检索结果-内蒙古大学图书馆

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (vol 51, pg 659, 2019)

引用

NATURE GENETICS 2019年第6期51卷 1068-1068页

作者： Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai New York NY USA Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY USA Vanderbilt University Medical Center Nashville TN USA MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff University Cardiff UK Department of Biomedicine Aarhus University Aarhus Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research iPSYCH Denmark Center for Integrative Sequencing Aarhus University Aarhus Denmark Department of Human Genetics David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Human Brain Collection Core National Institute of Mental Health Bethesda MD USA Laboratory of Neurogenomic Biomarkers Centre for Integrative Biology (CIBIO) University of Trento Trento Italy Clare Hall University of Cambridge Cambridge UK University of North Carolina at Chapel Hill Chapel Hill NC USA Karolinska Institutet Stockholm Sweden Department of Psychiatry University of Pittsburgh Pittsburgh PA USA Systems Biology Sage Bionetworks Seattle WA USA Section of Genetic Medicine Department of Medicine University of Chicago Chicago IL USA Integrated Technology Research Laboratories Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Japan Neuropsychiatry Section Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Neuropsychiatric Signaling Program Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Psychiatry JJ Peters Virginia Medical Center Bronx NY USA Department of Neuroscience Icahn School of Medicine at Mount Sinai New York New York NY USA Friedman Brain Institute

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.

关键词： Gene expression Genome-wide association studies Schizophrenia Transcriptomics

来源：评论

学校读者我要写书评

暂无评论

Inflammation Biomarkers: Label-Free Biophysical Markers from Whole Blood Microfluidic Immune Profiling Reveal Severe Immune Response Signatures (Small 12/2021)

引用

Small 2021年第12期17卷

作者： Kerwin Kwek Zeming Rohan Vernekar Mui Teng Chua Kai Yun Quek Greg Sutton Timm Krüger Win Sen Kuan Jongyoon Han Singapore-MIT Alliance for Research and Technology (SMART) – Critical Analytics for Manufacturing of Personalized Medicine (CAMP) IRG 1 Create Way Enterprise Wing #04-13/14 Singapore 138602 Singapore School of Engineering Institute for Multiscale Thermofluids University of Edinburgh Peter Guthrie Tait Road King's Buildings Edinburgh EH9 3FD UK Department of Surgery Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Level 8 NUHS Tower Block Singapore 119228 Singapore Emergency Medicine Department National University Hospital National University Health System National University Centre for Oral Health 9 Lower Kent Ridge Road Level 4 Singapore 119085 Singapore University/BHF Centre for Cardiovascular Science The Queen's Medical Research Institute 47 Little France Crescent Edinburgh EH16 4TJ UK Department of Electrical Engineering and Computer Science & Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue Room 36–841 Cambridge MA 02139 USA

来源：评论

学校读者我要写书评

暂无评论

Predicting Spring Phenology in Deciduous Broadleaf Forests: An Open Community Forecast Challenge

