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Harmonized-Multinational qEEG norms (HarMNqEEG)

NEUROIMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, Carlos Hu, Shiang Reyes, Ronaldo Cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini Ismafairus Abd Evans, Alan C. Savostyanov, Alexander N. Calzada-Reyes, Ana Villringer, Arno Tobon-Quintero, Carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-Chacon, Lilia Valdes-Sosa, Mitchell J. Trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, Thomas Virues-Alba, Trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio [a]The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China [b]Cuban Center for Neurocience La Habana Cuba [c]McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada [d]Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [e]Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [f]Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia [g]Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia [h]Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia [i]Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia [j]University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba [k]Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany [l]Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany [m]Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany [n]Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia [o]Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia [p]The Cuban center aging longevity and health Havana Cuba [q]Research Unit of NeuroInformation Chinese Academy of Medical Sciences Chengdu 2019RU035 China [r]School of Electrical Engineering Zhengzhou University Zhengzhou 4500

This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition Covid induced brain dysfunction Developmental Brain Chart

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National identity predicts public health support during a global pandemic (vol 13, 517, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 517-517页

作者： Van Bavel, Jay J. Cichocka, Aleksandra Capraro, Valerio Sjastad, Hallgeir Nezlek, John B. Pavlovic, Tomislav Alfano, Mark Gelfand, Michele J. Azevedo, Flavio Birtel, Michele D. Cislak, Aleksandra Lockwood, Patricia L. Ross, Robert Malcolm Abts, Koen Agadullina, Elena Aruta, John Jamir Benzon Besharati, Sahba Nomvula Bor, Alexander Choma, Becky L. Crabtree, Charles David Cunningham, William A. De, Koustav Ejaz, Waqas Elbaek, Christian T. Findor, Andrej Flichtentrei, Daniel Franc, Renata Gjoneska, Biljana Gruber, June Gualda, Estrella Horiuchi, Yusaku Huynh, Toan Luu Duc Ibanez, Agustin Imran, Mostak Ahamed Israelashvili, Jacob Jasko, Katarzyna Kantorowicz, Jaroslaw Kantorowicz-Reznichenko, Elena Krouwel, Andre Laakasuo, Michael Lamm, Claus Leygue, Caroline Lin, Ming-Jen Mansoor, Mohammad Sabbir Marie, Antoine Mayiwar, Lewend Mazepus, Honorata McHugh, Cillian Minda, John Paul Mitkidis, Panagiotis Olsson, Andreas Otterbring, Tobias Packer, Dominic J. Perry, Anat Petersen, Michael Bang Puthillam, Arathy Riano-Moreno, Julian C. Rothmund, Tobias Santamaria-Garcia, Hernando Schmid, Petra C. Stoyanov, Drozdstoy Tewari, Shruti Todosijevic, Bojan Tsakiris, Manos Tung, Hans H. Umbres, Radu G. Vanags, Edmunds Vlasceanu, Madalina Vonasch, Andrew Yucel, Meltem Zhang, Yucheng Abad, Mohcine Adler, Eli Akrawi, Narin Mdarhri, Hamza Alaoui Amara, Hanane Amodio, David M. Antazo, Benedict G. Apps, Matthew Ay, F. Ceren Ba, Mouhamadou Hady Barbosa, Sergio Bastian, Brock Berg, Anton Bernal-Zarate, Maria P. Bernstein, Michael Bialek, Michal Bilancini, Ennio Bogatyreva, Natalia Boncinelli, Leonardo Booth, Jonathan E. Borau, Sylvie Buchel, Ondrej Cameron, C. Daryl Carvalho, Chrissie F. Celadin, Tatiana Cerami, Chiara Chalise, Hom Nath Cheng, Xiaojun Cian, Luca Cockcroft, Kate Conway, Jane Cordoba-Delgado, Mateo Andres Crespi, Chiara Crouzevialle, Marie Cutler, Jo Cypryanska, Marzena Dabrowska, Justyna Daniels, Michael A. Davis, Victoria H. Dayley, Pamala N. Delouvee, Sylvain Denkovski, Ognjan Dezecache, Guillaume Dhaliwal, Nathan A. Diato, Department of Psychology and Neural Science New York University New York NY USA School of Psychology University of Kent Canterbury England Department of Economics Middlesex University London London England Department of Strategy and Management Norwegian School of Economics Bergen Norway SWPS University of Social Sciences and Humanities Poznań Poland Department of Psychological Sciences College of William and Mary Williamsburg VA USA Institute of Social Sciences Ivo Pilar Zagreb Croatia Department of Philosophy Macquarie University Sydney NSW Australia Stanford Graduate School of Business Stanford University Stanford CA USA Institute of Communication Science Friedrich-Schiller University Jena Jena Germany School of Human Sciences Institute for Lifecourse Development University of Greenwich London England Department of Experimental Psychology University of Oxford Oxford England Center for Human Brain Health School of Psychology University of Birmingham Birmingham England Department of Psychology Macquarie University Sydney NSW Australia KU Leuven Leuven Belgium National Research University Higher School of Economics (HSE) Moscow Russia De La Salle University Manila Philippines Department of Psychology University of the Witwatersrand Johannesburg South Africa Department of Political Science Aarhus University Aarhus Denmark X University Toronto Canada Department of Government Dartmouth College Hanover NH USA Department of Psychology University of Toronto Toronto ON Canada Gatton College of Business and Economics University of Kentucky Lexington KY USA Department of Mass Communication National University of Science and Technology (NUST) Islamabad Pakistan Department of Management Aarhus University Aarhus Denmark Faculty of Social and Economic Sciences Comenius University Bratislava Slovakia IntraMed Buenos Aires Argentina Macedonian Academy of Sciences and Arts North Macedonia Republic of North Macedonia University of Colorado Boulder Bould

