Based on the present situation of running of the belt on coal mine, researched and developed the adaptive control system of the ground belt of Wangzhuang coal mine, this system can basis on the dynamic load, then pred...
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The mathematical model of Three-phase Voltage Pulse Width Modulation (PWM) DC/AC inverter is non-linear, in view of the traditional linear control strategy can not meet the requirements of designing high-performance D...
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Somatic Copy Number Alterations (CNAs) are quite common in human cancers. Identifying CNAs and Significant Copy number Aberrations (SCAs) in cancer genomes is a critical task in searching for cancer-associated genes. ...
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ISBN:
(纸本)9781467352345
Somatic Copy Number Alterations (CNAs) are quite common in human cancers. Identifying CNAs and Significant Copy number Aberrations (SCAs) in cancer genomes is a critical task in searching for cancer-associated genes. The advanced genomic technologies, such as SNP array technology, facilitate copy number study at a genome-wide scale with high resolution. However, in reality, due to normal tissue contamination, the observed intensity signals are actually the mixture of copy number signals contributed from both tumor cells and normal cells. This genetic heterogeneity could significantly affect the subsequent copy number analysis and SCAs detection. In order to accurately identify significant aberrations in contaminated cancer genome, we devise an approach including two major steps. We first use a statistical method, Bayesian Analysis of Copy number Mixtures (BACOM) to estimate the normal tissue contamination fraction and recover the “true” copy number profile. Then, based on the recovered profiles, we detect SCAs using Genome-wide Identification of Significant Aberrations in Cancer Genome (SAIC). We comprehensively evaluate the performance of the proposed algorithm on a large number of simulation data. The results show that the algorithm has higher detection power than peer methods including the most popular GISTIC. We then apply the method to the real copy number data of Glioblastoma Multiforme and successfully identified majority of SCAs reported by GISTIC, and some novel SCAs that contain some cancer-associated genes.
A computer experiments center management system is designed based on network. Using network programming technology and database technology, the purpose of this system is convenient to manage the university's compu...
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Photovoltaic (PV) grid-connected system requires the inverter possesses excellent dynamic and static characteristics. In view of the mathematical model of the inverter is nonlinear, we will adopt a kind of nonlinear c...
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In this paper, we proposed a robust timing synchronization method for OFDM systems using an antenna array, where the effect of carrier frequency offset (CFO) was eliminated by the crossed product of the array signal v...
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This paper presents a method for the detection of arbitrary triangle based on the property that the distance of the incenter to the edges of the triangle is equidistant and equal to the radius of the inscribed circle....
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Seven layered C5N configurations constructed from hexagonal BN and graphite structures are studied using an ab initio pseudopotential density functional *** structural and electronic properties,and pressure−induced ph...
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Seven layered C5N configurations constructed from hexagonal BN and graphite structures are studied using an ab initio pseudopotential density functional *** structural and electronic properties,and pressure−induced phase transition are investigated by calculating the total energy,structural parameter,formation energy,elastic constant,band structure and electron density of *** results show that the three C5N configurations constructed from the h−BN structure are more stable energetically than those four configurations from graphite *** C5N−I configuration with the highest symmetry and the AA stacking sequence along the c−axis is the most *** structure is stable mechanically and its phase separation is *** C5N phase is expected to have a metallic character.A critical pressure of about 20 GPa is predicted for the synthesis of a monoclinic C5N phase from the layered C5N phase.
Abstract: In order to improve the speed and accuracy of traffic signs recognition (TSR), a novel method based on visual attention mechanism is present in this paper. According to this method, the potential regions of ...
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User trust cloud model and the capability trust assessment model were proposed respectively based on the user subjective trust and the capability objective trust. User trust cloud model was used to assess subjective t...
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User trust cloud model and the capability trust assessment model were proposed respectively based on the user subjective trust and the capability objective trust. User trust cloud model was used to assess subjective trust on randomness and fuzziness complex user by using expectation, entropy and hyper entropy;and user capability trust evaluation model was introduced to assess a user's objective capability trust based on interactive objects and interactive behavior properties. A comprehensive trust evaluation model was implemented by combining the proposed two models, and the experiment results show that it can be useful for user trust evaluation for education cloud-oriented electronic learning (E-learning) services.
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