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Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products

engineering 2020年第11期6卷 1217-1221页

作者： Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai Department of Orthopedics Peking Union Medical College HospitalChinese Academy of Medical Science 8 Peking Union Medical CollegeBejjing 100730.China National Engineering Research Center of Light Alloys Net Forming&State Key Laboratony of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Notional Engineering Research Center of Mg Materials and Applicarions and School of Materials Science 8r Engineering.Shanghai Jlao Tong University Shanghai 200240China Department of Spine Surgery Beijing Jishuitan HospitalBeijing 100035China Center for Troanslational Medicine Research and Development Institute of Biomedical and Health EngineeringShenzhen Insitute of Advanced Technology.Chinese Academy of SciencesShenzhen 518055China Guangdong Engineering Laboratony of Biomaterials Additive Manufacturing Guangdong 518055China Musculoskeletal Research Laboratory of the Department of Orthopedics 8 Traumatology and Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077.China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Center for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstiuteShenzhen 518057.China Hong Kong Branch of National Precious Metals Material Engineering Research Center Department of Material Science and EngineeringCity Untiversity of Hong KongHong Kong 999077.China Department of Mechanical Engineering ity Untiversity of Hong Kong.Hong Kong 9977 China School of Pharmacy.Shanghai Jiao Tong University Shanghai 200240China China State Instute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical IndustryShonghai 201203China Shanghai Innovation Instinute for Materials Shanghai 200444.China State Key Laboratory of High-Performance Ceramies and Superfine Microstructure Shanghai Institute of CeramicsChinese Acadermy 0f SciencesShanghai 200050Ch

*** and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)*** and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common *** example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of *** most widely used materials in biomedicine are *** homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging.

关键词： composites printing additive

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xSCYTE: Express Single-frame Cytometer through Tomographic Phase

arXiv

引用

arXiv 2022年

作者： Ge, Baoliang He, Yanping Deng, Mo Rahman, Md Habibur Wang, Yijin Wu, Ziling Yang, Yongliang Kuang, Cuifang Wong, Chung Hong N. Chan, Michael K. Ho, Yi-Ping Duan, Liting Yaqoob, Zahid So, Peter T.C. Barbastathis, George Zhou, Renjie Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Laser Biomedical Research Center Massachusetts Institute of Technology CambridgeMA02139 United States Department of Biomedical Engineering The Chinese University of Hong Kong Shatin New Territories Hong Kong School of Artificial Intelligence Science and Technology University of Shanghai for Science and Technology Shanghai200093 China Institute of Photonic Chips University of Shanghai for Science and Technology Shanghai200093 China The State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang110016 China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou310027 China School of Life Sciences The Chinese University of Hong Kong Shatin New Territories Hong Kong Centre for Novel Biomaterials The Chinese University of Hong Kong Shatin New Territories Hong Kong Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong Kong Shatin New Territories Hong Kong Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA02139 United States Singapore-MIT Alliance for Research and Technology Centre Singapore Singapore-MIT Alliance for Research and Technology Centre Singapore

Rapid, comprehensive, and accurate cell phenotyping without compromising viability, is crucial to many important biomedical applications, including stem-cell therapy, drug screening, and liquid biopsy. Typical image cytometry methods acquire two-dimensional (2D) fluorescence images, where the fluorescence labelling process may damage living cells, and the information from 2D images is not comprehensive enough for precise cell analysis. Although three-dimensional (3D) label-free image cytometry holds great promise, its high throughput development faces several technical challenges. Here, we report eXpress Single-frame CYtometer through Tomographic phasE (xSCYTE), which reconstructs 3D Refractive Index (RI) maps of cells with diffraction-limited resolution. xSCYTE is built on a versatile quantitative phase microscope, whose label-free imaging nature allows in-situ, long-time, reusable live-cell analysis. Further, with angle-multiplexing illumination and a pre-trained physics-incorporating Deep Neural Network, xSCYTE can map the 3D RI distribution of a cell by acquiring only a single frame that allows rapid image reconstruction and holds the potential for real-time analysis. By flowing large quantities of cells through a microfluidic channel and equipping xSCYTE with a high-speed camera, we have demonstrated an unprecedented 3D imaging throughput of over 20,000 cells/second while providing sufficient morphological information to distinguish different cellular species. The biomedical application potential of xSCYTE has been evaluated by visualizing and quantifying shear-induced 3D transient deformation of red blood cells that can be correlated with several blood pathologies. With these high-speed and high-precision imaging capabilities empowered by artificial intelligence, we envision xSCYTE may open up many new avenues of biomedical investigations and industries, such as multi-omic assays and quality control during cellular therapeutic manufacturing. © 2022, CC BY-NC-S

关键词： High speed cameras

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Synthesis of novel nanomaterials and their application in efficient removal of radionuclides

引用

Science China Chemistry 2019年第8期62卷 933-967页

作者： Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang Key Laboratory of Resources and Environmental Systems Optimization Ministry of EducationCollege of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China China Academy of Engineering Physics Mianyang 621900China State Key L aboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China Laboratory of Nuclear Energy Chemistry and Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Petroleum Resources Gansu ProvinceNorthwest Institute of Eco-Environment and Resources. Chinese Academy of SciencesLanzhou 730000China Radiochemistry Laboratory School of Nuclear Science and TechnologyLanzhou UniversityLanzhou 730000China CAS Key Laboratory of Photovoltaic and Energy Conservation Materials. Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and Technology Mianyang 621010China State Key Laboratory of Nuclear Resources and Environment School of BiologyChemistry and Material Science East China University of TechnologyFuzhou 344000China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China China Academy of Engineering Physics Mianyang 621900China

With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized.