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics. Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

关键词： Viral infection Human behaviour

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Author Correction: A shared neural basis underlying psychiatric comorbidity

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Nature medicine 2023年第9期29卷 2375页

作者： Chao Xie Shitong Xiang Chun Shen Xuerui Peng Jujiao Kang Yuzhu Li Wei Cheng Shiqi He Marina Bobou M John Broulidakis Betteke Maria van Noort Zuo Zhang Lauren Robinson Nilakshi Vaidya Jeanne Winterer Yuning Zhang Sinead King Tobias Banaschewski Gareth J Barker Arun L W Bokde Uli Bromberg Christian Büchel Herta Flor Antoine Grigis Hugh Garavan Penny Gowland Andreas Heinz Bernd Ittermann Hervé Lemaître Jean-Luc Martinot Marie-Laure Paillère Martinot Frauke Nees Dimitri Papadopoulos Orfanos Tomáš Paus Luise Poustka Juliane H Fröhner Ulrike Schmidt Julia Sinclair Michael N Smolka Argyris Stringaris Henrik Walter Robert Whelan Sylvane Desrivières Barbara J Sahakian Trevor W Robbins Gunter Schumann Tianye Jia Jianfeng Feng Institute of Science and Technology for Brain-Inspired Intelligence Fudan University Shanghai China. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University) Ministry of Education Shanghai China. Faculty of Psychology Technische Universität Dresden Dresden Germany. School of Health Sciences The University of Manchester Manchester UK. Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology and Neuroscience King's College London London UK. Clinical and Experimental Sciences Faculty of Medicine University of Southampton Southampton UK. Department of Psychology College of Science Northeastern University Boston MA USA. Department of Psychology MSB Medical School Berlin Berlin Germany. Department of Psychological Medicine Section for Eating Disorders Institute of Psychiatry Psychology and Neuroscience King's College London London UK. South London and Maudsley NHS Foundation Trust London UK. Centre for Population Neuroscience and Stratified Medicine (PONS) Department of Psychiatry and Neuroscience Charité Universitätsmedizin Berlin Berlin Germany. Department of Psychiatry and Psychotherapy Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin and Berlin Institute of Health Berlin Germany. Department of Education and Psychology Freie Universität Berlin Berlin Germany. Psychology Department B44 University Rd University of Southampton Southampton UK. School of Medicine Center for Neuroimaging Cognition and Genomics National University of Ireland (NUI) Galway Ireland. Department of Child and Adolescent Psychiatry and Psychotherapy Central Institute of Mental Health Medical Faculty Mannheim Heidelberg University Mannheim Germany. Department of Neuroimaging Institute of Psychiatry Psychology and Neuroscience King's College London London UK. Discipline of Psychiatry School of Medicine and Trinity College Institute of Neuroscience T

