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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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On the role of theory and modeling in neuroscience

arXiv

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arXiv 2020年

作者： Levenstein, Daniel Alvarez, Veronica A. Amarasingham, Asohan Azab, Habiba Chen, Zhe S. Gerkin, Richard C. Hasenstaub, Andrea Iyer, Ramakrishnan Jolivet, Renaud B. Marzen, Sarah Monaco, Joseph D. Prinz, Astrid A. Quraishi, Salma Santamaria, Fidel Shivkumar, Sabyasachi Singh, Matthew F. Traub, Roger Rotstein, Horacio G. Nadim, Farzan Redish, A. David Montreal Neurological Institute McGill University MontrealQC Canada Laboratory on Neurobiology of Compulsive Behaviors National Institute on Alcohol Abuse and Alcoholism NIH BethesdaMD United States Department of Neuroscience Center for Magnetic Resonance Research University of Minnesota MinneapolisMN United States School of Life Sciences Arizona State University TempeAZ United States Department of Otolaryngology - Head and Neck Surgery University of California San Francisco San FranciscoCA United States Allen Institute for Brain Science SeattleWA United States Maastricht University Maastricht Netherlands Department of Biomedical Engineering Johns Hopkins University School of Medicine BaltimoreMD United States Department of Biology University of Texas at San Antonio San AntonioTX United States Department of Psychological & Brain Sciences Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO United States IBM T.J. Watson Research Center AI Foundations Yorktown HeightsNY United States W. M. Keck Science Department Pitzer Scripps and Claremont McKenna Colleges ClaremontCA United States Department of Biology Emory University AtlantaGA United States Department of Mathematics City College of New York United States Departments of Biology Computer Science and Psychology The Graduate Center City University of New York United States Brain and Cognitive Sciences University of Rochester RochesterNY United States Federated Department of Biological Sciences New Jersey Institute of Technology Rutgers University Institute for Brain and Neuroscience Research New Jersey Institute of Technology NewarkNJ United States Department of Neuroscience University of Minnesota MinneapolisMN United States Department of Psychiatry Neuroscience & Physiology New York University School of Medicine United States Mila - Quebec AI Institute MontrealQC Canada

In recent years, the field of neuroscience has gone through rapid experimental advances and a significant increase in the use of quantitative and computational methods. This growth has created a need for clearer analyses of the theory and modeling approaches used in the field. This issue is particularly complex in neuroscience because the field studies phenomena that cross a wide range of scales and often require consideration at varying degrees of abstraction, from precise biophysical interactions to the computations they implement. We argue that a pragmatic perspective of science, in which descriptive, mechanistic, and normative models and theories each play a distinct role in defining and bridging levels of abstraction will facilitate neuroscientific practice. This analysis leads to methodological suggestions, including selecting a level of abstraction that is appropriate for a given problem, identifying transfer functions to connect models and data, and the use of models themselves as a form of experiment. © 2020, CC BY.

关键词： Computation theory

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Social and moral psychology of COVID-19 across 69 countries

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Scientific data 2023年第1期10卷 272页