关键词： nanomaterials radionuclides removal preconcentration interaction mechanism

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Back Cover: PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety (Angew. Chem. Int. Ed. 5/2023)

引用

Angewandte Chemie International Edition 2023年第5期62卷

作者： Dr. Jingfang Zhang Dr. Wenzhe Li Dr. Yafei Qi Dr. Guorong Wang Prof. Lele Li Prof. Zhengyu Jin Prof. Jie Tian Prof. Yang Du Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imaging the State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Radiology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Medicine Beihang University Beijing 100191 China

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Design Validation and Collision Studies of A Compliant Magnetorheological Fluid Actuator

Design Validation and Collision Studies of A Compliant Magne...

引用

IEEE International Conference on Human-Machine systems

作者： Guangzeng Chen Jie Pengyu Tongyi Shang Yunjiang Lou T.T. Wong Li Chen Jian Liu State Key Laboratory of Robotics and System School of Mechatronics Engineering and Automation Harbin Institute of Technology (Shenzhen) Shenzhen China. Shenzhen Institutes of Advanced Technology Shenzhen University Town Shenzhen China Emergency Department Chinese PLA General Hospital Department of Biomedical Engineering Shandong University Jinan China

ISBN: (数字)9781728158716

ISBN: (纸本)9781728158723

Robots are integrating into human society and become an important part. The robots and human must be considered as a whole system and the robots should be intelligent both in digital and physical like human to cooperate and interact with human non-physically or physically. For improving the physical intelligence of the robot, a magnetorheological fluid actuator (MRA) is proposed and studied in this paper. A collision model and a speed peak force planning method are proposed and some experiments are conducted. It shows that the collision peak force of the MRA with external objects can be easily controlled to different levels by controlling the compliance of the MRA for safe physical interaction with human or some striking works like hammering a nail.

关键词： Torque Robots Actuators Force Collision avoidance Rotors Couplings

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Rücktitelbild: PD-L1 Aptamer-Functionalized Metal–Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety (Angew. Chem. 5/2023)

引用

Angewandte Chemie 2023年第5期135卷

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Berberrubine-mediated pH indicator response enhances the efficacy of hydroxycamptothecin by reversing lysosomal drug resistance

引用

Chinese Chemical Letters 2024年

作者： Daili Liu Changxiang Yu Liyuan Lin Zhidong Liu Guiqian Fang Qingqiang Yao Qixin Chen Xintian Shao School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin 301617 China School of Life Sciences Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Ji'nan 250117 China School of Pharmaceutical Sciences & Institute of Materia Medica Medical Science and Technology Innovation Center State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong First Medical University & Shandong Academy of Medical Sciences Ji'nan 250117 China State Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese Medicine Tianjin 301617 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Drug resistance poses a significant challenge to effective long-term treatment across various medical fields. This study proposed a feasible strategy to enhance lysosomal alkalinization by transporting mitochondria-targeting quaternary ammonium salts into lysosomes, creating a deprotonated environment. This environment allows drugs to bypass protonation issues in lysosomes, thereby reversing drug resistance and improving therapeutic efficacy. As a proof of concept, a quaternary ammonium salt-based pH indicator was developed, berberrubine (BRB), enhancing the action of the anticancer drug hydroxycamptothecin (HCPT) in resistant cells. BRB-induced alkalinization increased lysosomal pH and deactivated lysosomal activity, enabling HCPT to bypass protonation constraints. This enhancement markedly improved the anticancer efficacy of HCPT in resistant cells, providing an innovative approach to address drug resistance and advancing therapeutic technologies.

关键词： Drug resistance Lysosomes Berberrubine Hydroxycamptothecin Quaternary ammonium salts Alkalinization

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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