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Neuromatch academy: Teaching computational neuroscience with global accessibility

arXiv

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arXiv 2020年

作者： van Viegen, Tara Akrami, Athena Bonnen, Kate DeWitt, Eric Hyafil, Alexandre Ledmyr, Helena Lindsay, Grace W. Mineault, Patrick Murray, John D. Pitkow, Xaq Puce, Aina Sedigh-Sarvestani, Madineh Stringer, Carsen Achakulvisut, Titipat Alikarami, Elnaz Atay, Melvin Selim Batty, Eleanor Erlich, Jeffrey C. Galbraith, Byron V. Guo, Yueqi Juavinett, Ashley L. Krause, Matthew R. Li, Songting Pachitariu, Marius Straley, Elizabeth Valeriani, Davide Vaughan, Emma Vaziri-Pashkam, Maryam Waskom, Michael L. Blohm, Gunnar Kording, Konrad Schrater, Paul Wyble, Brad Escola, Sean Peters, Megan A.K. Princeton Neuroscience Institute Princeton University PrincetonNJ United States Sainsbury Wellcome Centre University College London London United Kingdom Center for Neural Science New York University New York CityNY United States Champalimaud Research Champalimaud Foundation Lisbon Portugal Centre de Recerca Matemàtica Bellaterra Universitat Autònoma de Barcelona Barcelona Spain International Neuroinformatics Coordinating Facility Sweden Gatsby Computational Neuroscience Unit Sainsbury Wellcome Centre University College London London United Kingdom Department of Psychiatry Yale University New HavenCT United States Baylor College of Medicine Dept. of Neuroscience HoustonTX United States Baylor College of Medicine Center for Neuroscience and Artificial Intelligence HoustonTX United States Rice University Dept of Electrical and Computer Engineering HoustonTX United States Psychological & Brain Sciences Indiana University BloomingtonIN United States Max Planck Florida Institute for Neuroscience JupiterFL United States HHMI Janelia Research Campus AshburnVA United States University of Pennsylvania Dept of Neuroscience and Bioengineering PhiladelphiaPA United States Faculty of dentistry McGill University MontrealQB Canada Middle East Technical University Ankara Turkey Department of Neurobiology Harvard University CambridgeMA United States New York University Shanghai Shanghai China Talla Inc BostonMA United States Johns Hopkins University Department of Biomedical Engineering BaltimoreMD United States Division of Biological Sciences UC San Diego San diegoCA United States Montreal Neurological Institute McGill University MontrealQB Canada School of Mathematical Sciences MOE-LSC Institute of Natural Sciences Shanghai Jiao Tong University Shanghai China Department of Otolaryngology - Head & Neck Surgery Massachusetts Eye and Ear BostonMA United States Department of Otolaryngology - Head & Neck Surgery Harvard Medical School BostonM

Neuromatch Academy designed and ran a fully online 3-week computational neuroscience summer school for 1757 students with 191 teaching assistants working in virtual inverted (or flipped) classrooms and on small group projects. Fourteen languages, active community management, and low cost allowed for an unprecedented level of inclusivity and universal accessibility. © 2020, CC BY.

关键词： Python

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Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research

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Molecular psychiatry 2025年第4期30卷 1715页

作者： Na Cai Brad Verhulst Ole A Andreassen Jan Buitelaar Howard J Edenberg John M Hettema Michael Gandal Andrew Grotzinger Katherine Jonas Phil Lee Travis T Mallard Manuel Mattheisen Michael C Neale John I Nurnberger Wouter J Peyrot Elliot M Tucker-Drob Jordan W Smoller Kenneth S Kendler Helmholtz Pioneer Campus Helmholtz Munich Neuherberg Germany. Computational Health Centre Helmholtz Munich Neuherberg Germany. School of Medicine and Health Technical University of Munich Munich Germany. Department of Psychiatry and Behavioral Sciences Texas A&M University College Station TX USA. Centre of Precision Psychiatry University of Oslo Oslo Norway. Division of Mental Health and Addiction Oslo University Hospital Oslo Norway. KG Jebsen Centre for Neurodevelopmental disorders University of Oslo Oslo Norway. Department of Cognitive Neuroscience Donders Institute for Brain Cognition and Behavior Radboud University Medical Center Nijmegen The Netherlands. Karakter Child and Adolescent University Center Nijmegen The Netherlands. Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis IN USA. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN USA. Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Richmond VA USA. Departments of Psychiatry and Genetics University of Pennsylvania Philadelphia PA USA. Lifespan Brain Institute at Penn Med and the Children's Hospital of Philadelphia Philadelphia PA USA. Institute for Behavioral Genetics University of Colorado Boulder Boulder CO USA. Department of Psychology and Neuroscience University of Colorado Boulder Boulder CO USA. Department of Psychiatry & Behavioral Health Stony Brook University Stony Brook NY USA. Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. Department of Psychiatry Harvard Medical School Boston MA USA. Center for Precision Psychiatry Department of Psychiatry Massachusetts General Hospital Boston MA USA. Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine Massachusetts General Hospital Boston MA USA. Department of Community Health and Epidemiology and Faculty of Computer Science Dalhousie Unive

