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arXiv 2024年

作者： Ding, Tong Wagner, Sophia J. Song, Andrew H. Chen, Richard J. Lu, Ming Y. Zhang, Andrew Vaidya, Anurag J. Jaume, Guillaume Shaban, Muhammad Kim, Ahrong Williamson, Drew F.K. Chen, Bowen Almagro-Perez, Cristina Doucet, Paul Sahai, Sharifa Chen, Chengkuan Komura, Daisuke Kawabe, Akihiro Ishikawa, Shumpei Gerber, Georg Peng, Tingying Le, Long Phi Mahmood, Faisal Department of Pathology Mass General Brigham Harvard Medical School BostonMA United States Data Science Program Dana-Farber Cancer Institute BostonMA United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA United States Helmholtz Munich German Research Center for Environment and Health Munich Germany School of Computation Information and Technology Technical University of Munich Munich Germany Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology CambridgeMA United States Department of Pathology Pusan National University Busan Korea Republic of Department of Pathology and Laboratory Medicine Emory University School of Medicine AtlantaGA United States Harvard Data Science Initiative Harvard University CambridgeMA United States Department of Systems Biology Harvard Medical School BostonMA United States Department of Preventive Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Pathology National Cancer Center Exploratory Oncology Research & Clinical Trial Center Chiba Japan

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation. The model is publicly accessible at https://***/mahmoodlab/TITAN © 2024, CC BY-NC-ND.

关键词： Self-supervised learning

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Efficient Learning of Continuous-Variable Quantum States

arXiv

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arXiv 2023年

作者： Wu, Ya-Dong Zhu, Yan Chiribella, Giulio Liu, Nana John Hopcroft Center for Computer Science Shanghai Jiao Tong University Shanghai200240 China QICI Quantum Information and Computation Initiative Department of Computer Science The University of Hong Kong Pokfulam Road Hong Kong Department of Computer Science Parks Road OxfordOX1 3QD United Kingdom Perimeter Institute for Theoretical Physics WaterlooONN2L 2Y5 Canada Institute of Natural Sciences Shanghai Jiao Tong University Shanghai200240 China Ministry of Education Key Laboratory in Scientific and Engineering Computing Shanghai Jiao Tong University Shanghai200240 China School of Mathematical Sciences Shanghai Jiao Tong University Shanghai200240 China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai200240 China

The characterization of continuous-variable quantum states is crucial for applications in quantum communication, sensing, simulation and computing. However, a full characterization of multimode quantum states requires a number of experiments that grows exponentially with the number of modes. Here we propose an alternative approach where the goal is not to reconstruct the full quantum state, but rather to estimate its characteristic function at a given set of points. For multimode states with reflection symmetry, we show that the characteristic function at M points can be estimated using only O(log M) copies of the state, independently of the number of modes. When the characteristic function is known to be positive, as in the case of squeezed vacuum states, the estimation is achieved by an experimentally friendly setup using only beamsplitters and homodyne measurements. © 2023, CC BY-NC-SA.

关键词： Quantum communication

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IC-U-Net: A U-Net-based denoising autoencoder using mixtures of independent components for automatic EEG artifact removal

arXiv

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arXiv 2021年

作者： Chuang, Chun-Hsiang Chang, Kong-Yi Huang, Chih-Sheng Jung, Tzyy-Ping Research Center for Education and Mind Sciences College of Education National Tsing Hua University Hsinchu Taiwan Institute of Information Systems and Applications College of Electrical Engineering and Computer Science National Tsing Hua University Hsinchu Taiwan Department of Computer Science and Engineering National Taiwan Ocean University Keelung Taiwan Department of Artificial Intelligence Research and Development Elan Microelectronics Corporation Hsinchu Taiwan Institute of Engineering in Medicine Institute for Neural Computation University of California San Diego La Jolla United States