作者： Flavio Azevedo Tomislav Pavlović Gabriel G Rêgo F Ceren Ay Biljana Gjoneska Tom W Etienne Robert M Ross Philipp Schönegger Julián C Riaño-Moreno Aleksandra Cichocka Valerio Capraro Luca Cian Chiara Longoni Ho Fai Chan Jay J Van Bavel Hallgeir Sjåstad John B Nezlek Mark Alfano Michele J Gelfand Michèle D Birtel Aleksandra Cislak Patricia L Lockwood Koen Abts Elena Agadullina John Jamir Benzon Aruta Sahba Nomvula Besharati Alexander Bor Becky L Choma Charles David Crabtree William A Cunningham Koustav De Waqas Ejaz Christian T Elbaek Andrej Findor Daniel Flichtentrei Renata Franc June Gruber Estrella Gualda Yusaku Horiuchi Toan Luu Duc Huynh Agustin Ibanez Mostak Ahamed Imran Jacob Israelashvili Katarzyna Jasko Jaroslaw Kantorowicz Elena Kantorowicz-Reznichenko André Krouwel Michael Laakasuo Claus Lamm Caroline Leygue Ming-Jen Lin Mohammad Sabbir Mansoor Antoine Marie Lewend Mayiwar Honorata Mazepus Cillian McHugh John Paul Minda Panagiotis Mitkidis Andreas Olsson Tobias Otterbring Dominic J Packer Anat Perry Michael Bang Petersen Arathy Puthillam Tobias Rothmund Hernando Santamaría-García Petra C Schmid Drozdstoy Stoyanov Shruti Tewari Bojan Todosijević Manos Tsakiris Hans H Tung Radu G Umbres Edmunds Vanags Madalina Vlasceanu Andrew Vonasch Meltem Yucel Yucheng Zhang Mohcine Abad Eli Adler Narin Akrawi Hamza Alaoui Mdarhri Hanane Amara David M Amodio Benedict G Antazo Matthew Apps Mouhamadou Hady Ba Sergio Barbosa Brock Bastian Anton Berg Maria P Bernal-Zárate Michael Bernstein Michał Białek Ennio Bilancini Natalia Bogatyreva Leonardo Boncinelli Jonathan E Booth Sylvie Borau Ondrej Buchel C Daryl Cameron Chrissie F Carvalho Tatiana Celadin Chiara Cerami Hom Nath Chalise Xiaojun Cheng Kate Cockcroft Jane Conway Mateo Andres Córdoba-Delgado Chiara Crespi Marie Crouzevialle Jo Cutler Marzena Cypryańska Justyna Dabrowska Michael A Daniels Victoria H Davis Pamala N Dayley Sylvain Delouvée Ognjan Denkovski Guillaume Dezecache Nathan A Dhaliwal Alelie B Diato Roberto Di Paolo Marianna Drosinou Uwe Dulleck Jānis Ekmanis Department of Psychology University of Cambridge Cambridge England. fa441@cam.ac.uk. Institute of Communication Science Friedrich-Schiller University Jena Jena Germany. fa441@cam.ac.uk. Institute of Social Sciences Ivo Pilar Zagreb Croatia. Social and Cognitive Neuroscience Laboratory Mackenzie Presbyterian University São Paulo Brazil. Department of Economics Norwegian School of Economics Bergen Norway. Telenor Research Oslo Norway. Macedonian Academy of Sciences and Arts Skopje Republic of North Macedonia. Kieskompas - Election Compass Amsterdam Netherlands. Department of Political Science & Annenberg School for Communication University of Pennsylvania Philadelphia PA USA. Department of Psychology Macquarie University Sydney NSW Australia. Department of Philosophy University of St Andrews St Andrews Scotland. School of Economics and Finance University of St Andrews St Andrews Scotland. Medicine Faculty Cooperative University of Colombia Villavicencio Colombia. Department of Bioethics El Bosque University Bogotá Colombia. School of Psychology University of Kent Canterbury England. Department of Economics Middlesex University London London England. Darden School of Business University of Virginia Charlottesville VA USA. Questrom School of Business Boston University Boston MA USA. School of Economics and Finance Queensland University of Technology Brisbane QLD Australia. Center for Behavioural Economics Society and Technology Queensland University of Technology Brisbane QLD Australia. Department of Psychology and Neural Science New York University New York NY USA. Department of Strategy and Management Norwegian School of Economics Bergen Norway. SWPS University of Social Sciences and Humanities Warsaw Poland. Department of Psychological Sciences College of William and Mary Williamsburg VA USA. Department of Philosophy Macquarie University Sydney NSW Australia. Stanford Graduate School of Business Stanford University Stanford CA USA.

The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Author Correction: National identity predicts public health support during a global pandemic

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Nature communications 2022年第1期13卷 1949页