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Social and moral psychology of COVID-19 across 69 countries

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Scientific data 2023年第1期10卷 272页

作者： Flavio Azevedo Tomislav Pavlović Gabriel G Rêgo F Ceren Ay Biljana Gjoneska Tom W Etienne Robert M Ross Philipp Schönegger Julián C Riaño-Moreno Aleksandra Cichocka Valerio Capraro Luca Cian Chiara Longoni Ho Fai Chan Jay J Van Bavel Hallgeir Sjåstad John B Nezlek Mark Alfano Michele J Gelfand Michèle D Birtel Aleksandra Cislak Patricia L Lockwood Koen Abts Elena Agadullina John Jamir Benzon Aruta Sahba Nomvula Besharati Alexander Bor Becky L Choma Charles David Crabtree William A Cunningham Koustav De Waqas Ejaz Christian T Elbaek Andrej Findor Daniel Flichtentrei Renata Franc June Gruber Estrella Gualda Yusaku Horiuchi Toan Luu Duc Huynh Agustin Ibanez Mostak Ahamed Imran Jacob Israelashvili Katarzyna Jasko Jaroslaw Kantorowicz Elena Kantorowicz-Reznichenko André Krouwel Michael Laakasuo Claus Lamm Caroline Leygue Ming-Jen Lin Mohammad Sabbir Mansoor Antoine Marie Lewend Mayiwar Honorata Mazepus Cillian McHugh John Paul Minda Panagiotis Mitkidis Andreas Olsson Tobias Otterbring Dominic J Packer Anat Perry Michael Bang Petersen Arathy Puthillam Tobias Rothmund Hernando Santamaría-García Petra C Schmid Drozdstoy Stoyanov Shruti Tewari Bojan Todosijević Manos Tsakiris Hans H Tung Radu G Umbres Edmunds Vanags Madalina Vlasceanu Andrew Vonasch Meltem Yucel Yucheng Zhang Mohcine Abad Eli Adler Narin Akrawi Hamza Alaoui Mdarhri Hanane Amara David M Amodio Benedict G Antazo Matthew Apps Mouhamadou Hady Ba Sergio Barbosa Brock Bastian Anton Berg Maria P Bernal-Zárate Michael Bernstein Michał Białek Ennio Bilancini Natalia Bogatyreva Leonardo Boncinelli Jonathan E Booth Sylvie Borau Ondrej Buchel C Daryl Cameron Chrissie F Carvalho Tatiana Celadin Chiara Cerami Hom Nath Chalise Xiaojun Cheng Kate Cockcroft Jane Conway Mateo Andres Córdoba-Delgado Chiara Crespi Marie Crouzevialle Jo Cutler Marzena Cypryańska Justyna Dabrowska Michael A Daniels Victoria H Davis Pamala N Dayley Sylvain Delouvée Ognjan Denkovski Guillaume Dezecache Nathan A Dhaliwal Alelie B Diato Roberto Di Paolo Marianna Drosinou Uwe Dulleck Jānis Ekmanis Department of Psychology University of Cambridge Cambridge England. fa441@cam.ac.uk. Institute of Communication Science Friedrich-Schiller University Jena Jena Germany. fa441@cam.ac.uk. Institute of Social Sciences Ivo Pilar Zagreb Croatia. Social and Cognitive Neuroscience Laboratory Mackenzie Presbyterian University São Paulo Brazil. Department of Economics Norwegian School of Economics Bergen Norway. Telenor Research Oslo Norway. Macedonian Academy of Sciences and Arts Skopje Republic of North Macedonia. Kieskompas - Election Compass Amsterdam Netherlands. Department of Political Science & Annenberg School for Communication University of Pennsylvania Philadelphia PA USA. Department of Psychology Macquarie University Sydney NSW Australia. Department of Philosophy University of St Andrews St Andrews Scotland. School of Economics and Finance University of St Andrews St Andrews Scotland. Medicine Faculty Cooperative University of Colombia Villavicencio Colombia. Department of Bioethics El Bosque University Bogotá Colombia. School of Psychology University of Kent Canterbury England. Department of Economics Middlesex University London London England. Darden School of Business University of Virginia Charlottesville VA USA. Questrom School of Business Boston University Boston MA USA. School of Economics and Finance Queensland University of Technology Brisbane QLD Australia. Center for Behavioural Economics Society and Technology Queensland University of Technology Brisbane QLD Australia. Department of Psychology and Neural Science New York University New York NY USA. Department of Strategy and Management Norwegian School of Economics Bergen Norway. SWPS University of Social Sciences and Humanities Warsaw Poland. Department of Psychological Sciences College of William and Mary Williamsburg VA USA. Department of Philosophy Macquarie University Sydney NSW Australia. Stanford Graduate School of Business Stanford University Stanford CA USA.