Electroencephalography (EEG) signals are often contaminated with artifacts. It is imperative to develop a practical and reliable artifact removal method to prevent misinterpretations of neural signals and underperformance of brain-computer interfaces. This study developed a new artifact removal method, IC-U-Net, which is based on the U-Net architecture for removing pervasive EEG artifacts and reconstructing brain sources. The IC-U-Net was trained using mixtures of brain and non-brain sources decomposed by independent component analysis and employed an ensemble of loss functions to model complex signal fluctuations in EEG recordings. The effectiveness of the proposed method in recovering brain sources and removing various artifacts (e.g., eye blinks/movements, muscle activities, and line/channel noises) was demonstrated in a simulation study and three real-world EEG datasets collected at rest and while driving and walking. IC-U-Net is user-friendly and publicly available, does not require parameter tuning or artifact type designations, and has no limitations on channel numbers. Given the increasing need to image natural brain dynamics in a mobile setting, ICU-Net offers a promising end-to-end solution for automatically removing artifacts from EEG recordings. Copyright © 2021, The Authors. All rights reserved.

关键词： Electroencephalography

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Methodology for creation of labeled image datasets of entrained air voids and aggregates in concrete surfaces using confocal laser scanning microscopy

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Advanced engineering Informatics 2025年 67卷

作者： Viktor Kostic Qadeer Khan Daniel Cremers Jithender Timothy Thomas Kränkel Christoph Gehlen TUM School of Engineering and Design Department of Materials Engineering Chair of Materials Science and Testing Centre for Building Materials (cbm) Technical University of Munich Munich 81245 BY Germany TUM School of Computation Information and Technology Computer Vision Group Technical University of Munich Munich 81245 BY Germany Munich Center for Machine Learning Munich 81245 BY Germany

Several strategies using neural network algorithms have been established to automate the process of evaluating parameters regarding the freeze–thaw resistance of hardened concrete from image data. However, the performance of such models is dependent on the quality of the datasets used for training. Hand-labeling concrete image data is challenging, where especially small micro air voids (<300 μ m) can be overlooked. This potentially leads to algorithms that are unable to accurately detect the micro air void content, despite being required by current standards (e.g. DIN EN 480-11). To account for this, a method was developed using confocal laser scanning microscopy and the “Segment Anything” model. Acquiring surface height-data through confocal laser scanning microscopy expendites the labeling process and creates more reliable training data due to the detectability of air voids through height differences. Furthermore, by combining the height-data with RGB-images it was possible to accurately distinguish between air voids, aggregates and cement paste with high repeatability between repeated labeling iterations. Keeping high magnification levels (120-480x) enabled the detection of air voids down to 5 μ m. The framework and dataset presented in this study are fundamental for further development of new neural network based algorithms, specialized for the characterization and evaluation of the freeze–thaw resistance of concrete.

关键词： Concrete Freeze–thaw resistance Air voids Labeling Confocal laser scanning microscopy Segment anything model

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Efficient reinforcement learning in continuous state and action spaces with Dyna and policy approximation

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Frontiers of computer science 2019年第1期13卷 106-126页

作者： Shan ZHONG Quan LIU Zongzhang ZHANG Qiming FU School of Computer Science and Technology Soochow UniversitySuzhou 215000China School of Computer Science and Engineering Changshu Institute of TechnologyChangshu 215500China Jiangsu Province Key Laboratory of Intelligent Building Energy Efficiency Suzhou University of Science and TechnologySuzhou 215006China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210000China College of Electronic &Information Engineering Suzhou University of Science and TechnologySuzhou 215000China