SSRN

引用

SSRN 2023年

作者： Wheeler, Kathryn I. Dietze, Michael C. LeBauer, David Peters, Jody Richardson, Andrew D. Thomas, R. Quinn Zhu, Kai Bhat, Uttam Munch, Stephan Buzbee, Raphaela Floreani Chenp, Min Goldstein, Benjamin Guo, Jessica S. Haoq, Dalei Jones, Chris Kelly-Fair, Mira Liup, Haoran Malmborg, Charlotte Neupane, Naresh Pal, Debasmita Ross, Arun A. Shirey, Vaughn Song, Yiluan Steen, McKalee Vance, Eric A. Woelmer, Whitney M. Wynne, Jacob Zachmann, Luke Department of Earth and Environment Boston University 685 Commonwealth Avenue BostonMA02215 United States Cooperative Programs for the Advancement of Earth System Science University Corporation for Atmospheric Research Foothills Laboratory Bldg 4 3300 Mitchell Lane BoulderCO80301 United States National Oceanic and Atmospheric Administration Foothills Laboratory Bldg 4 3300 Mitchell Lane BoulderCO80301 United States Department of Civil and Environmental Engineering Massachusetts Institute of Technology 15 Vassar St CambridgeMA02142 United States Arizona Experiment Station University of Arizona 1230 N Cherry Ave TucsonAZ85721 United States Department of Biological Sciences University of Notre Dame 100 Galvin Notre DameIN46556 United States School of Informatics Computing and Cyber Systems Northern Arizona University 1295 Knoles Dr. FlagstaffAZ86011 United States Center for Ecosystem Science and Society Northern Arizona University PO Box 5620 FlagstaffAZ86011 United States Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute State University 310 West Campus Drive BlacksburgVA24061 United States Department of Biological Sciences Virginia Polytechnic Institute State University 926 West Campus Drive BlacksburgVA24061 United States Institute for Global Change Biology University of Michigan 440 Church Street Ann ArborMI48109 United States School for Environment and Sustainability University of Michigan 440 Church Street Ann ArborMI48109 United States Institute of Marine Sciences University of California Santa Cruz 1156 High Street Santa CruzCA95060 United States Department of Applied Mathematics University of California Santa Cruz 1156 High Street Santa CruzCA95060 United States Department of Environmental Science Policy and Management University of California Berkeley 4004 Valley Life Sciences Building University of California Berkeley BerkeleyCA94720 United States Department of For

Accurate phenology models are important to predict how global climate change will continue to alter the timing of plant phenological events, such as spring greenup in deciduous broadleaf forests. While there is merit in long-term predictions, investigating how models can predict near-term (1– 35 days) canopy greenness throughout the spring allows us to validate performance and understanding now. The Ecological Forecasting Initiative’s NEON Forecasting Challenge, is an open challenge to the community to predict daily greenness values, measured through digital images collected by the PhenoCam Network at National Ecological Observatory Network (NEON) sites. For the first round of the challenge, which is presented here, teams were tasked to forecast phenology at eight deciduous broadleaf sites. A total of 192,536 predictions were submitted, representing eighteen models, including a persistence and a day of year mean null models. We found that forecast skill was highest when forecasting earlier in the greenup curve compared to the end, for shorter lead times, for sites that greened up earlier, and when submitting forecasts during times other than near budburst. The models based on day of year historical mean had the highest predictive skill across the challenge period. In this first round of the challenge, by synthesizing across forecasts, we started to elucidate what factors affect the predictive skill of near-term phenology forecasts, which future rounds will continue to investigate. © 2023, The Authors. All rights reserved.

关键词： Forecasting

来源：评论

学校读者我要写书评

暂无评论

Predicting Spring Phenology in Deciduous Broadleaf Forests: Neon Phenology Forecasting Community Challenge

