The rapid expansion of Internet of Things (IoT) applications necessitates the demand for efficient IoT middleware platforms, especially Context Management Platforms (CMPs) for accessing real-time contextual informatio...
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Multivariate time series anomaly detection aims to identify time periods in time series data that are abnormal or deviate from historical data patterns. The increasing dimension of multivariate time series data and th...
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Learners' affective states play a crucial role in learning evaluation, and the external expressions that can directly reflect affect are facial expressions. However, the sample size of the database for the learnin...
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Medical image generation has recently garnered significant interest among ***,the primary generative models,such as Generative Adversarial Networks(GANs),often encounter challenges during training,including mode *** a...
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Medical image generation has recently garnered significant interest among ***,the primary generative models,such as Generative Adversarial Networks(GANs),often encounter challenges during training,including mode *** address these issues,we proposed the AECOT-GAN model(Autoencoder-based Conditional Optimal Transport Generative Adversarial Network)for the generation of medical images belonging to specific *** training process of our model comprises three fundamental *** training process of our model encompasses three fundamental ***,we employ an autoencoder model to obtain a low-dimensional manifold representation of real ***,we apply extended semi-discrete optimal transport to map Gaussian noise distribution to the latent space distribution and obtain corresponding labels *** procedure leads to the generation of new latent codes with known ***,we integrate a GAN to train the decoder further to generate medical *** evaluate the performance of the AE-COT-GAN model,we conducted experiments on two medical image datasets,namely DermaMNIST and *** model’s performance was compared with state-of-the-art generative *** show that the AE-COT-GAN model had excellent performance in generating medical ***,it effectively addressed the common issues associated with traditional GANs.
This paper presents the design and simulation of a plasmonic refractive index (RI) sensor and a temperature sensor. The suggested design comprises a MIM waveguide integrated with a grill-shaped rectangular cavity. Sim...
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The rational design of materials at atomic scale as efficient and stable electrocatalysts for hydrogen evolution reaction(HER)is critical for energy ***,we report a novel hybrid nanostructure with iridium(Ir)and cobal...
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The rational design of materials at atomic scale as efficient and stable electrocatalysts for hydrogen evolution reaction(HER)is critical for energy ***,we report a novel hybrid nanostructure with iridium(Ir)and cobalt(Co)atomic pair configuration anchored in porous nitrogen-doped carbon(pNC)nanosheets(denoted as IrCo-pNC)for electrocatalytic *** investigations and theoretical calculations reveal that the interaction between Ir and Co species in pNC promotes electron accumulation and depletion around isolated Ir and Co atoms,respectively,resulting in a local asymmetry electron density *** functional theory calculations also suggest that the electrons transfer from Co to adjacent Ir atom causing the down shift of the d-band center of Ir 5d in IrCo-pNC catalyst,thus optimizing the adsorption of hydrogen on Ir *** as-prepared IrCo-pNC exhibits significant HER performance with an overpotential of 21 mV to achieve a current density of 10 mA·cm^(−2)in 0.5 M *** work provides insight into the role of asymmetry electron density distribution in nanomaterials in regulating HER electrocatalysis.
With the rapid development of power transmission line construction in China, the stable operation of overhead power transmission lines has become crucial for national energy security. The frequent occurrence of safety...
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The recent release of ChatGPT has garnered widespread recognition for its exceptional ability to generate human-like responses in dialogue. Given its usage by users from various nations and its training on a vast mult...
Mutations in BRG1-associated factor 45D (BAF45D, also known as double PHD fingers 2 (DPF2)) are linked to Coffin-Siris syndrome (CSS).1 However, the underlying molecular mechanisms remain ill-defined. Here, we identif...
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Mutations in BRG1-associated factor 45D (BAF45D, also known as double PHD fingers 2 (DPF2)) are linked to Coffin-Siris syndrome (CSS).1 However, the underlying molecular mechanisms remain ill-defined. Here, we identified that wild-type but not CSS-associated BAF45D mutants increased the expression of PAX6,2 a neural stem cell marker, and phosphorylated SMAD3 (p-SMAD3) in spinal cord neural stem cells (NSCs) derived from H9 human embryonic stem cells. Both BAF45D and SMAD3 are required for the induction of p-SMAD3 and PAX6 together with STAT3 and SMAD7 by retinoic acid (RA). In the presence of RA, BAF45D knockdown decreased the expression of genes that regulate stem cell pluripotency. Moreover, the same genes in the spinal cord NSCs had more binding sites with BAF45D than those in H9 cells. Furthermore, Gene Ontology (GO) assay results indicated that BAF45D targets more pathways responsible for stem cell maintenance in NSCs. Finally, BAF45D is associated with BRG1, p-SMAD3, and PAX6. Together, these findings suggest a role for BAF45D in modulating PAX6 expression through SMAD signaling, highlighting the importance of BAF45D in neural stem/progenitor cell fate commitment.
Container virtualization technology represented by Docker has been widely used in the industry due to its advantages of lightweight, fast deployment, and easy portability. It can bring convenience to system deployment...
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