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arXiv 2023年

作者： Tuz, Vladimir R. Evlyukhin, Andrey B. Fesenko, Volodymyr I. State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering International Center of Future Science Jilin University 2699 Qianjin St. Changchun130012 China School of Radiophysics Biomedical Electronics and Computer Systems V. N. Karazin Kharkiv National University 4 Svobody Sq. Kharkiv61022 Ukraine Institute of Quantum Optics Leibniz Universität Hannover Hannover30167 Germany Institute of Radio Astronomy of National Academy of Sciences of Ukraine 4 Mystetstv St. Kharkiv61002 Ukraine

The change in the arrangement of magnetic dipole moments in a magnetic metasurface, due to the influence of an external static magnetic field, is discussed. Each meta-atom of the metasurface is composed of three identical disk-shaped resonators (trimer) made of magnetically saturated ferrite. To provide physical insight, full-wave numerical simulations of the near-fields and transmission characteristics of the metasurface are complemented by the theoretical description based on the multipole decomposition method. With these methods, the study of eigenmodes and scattering conditions of a single magnetic resonator, trimer, and their array forming the metasurface is performed. It is found that the magnetic dipole-based collective hybrid mode of the trimer can be gradually transformed from the radial (pseudomonopole) to azimuthal (toroidal) order and vice versa by varying the bias magnetic field strength. This is because the magnetic dipole moment of each individual disk constituting the trimer undergoes rotation as the bias magnetic field strength changes. This transition between two orders is accompanied by various patterns of localization of the electric field inside the meta-atoms. Due to the unique field configuration of these modes, the proposed metasurface can be considered for designing magnetic field sensors and nonreciprocal devices. © 2023, CC BY.

关键词： Magnetic fields

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Haptic display for virtual reality: progress and challenges

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Virtual Reality & Intelligent Hardware 2019年第2期1卷 136-162页

作者： Dangxiao WANG Yuan GUO Shiyi LIU Yuru ZHANG Weiliang XU Jing XIAO State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100083China Peng Cheng Laboratory Shenzhen 518055China Department of Mechanical Engineering University of AucklandAuckland 1142New Zealand School of Computer Science and the Robotics Engineering Program Worcester Polytechnic InstituteWorcesterMA 01609-2280USA

Immersion, interaction, and imagination are three features of virtual reality (VR). Existing VR systems possess fairly realistic visual and auditory feedbacks, and however, are poor with haptic feedback, by means of which human can perceive the physical world via abundant haptic properties. Haptic display is an interface aiming to enable bilateral signal communications between human and computer, and thus to greatly enhance the immersion and interaction of VR systems. This paper surveys the paradigm shift of haptic display occurred in the past 30 years, which is classified into three stages, including desktop haptics, surface haptics, and wearable haptics. The driving forces, key technologies and typical applications in each stage are critically reviewed. Toward the future high-fidelity VR interaction, research challenges are highlighted concerning handheld haptic device, multimodal haptic device, and high fidelity haptic rendering. In the end, the importance of understanding human haptic perception for designing effective haptic devices is addressed.

关键词： Haptic display Virtual reality Desktop haptics Surface haptics Wearable haptics Multimodal haptics

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The Importance of Superoxide Anion for Escherichia Coli Biofilm Removal Using Plasma-Activated Water

SSRN

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SSRN 2022年

作者： Xia, Binbin Vyas, Heema Kumari Nilesh Zhou, Renwu Zhang, Tianqi Hong, Jungmi Rothwell, Joanna G. Rice, Scott A. Carter, Dee Ostrikov, Kostya Cullen, Patrick J. Mai-Prochnow, Anne School of Chemical and Biomolecular Engineering The University of Sydney Australia Sydney Institute for Infectious Diseases The University of Sydney Australia State Key Laboratory of Electrical Insulation and Power Equipment Center for Plasma Biomedicine Xi’an Jiaotong University Xi’an China School of Life and Environmental Sciences The University of Sydney Australia Agriculture and Food Microbiomes for One Systems Health Commonwealth Scientific and Industrial Research Organisation Sydney Australia School of Chemistry and Physics QUT Centre for Biomedical Technologies Queensland University of Technology BrisbaneQLD4000 Australia

