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Getting Ready for the European Health data Space (Ehds): The Iderha's Plan to Align with the Ehds Requirements for the Secondary Use of Health data

SSRN

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SSRN 2024年

作者： Hussein, Rada Balaur, Irina Burmann, Anja Ćwiek-Kupczyńska, Hanna Gadiya, Yojana Ghosh, Soumyabrata Jayathissa, Prabath Katsch, Florian Kremer, Andreas Lähteenmäki, Jaakko Meng, Zhaoling Morasek, Kathrin Rancourt, Rebecca C. Satagopam, Venkata Sauermann, Stefan Scheider, Simon Stamm, Tanja A. Muehlendyck, Christian Gribbon, Philip Ludwig Boltzmann Institute for Digital Health and Prevention Salzburg Austria Luxembourg Centre for Systems Biology University of Luxembourg Luxembourg Fraunhofer Institute for Software and Systems Engineering Dortmund Germany Discovery Research Screening Port Hamburg Germany Theodor Stern Kai 7 Frankfurt60590 Germany Bonn-Aachen International Center for Information Technology University of Bonn Bonn Germany Center for Medical Data Science Medical University of Vienna Vienna Austria ITTM S.A. Luxembourg VTT Technical Research Centre of Finland Ltd Espoo Finland Clinical Modeling and Evidence Integration Sanofi CambridgeMA United States Institute of Outcomes Research Center for Medical Data Science Medical University of Vienna Austria Ludwig Boltzmann Institute for Arthritis and Rehabilitation Vienna Austria Medical School Berlin Berlin Germany Faculty Life Science Engineering FH Technikum Wien Vienna Austria TU Dortmund Dortmund Germany Johnson & Johnson Medical GmbH Norderstedt Germany

Objective: The European Health data Space (EHDS) shapes the digital transformation of healthcare in Europe. The EHDS regulations will also accelerate the use of health data for research, innovation, policy-making, and regulatory activities for secondary use of data (known as EHDS2). The Integration of heterogeneous data and Evidence towards Regulatory and HTA Acceptance (IDERHA) project builds one of the first pan-European health data spaces in alignment with the EHDS2 requirements, addressing lung cancer as a *** and Methods: In this study, we conducted a comprehensive review of the EHDS regulations and technical requirements for EHDS2. Mainly utilizing the results of the Joint Action Towards the European Health data Space (TEHDAS) project to identify the framework of IDERHA’s alignment with EHDS. We also conducted an internal webinar and an external workshop with EHDS experts to share expertise on the EHDS requirements and ***: We identified the minimum-set of requirements for aligning IDERHA infrastructure with the planned EHDS regulations, including user journey, concepts, terminologies, and standards. The future IDERHA framework (i.e., platform architecture, standardization approaches, documentation, etc.) will be developed ***: The IDERHA's alignment plan with EHDS2 necessitates the implementation of three categories of standardization for: data discoverability (DCAT-AP), enabling semantics interoperability (OMOP), and health data exchange (DICOM and FHIR). The main challenge is that some standards are still being refined, e.g., the extension of the DCAT-AP (HealthDCAT-AP). Additionally, extensions to the OHDSI OMOP CMD for representing the Patient-Generated Health data are still needed. Finally, proper mapping between standards (FHIR/OMOP) is a prerequisite for proper data ***: Collaboration, sharing lessons learned, and creating synergy among the current EHDS initiatives and projects are critical

关键词： Electronic data interchange

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Vacancy-Type Defects in Thin HfO2 Layers Probed by Monoenergetic Positron Beams

Vacancy-Type Defects in Thin HfO2 Layers Probed by Monoenerg...

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Joint e-Manufacturing and Design Collaboration Symposium (eMDC) & International Symposium on Semiconductor Manufacturing (ISSM)

作者： Akira Uedono Kazuya Kawakami Tatsunori Kuribara Ryu Hasunuma Yosuke Harashima Yasuteru Shigeta Zeyuan Ni Ruolin Yan Hideo Nakamura Akira Notake Tsuyoshi Moriya Koji Michishio Shoji Ishibashi Faculty of Pure and Applied Science University of Tsukuba Tsukuba Ibaraki Japan Graduate School of Science and Technology Nara Institute of Science and Technology Ikoma Nara Japan S-Technology Development Center Tokyo Electron Technology Solutions Ltd. Nirasaki Yamanashi Japan Development Department 1 Tokyo Electron Technology Solutions Ltd. Nirasaki Yamanashi Japan Digital Design Center Tokyo Electron Ltd. Sapporo Hokkaido Japan Software and Data Engineering Division Tokyo Electron Technology Solutions Ltd. Nirasaki Yamanashi Japan Research Institute for Measurement and Analytical Instrumentation National Institute of Advanced Industrial Science and Technology Tsukuba Ibaraki Japan Research Center for Computational Design of Advanced Functional Materials National Institute of Advanced Industrial Science and Technology Tsukuba Ibaraki Japan

