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Microdroplet Patterning: Designer Hydrophilic Regions Regulate Droplet Shape for Controlled Surface Patterning and 3D Microgel Synthesis (Small 3/2012)

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Small 2012年第3期8卷

作者： Matthew J. Hancock Fumiki Yanagawa Yun-Ho Jang Jiankang He Nezamoddin N. Kachouie Hirokazu Kaji Ali Khademhosseini Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School 65 Landsdowne Street Cambridge MA 02139 USA State Key Laboratory of Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an Shaanxi 710049 China Department of Bioengineering and Robotics Graduate School of Engineering Tohoku University Sendai 980-8579 Japan Partners Research Building Room 252 65 Landsdowne Street Cambridge MA 02139 USA Wyss Institute for Biologically Inspired Engineering Harvard University Boston MA 02115 USA Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA

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Microfluidic synthesis of composite cross-gradient materials for investigating cell-biomaterial interactions

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Biotechnology and Bioengineering 2011年第1期108卷 175-185页

作者： He, Jiankang Du, Yanan Guo, Yuqi Hancock, Matthew J. Wang, Ben Shin, Hyeongho Wu, Jinhui Li, Dichen Khademhosseini, Ali Center for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA 02115 United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA United States State Key Laboratory of Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an Shaanxi China The Third Affiliated Hospital of Zhengzhou University Zhengzhou Henan China

Combinatorial material synthesis is a powerful approach for creating composite material libraries for the high-throughput screening of cell-material interactions. Although current combinatorial screening platforms have been tremendously successful in identifying target (termed "hit") materials from composite material libraries, new material synthesis approaches are needed to further optimize the concentrations and blending ratios of the component materials. Here we employed a microfluidic platform to rapidly synthesize composite materials containing cross-gradients of gelatin and chitosan for investigating cell-biomaterial interactions. The microfluidic synthesis of the cross-gradient was optimized experimentally and theoretically to produce quantitatively controllable variations in the concentrations and blending ratios of the two components. The anisotropic chemical compositions of the gelatin/chitosan cross-gradients were characterized by Fourier transform infrared spectrometry and X-ray photoelectron spectrometry. The three-dimensional (3D) porous gelatin/chitosan cross-gradient materials were shown to regulate the cellular morphology and proliferation of smooth muscle cells (SMCs) in a gradient-dependent manner. We envision that our microfluidic cross-gradient platform may accelerate the material development processes involved in a wide range of biomedical applications. © 2010 Wiley Periodicals, Inc.

关键词： Cells

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Grasping simulation of an underactuated finger mechanism for larm hand

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International Journal of Modelling and Simulation 2010年第1期30卷 87-97页

作者： Yao, S. Wu, L. Ceccarelli, M. Carbone, G. Lu, Z. School of Automation Science and Electrical Engineering Beihang University Beijing China College of Information Engineering Central University for Nationalities Beijing China State Key Laboratory of Intelligent Technology and Systems Department of Computer Science and Technology Tsinghua University Beijing China Beijing University of Aeronautics and Astronautics China and University of Cassino Italy LARM: Laboratory of Robotics and Mechatronics Cassino United States

In this paper, the grasp operation of an underactuated finger mechanism is simulated with the aim to characterize and analyze its performance. The design of the proposed mechanism is based on spring systems that give suitable underactuation characteristics. A CAD model is proposed and then it is used in a procedure for numerical simulation. Simulation results show suitable capability for grasping a wide range of objects in size and shape by operating the mechanism inside the finger body. The achieved grasp has been simulated as a human-like functionality with a grasp contact in each phalanx.

关键词： Computer aided design

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Kinematic modeling and analysis of novel eight-wheel lunar rover

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Journal of Harbin Institute of Technology(New Series) 2009年第6期16卷 751-755页

作者：高海波张朋邓宗全胡明 State Key Laboratory of Robotics and Systems School of Mechatronic Engineering Harbin Institute of Technology

A new kind of eight-wheel lunar rover is developed, which is a complex closed-chain system and has good capabilities of climbing slope, surmounting obstacles and adapting to uneven terrain. In this paper, the mechanical structure of the novel eight-wheel lunar rover is introduced, forward and inverse kinematic models of the rover are established according to the closed-chain coordinate transformation and instantaneous coincidence coordinate. Based on structural characteristics, its kinetic characteristics are analyzed. Wheel slippages are separated and calculated, and a method for closed-loop control modification using wheel slip estimation during the model establishment is proposed. The results can be applied to the motion control of lunar rover.

关键词： kinematic modeling locomotion system eight-wheel lunar rover lunar rover

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Individually prefabricated prosthesis for maxilla reconstruction

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Journal of Prosthodontics 2008年第2期17卷 135-140页

作者： Singare, Sekou Liu, Yaxiong Li, Dichen Lu, Bingheng Wang, Jue He, Sanhu Key Laboratory of Biomedical Information Engineering Xi'an Jiaotong University Ministry of Education Xi'an China State Key Lab. for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an China Department of Maxillofacial Surgery School of Stomatology Xi'an Jiaotong University Xi'an China Department of Mechatronic Engineering Dongguan University of Technology Guangdong China Key Laboratory of Biomedical Information Engineering Xi'an Jiaotong University Ministry of Education Xi'an 710049 China

The reconstruction of maxillofacial bone defects by the intraoperative modeling of implants may reduce the predictability of the esthetic result, leading to more invasive surgery and increased surgical time. To improve the maxillofacial surgery outcome, modern manufacturing methods such as rapid prototyping (RP) technology and methods based on reverse engineering (RE) and medical imaging data are applicable to the manufacture of custom-made maxillary prostheses. After acquisition of data, an individual computer-based 3D model of the bony defect is generated. These data are transferred into RE software to create the prosthesis using a computer-aided design (CAD) model, which is directed into the RP machine for the production of the physical model. The precise fit of the prosthesis is evaluated using the prosthesis and skull models. The prosthesis is then directly used in investment casting such as "Quick Cast" pattern to produce the titanium model. In the clinical reports presented here, reconstructions of two patients with large maxillary bone defects were performed using this new method. The custom prostheses perfectly fit the defects during the operations, and surgery time was reduced. These cases show that the prefabrication of a prosthesis using modern manufacturing technology is an effective method for maxillofacial defect reconstruction. © 2007 by The American College of Prosthodontists.

关键词： Computer-aided reconstruction Designed prosthesis Individual template Rapid prototyping Rapid tooling

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