The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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Standardized Assessment of Automatic Segmentation of White Matter Hyperintensities and Results of the WMH Segmentation Challenge

arXiv

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arXiv 2019年

作者： Kuijf, Hugo J. Biesbroek, J. Matthijs Bresser, Jeroen de Heinen, Rutger Andermatt, Simon Bento, Mariana Berseth, Matt Belyaev, Mikhail Cardoso, M. Jorge Casamitjana, Adrià Collins, D. Louis Dadar, Mahsa Georgiou, Achilleas Ghafoorian, Mohsen Jin, Dakai Khademi, April Knight, Jesse Li, Hongwei Lladó, Xavier Luna, Miguel Mahmood, Qaiser McKinley, Richard Mehrtash, Alireza Ourselin, Sébastien Park, Bo-yong Park, Hyunjin Park, Sang Hyun Pezold, Simon Puybareau, Elodie Rittner, Leticia Sudre, Carole H. Valverde, Sergi Vilaplana, Verónica Wiest, Roland Xu, Yongchao Xu, Ziyue Zeng, Guodong Zhang, Jianguo Zheng, Guoyan Chen, Christopher Flier, Wiesje van der Barkhof, Frederik Viergever, Max A. Biessels, Geert Jan Image Sciences Institute UMC Utrecht Utrecht University Netherlands Brain Center Rudolf Magnus UMC Utrecht Utrecht University Netherlands Department of Radiology UMC Utrecht Department of Radiology LUMC Leiden Netherlands Department of Biomedical Engineering University of Basel Allschwil Switzerland Radiology and Clinical Neuroscience Hotchkiss Brain Institute University of Calgary AB Canada NLP Logix Skolkovo Institute of Science and Technology School of Biomedical Engineering and Imaging Sciences King’s College London Centre for Medical Image Computing University College London Signal Theory and Communications Department Universitat Politècnica de Catalunya BarcelonaTech Barcelona Spain McGill University Canada Computational Statistics and Machine Learning MSc University College London TomTom Amsterdam Netherlands Department of Radiology and Imaging Science National Institutes of Health United States Ryerson University Canada University of Guelph Canada Sun Yat-sen University University of Dundee Technical University of Munich Research institute of Computer Vision and Robotics University of Girona Spain Department of Robotics Engineering Daegu Gyeongbuk Institute of Science and Technology Daegu Korea Republic of Pakistan Institute of Nuclear Science and Technology Support Center for Advanced Neuroimaging Institute for Diagnostic and Interventional Neuroradiology Inselspital University of Bern Switzerland Electrical and Computer Engineering Department University of British Columbia Vancouver Department of Radiology Brigham and Women’s Hospital Harvard Medical School Boston School of Biomedical Engineering and Imaging Sciences King’s College London Suwon Korea Republic of School of Electronic and Electrical Engineering Sungkyunkwan University Suwon Korea Republic of France School of Electrical and Computer Engineering University of Campinas SP Brazil School of Biomedical Engineering and Imaging Sciences King’s College London Centre for Medical I