SSRN

引用

SSRN 2023年

作者： Wheeler, Kathryn I. Dietze, Michael C. LeBauer, David Peters, Jody Richardson, Andrew D. Ross, Arun A. Thomas, R. Quinn Zhu, Kai Bhat, Uttam Munch, Stephan Buzbee, Raphaela Floreani Chen, Min Goldstein, Benjamin Guo, Jessica Hao, Dalei Jones, Chris Kelly-Fair, Mira Liu, Haoran Malmborg, Charlotte Neupane, Naresh Pal, Debasmita Shirey, Vaughn Song, Yiluan Steen, McKalee Vance, Eric A. Woelmer, Whitney M. Wynne, Jacob Zachmann, Luke Department of Earth and Environment Boston University 685 Commonwealth Avenue BostonMA02215 United States Cooperative Programs for the Advancement of Earth System Science University Corporation for Atmospheric Research Foothills Laboratory Bldg 4 3300 Mitchell Lane BoulderCO80301 United States National Oceanic and Atmospheric Administration Foothills Laboratory Bldg 4 3300 Mitchell Lane BoulderCO80301 United States Department of Civil and Environmental Engineering Massachusetts Institute of Technology 15 Vassar St CambridgeMA02142 United States Arizona Experiment Station University of Arizona 1230 N Cherry Ave TucsonAZ85721 United States Department of Biological Sciences University of Notre Dame 100 Galvin Notre DameIN46556 United States School of Informatics Computing and Cyber Systems Northern Arizona University 1295 Knoles Dr. FlagstaffAZ86011 United States Center for Ecosystem Science and Society Northern Arizona University PO Box 5620 FlagstaffAZ86011 United States Department of Computer Science and Engineering Michigan State University 428 South Shaw Lane East LansingMI48824 United States Department of Forest Resources and Environmental Conservation Virginia Polytechnic Instit 310 West Campus Drive BlacksburgVA24061 United States Department of Biological Sciences Virginia Tech 926 West Campus Drive BlacksburgVA24061 United States Institute for Global Change Biology University of Michigan 440 Church Street Ann ArborMI48109 United States School for Environment and Sustainability University of Michigan 440 Church Street Ann ArborMI48109 United States Institute of Marine Sciences University of California Santa Cruz 1156 High Street Santa CruzCA95060 United States Department of Applied Mathematics University of California Santa Cruz 1156 High Street Santa CruzCA95060 United States Department of Environmental Science Policy and Management University of California Berkeley 4004 Valley Life Sciences Building Universi

Accurate models are important to predict how global climate change will continue to alter plant phenology and near-term ecological forecasts can be used to iteratively improve models and evaluate predictions that are made a priori. The Ecological Forecasting Initiative’s National Ecological Observatory Network (NEON) Forecasting Challenge, is an open challenge to the community to forecast daily greenness values, measured through digital images collected by the PhenoCam Network at NEON sites before the data are collected. For the first round of the challenge, which is presented here, we forecasted canopy greenness throughout the spring at eight deciduous broadleaf sites to investigate what factors impact current predictive skill of phenology forecasts. A total of 192,536 predictions were submitted, representing eighteen models, including a persistence and a day of year mean null models. We found that overall forecast skill was highest when forecasting earlier in the greenup curve compared to the end, for shorter lead times, for sites that greened up earlier, and when submitting forecasts during times other than near budburst. The models based on day of year historical mean had the highest predictive skill across the challenge period. In this first round of the challenge, by synthesizing across forecasts, we started to elucidate what factors affect the predictive skill of near-term phenology forecasts. © 2023, The Authors. All rights reserved.

关键词： Forecasting

来源：评论

学校读者我要写书评

暂无评论

Publisher Correction: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

引用

Nature communications 2022年第1期13卷 4729页

作者： Pradipta Ghosh Gajanan D Katkar Chisato Shimizu Jihoon Kim Soni Khandelwal Adriana H Tremoulet John T Kanegaye Joseph Bocchini Soumita Das Jane C Burns Debashis Sahoo Department of Cellular and Molecular Medicine University of California San Diego San Diego USA. prghosh@ucsd.edu. Department of Medicine University of California San Diego San Diego USA. prghosh@ucsd.edu. Department of Cellular and Molecular Medicine University of California San Diego San Diego USA. Department of Pediatrics University of California San Diego San Diego USA. Rady Children's Hospital-San Diego San Diego CA USA. Department of Biomedical informatics University of California San Diego San Diego USA. Department of Computer Science and Engineering Jacob's School of Engineering University of California San Diego San Diego USA. Willis-Knighton Health System Shreveport LA USA. Department of Pathology University of California San Diego USA. Department of Pediatrics University of California San Diego San Diego USA. jcburns@health.ucsd.edu. Rady Children's Hospital-San Diego San Diego CA USA. jcburns@health.ucsd.edu. Department of Pediatrics University of California San Diego San Diego USA. dsahoo@ucsd.edu. Department of Computer Science and Engineering Jacob's School of Engineering University of California San Diego San Diego USA. dsahoo@ucsd.edu.