Dyna is an effective reinforcement learning (RL) approach that combines value function evaluation with model ***,existing works on Dyna mostly discuss only its efficiency in RL problems with discrete action *** paper proposes a novel Dyna variant,called Dyna-LSTD-PA,aiming to handle problems with continuous action ***-LSTD-PA stands for Dyna based on least-squares temporal difference (LSTD)and policy ***-LSTD-PA consists of two simultaneous,interacting *** learning process determines the probability distribution over action spaces using the Gaussian distribution;estimates the underlying value function,policy,and model by linear representation;and updates their parameter vectors online by LSTD(,t).The planning process updates the parameter vector of the value function again by using ofttine LSTD(2).Dyna-LSTD-PA also uses the Sherman-Morrison formula to improve the efficiency of LSTD(,t),and weights the parameter vector of the value function to bring the two processes ***,the global error bound is derived by considering approximation,estimation,and model ***,Dyna-LSTD-PA outperforms two representative methods in terms of convergence rate,success rate,and stability performance on four benchmark RL problems.

关键词： problem solving control methods heuristic search methods dynamic programming

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Harmonized-Multinational qEEG norms (HarMNqEEG)

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NEUROIMAGE 2022年 256卷 119190-119190页

作者： Li, Min Wang, Ying Lopez-Naranjo, Carlos Hu, Shiang Reyes, Ronaldo Cesar Garcia Paz-Linares, Deirel Areces-Gonzalez, Ariosky Hamid, Aini Ismafairus Abd Evans, Alan C. Savostyanov, Alexander N. Calzada-Reyes, Ana Villringer, Arno Tobon-Quintero, Carlos A. Garcia-Agustin, Daysi Yao, Dezhong Dong, Li Aubert-Vazquez, Eduardo Reza, Faruque Razzaq, Fuleah Abdul Omar, Hazim Abdullah, Jafri Malin Galler, Janina R. Ochoa-Gomez, John F. Prichep, Leslie S. Galan-Garcia, Lidice Morales-Chacon, Lilia Valdes-Sosa, Mitchell J. Trondle, Marius Zulkifly, Mohd Faizal Mohd Rahman, Muhammad Riddha Bin Abdul Milakhina, Natalya S. Langer, Nicolas Rudych, Pavel Koenig, Thomas Virues-Alba, Trinidad A. Lei, Xu Bringas-Vega, Maria L. Bosch-Bayard, Jorge F. Valdes-Sosa, Pedro Antonio The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for Neuroinformation School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China Brain and Behaviour Cluster School of Medical Sciences Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia Anhui Provincial Key Laboratory of Multimodal Cognitive Computation Key Laboratory of Intelligent Computing & Signal Processing of Ministry of Education School of Computer Science and Technology Anhui University Hefei 230601 China Cuban Center for Neurocience La Habana Cuba University of Pinar del Río “Hermanos Saiz Montes de Oca” Pinar del Río Cuba Department of Neurosciences School of Medical Sciences Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia Hospital Universiti Sains Malaysia Universiti Sains Malaysia Health Campus Kota Bharu Kelantan 16150 Malaysia McGill Centre for Integrative Neuroscience Ludmer Centre for Neuroinformatics and Mental Health Montreal Neurological Institute Canada Humanitarian Institute Novosibirsk State University Novosibirsk 630090 Russia Laboratory of Psychophysiology of Individual Differences Federal State Budgetary Scientific Institution Scientific Research Institute of Neurosciences and Medicine Novosibirsk 630117 Russia Laboratory of Psychological Genetics at the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia Department of Neurology Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany Department of Cognitive Neurology University Hospital Leipzig Leipzig Germany Center for Stroke Research Charité-Universitätsmedizin Berlin Berlin Germany Grupo Neuropsicología y Conducta - GRUNECO Faculty of Medicine Universidad de Antioquia Colombia Research Department Institución Prestadora de Servicios de Salud IPS Universitaria Colombia The Cuban center aging longevity and healt

This paper extends frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. (i) Create lifespan Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross spectral tensors were shared. After visual and automatic quality control, developmental equations for the mean and standard deviation of qEEG traditional and Riemannian DPs were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects " and provide methods to calculate harmonized z-scores. (ii) We also show that harmonized Riemannian norms produce z-scores with increased diagnostic accuracy predicting brain dysfunction produced by malnutrition in the first year of life and detecting COVID induced brain dysfunction. (iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

