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IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes

Journal of Genetics and Genomics 2024年第4期51卷 443-453页

作者： Shuyu Liang Sicheng Xu Shichong Zhou Cai Chang Zhiming Shao Yuanyuan Wang Sheng Chen Yunxia Huang Yi Guo Department of Electronic Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China The Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention(MICCAI)of Shanghai Shanghai 200032China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200433China Department of Ultrasound Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized *** present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic *** dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation *** better characterize tumor traits,12 multi-angle US images are fused using two distinct ***,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous *** radiomic and genomic features are screened using these *** addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC *** further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and *** together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.

关键词： IMAGGS Radiogenomic framework "lmage-gene-geneset"associations Molecular subtypes Breast cancer

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Optimal Logistics Activities Based Deep Learning Enabled Traffic Flow Prediction Model

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computers, Materials & Continua 2022年第12期73卷 5269-5282页

作者： Basim Aljabhan Mahmoud Ragab Sultanah M.Alshammari Abdullah S.Al-Malaise Al-Ghamdi Ports and Maritime Transportation Department Faculty of Maritime StudiesKing Abdulaziz UniversityJeddah21589Saudi Arabia Information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Mathematics Faculty of ScienceAl-Azhar UniversityNaser City11884CairoEgypt Center of Excellence in Smart Environment Research King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Information Systems Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia S 7Information Systems Department HECI SchoolDar Alhekma UniversityJeddahSaudi Arabia

Traffic flow prediction becomes an essential process for intelligent transportation systems(ITS).Though traffic sensor devices are manually controllable,traffic flow data with distinct length,uneven sampling,and missing data finds challenging for effective *** traffic data has been considerably increased in recent times which cannot be handled by traditional mathematical *** recent developments of statistic and deep learning(DL)models pave a way for the effectual design of traffic flow prediction(TFP)*** this view,this study designs optimal attentionbased deep learning with statistical analysis for TFP(OADLSA-TFP)*** presentedOADLSA-TFP model intends to effectually forecast the level of traffic in the *** attain this,the OADLSA-TFP model employs attention-based bidirectional long short-term memory(ABLSTM)model for predicting traffic *** order to enhance the performance of the ABLSTM model,the hyperparameter optimization process is performed using artificial fish swarm algorithm(AFSA).A wide-ranging experimental analysis is carried out on benchmark dataset and the obtained values reported the enhancements of the OADLSA-TFP model over the recent approaches mean square error(MSE),root mean square error(RMSE),and mean absolute percentage error(MAPE)of 120.342%,10.970%,and 8.146%respectively.

关键词： Traffic flow prediction deep learning artificial fish swarm algorithm mass gatherings statistical analysis logistics

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FAST: a dual-tier few-shot learning paradigm for whole slide image classification 24

FAST: a dual-tier few-shot learning paradigm for whole slide...

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Proceedings of the 38th International Conference on Neural Information Processing Systems

作者： Kexue Fu Xiaoyuan Luo Linhao Qu Shuo Wang Ying Xiong Ilias Maglogiannis Longxiang Gao Manning Wang Key Laboratory of Computing Power Network and Information Security Ministry of Education Shandong Computer Science Center (National Supercomputer Center in Jinan) Qilu University of Technology (Shandong Academy of Sciences) Jinan China and Shandong Provincial Key Laboratory of Computing Power Internet and Service Computing Shandong Fundamental Research Center for Computer Science Jinan China Digital Medical Research Center School of Basic Medical Sciences Fudan University and Shanghai Key Lab of Medical Image Computing and Computer Assisted Intervention Fudan University University of Piraeus

ISBN: (纸本)9798331314385

The expensive fine-grained annotation and data scarcity have become the primary obstacles for the widespread adoption of deep learning-based Whole Slide Images (WSI) classification algorithms in clinical practice. Unlike few-shot learning methods in natural images that can leverage the labels of each image, existing few-shot WSI classification methods only utilize a small number of fine-grained labels or weakly supervised slide labels for training in order to avoid expensive fine-grained annotation. They lack sufficient mining of available WSIs, severely limiting WSI classification performance. To address the above issues, we propose a novel and efficient dual-tier few-shot learning paradigm for WSI classification, named FAST. FAST consists of a dual-level annotation strategy and a dual-branch classification framework. Firstly, to avoid expensive fine-grained annotation, we collect a very small number of WSIs at the slide level, and annotate an extremely small number of patches. Then, to fully mining the available WSIs, we use all the patches and available patch labels to build a cache branch, which utilizes the labeled patches to learn the labels of unlabeled patches and through knowledge retrieval for patch classification. In addition to the cache branch, we also construct a prior branch that includes learnable prompt vectors, using the text encoder of visual-language models for patch classification. Finally, we integrate the results from both branches to achieve WSI classification. Extensive experiments on binary and multi-class datasets demonstrate that our proposed method significantly surpasses existing few-shot classification methods and approaches the accuracy of fully supervised methods with only 0.22% annotation costs. All codes and models will be publicly available on https://***/fukexue/FAST.