来源：评论

学校读者我要写书评

暂无评论

MedShapeNet - A Large-Scale Dataset of 3D Medical Shapes for computer Vision

arXiv

引用

arXiv 2023年

作者： Li, Jianning Zhou, Zongwei Yang, Jiancheng Pepe, Antonio Gsaxner, Christina Luijten, Gijs Qu, Chongyu Zhang, Tiezheng Chen, Xiaoxi Li, Wenxuan Wodzinski, Marek Friedrich, Paul Xie, Kangxian Jin, Yuan Ambigapathy, Narmada Nasca, Enrico Solak, Naida Melito, Gian Marco Vu, Viet Duc Memon, Afaque R. Schlachta, Christopher De Ribaupierre, Sandrine Patel, Rajnikant Eagleson, Roy Chen, Xiaojun Mächler, Heinrich Kirschke, Jan Stefan de la Rosa, Ezequiel Christ, Patrick Ferdinand Li, Hongwei Bran Ellis, David G. Aizenberg, Michele R. Gatidis, Sergios Küstner, Thomas Shusharina, Nadya Heller, Nicholas Andrearczyk, Vincent Depeursinge, Adrien Hatt, Mathieu Sekuboyina, Anjany Löffler, Maximilian Liebl, Hans Dorent, Reuben Vercauteren, Tom Shapey, Jonathan Kujawa, Aaron Cornelissen, Stefan Langenhuizen, Patrick Ben-Hamadou, Achraf Rekik, Ahmed Pujades, Sergi Boyer, Edmond Bolelli, Federico Grana, Costantino Lumetti, Luca Salehi, Hamidreza Ma, Jun Zhang, Yao Gharleghi, Ramtin Beier, Susann Sowmya, Arcot Garza-Villarreal, Eduardo A. Balducci, Thania Angeles-Valdez, Diego Souza, Roberto Rittner, Leticia Frayne, Richard Ji, Yuanfeng Ferrari, Vincenzo Chatterjee, Soumick Dubost, Florian Schreiber, Stefanie Mattern, Hendrik Speck, Oliver Haehn, Daniel John, Christoph Nürnberger, Andreas Pedrosa, João Ferreira, Carlos Aresta, Guilherme Cunha, António Campilho, Aurélio Suter, Yannick Garcia, Jose Lalande, Alain Vandenbossche, Vicky Van Oevelen, Aline Duquesne, Kate Mekhzoum, Hamza Vandemeulebroucke, Jef Audenaert, Emmanuel Krebs, Claudia van Leeuwen, Timo Vereecke, Evie Heidemeyer, Hauke Röhrig, Rainer Hölzle, Frank Badeli, Vahid Krieger, Kathrin Gunzer, Matthias Chen, Jianxu van Meegdenburg, Timo Dada, Amin Balzer, Miriam Fragemann, Jana Jonske, Frederic Rempe, Moritz Malorodov, Stanislav Bahnsen, Fin H. Seibold, Constantin Jaus, Alexander Marinov, Zdravko Jaeger, Paul F. Stiefelhagen, Rainer Santos, Ana Sofia Lindo, Mariana Ferreira, André Alves, Victor Kamp, Michael Abourayya, Amr Nensa, Felix Hörst, Fabian Brehmer, Alexander Hein Girardetstraße 2 Essen45131 Germany Graz University of Technology Inffeldgasse 16c Graz8010 Austria Graz Austria The Department of Computer Science Johns Hopkins University Malone Hall 3400 N Charles St BaltimoreMD21218 United States Rte Cantonale Lausanne1015 Switzerland The Department of Measurement and Electronics AGH University of Science and Technology Krakow Poland Sierre Switzerland Department of Biomedical Engineering University of Basel Hegenheimermattweg Allschwil167C CH-4123 Switzerland The Boston College 140 Commonwealth Ave Chestnut HillMA02467 United States University Hospital B7-200 339 Windermere Road LondonN6A 5A5 Canada The Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai200240 China The Research Center for Connected Healthcare Big Data ZhejiangLab Zhejiang Hangzhou311121 China The Faculty of Statistics Technical University Dortmund August-Schmidt-Straße 1 Dortmund44227 Germany The Institute of Mechanics Graz University of Technology Kopernikusgasse 24/IV Graz8010 Austria The Institute of Biomedical Manufacturing and Life Quality Engineering State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai200240 China The Department of Cardiac Surgery Medical University Graz Auenbruggerplatz 29 Graz8036 Austria The Department of Diagnostic and Interventional Radiology University Hospital Giessen Justus-Liebig-University Giessen Klinikstraße 33 Giessen35392 Germany The Department of Mechanical Engineering Mehran University of Engineering and Technology Jamshoro Sindh76062 Pakistan The Institute of Medical Robotics Shanghai Jiao Tong University Shanghai China The Geschäftsführender Oberarzt Abteilung für Interventionelle und Diagnostische Neuroradiologie Universitätsklinikum der Technischen Universität München Ismaningerstr. 22 München81675 Germany icometrix Kolonel Be

Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 datasets with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://***/ and https://***/Jianningli/*** Codes 68T01 © 2023, CC BY.

关键词： Large dataset

来源：评论

学校读者我要写书评

暂无评论

New views of old proteins: Clarifying the enigmatic proteome

arXiv

引用

arXiv 2021年

作者： Burnum-Johnson, Kristin E. Conrads, Thomas P. Drake, Richard R. Herr, Amy E. Iyengar, Ravi Kelly, Ryan T. Lundberg, Emma MacCoss, Michael J. Naba, Alexandra Nolan, Garry P. Pevzner, Pavel A. Rodland, Karin D. Sechi, Salvatore Slavov, Nikolai Spraggins, Jeffrey M. van Eyk, Jennifer E. Vidal, Marc Vogel, Christine Walt, David R. Kelleher, Neil L. The Environmental Molecular Sciences Laboratory Pacific Northwest National Laboratory RichlandWA United States Inova Women's Service Line Inova Health System Falls ChurchVA United States Cell and Molecular Pharmacology and Experimental Therapeutics Medical University of South Carolina CharlestonSC United States Department of Bioengineering University of California BerkeleyCA United States Department of Pharmacology and Systems Therapeutics Icahn School of Medicine at Mount Sinai New YorkNY United States Department of Chemistry and Biochemistry Brigham Young University ProvoUT United States Science for Life Laboratory KTH Royal Institute of Technology Stockholm Sweden Department of Genome Sciences University of Washington SeattleWA United States Department of Physiology and Biophysics University of Illinois at Chicago ChicagoIL United States Dept of Pathology Stanford University StanfordCA United States Department of Computer Science and Engineering University of California at San Diego San DiegoCA United States Biological Sciences Division Pacific Northwest National Laboratory RichlandWA United States National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health BethesdaMD United States Department of Bioengineering Northeastern University BostonMA United States Department of Chemistry Vanderbilt University NashvilleTN United States Advanced Clinical Biosystems Institute The Department of Biomedical Sciences Cedars-Sinai Medical Center Los AngelesCA United States Department of Genetics Harvard University CambridgeMA United States New York University Center for Genomics and Systems Biology New York University New YorkNY United States Department of Pathology Harvard Medical School Brigham and Women's Hospital Wyss Institute at Harvard University BostonMA United States Department of Chemistry Northwestern University EvanstonIL United States

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we offer potential futures for a next generation of disruptive approaches to define, quantify and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade. © 2021, CC0.