Quantification of cerebral white matter hyperintensities (WMH) of presumed vascular origin is of key importance in many neurological research studies. Currently, measurements are often still obtained from manual segmentations on brain MR images, which is a laborious procedure. Automatic WMH segmentation methods exist, but a standardized comparison of the performance of such methods is lacking. We organized a scientific challenge, in which developers could evaluate their method on a standardized multi-center/-scanner image dataset, giving an objective comparison: the WMH Segmentation Challenge (https://***/).Sixty T1+FLAIR images from three MR scanners were released with manual WMH segmentations for training. A test set of 110 images from five MR scanners was used for evaluation. Segmentation methods had to be containerized and submitted to the challenge organizers. Five evaluation metrics were used to rank the methods: (1) Dice similarity coefficient, (2) modified Hausdorff distance (95th percentile), (3) absolute log-transformed volume difference, (4) sensitivity for detecting individual lesions, and (5) F1-score for individual lesions. Additionally, methods were ranked on their inter-scanner *** participants submitted their method for evaluation. This paper provides a detailed analysis of the results. In brief, there is a cluster of four methods that rank significantly better than the other methods, with one clear winner. The inter-scanner robustness ranking shows that not all methods generalize to unseen *** challenge remains open for future submissions and provides a public platform for method evaluation. Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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Author Correction: National identity predicts public health support during a global pandemic

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Nature communications 2022年第1期13卷 1949页

作者： Jay J Van Bavel Aleksandra Cichocka Valerio Capraro Hallgeir Sjåstad John B Nezlek Tomislav Pavlović Mark Alfano Michele J Gelfand Flavio Azevedo Michèle D Birtel Aleksandra Cislak Patricia L Lockwood Robert Malcolm Ross Koen Abts Elena Agadullina John Jamir Benzon Aruta Sahba Nomvula Besharati Alexander Bor Becky L Choma Charles David Crabtree William A Cunningham Koustav De Waqas Ejaz Christian T Elbaek Andrej Findor Daniel Flichtentrei Renata Franc Biljana Gjoneska June Gruber Estrella Gualda Yusaku Horiuchi Toan Luu Duc Huynh Agustin Ibanez Mostak Ahamed Imran Jacob Israelashvili Katarzyna Jasko Jaroslaw Kantorowicz Elena Kantorowicz-Reznichenko André Krouwel Michael Laakasuo Claus Lamm Caroline Leygue Ming-Jen Lin Mohammad Sabbir Mansoor Antoine Marie Lewend Mayiwar Honorata Mazepus Cillian McHugh John Paul Minda Panagiotis Mitkidis Andreas Olsson Tobias Otterbring Dominic J Packer Anat Perry Michael Bang Petersen Arathy Puthillam Julián C Riaño-Moreno Tobias Rothmund Hernando Santamaría-García Petra C Schmid Drozdstoy Stoyanov Shruti Tewari Bojan Todosijević Manos Tsakiris Hans H Tung Radu G Umbreș Edmunds Vanags Madalina Vlasceanu Andrew Vonasch Meltem Yucel Yucheng Zhang Mohcine Abad Eli Adler Narin Akrawi Hamza Alaoui Mdarhri Hanane Amara David M Amodio Benedict G Antazo Matthew Apps F Ceren Ay Mouhamadou Hady Ba Sergio Barbosa Brock Bastian Anton Berg Maria P Bernal-Zárate Michael Bernstein Michał Białek Ennio Bilancini Natalia Bogatyreva Leonardo Boncinelli Jonathan E Booth Sylvie Borau Ondrej Buchel C Daryl Cameron Chrissie F Carvalho Tatiana Celadin Chiara Cerami Hom Nath Chalise Xiaojun Cheng Luca Cian Kate Cockcroft Jane Conway Mateo Andres Córdoba-Delgado Chiara Crespi Marie Crouzevialle Jo Cutler Marzena Cypryańska Justyna Dabrowska Michael A Daniels Victoria H Davis Pamala N Dayley Sylvain Delouvee Ognjan Denkovski Guillaume Dezecache Nathan A Dhaliwal Alelie B Diato Roberto Di Paolo Marianna Drosinou Uwe Dulleck Jānis Ekmanis Arhan S Ertan Tom W Etienne Hapsa Hossain Farhana Fahima Farkhari Har Department of Psychology and Neural Science New York University New York NY USA. jay.vanbavel@nyu.edu. School of Psychology University of Kent Canterbury England. Department of Economics Middlesex University London London England. Department of Strategy and Management Norwegian School of Economics Bergen Norway. SWPS University of Social Sciences and Humanities Poznań Poland. Department of Psychological Sciences College of William and Mary Williamsburg VA USA. Institute of Social Sciences Ivo Pilar Zagreb Croatia. Department of Philosophy Macquarie University Sydney NSW Australia. Stanford Graduate School of Business Stanford University Stanford CA USA. Institute of Communication Science Friedrich-Schiller University Jena Jena Germany. flavio.azevedo@uni-jena.de. School of Human Sciences Institute for Lifecourse Development University of Greenwich London England. Department of Experimental Psychology University of Oxford Oxford England. Center for Human Brain Health School of Psychology University of Birmingham Birmingham England. Department of Psychology Macquarie University Sydney NSW Australia. KU Leuven Leuven Belgium. National Research University Higher School of Economics (HSE) Moscow Russia. De La Salle University Manila Philippines. Department of Psychology University of the Witwatersrand Johannesburg South Africa. Department of Political Science Aarhus University Aarhus Denmark. X University Toronto ON Canada. Department of Government Dartmouth College Hanover NH USA. Department of Psychology University of Toronto Toronto ON Canada. Gatton College of Business and Economics University of Kentucky Lexington KY USA. Department of Mass Communication National University of Science and Technology (NUST) Islamabad Pakistan. Department of Management Aarhus University Aarhus Denmark. Faculty of Social and Economic Sciences Comenius University Bratislava Slovakia. IntraMed Buenos Aires Argentina. Macedonian Academy of Sciences and