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Digital Human Techniques for Education Reform 24

Digital Human Techniques for Education Reform

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7th International Conference on Educational technology Management, ICETM 2024

作者： Guo, Peirong Zhang, Qi Tian, Chunwei Xue, Wanli Feng, Xiaocheng School of Software Northwestern Polytechnical University Shaanxi Xi’an China School of Economics and Management Harbin Institute of Technology at Weihai Shandong Weihai China Shenzhen Research Institute of Northwestern Polytechnical University Northwestern Polytechnical University Guangdong Shenzhen China School of Computer Science and Engineering Tianjin University of Technology Tianjin China Research Center for Social Computing and Information Retrieval Harbin Institute of Technology Heilongjiang Harbin China Guangdong Key Laboratory of Intelligent Information Processing Shenzhen Key Laboratory of Media Security Shenzhen University Guangdong Shenzhen China

ISBN: (纸本)9798400717468

The rapid evolution of artificial intelligence, big data, and generative AI models has ushered in significant transformations across various sectors, including education. Digital Human Technique, an innovative technology grounded in advanced computer science and artificial intelligence, is reshaping educational paradigms by enabling virtual humans to simulate human behavior, express emotions, and interact with users. This paper explores the application of Digital Human Technique in education reform, focusing on creating immersive, intelligent classroom experiences that foster meaningful interactions between teachers and students. We define Digital Human Technique and delve into its key technical components such as character modeling and rendering, natural language processing, computer vision, and augmented reality technologies. Our methodology involves analyzing the role of educational digital humans created through these technologies, assessing their impact on educational processes, and examining various application scenarios in educational reform. Results indicate that Digital Human Technique significantly enhances the learning experience by enabling personalized teaching, increasing engagement, and fostering emotional connections. Educational digital humans serve as virtual teachers, interactive learning aids, and facilitators of emotional interaction, effectively addressing the challenges of traditional educational methods. They also promote a deeper understanding of complex concepts through simulated environments and interactive digital content. © 2024 Copyright held by the owner/author(s).

关键词： Digital elevation model

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MAPS: A Noise-Robust Progressive Learning Approach for Source-Free Domain Adaptive Keypoint Detection

arXiv

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arXiv 2023年

作者： Ding, Yuhe Liang, Jian Jiang, Bo Zheng, Aihua He, Ran The School of Computer Science and Technology Anhui University China The School of Artificial Intelligence Anhui University China The Center for Research on Intelligent Perception and Computing CASIA China

Existing cross-domain keypoint detection methods always require accessing the source data during adaptation, which may violate the data privacy law and pose serious security concerns. Instead, this paper considers a realistic problem setting called source-free domain adaptive keypoint detection, where only the well-trained source model is provided to the target domain. For the challenging problem, we first construct a teacher-student learning baseline by stabilizing the predictions under data augmentation and network ensembles. Built on this, we further propose a unified approach, Mixup Augmentation and Progressive Selection (MAPS), to fully exploit the noisy pseudo labels of unlabeled target data during training. On the one hand, MAPS regularizes the model to favor simple linear behavior in-between the target samples via self-mixup augmentation, preventing the model from over-fitting to noisy predictions. On the other hand, MAPS employs the self-paced learning paradigm and progressively selects pseudo-labeled samples from ‘easy’ to ‘hard’ into the training process to reduce noise accumulation. Results on four keypoint detection datasets show that MAPS outperforms the baseline and achieves comparable or even better results in comparison to previous non-source-free counterparts. The code will be released at https://***/YuheD/MAPS. Copyright © 2023, The Authors. All rights reserved.

关键词： Data privacy

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A Heuristic-based Dynamic Scheduling and Routing Method for Industrial TSN Networks

A Heuristic-based Dynamic Scheduling and Routing Method for ...