ISBN: (数字)9798331510589

ISBN: (纸本)9798331510596

Behaviors of vacancies during the amorphous-to-crystalline transition of thin HfO 2 layers were studied by monoenergetic positron beams. The HfO 2 layers with 4‒30 nm thickness were fabricated on TiN/Si templates by atomic layer deposition technique. The major vacancy-type defects in the layers were identified as (i) Hf vacancies (V Hf ) coupled with oxygen vacancies (V O s) and (ii) vacancy clusters. After annealing at 500°C, the concentration of vacancy clusters increased, which was attributed to the agglomeration of intrinsic open spaces in the amorphous phase upon the phase transition from amorphous to crystalline phases. The phase transition started near the interface between the HfO 2 layer and bottom electrodes (TiN). After the crystallization, the concentration of vacancy clusters decreased as the annealing temperature increased.

关键词： Electrodes Annealing Atomic layer deposition Positrons Crystallization Tin Semiconductor device manufacture Hafnium compounds

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A mobile cloud-based ehealth scheme

arXiv

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arXiv 2020年

作者： Liu, Yihe Abbasi, Aaqif Afzaal Aghaei, Atefeh Abbasi, Almas Mosavi, Amir Shamshirband, Shahab Al-qaness, Mohammed A.A. Data Recovery Key Laboratory of Sichuan Province College of Computer Science and AI Neijiang Normal University Neijiang641100 China Department of Software Engineering Foundation University Islamabad44000 Pakistan Department of Communication Faculty of Social Sciences University of Tehran Tehran*** Iran Department of Computer Science International Islamic University Islamabad46000 Pakistan Institute of Research and Development Duy Tan University Da Nang550000 Viet Nam Kalman Kando Faculty of Electrical Engineering Obuda University Budapest1034 Hungary School of the Built Environment Oxford Brookes University OxfordOX3 0BP United Kingdom Department for Management of Science and Technology Development Ton Duc Thang University Ho Chi Minh City Viet Nam Faculty of Information Technology Ton Duc Thang University Ho Chi Minh City Viet Nam School of Computer Science Wuhan University Wuhan430072 China

Mobile cloud computing is an emerging field that is gaining popularity across borders at a rapid pace. Similarly, the field of health informatics is also considered as an extremely important field. This work observes the collaboration between these two fields to solve the traditional problem of extracting Electrocardiogram signals from trace reports and then performing analysis. The developed system has two front ends, the first dedicated for the user to perform the photographing of the trace report. Once the photographing is complete, mobile computing is used to extract the signal. Once the signal is extracted, it is uploaded into the server and further analysis is performed on the signal in the cloud. Once this is done, the second interface, intended for the use of the physician, can download and view the trace from the cloud. The data is securely held using a password-based authentication method. The system presented here is one of the first attempts at delivering the total solution, and after further upgrades, it will be possible to deploy the system in a commercial *** Codes 68T05 Copyright © 2020, The Authors. All rights reserved.

关键词： Signal analysis

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Robust frequent directions with application in online learning

The Journal of Machine Learning Research

引用

The Journal of Machine Learning Research 2019年第1期20卷

作者： Luo Luo Cheng Chen Zhihua Zhang Wu-Jun Li Tong Zhang Department of Computer Science and Engineering Shanghai Jiao Tong University Shanghai China National Engineering Lab for Big Data Analysis and Applications School of Mathematical Sciences Peking University Beijing China National Key Laboratory for Novel Software Technology Collaborative Innovation Center of Novel Software Technology and Industrialization Department of Computer Science and Technology Nanjing University Nanjing China Computer Science & Mathematics Hong Kong University of Science and Technology Hong Kong

The frequent directions (FD) technique is a deterministic approach for online sketching that has many applications in machine learning. The conventional FD is a heuristic procedure that often outputs rank deficient matrices. To overcome the rank deficiency problem, we propose a new sketching strategy called robust frequent directions (RFD) by introducing a regularization term. RFD can be derived from an optimization problem. It updates the sketch matrix and the regularization term adaptively and jointly. RFD reduces the approximation error of FD without increasing the computational cost. We also apply RFD to online learning and propose an effective hyperparameter-free online Newton algorithm. We derive a regret bound for our online Newton algorithm based on RFD, which guarantees the robustness of the algorithm. The experimental studies demonstrate that the proposed method outperforms state-of-the-art second order online learning algorithms.