Microbial biofilms cause contamination of water pipelines, filters, membranes, and other critical infrastructure. These communities of microorganisms thrive on surfaces thus posing major risks to human health and necessitate costly cleaning and repair. Cold plasma, a partially ionised gas, and plasma-activated water (PAW) exhibit powerful disinfectant activity. However, the optimal generating conditions, such as the choice of gas used to produce PAW, remain unclear. Here, a range of different PAWs were generated from argon, nitrogen, air, and oxygen in a plasma bubble spark discharge (BSD) reactor capable of directly treating Escherichia coli (ATCC 25922) biofilms in situ. We measured the reactive oxygen and nitrogen species (RONS) (H2O2, NO3-, NO2-) in PAW and the excited species via optical emission spectroscopy (OES). PAW generated using oxygen (PAW-O2) was the most effective and completely removed E. coli biofilms on stainless steel surfaces. Confocal microscopy demonstrated that PAW treatment removed most biofilm cells from the surface with only a few dead cells remaining. We demonstrated that intracellular ROS level increases significantly in the PAW-O2-treated biofilms. Using molecular scavengers, we showed that superoxide anion radical (•O2-) played a critical role in the inactivation of E. coli biofilms. We also confirmed the generation of •O2- in the PAW-O2 via electron paramagnetic resonance (EPR) spectrometry. The potential chemical reactions that occurred in PAW were hypothesized via optical emission spectra (OES). Our results demonstrate the importance of input gas and plasma operating conditions to maximise effective RONS production for optimal biofilm removal under real environmental and industry-relevant conditions. © 2022, The Authors. All rights reserved.

关键词： Escherichia coli

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Mobility in China, 2020: a tale of four phases

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National Science Review 2021年第11期8卷 110-120页

作者： Suoyi Tan Shengjie Lai Fan Fang Ziqiang Cao Bin Sai Bing Song Bitao Dai Shuhui Guo Chuchu Liu Mengsi Cai Tong Wang Mengning Wang Jiaxu Li Saran Chen Shuo Qin Jessica R.Floyd Zhidong Cao Jing Tan Xin Sun Tao Zhou Wei Zhang Andrew J.Tatem Petter Holme Xiaohong Chen Xin Lu College of Systems Engineering National University of Defense Technology WorldPop School of Geography and Environmental ScienceUniversity of Southampton School of Mathematics and Big Data Foshan University State Key Laboratory on Blind Signal Processing State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of Sciences Chinese Evidence-Based Medicine Center National Clinical Research Center for Geriatrics West China Hospital Sichuan University Big Data Research Center University of Electronic Science and Technology of China West China Biomedical Big Data Center West China Hospital Sichuan University Tokyo Tech World Hub Research Initiative Institute of Innovative Research Tokyo Institute of Technology School of Business Central South University Institute of Big Data and Internet Innovations Hunan University of Technology and Business

2020 was an unprecedented year,with rapid and drastic changes in human mobility due to the COVID-19 *** understand the variation in commuting patterns among the Chinese population across stable and unstable periods,we used nationwide mobility data from 318 million mobile phone users in China to examine the extreme fluctuations of population movements in 2020,ranging from the Lunar New Year travel season(chunyun), to the exceptional calm of COVID-19 lockdown,and then to the recovery *** observed that cross-city movements,which increased substantially in chunyun and then dropped sharply during the lockdown,are primarily dependent on travel distance and the socio-economic development of *** the Lunar New Year holiday,national mobility remained low until mid-February,and COVID-19 interventions delayed more than 72.89 million people returning to large *** network analysis revealed clusters of highly connected cities,conforming to the social-economic division of urban agglomerations in *** the mass migration back to large cities was delayed,smaller cities connected more densely to form new *** the recovery period after travel restrictions were lifted,the netflows of over 55% city pairs reversed in direction compared to before the *** findings offer the most comprehensive picture of Chinese mobility at fine resolution across various scenarios in China and are of critical importance for decision making regarding future public-health-emergency response,transportation planning and regional economic development,among others.