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IEEE International Conference on Cyber Security and Cloud computing (CSCloud)

作者： Honglong Chen Mindong Liu Jing Huang Zhiling Zheng Weihong Huang Yufeng Xiao School of Computer Science and Engineering Hunan University of Science and Technology Hunan Key Laboratory for Service Computing and Novel Software Technology Xiangtan China Information Center Hunan Industry Polytechnic Changsha China

In the industrial environment, machines often need to reflect the anomaly detection results to the total control center in time, and the general industrial network can not achieve high real-time. In order to solve such challenges, a set of protocol standards developed by IEEE802.1 working group, namely Time-sensitive Networking (TSN), has been introduced into industrial networks. TSN can provide high real-time and reliability for data transmission, where the reliability is achieved by Frame duplication and Frame Elimination (FRER). In the realization process of FRER, it is necessary to determine the source node, destination node, and multiple disjoint paths to transmit redundant data. However, the transmission of these redundant traffic may result in the delay of other flows, and then affects the user experience. Therefore, it is very important to choose excellent redundant traffic paths to ensure reliability and reduce the impact on other flows. In the existing research, there are many dynamic scheduling and routing heuristics to determine the path, but they do not consider the influence of the location of the source node on the whole route scheduling. This paper proposes an improved dynamic scheduling and routing heuristic method, which takes the source node into account in the routing selection. In the flow test experiments of different magnitudes, it is found that the total delay of all flows is reduced by 1.4%-4.5% under the same magnitude of schedulability compared with Ant Colony Optimization.

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HiCoCS: High Concurrency Cross-Sharding on Permissioned Blockchains

arXiv

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arXiv 2025年

作者： Yang, Lingxiao Dong, Xuewen Wan, Zhiguo Lu, Di Zhang, Yushu Shen, Yulong School of Computer Science and Technology Xidian University Engineering Research Center of Blockchain Technology Application and Evaluation Ministry of Education Shaanxi Key Laboratory of Blockchain and Secure Computing Xi’an710071 China Zhejiang Lab Zhejiang Hangzhou311121 China School of Computer Science and Technology Xidian University Shaanxi Key Laboratory of Network and System Security Xi’an710071 China College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Jiangsu Nanjing210016 China

As the foundation of the Web3 trust system, blockchain technology faces increasing demands for scalability. Sharding emerges as a promising solution, but it struggles to handle highly concurrent cross-shard transactions (CSTxs), primarily due to simultaneous ledger operations on the same account. Hyperledger Fabric, a permissioned blockchain, employs multi-version concurrency control for parallel processing. Existing solutions use channels and intermediaries to achieve cross-sharding in Hyperledger Fabric. However, the conflict problem caused by highly concurrent CSTxs has not been adequately resolved. To fill this gap, we propose HiCoCS, a high concurrency cross-shard scheme for permissioned blockchains. HiCoCS creates a unique virtual sub-broker for each CSTx by introducing a composite key structure, enabling conflict-free concurrent transaction processing while reducing resource overhead. The challenge lies in managing large numbers of composite keys and mitigating intermediary privacy risks. HiCoCS utilizes virtual sub-brokers to receive and process CSTxs concurrently while maintaining a transaction pool. Batch processing is employed to merge multiple CSTxs in the pool, improving efficiency. We explore composite key reuse to reduce the number of virtual sub-brokers and lower system overhead. Privacy preservation is enhanced using homomorphic encryption. Evaluations show that HiCoCS improves cross-shard transaction throughput by 3.5-20.2 times compared to the baselines. Copyright © 2025, The Authors. All rights reserved.

关键词： Concurrency control

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Robin: A Novel Method to Produce Robust Interpreters for Deep Learning-Based Code Classifiers

arXiv

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arXiv 2023年

作者： Li, Zhen Zhang, Ruqian Zou, Deqing Wang, Ning Li, Yating Xu, Shouhuai Chen, Chen Jin, Hai National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Hubei Key Laboratory of Distributed System Security Hubei Engineering Research Center on Big Data Security Cluster and Grid Computing Lab China School of Cyber Science and Engineering Huazhong University of Science and Technology Wuhan430074 China Department of Computer Science University of Colorado Colorado Springs United States Center for Research in Computer Vision University of Central Florida United States School of Computer Science and Technology Huazhong University of Science and Technology Wuhan430074 China

