, and hip position estimation are 4.2 ± 1.3, 4.2 ± 1.1 and 3.5 ± 0.9 cm, respectively.

关键词： Legged locomotion Knee Training Measurement units Thigh Estimation Predictive models

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Applications of smartphone-based near-infrared(NIR)imaging,measurement,and spectroscopy technologies to point-of-care(POC)diagnostics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第3期22卷 171-189页

作者： Wenjing HUANG Shenglin LUO Dong YANG Sheng ZHANG Ningbo Research Institute Zhejiang UniversityNingbo315100China Department of Bioengineering School of EngineeringThe University of TokyoTokyo113-8656Japan Institute of Combined Injury State Key Laboratory of TraumaBurn and Combined InjuryCollege of Preventive MedicineThird Military Medical UniversityChongqing400038China Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownBoston02129USA Division of Biomedical Engineering Renal DivisionDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridge02139USA State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310027China

The role of point-of-care(POC)diagnostics is important in public *** the support of smartphones,POC diagnostic technologies can be greatly *** opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic *** a tool,the smartphone is regarded as part of a compact,portable,and low-cost system for real-time POC,even in areas with few *** combining near-infrared(NIR)imaging,measurement,and spectroscopy techniques,pathogens can be detected with high *** whole process is rapid,accurate,and low-cost,and will set the future trend for POC *** this review,the development of smartphone-based NIR fluorescent imaging technology was described,and the quality and potential of POC applications were discussed.

关键词： Point-of-care(POC)diagnostics Near-infrared(NIR)fluorescent imaging Aggregation-induced emission(AIE) Smartphone-based imaging Fluorescent probe

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Online 4D Ultrasound-Guided Robotic Tracking Enables 3D Ultrasound Localisation Microscopy with Large Tissue Displacements

arXiv

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arXiv 2024年

作者： Yan, Jipeng Tan, Qingyuan Kawara, Shusei Zhu, Jingwen Wang, Bingxue Toulemonde, Matthieu Liu, Honghai Tan, Ying Tang, Meng-Xing Ultrasound Lab for Imaging and Sensing Department of Bioengineering Imperial College London LondonSW7 2AZ United Kingdom the State Key Laboratory of Robotics and Systems Harbin Institute of Technology Harbin150001 China the Department of Bioengineering Imperial College London LondonSW7 2AZ United Kingdom the School of Computing University of Portsmouth PortsmouthPO1 2UP United Kingdom the Department of Mechanical Engineering University of Melbourne ParkvilleVIC3010 Australia

Super-Resolution Ultrasound (SRUS) imaging through localising and tracking microbubbles, also known as Ultrasound Localisation Microscopy (ULM), has demonstrated significant potential for reconstructing microvasculature and flows with sub-diffraction resolution in clinical diagnostics. However, imaging organs with large tissue movements, such as those caused by respiration, presents substantial challenges. Existing methods often require breath holding to maintain accumulation accuracy, which limits data acquisition time and ULM image saturation. To improve image quality in the presence of large tissue movements, this study introduces an approach integrating high-frame-rate ultrasound with online precise robotic probe control. Tested on a microvasculature phantom with translation motions up to 20 mm, twice the aperture size of the matrix array used, our method achieved real-time tracking of the moving phantom and imaging volume rate at 85 Hz, keeping majority of the target volume in the imaging field of view. ULM images of the moving cross channels in the phantom were successfully reconstructed in post-processing, demonstrating the feasibility of super-resolution imaging under large tissue motions. This represents a significant step towards ULM imaging of organs with large motion. © 2024, CC BY-NC-ND.

关键词： Image enhancement

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Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice

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Neuroscience Bulletin 2021年第9期37卷 1325-1338页

作者： Xinyi Zhou Bifeng Wu Wenhao Liu Qian Xiao Wei He Ying Zhou Pengfei Wei Xu Zhang Yue Liu Jie Wang Jufang He Zhigang Zhang Weidong Li Liping Wang Jie Tu Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease InstituteShenzhen-Hong Kong Institute of Brain ScienceShenzhen Fundamental Research InstitutionsShenzhen Institute of Advanced TechnologyChinese Academy of Sciences518055 ShenzhenChina University of Chinese of Academy of Sciences Beijing 100049China Department of Information Technology and Electrical Engineering Zurich Swiss Federal Institute of Technology Zurich8092 ZurichSwitzerland Department of Biomedical Sciences City University of Hong KongKowloon TongHong Kong Virginia Polytechnic Institute and State University BlacksburgVirginia 24061USA Department of Psychiatry and Behavioral Sciences Emory University School of MedicineAtlanta 30322USA Bio-X Institutes Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders(Ministry of Education)Shanghai Key Laboratory of Psychotic Disordersand Brain Science and Technology Research CenterShanghai Jiao Tong UniversityShanghai 200240China Center of Brain Science State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsInnovation Academy for Precision Measurement Science and TechnologyNational Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsWuhan Institute of Physics and MathematicsChinese Academy of Sciences430071 WuhanChina Department of Neuroscience City University of Hong KongKowloon TongHong Kong City University of Hong Kong Shenzhen Research Institute Shenzhen 518057China