关键词： human mobility travel restrictions COVID-19 mobile phone data behavioral response

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Super-resolution multicolor fluorescence microscopy enabled by an apochromatic super-oscillatory lens with extended depth-of-focus

arXiv

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arXiv 2022年

作者： Li, Wenli He, Pei Fan, Yulong Du, Yangtao Gao, Bo Chu, Zhiqin An, Chengxu Lei, Dangyuan Yuan, Weizheng Yu, Yiting Research & Development Institute of Northwestern Polytechnical University in Shenzhen College of Mechanical Engineering Ningbo Institute of Northwestern Polytechnical University Northwestern Polytechnical University Xi'An710072 China Northwestern Polytechnical University Xi'An710072 China Shaanxi Province Key Laboratory of Micro and Nano Electro-Mechanical Systems Northwestern Polytechnical University Xi'An710072 China Department of Materials Science and Engineering City University of Hong Kong 999077 Hong Kong The Institute of Ai and Robotics Fudan University Shanghai200433 China Key Laboratory of Spectral Imaging Technology of Chinese Academy of Sciences Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xian710119 China Department of Electrical and Electronic Engineering Joint Appointment with School of Biomedical Sciences The University of Hong Kong 999077 Hong Kong

Multicolor super-resolution imaging remains an intractable challenge for both far-field and near-field based super-resolution techniques. Planar super-oscillatory lens (SOL), a far-field subwavelength-focusing diffractive lens device, holds great potential for achieving sub-diffraction-limit imaging at multiple wavelengths. However, conventional SOL devices suffer from a numerical aperture (NA) related intrinsic tradeoff among the depth of focus (DoF), chromatic dispersion and focus spot size, being an essential characteristics of common diffractive optical elements. Typically, the limited DoF and significant chromatism associated with high NA can lead to unfavorable degradation of image quality although increasing NA imporves the resolution. Here, we apply a multi-objective genetic algorithm (GA) optimization approach to design an apochromatic binary-phase SOL that generates axially jointed multifoci concurrently having prolonged DoF, customized working distance (WD) and suppressed side-lobes yet minimized main-lobe size, optimizing the aforementioned NA-dependent tradeoff. Experimental implementation of this GA-optimized SOL demonstrates simultaneous focusing of blue, green and red light beams into an optical needle of ∼0.5λ in diameter and >10λ in length (DoF) at 428 μm WD, resulting in an ultimate resolution better than λ/3 in the lateral dimension. By integrating this apochromatic SOL device with a commercial fluorescence microscope, we employ the optical needle to perform, for the first time, three-dimensional super-resolution multicolor fluorescence imaging of the "unseen" fine structure of neurons at one go. The present study provides not only a practical route to far-field multicolor super-resolution imaging but also a viable approach for constructing imaging systems avoiding complex sample positioning and unfavorable photobleaching. Copyright © 2022, The Authors. All rights reserved.

关键词： Needles

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Cancer nanomedicine meets immunotherapy: opportunities and challenges

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中国药理学报（英文版） 2020年第7期41卷 954-958页