关键词： Proteins

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to "Constructing transferable and interpretable machine learning models for black carbon concentrations" [Environ. Int. 184 (2024) 108449]

引用

Environment international 2024年 185卷 108561页

作者： Pak Lun Fung Marjan Savadkoohi Martha Arbayani Zaidan Jarkko V Niemi Hilkka Timonen Marco Pandolfi Andrés Alastuey Xavier Querol Tareq Hussein Tuukka Petäjä Institute for Atmospheric and Earth System Research/Physics Faculty of Science University of Helsinki Helsinki FI-00560 Finland Helsinki Institute of Sustainability Science Faculty of Science University of Helsinki Helsinki FI-00560 Finland. Electronic address: pak.fung@helsinki.fi. Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain Department of Mining Industrial and ICT Engineering (EMIT) Manresa School of Engineering (EPSEM) Universitat Politècnica de Catalunya (UPC) Manresa 08242 Spain. Electronic address: marjan.savadkoohi@idaea.csic.es. Helsinki Institute of Sustainability Science Faculty of Science University of Helsinki Helsinki FI-00560 Finland Department of Computer Science Faculty of Science University of Helsinki Helsinki FI-00560 Finland. Electronic address: martha.zaidan@helsinki.fi. Helsinki Region Environmental Services Authority (HSY) Helsinki FI-00066 Finland. Electronic address: jarkko.niemi@hsy.fi. Atmospheric Composition Research Finnish Meteorological Institute Helsinki FI-00560 Finland. Electronic address: hilkka.timonen@fmi.fi. Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain. Electronic address: marco.pandolfi@idaea.csic.es. Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain. Electronic address: andres.alastuey@idaea.csic.es. Institute of Environmental Assessment and Water Research (IDAEA-CSIC) Barcelona Spain. Electronic address: xavier.querol@idaea.csic.es. Environmental and Atmospheric Research Laboratory (EARL) Department of Physics School of Science University of Jordan Amman 11942 Jordan. Electronic address: tareq.hussein@helsinki.fi. Institute for Atmospheric and Earth System Research/Physics Faculty of Science University of Helsinki Helsinki FI-00560 Finland. Electronic address: tuukka.petaja@helsinki.fi.

来源：评论

学校读者我要写书评

暂无评论

Mental health care needs of caregivers of people with Alzheimer's disease from online forum analysis

Npj mental health research

引用

Npj mental health research 2024年第1期3卷 54页

作者： Jiyeong Kim Zhuo Ran Cai Michael L Chen Shawheen J Rezaei Sonia Onyeka Carolyn I Rodriguez Tina Hernandez-Boussard Vladimir Filkov Rachel A Whitmer Eleni Linos Yong K Choi Department of Medicine Stanford Center for Digital Health Stanford University Stanford CA USA. jykim3@stanford.edu. Department of Dermatology School of Medicine Stanford University Stanford CA USA. jykim3@stanford.edu. Department of Medicine Stanford Center for Digital Health Stanford University Stanford CA USA. Department of Dermatology School of Medicine Stanford University Stanford CA USA. Department of Psychiatry and Behavioral Sciences School of Medicine Stanford University Stanford CA USA. Veterans Affairs Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Biomedical Informatics Stanford University Stanford CA USA. Department of Computer Science College of Engineering University of California Davis Davis CA USA. Department of Public Health Sciences School of Medicine University of California Davis Davis CA USA. Department of Health Information Management School of Health and Rehabilitation Sciences University of Pittsburgh Pittsburgh PA USA.

Informal caregivers of people with Alzheimer's disease and related dementias (ADRD) are at risk of poor mental health. This study aimed to investigate the feasibility and validity of studying caregivers' mental stressors using online caregiving forum data (March 2018-February 2022) and natural language processing and machine learning (NLP/ML). NLP/ML topic modeling generated eight prominent topics, which we compared with qualitatively defined themes and the existing caregiving framework to assess validity. Among a total of 60,182 posts, 5848 were mental distress-related; for the ADRD patients (symptoms, medication, relocation, care duty share, diagnosis, conversation strategy) and the caregivers (caregiving burden and support). While we observed novel topics from NLP/ML-defined topics, mostly those were aligned with the existing framework. For feasibility assessment, qualitative title screening was done. The findings shed new light on the potential of NLP/ML text analysis of the online forum for informal caregivers to prepare tailored support for this vulnerable population.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

引用

The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：