作者： Jay J Van Bavel Aleksandra Cichocka Valerio Capraro Hallgeir Sjåstad John B Nezlek Tomislav Pavlović Mark Alfano Michele J Gelfand Flavio Azevedo Michèle D Birtel Aleksandra Cislak Patricia L Lockwood Robert Malcolm Ross Koen Abts Elena Agadullina John Jamir Benzon Aruta Sahba Nomvula Besharati Alexander Bor Becky L Choma Charles David Crabtree William A Cunningham Koustav De Waqas Ejaz Christian T Elbaek Andrej Findor Daniel Flichtentrei Renata Franc Biljana Gjoneska June Gruber Estrella Gualda Yusaku Horiuchi Toan Luu Duc Huynh Agustin Ibanez Mostak Ahamed Imran Jacob Israelashvili Katarzyna Jasko Jaroslaw Kantorowicz Elena Kantorowicz-Reznichenko André Krouwel Michael Laakasuo Claus Lamm Caroline Leygue Ming-Jen Lin Mohammad Sabbir Mansoor Antoine Marie Lewend Mayiwar Honorata Mazepus Cillian McHugh John Paul Minda Panagiotis Mitkidis Andreas Olsson Tobias Otterbring Dominic J Packer Anat Perry Michael Bang Petersen Arathy Puthillam Julián C Riaño-Moreno Tobias Rothmund Hernando Santamaría-García Petra C Schmid Drozdstoy Stoyanov Shruti Tewari Bojan Todosijević Manos Tsakiris Hans H Tung Radu G Umbreș Edmunds Vanags Madalina Vlasceanu Andrew Vonasch Meltem Yucel Yucheng Zhang Mohcine Abad Eli Adler Narin Akrawi Hamza Alaoui Mdarhri Hanane Amara David M Amodio Benedict G Antazo Matthew Apps F Ceren Ay Mouhamadou Hady Ba Sergio Barbosa Brock Bastian Anton Berg Maria P Bernal-Zárate Michael Bernstein Michał Białek Ennio Bilancini Natalia Bogatyreva Leonardo Boncinelli Jonathan E Booth Sylvie Borau Ondrej Buchel C Daryl Cameron Chrissie F Carvalho Tatiana Celadin Chiara Cerami Hom Nath Chalise Xiaojun Cheng Luca Cian Kate Cockcroft Jane Conway Mateo Andres Córdoba-Delgado Chiara Crespi Marie Crouzevialle Jo Cutler Marzena Cypryańska Justyna Dabrowska Michael A Daniels Victoria H Davis Pamala N Dayley Sylvain Delouvee Ognjan Denkovski Guillaume Dezecache Nathan A Dhaliwal Alelie B Diato Roberto Di Paolo Marianna Drosinou Uwe Dulleck Jānis Ekmanis Arhan S Ertan Tom W Etienne Hapsa Hossain Farhana Fahima Farkhari Har Department of Psychology and Neural Science New York University New York NY USA. jay.vanbavel@nyu.edu. School of Psychology University of Kent Canterbury England. Department of Economics Middlesex University London London England. Department of Strategy and Management Norwegian School of Economics Bergen Norway. SWPS University of Social Sciences and Humanities Poznań Poland. Department of Psychological Sciences College of William and Mary Williamsburg VA USA. Institute of Social Sciences Ivo Pilar Zagreb Croatia. Department of Philosophy Macquarie University Sydney NSW Australia. Stanford Graduate School of Business Stanford University Stanford CA USA. Institute of Communication Science Friedrich-Schiller University Jena Jena Germany. flavio.azevedo@uni-jena.de. School of Human Sciences Institute for Lifecourse Development University of Greenwich London England. Department of Experimental Psychology University of Oxford Oxford England. Center for Human Brain Health School of Psychology University of Birmingham Birmingham England. Department of Psychology Macquarie University Sydney NSW Australia. KU Leuven Leuven Belgium. National Research University Higher School of Economics (HSE) Moscow Russia. De La Salle University Manila Philippines. Department of Psychology University of the Witwatersrand Johannesburg South Africa. Department of Political Science Aarhus University Aarhus Denmark. X University Toronto ON Canada. Department of Government Dartmouth College Hanover NH USA. Department of Psychology University of Toronto Toronto ON Canada. Gatton College of Business and Economics University of Kentucky Lexington KY USA. Department of Mass Communication National University of Science and Technology (NUST) Islamabad Pakistan. Department of Management Aarhus University Aarhus Denmark. Faculty of Social and Economic Sciences Comenius University Bratislava Slovakia. IntraMed Buenos Aires Argentina. Macedonian Academy of Sciences and

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000-17: analysis for the Global Burden of Disease Study 2017 (vol 395, pg 1779, 2020)

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LANCET 2020年第10239期395卷 1762-1762页

作者： Reiner, R. C., Jr. Hay, S., I Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health School of Medicine University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States College of Health and Medical Sciences Haramaya University Harar Ethiopia Department of Epidemiology and Biostatistics Haramaya University Harar Ethiopia Department of Medical Laboratory Sciences Haramaya University Harar Ethiopia School of Nursing and Midwifery Haramaya University Harar Ethiopia School of Pharmacy Haramaya University Harar Ethiopia School of Public Health Haramaya University Harar Ethiopia Haramaya University Harar Ethiopia Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Biology Research Center Tehran University of Medical Sciences Tehran Iran Cancer Research Institute Tehran University of Medical Sciences Tehran Iran Department of Economics and Management Sciences for Health Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Department of Health Management and Economics Tehran University of Medical Sciences Tehran Iran Department of Microbiology Tehran University of Medical Sciences Tehran Iran Department of Pharmacology Tehran University of Medical Sciences Tehran Iran Digestive Diseases Research Institute Tehran University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran Iran Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran Iran National Institute of Health Research Tehran University of Medical Sciences Tehran Iran Metabolomics and