作者： Qingxue Sun Xiangyang Bai Alexandros Marios Sofias Roy van der Meel Eduardo Ruiz-Hernandez Gert Storm Wim E.Hennink Bruno De Geest Fabian Kiessling Hai-jun Yu Twan Lammers Yang Shi Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering Faculty of Medicine RWTH Aachen University AachenGermany Laboratory of Chemical Biology Department of Biomedical Engineering and Institute for Complex Molecular Systems Eindhoven University of Technology EindhovenThe Netherlands School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin Dublin Ireland Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands Department of Targeted Therapeutics MIRA Institute for Biomedical Technology and Technical Medicine University of Twente Enschede The Netherlands Department of Pharmaceutics Ghent University Ghent Belgium Fraunhofer MEVlS Institute for Medical Image Computing AachenGermany State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Cancer nanomedicines have shown promise in combination immunotherapy,thus far mostly preclinically but also already in clinical *** nanomedicines with immunotherapy aims to reinforce the cancer-immunity cycle,via potentiating key steps in the immune reaction cascade,namely antigen release,antigen processing,antigen presentation,and immune cell-mediated *** nano-immunotherapy can be realized via three targeting strategies,i.e.,by targeting cancer cells,targeting the tumor immune microenvironment,and targeting the peripheral immune *** clinical potential of nano-immunotherapy has recently been demonstrated in a phase Ⅲ trial in which nano-albumin paclitaxel (Abraxane(R)) was combined with atezolizumab (Tecentriq(R)) for the treatment of patients suffering from advanced triple-negative breast *** the present paper,besides strategies and initial (pre)clinical success stories,we also discuss several key challenges in *** together,nanomedicines combined with immunotherapy are gaining significant attention,and it is anticipated that they will play an increasingly important role in clinical cancer therapy.

关键词： nanomedicine immunotherapy targeting combination therapy clinical translation

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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications (vol 23, pg 424, 2021)

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NATURE CELL BIOLOGY 2021年第6期23卷 676-676页

作者： Shi, Junchao Zhang, Yunfang Tan, Dongmei Zhang, Xudong Yan, Menghong Zhang, Ying Franklin, Reuben Shahbazi, Marta Mackinlay, Kirsty Liu, Shichao Kuhle, Bernhard James, Emma R. Zhang, Liwen Qu, Yongcun Zhai, Qiwei Zhao, Wenxin Zhao, Linlin Zhou, Changcheng Gu, Weifeng Murn, Jernej Guo, Jingtao Carrell, Douglas T. Wang, Yinsheng Chen, Xuemei Cairns, Bradley R. Yang, Xiang-lei Schimmel, Paul Zernicka-Goetz, Magdalena Cheloufi, Sihem Zhang, Ying Zhou, Tong Chen, Qi Division of Biomedical Sciences School of Medicine University of California Riverside Riverside CA USA Department of Physiology and Cell Biology University of Nevada Reno School of Medicine Reno NV USA Pudong Medical Center Institutes of Biomedical Sciences Shanghai Medical College Fudan University Shanghai China Department of Biochemistry Stem Cell Center University of California Riverside Riverside CA USA Department of Physiology Development and Neuroscience University of Cambridge Cambridge UK MRC Laboratory of Molecular Biology Cambridge UK Department of Molecular Medicine The Scripps Research Institute La Jolla CA USA Division of Urology Department of Surgery University of Utah School of Medicine Salt Lake City UT USA State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China CAS Key Laboratory of Nutrition Metabolism and Food Safety CAS Center for Excellence in Molecular Cell Sciences Shanghai Institute of Nutrition and Health Chinese Academy of Sciences Shanghai China Department of Chemistry University of California Riverside Riverside CA USA Department of Molecular Cell and Systems Biology University of California Riverside Riverside CA USA Howard Hughes Medical Institute Department of Oncological Sciences and Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City UT USA Department of Botany and Plant Sciences University of California Riverside Riverside CA USA Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA

A Correction to this paper has been published: https://***/10.1038/s41556-021-00687-w.

关键词： Non-coding RNAs Reprogramming RNA sequencing Small RNAs

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Characterization of OAM Antenna Operating in a Multiplexing state

Characterization of OAM Antenna Operating in a Multiplexing ...