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LifeTime and improving European healthcare through cell-based interceptive medicine (vol 587, pg 377, 2020)

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NATURE 2021年第7852期592卷 E8-E8页

作者： Rajewsky, Nikolaus Almouzni, Genevieve Gorski, Stanislaw A. Aerts, Stein Amit, Ido Bertero, Michela G. Bock, Christoph Bredenoord, Annelien L. Cavalli, Giacomo Chiocca, Susanna Clevers, Hans De Strooper, Bart Eggert, Angelika Ellenberg, Jan Fernandez, Xose M. Figlerowicz, Marek Gasser, Susan M. Hubner, Norbert Kjems, Jorgen Knoblich, Jurgen A. Krabbe, Grietje Lichter, Peter Linnarsson, Sten Marine, Jean-Christophe Marioni, John C. Marti-Renom, Marc A. Netea, Mihai G. Nickel, Dorthe Nollmann, Marcelo Novak, Halina R. Parkinson, Helen Piccolo, Stefano Pinheiro, Ines Pombo, Ana Popp, Christian Reik, Wolf Roman-Roman, Sergio Rosenstiel, Philip Schultze, Joachim L. Stegle, Oliver Tanay, Amos Testa, Giuseppe Thanos, Dimitris Theis, Fabian J. Torres-Padilla, Maria-Elena Valencia, Alfonso Vallot, Celine van Oudenaarden, Alexander Vidal, Marie Voet, Thierry Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany Charité-Universitätsmedizin Berlin Germany Berlin Institute of Health (BIH) Berlin Germany German Center for Cardiovascular Research (DZHK) Partner Site Berlin Berlin Germany Institute for Biology Humboldt University of Berlin Berlin Germany Cardiovascular and Metabolic Sciences Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany Department of Pediatric Oncology/Hematology Charité-Universitätsmedizin Berlin Berlin Germany Institut Curie CNRS PSL Research University Sorbonne Université Nuclear Dynamics Unit Equipe Labellisée Ligue contre le cancer Paris France VIB Center for Brain and Disease Research Leuven Belgium Department of Human Genetics KU Leuven Leuven Belgium Department of Neurosciences KU Leuven Leuven Belgium UK Dementia Research Institute at UCL University College London London UK Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK Department of Immunology Weizmann Institute of Science Rehovot Israel Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology Barcelona Spain CNAG-CRG Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain Universitat Pompeu Fabra Barcelona Spain ICREA Barcelona Spain CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Department of Laboratory Medicine Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases Vienna Austria Department of Medical Humanities Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands Institute of Human Genetics UMR 9002 CNRS and University of Montpellier Montpellier France Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy Department of Oncology and Hemato

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