关键词： Quantitative EEG EEG cross-spectrum Riemannian geometry Batch effects Z-score Harmonization Malnutrition Covid induced brain dysfunction Developmental Brain Chart

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Hierarchical Event Descriptor library schema for EEG data annotation

arXiv

引用

arXiv 2023年

作者： Hermes, Dora Attia, Tal Pal Beniczky, Sándor Bosch-Bayard, Jorge Delorme, Arnaud Lundstrom, Brian Nils Rogers, Christine Rampp, Stefan Shirazi, Seyed Yahya Truong, Dung Valdes-Sosa, Pedro Worrell, Greg Makeig, Scott Robbins, Kay Multimodal Neuroimaging Laboratory Department of Physiology and Biomedical Engineering Mayo Clinic RochesterMN United States Department of Computer Science University of Texas San Antonio San AntonioTX United States The Danish Epilepsy Centre Filadelfia Denmark Aarhus University Aarhus University Hospital Aarhus Denmark Department of Biological and Health Psychology Faculty of Psychology Universidad Autónoma de Madrid Spain Swartz Center for Computational Neuroscience Institute for Neural Computation University of California San Diego La Jolla CA United States Bioelectronics Neurophysiology and Engineering Laboratory Department of Neurology Mayo Clinic RochesterMN United States McGill Centre for Integrative Neuroscience Montreal Neurological Institute Montreal Canada Department of Neurosurgery University Hospital Erlangen Erlangen Germany Germany

Standardizing terminology to annotate electrophysiological events can improve both computational research and clinical care. Sharing data enriched with standard terms can facilitate data exploration, from case studies to mega-analyses. The machine readability of such electrophysiological event annotations is essential for performing analyses efficiently across software tools and packages. Hierarchical Event Descriptors (HED) provide a framework for describing events in neuroscience experiments. HED library schemas extend the standard HED schema vocabulary to include specialized vocabularies, such as standardized clinical terms for electrophysiological events. The Standardized computer-based Organized Reporting of EEG (SCORE) defines terms for annotating EEG events, including artifacts. This study developed a HED library schema for SCORE, making the terms machine-readable. We demonstrate that the HED-SCORE library schema can be used to annotate events in EEG data stored in the Brain Imaging Data Structure (BIDS). Clinicians and researchers worldwide can now use the HED-SCORE library schema to annotate and compute on electrophysiological data obtained from the human brain. © 2023, CC BY-NC-ND.

关键词： Brain mapping

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Convex Optimization for Nonequilibrium Steady States on a Hybrid Quantum Processor

引用

Physical Review Letters 2023年第24期130卷 240601-240601页

作者： Jonathan Wei Zhong Lau Kian Hwee Lim Kishor Bharti Leong-Chuan Kwek Sai Vinjanampathy Centre for Quantum Technologies National University of Singapore 3 Science Drive 2 Singapore 117543 Joint Center for Quantum Information and Computer Science and Joint Quantum Institute NIST/University of Maryland College Park Maryland 20742 USA Institute of High Performance Computing (IHPC) Agency for Science Technology and Research (A*STAR) 1 Fusionopolis Way No. 16-16 Connexis Singapore 138632 Republic of Singapore MajuLab CNRS-UNS-NUS-NTU International Joint Research Unit Singapore UMI 3654 Singapore National Institute of Education Nanyang Technological University 1 Nanyang Walk Singapore 637616 Singapore School of Electrical and Electronic Engineering Block S2.1 50 Nanyang Avenue Singapore 639798 Singapore Department of Physics Indian Institute of Technology-Bombay Powai Mumbai 400076 India Centre of Excellence in Quantum Information Computation Science and Technology Indian Institute of Technology Bombay Powai Mumbai 400076 India

Finding the transient and steady state properties of open quantum systems is a central problem in various fields of quantum technologies. Here, we present a quantum-assisted algorithm to determine the steady states of open system dynamics. By reformulating the problem of finding the fixed point of Lindblad dynamics as a feasibility semidefinite program, we bypass several well-known issues with variational quantum approaches to solving for steady states. We demonstrate that our hybrid approach allows us to estimate the steady states of higher dimensional open quantum systems and discuss how our method can find multiple steady states for systems with symmetries.