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IEEE Conference on Antenna Measurements & Applications (CAMA)

作者： Zuxian He Vladimir R. Tuz Patrizia Savi Dmytro Vavriv Volodymyr Fesenko State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering International Center of Future Science Jilin University Changchun China School of Radiophysics Biomedical Electronics and Computer Systems V. N. Karazin Kharkiv National University Kharkiv Ukraine Electronics and Telecommunications Department (DET) Politecnico di Torino Torino Italy Department of Microwave Electronics Institute of Radio Astronomy National Academy of Sciences of Ukraine Kharkiv Ukraine

ISBN: (纸本)9781665490382

Orbital angular momentum (OAM), which characterizes the helical phase pattern of optical beams, has recently attracted enormous interest due to its potential applications in different practice areas. Here we propose an antenna design for generating multiple beams carrying OAM with different topological states at the same frequency. The numerical full-wave simulation is performed for an actual size OAM generator using the ANSYS HFSS electromagnetic solver, and an antenna prototype operating in the microwave band is fabricated and tested. Obtained results prove that the proposed antenna can be used as a compact and low-cost generator of multiple beams with different OAM states.

关键词： Microwave antennas Antenna measurements Multiplexing Microwave measurement Prototypes Generators Orbits

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Correction: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5Amediated chromatin accessibility

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Journal of experimental & clinical cancer research : CR 2024年第1期43卷 167页

作者： Nan Jing Xinxing Du Yu Liang ZhenKeke Tao Shijia Bao Huixiang Xiao Baijun Dong Wei-Qiang Gao Yu-Xiang Fang State Key Laboratory of Systems Medicine for Cancer Renji-Med-X Stem Cell Research Center Ren Ji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200127 China. Med-X Research Institutes Shanghai Jiao Tong University Shanghai 200030 China. Department of Urology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China. State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China. State Key Laboratory of Systems Medicine for Cancer Renji-Med-X Stem Cell Research Center Ren Ji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200127 China. gao.weiqiang@***. Med-X Research Institutes Shanghai Jiao Tong University Shanghai 200030 China. gao.weiqiang@***. State Key Laboratory of Systems Medicine for Cancer Renji-Med-X Stem Cell Research Center Ren Ji Hospital School of Medicine School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200127 China. fyx2003@***.

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Cryo-EM structure of SMG1-SMG8-SMG9 complex

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细胞研究（英文版） 2019年第12期29卷 1027-1034页

作者： Li Zhu Liang Li Yilun Qi Zishuo Yu Yanhui Xu Fudan University Shanghai Cancer Center Institutes of Biomedical Sciences State Key Laboratory of Genetic Engineering and Key Laboratory of Medical Epigenetics and Metabolism Shanghai Medical College of Fudan University Shanghai 200032 China Fudan University Shanghai Cancer Center Institutes of Biomedical Sciences State Key Laboratory of Genetic Engineering and Key Laboratory of Medical Epigenetics and Metabolism Shanghai Medical College of Fudan University Shanghai 200032 China Key Laboratory of Molecular Medicine Ministry of Education Department of Systems Biology for Medicine School of Basic Medical Sciences Shanghai Medical College of Fudan University Shanghai 200032 China Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Shanghai 200433 China CAS Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031 China

Nonsense-mediated mRNA decay (NMD) targets premature stop codon (PTC)-containing mRNAs for rapid degradation,and is essential for mammalian embryonic development,brain development and modulation of the stress *** key event in NMD is the SMG1-mediated phosphorylation of an RNA helicase UPF1 and SMG1 kinase activity is inhibited by SMG8 and SMG9 in an unknown ***,we determined the cryo-EM structures of human SMG1 at 3.6(A) resolution and the SMG1-SMG8-SMG9 complex at 3A (A) resolution,***8 has a C-terminal kinase inhibitory domain (KID),which covers the catalytic pocket and inhibits the kinase activity of *** analyses suggest that GTP hydrolysis of SMG9 would lead to a dramatic conformational change of SMG8-SMG9 and the KID would move away from the inhibitory position to restore SMG1 kinase ***,our structural and biochemical analyses provide a mechanistic understanding of SMG1-SMG8-SMG9 complex assembly and the regulatory mechanism of SMG1 kinase activity.

关键词： embryonic development conformational change rapid degradation stress response

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