A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid *** humans,a large proportion of mental disorders are accompanied by impairments in risk *** of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1(DISC1),and animal models in which this gene has some level of dysfunction show emotion-related ***,it is not known whether DISC1 mouse models have an impairment in avoiding potential *** the present study,we used DISC1-N terminal truncation(DISC1-N^(TM))mice to investigate risk avoidance and found that these mice were impaired in risk avoidance on the elevated plus maze(EPM)and showed reduced social preference in a three-chamber social interaction *** EPM tests,c-Fos expression levels indicated that the nucleus accumbens(NAc)was associated with risk-avoidance behavior in DISC1-N^(TM)*** addition,in vivo electrophysiological recordings following tamoxifen administration showed that the firing rates of fast-spiking neurons(FS)in the NAc were significantly lower in DISC1-N^(TM)mice than in wild-type(WT)*** addition,in vitro patch clamp recording revealed that the frequency of action potentials stimulated by current injection was lower in parvalbumin(PV)neurons in the NAc of DISC1-N^(TM)mice than in WT *** impairment of risk avoidance in DISC1-N^(TM)mice was rescued using optogenetic tools that activated NAcPV ***,inhibition of the activity of NAcPV neurons in PV-Cre mice mimicked the risk-avoidance impairment found in DISC1-N^(TM)mice during tests on the elevated zero *** together,our findings confirm an impairment in risk avoidance in DISC1-N^(TM)mice and suggest that reduced excitability of NAc^(PV) neurons is responsible.

关键词： DISC1 Risk avoidance Parvalbumin Nucleus accumbens

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Phase-field numerical study on the dynamic process of thermocapillary patterning

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Physical Review E 2022年第1期106卷 015111-015111页

作者： Qingzhen Yang Yankui Liu Xinmiao Jia Tingting Zhang Hongmiao Tian Jing Fan Quange Xu Fenhong Song The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 People's Republic of China Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an Shaanxi 710049 People's Republic of China Micro-/Nano-technology Research Center State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an Shaanxi 710049 People's Republic of China Research Institute of Xi'an Jiaotong University Hangzhou Zhejiang 311215 People's Republic of China School of Energy and Power Engineering Northeast Electric Power University Jilin Jilin 132012 People's Republic of China College of Mechanical and Electrical Engineering Shaanxi University of Science and Technology Xi'an Shaanxi 710021 People's Republic of China

It is well known that surface tension is dependent on temperature, and thus a nonuniform temperature may cause thermocapillary flow which is referred to as the Marangoni effect. For a thin liquid-air film confined between a flat hot plate and a topographical cold template, it undergoes deformation due to thermocapillary flow. This phenomenon is termed as thermocapillary patterning, and has been used to fabricate micro- and nanostructure in polymer films. In most cases, the obtained structure conforms to the template; i.e., it can be considered as a replication technique. In this paper, we developed a two-phase flow numerical model based on the phase field to study the dynamic process of thermocapillary patterning. As a remeshing-free method, the phase field enables the incorporation of thermal field and multiphase flow with free surface deformation. The numerical model was employed to study the dynamic process of thermocapillary patterning. Meanwhile, the effects of some parameters, e.g., temperature, geometry parameters, and contact angle, were also investigated.

关键词： Flow instability Marangoni convection Viscosity Phase-field modeling

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An Easy-implemented Optimization Method of Trajectory Planning Based on Polynomial Interpolation

An Easy-implemented Optimization Method of Trajectory Planni...

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第40届中国控制会议

作者： Guangrong Chen Ming Ma Sheng Guo Bowen Hou Junzheng Wang Robotics Research Center Beijing Jiaotong University Beijing Engineering and Technology Research Center of Rail Transit Line Safety and Disaster Prevention State Key Laboratory of Intelligent Control and Decision of Complex Systems School of AutomationBeijing Institute of Technology

Firstly,the forward kinematics and inverse kinematics of a five axis manipulator are ***,an easyimplemented optimization method of trajectory planning based on seventh order polynomial interpolation is *** proposed optimization method can capture the time optimal trajectory,while the actuators specifications including speed,acceleration of motor can be guaranteed as ***,simulation results validate the effectiveness and efficiency of proposed optimization *** research provides an insight for the application of trajectory optimization on the controller with low computing capability and real-time requirement.

关键词： Trajectory planning Optimization method Polynomial interpolation Manipulator

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A Novel Fractional Order Impedance Control and Its Performance Analysis

A Novel Fractional Order Impedance Control and Its Performan...

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第33届中国控制与决策会议

作者： Guangrong Chen Huafeng Lu Bowen Hou Sheng Guo Junzheng Wang Robotics Research Center Beijing Jiaotong University Beijing Engineering and Technology Research Center of Rail Transit Line Safety and Disaster Prevention State Key Laboratory of Intelligent Control and Decision of Complex Systems School of AutomationBeijing Institute of Technology

In traditional impedance control model,the contact force can be reduced ***,there exists a tracking error at the stable state due to the existence of stiffness,which is not conducive to tackle tasks based on high performance position control for ***,this paper proposes a novel dynamic interaction model:fractional order impedance control,to address this ***,an integral item is added into the traditional impedance model to eliminate the tracking ***,the idea of fractional order is introduced to make the orders of inertia,damping,and stiffness change from integers to fractions to achieve more significant compliant ***,simulation results validate the advantages of proposed fractional order impedance control and it can be also employed to absorb/increase,hold/keep,and dissipate/decrease system energy to achieve jumping,bouncing and friendly contact,***,stability analysis and three criterions of choosing and tuning 6 classic parameters in the proposed fractional order impedance control are both given out.

关键词： Dynamic interaction Compliance control Fractional order Impedance control Performance analysis

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