Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and t...
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Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.
With the rapid advancement of 5G technology,the Internet of Things(IoT)has entered a new phase of appli-cations and is rapidly becoming a significant force in promoting economic *** to the vast amounts of data created...
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With the rapid advancement of 5G technology,the Internet of Things(IoT)has entered a new phase of appli-cations and is rapidly becoming a significant force in promoting economic *** to the vast amounts of data created by numerous 5G IoT devices,the Ethereum platform has become a tool for the storage and sharing of IoT device data,thanks to its open and tamper-resistant ***,Ethereum account security is necessary for the Internet of Things to grow quickly and improve people's *** modeling Ethereum trans-action records as a transaction network,the account types are well identified by the Ethereum account classifi-cation system established based on Graph Neural Networks(GNNs).This work first investigates the Ethereum transaction ***,experimental metrics reveal that the Ethereum transaction network is neither optimal nor even satisfactory in terms of accurately representing transactions per *** flaw may significantly impede the classification capability of GNNs,which is mostly governed by their *** work proposes an Adaptive Multi-channel Bayesian Graph Attention Network(AMBGAT)for Ethereum account clas-sification to address this *** uses attention to enhance node features,estimate graph topology that conforms to the ground truth,and efficiently extract node features pertinent to downstream *** extensive experiment with actual Ethereum transaction data demonstrates that AMBGAT obtains competitive performance in the classification of Ethereum accounts while accurately estimating the graph topology.
The importance of Model Predictive control(MPC)has significant applications in the agricultural industry,more specifically for greenhouse’s control ***,the complexity of the greenhouse and its limited prior knowledge...
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The importance of Model Predictive control(MPC)has significant applications in the agricultural industry,more specifically for greenhouse’s control ***,the complexity of the greenhouse and its limited prior knowledge prevent an exact mathematical description of the *** methods provide a promising solution to this issue through their capacity to identify the system’s comportment using the fit between model output and observed *** this paper,we introduce an application of Constrained Model Predictive control(CMPC)for a greenhouse temperature and relative *** this purpose,two Multi Input Single Output(MISO)systems,using Numerical Subspace State Space System Identification(N4SID)algorithm,are firstly suggested to identify the temperature and the relative humidity comportment to heating and ventilation *** this sense,linear state space models were adopted in order to evaluate the robustness of the control *** the system is identified,the MPC technique is applied for the temperature and the humidity *** results show that the regulation of the temperature and the relative humidity under constraints was guaranteed,both parameters respect the ranges 15℃≤T_(int)≤30℃and 50%≤H_(int)≤70%*** the other hand,the control signals uf and uh applied to the fan and the heater,respect the hard constraints notion,the control signals for the fan and the heater did not exceed 0≤uf≤4.3 Volts and 0≤uh≤5 Volts,respectively,which proves the effectiveness of the MPC and the tracking ***,we show that with the proposed technique,using a new optimization toolbox,the computational complexity has been significantly *** greenhouse in question is devoted to Schefflera Arboricola cultivation.
Construction is the pillar industry of Chinese national economy, but the profit rate has continued to decline in recent years. The conventional job-centric construction information system cannot meet the requirements ...
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Recently,the physics-informed neural network shows remarkable ability in the context of solving the low-dimensional nonlinear partial differential ***,for some cases of high-dimensional systems,such technique may be t...
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Recently,the physics-informed neural network shows remarkable ability in the context of solving the low-dimensional nonlinear partial differential ***,for some cases of high-dimensional systems,such technique may be time-consuming and *** this paper,the authors put forward a pre-training physics-informed neural network with mixed sampling(pPINN)to address these *** based on the initial and boundary conditions,the authors design the pre-training stage to filter out the set of the misfitting points,which is regarded as part of the training points in the next *** authors further take the parameters of the neural network in Stage 1 as the initialization in Stage *** advantage of the proposed approach is that it takes less time to transfer the valuable information from the first stage to the second one to improve the calculation accuracy,especially for the high-dimensional *** verify the performance of the pPINN algorithm,the authors first focus on the growing-and-decaying mode of line rogue wave in the Davey-Stewartson I *** case is the accelerated motion of lump in the inhomogeneous Kadomtsev-Petviashvili equation,which admits a more complex evolution than the uniform *** exact solution provides a perfect sample for data experiments,and can also be used as a reference frame to identify the performance of the *** experiments confirm that the pPINN algorithm can improve the prediction accuracy and training efficiency well,and reduce the training time to a large extent for simulating nonlinear waves of high-dimensional equations.
Quantum coherence serves as a defining characteristic of quantum mechanics,finding extensive applications in quantum computing and quantum communication *** study explores quantum block coherence in the context of pro...
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Quantum coherence serves as a defining characteristic of quantum mechanics,finding extensive applications in quantum computing and quantum communication *** study explores quantum block coherence in the context of projective measurements,focusing on the quantification of such ***,we define the correlation function between the two general projective measurements P and Q,and analyze the connection between sets of block incoherent states related to two compatible projective measurements P and ***,we discuss the measure of quantum block coherence with respect to projective *** on a given measure of quantum block coherence,we characterize the existence of maximal block coherent states through projective *** research integrates the compatibility of projective measurements with the framework of quantum block coherence,contributing to the advancement of block coherence measurement theory.
In short text classification, extracting text features is crucial. Static word vector training, the traditional method, has limitations such as insufficient semantics and sparse features, while dynamic training word v...
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Traffic sign detection (TSD) is a significant task in the field of computer vision, which has important applications in traffic safety and driverless driving. However, this fundamental but challenging task still has a...
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Although cross-domain recommendation systems play a crucial role in solving the data sparseness and cold start challenges in recommendation systems, current algorithms primarily rely on the user-item rating matrix for...
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With the advancement of industrial automation, the quality requirements for automotive engine assembly bolt tightening have become increasingly stringent, as they are directly related to engine performance and vehicle...
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