引用

Nature Communications 2023年第1期14卷 1-17页

作者： Saha, Itika Yuste-Checa, Patricia Da Silva Padilha, Miguel Guo, Qiang Körner, Roman Holthusen, Hauke Trinkaus, Victoria A. Dudanova, Irina Fernández-Busnadiego, Rubén Baumeister, Wolfgang Sanders, David W. Gautam, Saurabh Diamond, Marc I. Hartl, F. Ulrich Hipp, Mark S. Department of Cellular Biochemistry Max Planck Institute of Biochemistry Am Klopferspitz 18 Martinsried 82152 Germany Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network Chevy Chase MD United States Molecular Neurodegeneration Group Max Planck Institute for Biological Intelligence Martinsried 82152 Germany Department of Molecules – Signaling – Development Max Planck Institute for Biological Intelligence Am Klopferspitz 18 Martinsried 82152 Germany Center for Anatomy Faculty of Medicine and University Hospital Cologne University of Cologne Cologne 50931 Germany Department of Structural Molecular Biology Max Planck Institute of Biochemistry Am Klopferspitz 18 Martinsried 82152 Germany Munich Cluster for Systems Neurology (SyNergy) Munich Germany Institute of Neuropathology University Medical Center Göttingen Göttingen 37099 Germany Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC) University of Göttingen Göttingen Germany Center for Alzheimer’s and Neurodegenerative Diseases Peter O’Donnell Jr. Brain Institute University of Texas Southwestern Medical Center Dallas 75390 TX United States School of Medicine and Health Sciences Carl von Ossietzky University Oldenburg Oldenburg Germany Department of Biomedical Sciences of Cells and Systems University Medical Center Groningen University of Groningen Antonius Deusinglaan 1 Groningen 9713 AV Netherlands State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Peking University Beijing 100871 China Department of Chemical and Biological Engineering Princeton University Princeton 08544 NJ United States Boehringer Ingelheim International GmbH Ingelheim 55216 Germany ViraTherapeutics GmbH Rum 6063 Austria

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The existence of cellular machinery for the removal of such aggregates has remained unclear, as specialized disaggregase chaperones are thought to be absent in mammalian cells. Here we show in cell culture and in neurons that the hexameric ATPase valosin-containing protein (VCP) is recruited to ubiquitylated Tau fibrils, resulting in their efficient disaggregation. Aggregate clearance depends on the functional cooperation of VCP with heat shock 70 kDa protein (Hsp70) and the ubiquitin-proteasome machinery. While inhibition of VCP activity stabilizes large Tau aggregates, disaggregation by VCP generates seeding-active Tau species as byproduct. These findings identify VCP as a core component of the machinery for the removal of neurodegenerative disease aggregates and suggest that its activity can be associated with enhanced aggregate spreading in tauopathies. © 2023, The Author(s).

关键词： Chaperones Protein aggregation Protein quality control

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Corrigendum to “Makerchain: A blockchain with chemical signature for self-organizing process in social manufacturing” [J. Clean. Prod. 234 (2019) 767–778]

引用

Journal of Cleaner Production 2022年 360卷

作者： Jiewu Leng Pingyu Jiang Kailin Xu Qiang Liu J. Leon Zhao Yiyang Bian Rui Shi Guangdong Provincial Key Laboratory of Computer Integrated Manufacturing System State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment And School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou Guangdong 510006 China Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an Shaanxi 710049 China School of Information Management Nanjing University Nanjing Jiangsu 210000 China

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Phase Transformation and Equation of state in Ti-45al Alloy Under High Pressure

SSRN

引用

SSRN 2023年

作者： Li, Xi Zhu, Ruixiang Xin, Jinghua Luo, Minsi Shang, Shun-Li Liu, Zi-Kui Yin, Chongshan Funakoshi, Ken-Ichi Dippenaar, Rian Johannes Higo, Yuji Shiro, Ayumi Reid, Mark Shobu, Takahisa Akita, Koichi Zhang, Wei-Bing Liss, Klaus-Dieter Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering Changsha University of Science and Technology Changsha410004 China Safety Energy Conservation and Emergency Technology Research Center Tianjin Research Institute for Water Transport Engineering. M.O.T. Tianjin300000 China Department of Materials Science and Engineering The Pennsylvania State University University ParkPA16802 United States Neutron Science and Technology Center Comprehensive Research Organization for Science and Society Ibaraki Tokai319-1106 Japan School of Mechanical Materials Mechatronic and Biomedical Engineering University of Wollongong Northfields Avenue NSW2522 Australia SPring-8 Japan Synchrotron Radiation Research Institute Kouto Sayo Hyogo679-5198 Japan Materials Sciences Research Center Japan Atomic Energy Agency Ibaraki Tokai319-1195 Japan Synchrotron Radiation Research Center National Institutes for Quantum Science and Technology Sayo Hyogo679-5148 Japan Department of Mechanical Systems Engineering Faculty of Science and Engineering Tokyo City University Tamazutsumi Setagaya Tokyo158-8557 Japan

The phase transformations and pressure-volume dependencies of the Ti-45Al alloy with respect to pressure have been investigated by means of in-situ observation using multi anvil-type high-pressure devices and synchrotron radiation. Under hydrostatic compression from 0 to 10.1 GPa, about 2.3 vol. % of γ transforms continuously to α2. Lattice parameters as well as volume fractions of these two phases have been determined as a function of pressure. Bulk moduli estimated using Birch-Murnaghan’s equation of state are 148 GPa for the γ phase, 138 GPa for the α2 phase, and 149 GPa for their two-phase mixture of Ti-45Al alloy. First-principles have also applied to investigate bulk moduli of two single phases, and the deviation between calculations and measurements is discussed and attributed to mainly phase transformation. The presently study provides useful insights into thermodynamics of α2 and γ phases under high pressure. © 2023, The Authors. All rights reserved.

关键词： Synchrotron radiation

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