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This study presents a biosensor architecture for high-sensitivity detection of isoquercitrin, a biomedically relevant flavonoid compound. Full-wave electromagnetic simulations conducted using COMSOL Multiphysics reveal exceptional sensing performance, achieving a maximum sensitivity of 500 GHz RIU−1 within the frequency range of 0.701–0.716 THz. The sensor demonstrates consistent absorption enhancement ranging from 42.65% to 44.96% corresponding to refractive index variations from 1.333 to 1.385 RIU, exhibiting a linear frequency-refractive index relationship with high correlation (R2 = 98.309%). Parametric optimization studies reveal substantial performance improvements through graphene chemical potential modulation (absorption range: 17.75%–54.11%) and incident angle optimization (absorption up to 127.07%). A one-dimensional convolutional neural network (1D-CNN) machine learning model was successfully implemented to predict sensor behavior with exceptional accuracy (R2 = 99%–100%), facilitating real-time biosensing applications. Comparative analysis with existing sensor technologies confirms the competitive sensitivity and practical viability of the proposed design for label-free biomedical diagnostics in the terahertz frequency regime.
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版权所有:内蒙古大学图书馆 技术提供:维普资讯• 智图
内蒙古自治区呼和浩特市赛罕区大学西街235号 邮编: 010021
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