关键词： Learning theory Machine learning Open quantum systems & decoherence Quantum algorithms Nonequilibrium systems

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Learning to Predict IR Drop with Effective Training for ReRAM-based neural Network Hardware

Learning to Predict IR Drop with Effective Training for ReRA...

引用

Design Automation Conference

作者： Sugil Lee Giju Jung Mohammed E. Fouda Jongeun Lee Ahmed Eltawil Fadi Kurdahi School of Electrical and Computer Engineering UNIST Ulsan Korea Neural Processing Research Center Seoul National University Seoul Korea Department of Electrical Engineering and Computer Science University of California-Irvine CA USA

ISBN: (数字)9781728110851

ISBN: (纸本)9781728158020

Due to the inevitability of the IR drop problem in passive ReRAM crossbar arrays, finding a software solution that can predict the effect of IR drop without the need of expensive SPICE simulations, is very desirable. In this paper, two simple neural networks are proposed as software solution to predict the effect of IR drop. These networks can be easily integrated in any deep neural network framework to incorporate the IR drop problem during training. As an example, the proposed solution is integrated in BinaryNet framework and the test validation results, done through SPICE simulations, show very high improvement in performance close to the baseline performance, which demonstrates the efficacy of the proposed method. In addition, the proposed solution outperforms the prior work on challenging datasets such as CIFAR10 and SVHN.

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Polarization dynamics of solid-state quantum emitters

arXiv

引用

arXiv 2023年

作者： Kumar, Anand Samaner, Çağlar Cholsuk, Chanaprom Matthes, Tjorben Paçal, Serkan Oyun, Yağız Zand, Ashkan Chapman, Robert J. Saerens, Grégoire Grange, Rachel Suwanna, Sujin Ateş, Serkan Vogl, Tobias Department of Computer Engineering School of Computation Information and Technology Technical University of Munich Munich80333 Germany Abbe Center of Photonics Institute of Applied Physics Friedrich Schiller University Jena Jena07745 Germany Department of Physics İzmir Institute of Technology İzmir35430 Turkey Department of Photonics İzmir Institute of Technology İzmir35430 Turkey Optical Nanomaterial Group Institute for Quantum Electronics Department of Physics ETH Zurich Zurich8093 Switzerland Optical and Quantum Physics Laboratory Department of Physics Faculty of Science Mahidol University Bangkok10400 Thailand

Quantum emitters in solid-state crystals have recently attracted a lot of attention due to their simple applicability in optical quantum technologies. The polarization of single photons generated by quantum emitters is one of the key parameters that play a crucial role in the applications, such as quantum computation that uses the indistinguishability of photons. However, the degree of single photon polarization is typically quantified using time-averaged photoluminescence intensity of single emitters, which provides limited information about the dipole properties in solids. In this work, we use single defects in hexagonal boron nitride and nanodiamond as efficient room-temperature single photon sources to reveal the origin and the temporal evolution of dipole orientation in solid-state quantum emitters. The angle of excitation and emission dipoles relative to the crystal axes are determined experimentally and then calculated using density functional theory, which results in characteristic angles for every specific defect that can be used as an efficient tool for defect identification and understanding their atomic structure. Moreover, the temporal polarization dynamics reveal a strongly modified linear polarization visibility that depends on the excited state decay time of individual excitation. This effect can be traced back potentially to the excitation of excess charges in the local crystal environment. Understanding such hidden time-dependent mechanisms can further be used to improve the performance of polarization-sensitive experiments, in particular that of quantum communication with single photon emitters. © 2023, CC BY.

关键词： Density functional theory

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