关键词： frequent directions matrix approximation online Newton algorithm online convex optimization sketching

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Application of Improved Mask R-CNN Algorithm Based on Gastroscopic Image in Detection of Early Gastric Cancer

Application of Improved Mask R-CNN Algorithm Based on Gastro...

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IEEE Annual International Computer software and Applications Conference (COMPSAC)

作者： Zhi-Heng Cui Qin-Yan Zhang Jing-Wei Zhang Xue Sun Qing Wang Yi Lei Lin Zang Li Zhao Ji-Jiang Yang School of Modern Posts Beijing University of Posts and Telecommunications Beijing China VIP Department and Family Medicine Department Chinese Academy of Medical Sciences Beijing Hospital Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Beijing China Department of Automation Tsinghua University Beijing China Faculty of Information Technology School of Software Engineering Beijing University of Technology Beijing China Pharmacovigilance Research Center for information technology and Data Science Cross-strait Tsinghua Research Institute Xiamen China Department of Gastroenterology Beijing Hospital National Center of Gerontology Chinese Academy of Medical Sciences Beijing Hospital Institute of Geriatric Medicine Beijing China

ISBN: (数字)9781665488105

ISBN: (纸本)9781665488112

Gastroscopy is an important step in the diagnosis of early gastric cancer. However, because the morphological manifestations of early gastric cancer are not obvious, endoscopists need long-term specialized training and experience accumulation to correctly identify early cancer through magnification gastroscopy. In this paper, the data set of gastroscopy image is collected and enhanced, and target detection method is combined with gastroscopy image. The Mask R-CNN+BiFPN model was proposed to enhance the feature fusion and improve the detection effect of early gastric cancer lesions. Compared with Mask R-CNN, the improved Mask R-CNN model has better performance, with the sensitivity and specificity of 91.67% and 88.95% in accurately labeled gastroscopic datasets, respectively, showing a good segmentation effect for surface swelling lesions.

关键词： Training Image segmentation software algorithms Surface morphology Object detection Sensitivity and specificity Feature extraction

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A Brief Review of Explainable Artificial Intelligence in Healthcare

SSRN

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SSRN 2023年

作者： Sadeghi, Zahra Alizadehsani, Roohallah Cifci, Mehmet Akif Kausar, Samina Rehman, Rizwan Mahanta, Priyakshi Bora, Pranjal Kumar Almasri, Ammar Alkhawaldeh, Rami S. Hussain, Sadiq Alatas, Bilal Shoeibi, Afshin Moosaei, Hossein Hladík, Milan Nahavandi, Saeid Pardalo, Panos M. Institute for Big Data Analytics Faculty of Computer Science Dalhousie University Canada Deakin University Geelong Australia The Institute of Computer Technology Tu Wien University Vienna1040 Austria University of Kotli Azad Jammu and Kashmir Azad Kashmir Kotli Pakistan Centre for Computer Science and Applications Dibrugarh University Assam India Department of Management Information Sys Al-Balqa Applied University Salt19117 Jordan Department of Computer Information Systems The University of Jordan Aqaba77110 Jordan Examination Branch Dibrugarh University Assam Dibrugarh India Department of Software Eng. Firat University Elazig23100 Turkey Data Science and Computational Intelligence Institute University of Granada Spain Department of Informatics Faculty of Science Jan Evangelista Purkyně University in Ústí nad Labem Czech Republic Department of Applied Mathematics School of Computer Science Faculty of Mathematics and Physics Charles University Prague Czech Republic Harvard Paulson School of Engineering and Applied Sciences Harvard University AllstonMA02134 United States Swinburne University of Technology HawthornVIC3122 Australia Center for Applied Optimization Department of Industrial and Systems Engineering University of Florida Gainesville32611 United States