Deep learning has been widely used in source code classification tasks, such as code classification according to their functionalities, code authorship attribution, and vulnerability detection. Unfortunately, the black-box nature of deep learning makes it hard to interpret and understand why a classifier (i.e., classification model) makes a particular prediction on a given example. This lack of interpretability (or explainability) might have hindered their adoption by practitioners because it is not clear when they should or should not trust a classifier's prediction. The lack of interpretability has motivated a number of studies in recent years. However, existing methods are neither robust nor able to cope with out-of-distribution examples. In this paper, we propose a novel method to produce Robust interpreters for a given deep learning-based code classifier;the method is dubbed Robin. The key idea behind Robin is a novel hybrid structure combining an interpreter and two approximators, while leveraging the ideas of adversarial training and data augmentation. Experimental results show that on average the interpreter produced by Robin achieves a 6.11% higher fidelity (evaluated on the classifier), 67.22% higher fidelity (evaluated on the approximator), and 15.87x higher robustness than that of the three existing interpreters we evaluated. Moreover, the interpreter is 47.31% less affected by out-of-distribution examples than that of LEMNA. Copyright © 2023, The Authors. All rights reserved.

关键词： Deep learning

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Securing Consumer IoT Swarms Using Graph Transformers and SRAM for Firmware Attestation

Securing Consumer IoT Swarms Using Graph Transformers and SR...

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Consumer Communications and Networking Conference, CCNC IEEE

作者： Varun Kohli Bhavya Kohli Muhammad Naveed Aman Biplab Sikdar Department of Electrical and Computer Engineering National University of Singapore Singapore Center for Machine Intelligence and Data Science Indian Institute of Technology Bombay India School of Computing University of Nebraska-Lincoln USA

ISBN: (数字)9798331508050

ISBN: (纸本)9798331508067

Consumer Internet of Things (IoT) networks have gained widespread popularity due to their convenience, automation, and security provisions in personal and home environments. Ubiquitous resource-constrained devices, however, are plagued with security issues that often arise from firmware-related issues and their propagated effects. While various studies on firmware attestation are available, they require firmware copies, specific hardware, and complex computation on the IoT device. This paper presents a study on the application of Graph Transformer Networks (GTN) in verifying the firmware integrity of consumer IoT swarms using SRAM as an attestation feature. The proposed method achieves an overall 0.99 accuracy on authentic samples from development and physical twin networks, 0.99 on malware, and 0.97 on propagated misbehavior at a $\sim 10^{-4}$ second inference latency on a laptop CPU.

关键词： Portable computers Accuracy Random access memory Transformers Malware Graph neural networks Hardware Internet of Things Security Microprogramming

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CAMG: Context-Aware Moment Graph Network for Multimodal Temporal Activity Localization via Language 12th

CAMG: Context-Aware Moment Graph Network for Multimodal Tem...

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12th National CCF Conference on Natural Language Processing and Chinese computing, NLPCC 2023

作者： Hu, Yuelin Xu, Yuanwu Zhang, Yuejie Feng, Rui Zhang, Tao Lu, Xuequan Gao, Shang School of Computer Science Shanghai Key Laboratory of Intelligent Information Processing Shanghai Collaborative Innovation Center of Intelligent Visual Computing Fudan University Shanghai200433 China School of Information Management and Engineering Shanghai Key Laboratory of Financial Information Technology Shanghai University of Finance and Economics Shanghai200433 China School of Information Technology Deakin University Waurn PondsVIC3216 Australia

ISBN: (纸本)9783031446924

Temporal Activity Localization via Language (TALL) is a challenging task for language based video understanding, especially when a video contains multiple moments of interest and the language query has words describing complex context dependencies between the moments. Latest studies have proposed various ways to exploit the temporal context of adjacent moments, but two apparent limitations remained. First, only limited context information was encoded based on RNNs or 2-D convolutions, which highly depended on the pre-sorting of proposals and lacked flexibility. Second, semantically correlated content in different moments was ignored, i.e., semantic context. To address these limitations, we propose a novel GCN-based framework, i.e., Context-Aware Moment Graph (CAMG) network, to jointly model the temporal context and semantic context. Also, we design a multi-step fusion scheme to aggregate object, motion and textual features. A Query-Gated Integration Module is further designed to select queried objects and filter out noisy ones. Our model achieves superior performance to state-of-the-art methods on two widely-used benchmark datasets. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Semantics

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