Summary Background Across low-income and middle-income countries (LMICs), one in ten deaths in children younger than 5 years is attributable to diarrhoea. The substantial between-country variation in both diarrhoea incidence and mortality is attributable to interventions that protect children, prevent infection, and treat disease. Identifying subnational regions with the highest burden and mapping associated risk factors can aid in reducing preventable childhood *** We used Bayesian model-based geostatistics and a geolocated dataset comprising 15 072 746 children younger than 5 years from 466 surveys in 94 LMICs, in combination with findings of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, to estimate posterior distributions of diarrhoea prevalence, incidence, and mortality from 2000 to 2017. From these data, we estimated the burden of diarrhoea at varying subnational levels (termed units) by spatially aggregating draws, and we investigated the drivers of subnational patterns by creating aggregated risk factor *** The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1-65·8), 17·4% (7·7-28·4), and 59·5% (34·2-86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. Although children in much of Africa remain at high risk of death due to diarrhoea, regions with the most deaths were outside Africa, with the highest mortality units located in Pakistan. Indonesia showed the greatest within-country geographical inequality; some regions had mortality rates nearly four times the average country rate. Reductions in mortality were correlated to improvements in water, sanitation, and hygiene (WASH) or reductions in child growth failure (CGF). Similarly, most high-risk areas had poor WASH, high CGF, or low oral rehydration therapy *** By co-analysing geospatial trends in d

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

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NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

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Verifying effectiveness of an expression education support robot that nods and gives hints

Verifying effectiveness of an expression education support r...

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Congress on Evolutionary Computation

作者： Koki Suzuki Shogo Yamada Masayoshi Kanoh Graduate School of Computer and Cognitive Sciences Chukyo University Nagoya Japan School of Information Science and Technology Chukyo University Nagoya Japan School of Engineering Chukyo University Nagoya Japan

In recent years, expression education that improves imagination and communication skills has been of increasing interest. Suitable support and evaluation for each student in expression education is necessary because students have different skill levels. However, many existing educational institutions educate learners in a one-to-many environment. This makes it difficult for teachers to support and evaluate all learners adequately. In this study, we use a robot as an alternative to a teacher in a one-to-one environment. Suzuki et al. proposed a robot for supporting expression education that gives hints to arouse imagination. They suggested that the robot has a positive effect on learning support but cautioned that it is necessary for learners to have an interest in the robot and to pay attention to it in order for the effect to be felt. In this paper, we focus on the nod in non-verbal communication and propose a robot for supporting expression education that nods and gives hints. To determine the effectiveness of the proposed robot, we performed experiments in which we compare its performance with that of a robot that nods but does not give hints, a robot that gives hints but does not nod, and a robot that neither nods nor gives hints.

关键词： Education Robot sensing systems Regulators Electronic mail Shape Evolutionary computation

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Multiple-Stage Structure Transformation of Organic-Inorganic Hybrid Perovskite CH3NH3PbI3

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Physical Review X 2016年第3期6卷 031042-031042页

作者： Qiong Chen Henan Liu Hui-Seon Kim Yucheng Liu Mengjin Yang Naili Yue Gang Ren Kai Zhu Shengzhong Liu Nam-Gyu Park Yong Zhang Department of Electrical and Computer Engineering The University of North Carolina at Charlotte Charlotte North Carolina 28223 USA Graduate Programs in Optical Science and Engineering The University of North Carolina at Charlotte Charlotte North Carolina 28223 USA School of Chemical Engineering and Department of Energy Science Sungkyunkwan University Suwon 440-746 South Korea Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education Institute for Advanced Energy Materials School of Materials Science and Engineering Shaanxi Normal University Xi’an 710062 China Chemical and Materials Science Center National Renewable Energy Laboratory Golden Colorado 80401 USA Molecular Foundry Lawrence Berkeley National Laboratory Berkeley California 94720 USA

By performing spatially resolved Raman and photoluminescence spectroscopy with varying excitation wavelength, density, and data acquisition parameters, we achieve a unified understanding towards the spectroscopy signatures of the organic-inorganic hybrid perovskite, transforming from the pristine state (CH3NH3PbI3) to the fully degraded state (i.e., PbI2) for samples with varying crystalline domain size from mesoscopic scale (approximately 100 nm) to macroscopic size (centimeters), synthesized by three different techniques. We show that the hybrid perovskite exhibits multiple stages of structure transformation occurring either spontaneously or under light illumination, with exceptionally high sensitivity to the illumination conditions (e.g., power, illumination time, and interruption pattern). We highlight four transformation stages (stages I–IV, with stage I being the pristine state) along either the spontaneous or photoinduced degradation path exhibiting distinctly different Raman spectroscopy features at each stage, and point out that previously reported Raman spectra in the literature reflect highly degraded structures of either stage III or stage IV. Additional characteristic optical features of partially degraded materials under the joint action of spontaneous and photodegradation are also given. This study offers reliable benchmark results for understanding the intrinsic material properties and structure transformation of this unique category of hybrid materials, and the findings are pertinently important to a wide range of potential applications where the hybrid material is expected to function in greatly different environment and light-matter interaction conditions.

关键词： Lead compounds

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