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have increased the demand for transparency and explainability since wrong predictions may have severe consequences. Model explainability and interpretability are vital successful deployment of AI models in healthcare practices. AI applications' underlying reasoning needs to be transparent to clinicians in order to gain their trust. This paper presents a systematic review of XAI aspects and challenges in the healthcare domain. The primary goals of this study are to review various XAI methods, their challenges, and related machine learning models in healthcare. The methods are discussed under six categories: Features-oriented methods, global methods, concept models, surrogate models, local pixel-based methods, and human-centric methods. Most importantly, the paper explores XAI role in healthcare problems to clarify its necessity in safety-critical applications. The paper intends to establish a comprehensive understanding of XAI-related applications in the healthcare field by reviewing the related experimental results. To facilitate future research for filling research gaps, the importance of XAI models from different viewpoints and their limitations are investigated. © 2023, The Authors. All rights reserved.

关键词： Decision making

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Corrigendum: “Provably-secure electronic cash based on certicateless partially-blind signatures”

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Electronic Commerce Research and Applications 2013年第1期12卷 60-60页

作者： Lei Zhang Futai Zhang Bo Qin Shubo Liu East China Normal University Software Engineering Institute Shanghai Key Laboratory of Trustworthy Computing Shanghai China Universitat Rovira i Virgili Department of Computer Engineering and Mathematics UNESCO Chair in Data Privacy Tarragona Catalonia Spain Nanjing Normal University School of Computer Science and Technology China Xi’an University of Technology School of Science Department of Maths China Wuhan University School of Computer Science Wuhan China

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Micro-Expression Recognition based on 2D Gabor Filter and Sparse Representation

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Journal of Physics: Conference Series 2017年第1期787卷

作者： Hao Zheng Key Laboratory of Trusted Cloud Computing and Big Data Analysis School of Information Engineering Nanjing XiaoZhuang University Nanjing China MOE Key Laboratory of Computer Network and Information Integration School of Computer Science and Engineering Southeast University Nanjing China State Key Laboratory for Novel Software Technology Nanjing University Nanjing China

Micro-expression recognition is always a challenging problem for its quick facial expression. This paper proposed a novel method named 2D Gabor filter and Sparse Representation (2DGSR) to deal with the recognition of micro-expression. In our method, 2D Gabor filter is used for enhancing the robustness of the variations due to increasing the discrimination power. While the sparse representation is applied to deal with the subtlety, and cast recognition as a sparse approximation problem. We compare our method to other popular methods in three spontaneous micro-expression recognition databases. The results show that our method has more excellent performance than other methods.

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Erratum to: An improved block-based matching algorithm of copy-move forgery detection

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Multimedia Tools and Applications 2017年第12期77卷 15111-15111页

作者： Lai, Yuecong Huang, Tianqiang Lin, Jing Lu, Henan School of Mathematics and Computer Science Fujian Normal University Fuzhou China Faculty of Software Fujian Normal University Fuzhou China Fujian Engineering Research Center of Public Service Big Data Mining and Application Fujian Normal University Fuzhou China

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The mechanism of bone healing after traumatic brain injury

Brain‐X

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Brain‐X 2023年第3期1卷

作者： Yuan Xiong Wenbin Zhong Bobin Mi School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore Singapore Department of Orthopedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Contribution: Data curation Resources Software Supervision Writing - original draft Contribution: Data curation Software Supervision Writing - original draft Contribution: Conceptualization Investigation Supervision Validation Visualization Writing - review & editing

A growing body of evidence suggests that patients who experience traumatic brain injuries (TBIs) exhibit significantly shorter healing periods compared to those with isolated fractures. However, the precise underlying mechanism behind this phenomenon remains unclear. Recent studies have shed light on the potential role of hormonal signals and neural circuits originating in the hypothalamus, which play vital roles in regulating the skeletal system. Despite these advances, there is a lack of comprehensive research summarizing the crucial role of bone healing in TBIs and the underlying mechanisms. This review aimed to explore the underlying mechanisms responsible for the accelerated bone healing observed in TBI patients, with a specific focus on the intricate crosstalk between TBI and bone remodeling. Additionally, we comprehensively discuss and summarize the beneficial effects of TBI on the skeletal system and examine the TBI-induced signaling pathways that result in accelerated fracture healing and bone remodeling. By dissecting these pathways, we aim to identify potential targets for intervention and bone repair promotion.

关键词： bone crosstalk mechanisms TBI

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